Research Topics
| Helene D BenvenisteSummaryAffiliation: Brookhaven National Laboratory Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
MR microscopy and high resolution small animal MRI: applications in neuroscience researchHelene Benveniste
Medical Department, Brookhaven National Laboratory, Building 490, 30 Bell Avenue, Upton, NY 11793, USA
Prog Neurobiol 67:393-420. 2002..We also take a critical look at the biological information that small animal (rodent) MR imaging has provided in neuroscience research...- Anatomical and functional phenotyping of mice models of Alzheimer's disease by MR microscopyHelene Benveniste
Brookhaven National Laboratory, Medical Department, Bldg 490, 30 Bell Avenue, Upton, NY 11973, USA
Ann N Y Acad Sci 1097:12-29. 2007..We will present MRM data of brain and cardiac phenotyping in transgenic mouse models with behavioral deficits... - Glutamate, microdialysis, and cerebral ischemia: lost in translation?Helene Benveniste
Department of Anesthesiology, Stony Brook University, New York 11794, USA
Anesthesiology 110:422-5. 2009..It is suggested that the large increase in the content of extracellular glutamate and aspartate in the hippocampus induced by the ischemia may be one of the causal factors in the damage to certain neurons observed after ischemia... - Translational neuroscience and magnetic-resonance microscopyHelene Benveniste
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Lancet Neurol 5:536-44. 2006..Two of the major magnetic-resonance microscopy applications in the neurosciences-structural and functional magnetic-resonance microscopy-will be reviewed... - Cocaine is pharmacologically active in the nonhuman primate fetal brainHelene Benveniste
Department of Anesthesiology, Stony Brook University, Stony Brook, NY 11794, USA
Proc Natl Acad Sci U S A 107:1582-7. 2010.... - Maternal and fetal 11C-cocaine uptake and kinetics measured in vivo by combined PET and MRI in pregnant nonhuman primatesHelene Benveniste
Medical Department, Brookhaven National Laboratory, Upton, New York 11793, USA
J Nucl Med 46:312-20. 2005..Here, we evaluate the utility of PET to measure the uptake and distribution of (11)C-cocaine in the third-trimester fetus... - Maternal-fetal in vivo imaging: a combined PET and MRI studyHelene Benveniste
Medical Department, Brookhaven National Laboratory, Upton, New York 11793, USA
J Nucl Med 44:1522-30. 2003.... - Differential effects of anesthetics on cocaine's pharmacokinetic and pharmacodynamic effects in brainCongwu Du
Department of Anesthesiology, State University of New York at Stony Brook, Stony Brook, NY, USA
Eur J Neurosci 30:1565-75. 2009.... - Computed tomography of amyloid plaques in a mouse model of Alzheimer's disease using diffraction enhanced imagingDean M Connor
National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA
Neuroimage 46:908-14. 2009..Several anatomical structures, including hippocampal subregions and white matter tracks, were also observed. Thus, DEI has strong promise in early diagnosis of AD, as well as general studies of the mouse brain... - The effect of intravenous lidocaine on brain activation during non-noxious and acute noxious stimulation of the forepaw: a functional magnetic resonance imaging study in the ratZhongchi Luo
Departments of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York, USA
Anesth Analg 108:334-44. 2009..Here, we therefore characterized the effect of systemic lidocaine on the brain's response to innocuous and acute noxious stimulation in the rat using functional magnetic resonance imaging (fMRI)... - The effects of cocaine on regional brain glucose metabolism is attenuated in dopamine transporter knockout micePanayotis K Thanos
Behavioral Neuropharmacology Lab, Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
Synapse 62:319-24. 2008..The greater baseline metabolism in DAT(-/-) than DAT(+/+) mice in cerebellum (brain region mostly devoid of DAT) suggests that dopamine indirectly regulates activity of these brain regions... - PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and ( --)-cocaineJoanna S Fowler
Brookhaven National Laboratory, Upton, New York, USA
J Nucl Med 48:1724-32. 2007.... - Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodentsPanayotis K Thanos
Behavioral Neuropharmacology and Neuroimaging Lab, Medical Department, Building 490, Brookhaven National Laboratory, Upton, NY 11973 5000, United States
Pharmacol Biochem Behav 87:426-33. 2007.... - Cocaine increases the intracellular calcium concentration in brain independently of its cerebrovascular effectsCongwu Du
Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
J Neurosci 26:11522-31. 2006..These findings support the use of calcium channel blockers as a strategy to minimize the neurotoxic effects of cocaine... - Interlaced x-ray microplanar beams: a radiosurgery approach with clinical potentialF Avraham Dilmanian
Medical Department, National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA
Proc Natl Acad Sci U S A 103:9709-14. 2006..These findings strongly suggest potential application of interlaced microbeams to treat tumors or to ablate nontumorous abnormalities with minimal damage to surrounding normal tissue... - Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxYu Shin Ding
Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Neurochem 94:337-51. 2005..Thus, to our knowledge (S,S)-[11C]MRB remains by far the most promising NET ligand for PET studies... - Simultaneous detection of blood volume, oxygenation, and intracellular calcium changes during cerebral ischemia and reperfusion in vivo using diffuse reflectance and fluorescenceCongwu Du
Brookhaven National Laboratory, Medical Department, Upton, New York 11973 5000, USA
J Cereb Blood Flow Metab 25:1078-92. 2005.... - Transient focal ischemia results in persistent and widespread neuroinflammation and loss of glutamate NMDA receptorsJasbeer Dhawan
Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY 11973, USA
Neuroimage 51:599-605. 2010..Persistent, bilateral loss of NMDAR, probably reflecting receptor down regulation and internalization, may be responsible for some of the effects of stroke on cognitive function which cannot be explained by infarction alone... - Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brainLouis N Manganas
SUNY Stony Brook, Stony Brook, NY 11794, USA
Science 318:980-5. 2007..Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders...
Research Grants
- A 3D C57BL6/J MOUSE BRAIN ATLAS MAGNETIC RESONANCE MICROHelene Benveniste; Fiscal Year: 2003..Further, a probabilistic (averaged from many brain specimens) atlas with error estimations will be created for registration of actual gene-expression data. ..