Edward J Filardo

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
    Edward J Filardo
    Department of Medicine, Division of Clinical Pharmacology, Rhode Island Hospital and Brown University, Aldrich Bldg Rm 718, 593 Eddy Street, Providence, RI 02903, USA
    J Steroid Biochem Mol Biol 80:231-8. 2002
  2. ncbi Association of the membrane estrogen receptor, GPR30, with breast tumor metastasis and transactivation of the epidermal growth factor receptor
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
    Steroids 73:870-3. 2008
  3. ncbi Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30
    Jeffrey A Quinn
    Department of Medicine, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Mol Endocrinol 23:1052-64. 2009
  4. ncbi Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis
    Edward J Filardo
    Department of Surgery, Rhode Island Hospital, and Brown University, Providence, Rhode Island 02903, USA
    Mol Endocrinol 16:70-84. 2002
  5. ncbi Retrograde transport of the transmembrane estrogen receptor, G-protein-coupled-receptor-30 (GPR30/GPER) from the plasma membrane towards the nucleus
    Shi Bin Cheng
    Division of Hematology and Oncology Rhode Island Hospital and Brown University School of Medicine Providence, RI 02903, USA
    Steroids 76:892-6. 2011
  6. ncbi GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
    Trends Endocrinol Metab 16:362-7. 2005
  7. ncbi Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital, and Department of Pathology, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Clin Cancer Res 12:6359-66. 2006
  8. ncbi Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway
    Shi Bin Cheng
    Division of Hematology and Oncology, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
    J Biol Chem 286:22441-55. 2011

Collaborators

Detail Information

Publications8

  1. ncbi Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
    Edward J Filardo
    Department of Medicine, Division of Clinical Pharmacology, Rhode Island Hospital and Brown University, Aldrich Bldg Rm 718, 593 Eddy Street, Providence, RI 02903, USA
    J Steroid Biochem Mol Biol 80:231-8. 2002
    ..This novel mechanism by which estrogen activates growth factor-dependent signaling and its implications for breast cancer biology are discussed further in this review...
  2. ncbi Association of the membrane estrogen receptor, GPR30, with breast tumor metastasis and transactivation of the epidermal growth factor receptor
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
    Steroids 73:870-3. 2008
    ....
  3. ncbi Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30
    Jeffrey A Quinn
    Department of Medicine, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Mol Endocrinol 23:1052-64. 2009
    ..Our results suggest that GPR30 coordinates estrogen-mediated FN matrix assembly and growth factor release in human breast cancer cells via a Shc-dependent signaling mechanism that activates integrin alpha5beta1...
  4. ncbi Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis
    Edward J Filardo
    Department of Surgery, Rhode Island Hospital, and Brown University, Providence, Rhode Island 02903, USA
    Mol Endocrinol 16:70-84. 2002
    ....
  5. ncbi Retrograde transport of the transmembrane estrogen receptor, G-protein-coupled-receptor-30 (GPR30/GPER) from the plasma membrane towards the nucleus
    Shi Bin Cheng
    Division of Hematology and Oncology Rhode Island Hospital and Brown University School of Medicine Providence, RI 02903, USA
    Steroids 76:892-6. 2011
    ..g. ?1AR) or are degraded in lysosomes (e.g. CXCR4). The accumulation of GPER in the perinuclear space and its possible significance for attenuating estrogen action via this newly recognized membrane estrogen receptor is discussed herein...
  6. ncbi GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
    Trends Endocrinol Metab 16:362-7. 2005
    ..Thus, estrogen can signal by the same mechanism as various other hormones, through a specific 7TM receptor...
  7. ncbi Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital, and Department of Pathology, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Clin Cancer Res 12:6359-66. 2006
    ..Here, the significance of GPR30 in human breast cancer was evaluated by comparing its relationship to steroid hormone receptor expression and tumor progression variables...
  8. ncbi Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway
    Shi Bin Cheng
    Division of Hematology and Oncology, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
    J Biol Chem 286:22441-55. 2011
    ..Our results provide an explanation as to why GPER is not readily detected on the cell surface in some cell types and further suggest that TGN serves as the checkpoint for degradation of endocytosed GPER...