Research Topics
| B R BrodieSummaryCountry: USA Publications
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Publications
Facilitated percutaneous coronary interventionB R Brodie
Moses Cone Heart and Vascular Center, 313, Moses Cone Hospital, North Elm Street, Greensboro, NC 27408, USA
Heart 91:1527-9. 2005
Door-to-balloon time with primary percutaneous coronary intervention for acute myocardial infarction impacts late cardiac mortality in high-risk patients and patients presenting early after the onset of symptomsBruce R Brodie
LeBauer Cardiovascular Research Foundation and the Moses Cone Heart and Vascular Center, Greensboro, North Carolina, USA
J Am Coll Cardiol 47:289-95. 2006..The purpose of this study was to evaluate the impact of door-to-balloon time with primary percutaneous coronary intervention (PCI) on late cardiac mortality...
Poor long-term patient and graft survival after primary percutaneous coronary intervention for acute myocardial infarction due to saphenous vein graft occlusionBruce R Brodie
LeBauer Cardiovascular Research Foundation, Moses Cone Heart and Vascular Center, Greensboro, North Carolina, USA
Catheter Cardiovasc Interv 65:504-9. 2005..The introduction of new adjunctive therapies (distal protection, thrombectomy, and drug-eluting stents) may improve short-term outcomes, but improved long-term outcomes may require new and more durable revascularization strategies...
Relation between electrocardiographic ST-segment resolution and early and late outcomes after primary percutaneous coronary intervention for acute myocardial infarctionBruce R Brodie
LeBauer Cardiovascular Research Foundation and the Moses Cone Heart and Vascular Center, Greensboro, North Carolina, USA
Am J Cardiol 95:343-8. 2005..These data support the use of STR as a simple method to stratify patients by risk after primary PCI for acute myocardial infarction and support the use of STR as a surrogate end point in reperfusion trials of acute myocardial infarction...
Impact of treatment delays on outcomes of primary percutaneous coronary intervention for acute myocardial infarction: analysis from the CADILLAC trialBruce R Brodie
LeBauer Cardiovascular Research Foundation and Moses Cone Heart and Vascular Center, Greensboro, NC, USA
Am Heart J 151:1231-8. 2006..The impact of treatment delays on outcomes after primary percutaneous coronary intervention for acute myocardial infarction is controversial...
Adjunctive thrombectomy with primary percutaneous coronary intervention for ST-elevation myocardial infarction: summary of randomized trialsBruce R Brodie
Moses Cone Heart and Vascular Center, LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA
J Invasive Cardiol 18:C24-7. 2006..Adjunctive thrombectomy can effectively remove thrombus, and it seems appropriate to perform adjunctive thrombectomy prior to primary PCI in patients with large thrombus burden...
Comparison of late survival in patients with cardiogenic shock due to right ventricular infarction versus left ventricular pump failure following primary percutaneous coronary intervention for ST-elevation acute myocardial infarctionBruce R Brodie
LeBauer Cardiovascular Research Foundation and Moses Cone Heart and Vascular Center, Greensboro, North Carolina, USA
Am J Cardiol 99:431-5. 2007..This is in contrast to most previous reports. Improved survival is likely related to lower risk profile and previously documented substantial recovery of RV function after primary PCI...
Impact of time to treatment on myocardial reperfusion and infarct size with primary percutaneous coronary intervention for acute myocardial infarction (from the EMERALD Trial)Bruce R Brodie
LeBauer Cardiovascular Research Foundation and Moses Cone Heart and Vascular Center, Greensboro, North Carolina, USA
Am J Cardiol 99:1680-6. 2007..Incremental delays in reperfusion after 2 hours have less effect on infarct size. These data have implications regarding the triage of patients for primary PCI...
Very late stent thrombosis after primary percutaneous coronary intervention with bare-metal and drug-eluting stents for ST-segment elevation myocardial infarction: a 15-year single-center experienceBruce Brodie
LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina 27408, USA
JACC Cardiovasc Interv 4:30-8. 2011..The purpose of this study was to assess the frequency of very late stent thrombosis (VLST) after stenting with bare-metal stents (BMS) and drug-eluting stents (DES) for ST-segment elevation myocardial infarction (STEMI)...
Outcomes with drug-eluting stents versus bare metal stents in acute ST-elevation myocardial infarction: results from the Strategic Transcatheter Evaluation of New Therapies (STENT) GroupBruce R Brodie
The LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA
Catheter Cardiovasc Interv 72:893-900. 2008..This study compares outcomes with drug-eluting stents (DES) versus bare metal stents (BMS) in patients with ST-elevation myocardial infarction (STEMI)...
What anti-thrombotic therapy is best with primary PCI for acute ST elevation myocardial infarction: how should the HORIZONS trial change current practice?Bruce R Brodie
LeBauer Cardiovascular Research Foundation, Moses Cone Heart and Vascular Center, Greensboro, North Carolina, USA
Catheter Cardiovasc Interv 71:816-21. 2008..In the latter case, platelet glycoprotein IIb/IIIa inhibitors would be used as a bail-out strategy...
Outcomes and complications with off-label use of drug-eluting stents: results from the STENT (Strategic Transcatheter Evaluation of New Therapies) groupBruce R Brodie
LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA
JACC Cardiovasc Interv 1:405-14. 2008..This study evaluates outcomes and complications in patients treated with drug-eluting stents (DES) for "off-label" indications...
Outcomes with drug-eluting versus bare-metal stents in saphenous vein graft intervention results from the STENT (strategic transcatheter evaluation of new therapies) groupBruce R Brodie
The LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina 27408, USA
JACC Cardiovasc Interv 2:1105-12. 2009..This study compares outcomes of drug-eluting stents (DES) versus bare-metal stents (BMS) in patients undergoing saphenous vein graft (SVG) intervention...
Aspiration thrombectomy with primary PCI for STEMI: review of the data and current guidelinesBruce R Brodie
LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA
J Invasive Cardiol 22:2B-5B. 2010....
Benefit of coronary reperfusion before intervention on outcomes after primary angioplasty for acute myocardial infarctionB R Brodie
Department of Medicine, the Moses H Cone Memorial Hospital, and the LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA
Am J Cardiol 85:13-8. 2000..This should encourage new strategies to establish reperfusion before "primary" angioplasty with "catheterization laboratory friendly" platelet inhibitors and/or low-dose thrombolytic drugs...
Prediction of one-year mortality among 30-day survivors after primary percutaneous coronary interventionsRajendra H Mehta
Duke Clinical Research Institute, Durham, North Carolina, USA
Am J Cardiol 97:817-22. 2006....
Drug-eluting stents for emerging treatment strategies in complex lesionsCharles A Simonton
Sanger Clinic, PA, Carolinas Heart Institute, Charlotte, North Carolina, USA
Rev Cardiovasc Med 6:S38-47. 2005..Important data regarding much larger groups of these patient cohorts will emerge over the next year, to help guide the broader application of DES in "real-world" practice...
Importance of time-to-reperfusion in patients with acute myocardial infarction with and without cardiogenic shock treated with primary percutaneous coronary interventionBruce R Brodie
Department of Medicine, the Moses H Cone Memorial Hospital, and the LeBauer Cardiovascular Research Foundation, Greensboro, NC, USA
Am Heart J 145:708-15. 2003..Previous studies evaluating the importance of time-to-treatment with primary PCI have not analyzed patients with cardiogenic shock separately...
Comparison of coronary stenting versus conventional balloon angioplasty on five-year mortality in patients with acute myocardial infarction undergoing primary percutaneous coronary interventionRajendra H Mehta
Duke Clinical Research Institute, Durham, North Carolina, USA
Am J Cardiol 96:901-6. 2005..These data support the routine use of coronary stenting in most patients undergoing primary PCI, when feasible...
When is door-to-balloon time critical? Analysis from the HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) and CADILLAC (Controlled Abciximab and Device Investigation to Lower Late Angioplasty ComplicatioBruce R Brodie
LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina
J Am Coll Cardiol 56:407-13. 2010..Our objective was to evaluate the impact of door-to-balloon time (DBT) on mortality depending on clinical risk and time to presentation...
Is adjunctive balloon postdilatation necessary after coronary stent deployment? Final results from the POSTIT trialBruce R Brodie
LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina 27403, USA
Catheter Cardiovasc Interv 59:184-92. 2003..2 to 7.8 +/- 2.3 mm(2), and MSD increased from 2.6 +/- 0.5 to 2.8 +/- 0.4 mm. These data stress the continued need for adjunctive balloon postdilatation with modern stent delivery systems. Cathet Cardiovasc Intervent 2003;59:184-192...
Effect of treatment delay on outcomes in patients with acute myocardial infarction transferred from community hospitals for primary percutaneous coronary interventionBruce R Brodie
Department of Medicine, Moses Cone Heart and Vascular Center, Greensboro, North Carolina 27403, USA
Am J Cardiol 89:1243-7. 2002..These data should encourage further randomized trials to evaluate the role of transfer for mechanical reperfusion in patients presenting to community hospitals with acute myocardial infarction...
Impact of stenting and abciximab in patients with diabetes mellitus undergoing primary angioplasty in acute myocardial infarction (the CADILLAC trial)Thomas D Stuckey
LeBauer Cardiovascular Research Foundation and Moses Cone Heart and Vascular Center, Greensboro, North Carolina 27401, USA
Am J Cardiol 95:1-7. 2005....
Importance of time to reperfusion on outcomes with primary coronary angioplasty for acute myocardial infarction (results from the Stent Primary Angioplasty in Myocardial Infarction Trial)B R Brodie
LeBauer Cardiovascular Research Foundation, Moses Cone Hospital, Greensboro, North Carolina, USA
Am J Cardiol 88:1085-90. 2001..These data may also have implications regarding the triage of patients with AMI for primary PTCA...
Adjunctive balloon postdilatation after stent deployment: is it still necessary with drug-eluting stents?Bruce R Brodie
Moses Cone Heart and Vascular Center, LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina 27401, USA
J Interv Cardiol 19:43-50. 2006..Despite the lack of evidence from randomized clinical trials, we believe the observational data support the use of adjunctive balloon postdilatation following deployment of DES in the great majority of patients...
Facilitated PCI in patients with ST-elevation myocardial infarctionStephen G Ellis
Department of Cardiovascular Medicine, The Cleveland Clinic, F25, 9500 Euclid Ave, Cleveland, OH 44195, USA
N Engl J Med 358:2205-17. 2008....
Bivalirudin during primary PCI in acute myocardial infarctionGregg W Stone
Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY 10022, USA
N Engl J Med 358:2218-30. 2008..The safety and efficacy of bivalirudin in high-risk patients are unknown...
Contemporary outcomes of rescue percutaneous coronary intervention for acute myocardial infarction: comparison with primary angioplasty and the role of distal protection devices (EMERALD trial)George Dangas
Columbia University Medical Center, Cardiovascular Research Foundation, New York, NY, USA
Am Heart J 155:1090-6. 2008..The value of distal protection devices during rescue PCI has not been studied...
Left ventricular remodeling and systolic deterioration in acute myocardial infarction: findings from the Stent-PAMI StudyStephen J Mattichak
William Beaumont Hospital, Royal Oak, MI 48073, USA
J Interv Cardiol 18:255-60. 2005..We sought to determine predictors of LVSD by comparing demographic, procedural, angiographic variables, and 6-month major adverse cardiac events (MACE) in patients with and without LVSD after MI...
One-year survival in patients with acute myocardial infarction and a saphenous vein graft culprit treated with primary angioplastyThanh T Nguyen
William Beaumont Hospital, Royal Oak, Michigan 48073, USA
Am J Cardiol 91:1250-4. 2003
AngioJet experience from the multi-center STENT RegistryCharles A Simonton
Sanger Clinic, Carolinas Heart Institute, Charlotte, North Carolina 28203, USA
J Invasive Cardiol 18:C22-3. 2006..To explore the utilization and clinical outcomes of AngioJet Rheolytic thrombectomy from the Strategic Transcatheter Evaluation of New Therapies (STENT) multi-center prospective registry from May 2003 through December 2005...
Predictors of infarct size after primary coronary angioplasty in acute myocardial infarction from pooled analysis from four contemporary trialsGregg W Stone
Columbia University Medical Center, Cardiovascular Research Foundation, New York City, NY, USA
Am J Cardiol 100:1370-5. 2007....
Gender differences in outcomes after primary angioplasty versus primary stenting with and without abciximab for acute myocardial infarction: results of the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trAlexandra J Lansky
College of Physicians and Surgeons, Columbia University, and the Cardiovascular Research Foundation, New York, NY 10022, USA
Circulation 111:1611-8. 2005..Whether contemporary interventional treatment strategies have improved outcomes for women compared with men is unknown...
Does proximal location of culprit lesion confer worse prognosis in patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction?Kishore J Harjai
Guthrie Clinic, Sayre, Pennsylvania 18840, USA
J Interv Cardiol 19:285-94. 2006..In conclusion, proximal location of the culprit lesion is a strong independent predictor of worse in-hospital outcomes in patients with STEMI undergoing primary PCI...
Impact of collateral flow on myocardial reperfusion and infarct size in patients undergoing primary angioplasty for acute myocardial infarctionPaul Sorajja
Mayo Clinic, Rochester, MN, USA
Am Heart J 154:379-84. 2007..We sought to examine the impact of baseline collateral flow to the IRA on reperfusion success, infarct size, and clinical outcomes in patients undergoing primary PCI for acute myocardial infarction (AMI)...
Integrating complementary medicine into cardiovascular medicine. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and InJohn H K Vogel
J Am Coll Cardiol 46:184-221. 2005
Distal microcirculatory protection during percutaneous coronary intervention in acute ST-segment elevation myocardial infarction: a randomized controlled trialGregg W Stone
Columbia University Medical Center and Cardiovascular Research Foundation, New York, NY 10022, USA
JAMA 293:1063-72. 2005....
Editorial comment: which is the preferred drug-eluting stent?Bruce R Brodie
J Interv Cardiol 19:39-42. 2006
Letter regarding article by Nallamothu et al, "Times to treatment in transfer patients undergoing primary percutaneous coronary intervention in the United states"Bruce R Brodie
Circulation 112:e99; author reply e99-100. 2005
Primary percutaneous coronary intervention at hospitals without on-site cardiac surgery: expanding the use of mechanical reperfusion for acute myocardial infarctionBruce R Brodie
J Am Coll Cardiol 43:1951-3. 2004
Variation in hospital length of stay in patients with acute myocardial infarction undergoing primary angioplasty and the need to change the diagnostic-related group systemBeth A Bartholomew
William Beaumont Hospital, Royal Oak, Michigan 48073, USA
Am J Cardiol 92:830-3. 2003..Our investigation suggests the need for a multi-tier diagnostic-related group system for patients with acute myocardial infarction treated with percutaneous coronary intervention...
Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study)David E Kandzari
Duke Clinical Research Institute, Durham, North Carolina 27715, USA
Am J Cardiol 93:636-9. 2004..5 degrees C) and was well tolerated, which supports the evaluation of adjunctive hypothermia in pivotal trials to limit infarct size and decrease reperfusion injury...
