Research Topics
Species | Abdulamaged M TraishSummaryAffiliation: Boston University Country: USA Publications
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Publications
Are the adverse effects of glitazones linked to induced testosterone deficiency?M Carruthers
Centre for Men s Health, 20 20 Harley Street, London, UK
Cardiovasc Diabetol 7:30. 2008..The higher incidence of side-effects with RGZ than PGZ, may be explained by a detailed study of the mechanism by which glitazones down-regulate androgen biosynthesis and action, resulting in a state of androgen deficiency...- Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markersNoel N Kim
Institute for Sexual Medicine, Department of Urology, Boston University School of Medicine, Boston, USA
BMC Physiol 6:4. 2006..We further related these changes with estrogen receptor alpha (ERalpha) and androgen receptor (AR) expression... - Immunodetection of nmt55/p54nrb isoforms in human breast cancerM Pavao
Department of Biochemistry, Boston University School of Medicine, Center for Advanced Biomedical Research, 700 Albany Street, W607, Boston, MA 02118, USA
BMC Cancer 1:15. 2001..The objective of this study was to determine if this reduced expression in human breast tumors was attributed to the regulation of mRNA transcription or the presence of altered forms of this protein... - The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunctionAbdulmaged M Traish
Department of Biochemistry and Urology, Boston University School of Medicine, Boston, MA 02118, USA
J Androl 30:10-22. 2009..Specifically, we will focus on exploring the relationships between hypogonadism, obesity, MetS, and ED... - Androgens in female genital sexual arousal function: a biochemical perspectiveAbdulmaged M Traish
Departments of Biochemistry and Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Sex Marital Ther 28:233-44. 2002..Androgens modulate the growth and function of female genital sexual organs included the labia, vagina, and clitoris. This article discusses the potential role for androgens in facilitating female genital sexual arousal... - Is vardenafil "noninferior" or superior to sildenafil in the management of erectile dysfunction? Revisiting the biochemical, physiological, and clinical evidenceAbdulmaged Traish
Boston University-Laboratory for Sexual Medicine Research, Boston, MA 02118, USA
J Sex Med 5:1762-8; discussion 1768-9. 2008 - Role of androgens in female genital sexual arousal: receptor expression, structure, and functionAbdulmaged M Traish
Department of Biochemistry, Boston University School of Medicine, Massachusetts, Boston 02118, USA
Fertil Steril 77:S11-8. 2002..In this article, we review the mechanisms of androgen action and discuss new data on the effects of androgens in vaginal and clitoral tissues... - Biochemical and physiological mechanisms of female genital sexual arousalAbdulmaged M Traish
Arch Sex Behav 31:393-400. 2002..A comprehensive and integral understanding of female sexual function requires detailed investigation of the vascular, neurological (central and peripheral), and structural components of this complex physiological process... - Are the Endocrine Society's Clinical Practice Guidelines on Androgen Therapy in Women misguided? A commentaryAbdulmaged Traish
Laboratory for Sexual Medicine Research, Boston University, Boston, MA 02118, USA
J Sex Med 4:1223-34; discussion 1234-5. 2007.... - Dehydroepiandrosterone (DHEA)--a precursor steroid or an active hormone in human physiologyAbdulmaged M Traish
Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
J Sex Med 8:2960-82; quiz 2983. 2011..In the central nervous system, DHEA is considered a neurosteroid with a wide range of functions... - Effects of medical or surgical castration on erectile function in an animal modelAbdulmaged M Traish
Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
J Androl 24:381-7. 2003..We conclude that androgen deprivation produces structural alterations in the corpus cavernosum leading to corporal veno-occlusive dysfunction... - Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidenceAbdulmaged M Traish
Department of Biochemistry and Urology, Institute for Sexual Medicine, Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, MA, USA
J Sex Med 3:382-404; discussion 404-7. 2006..Nevertheless, based on the preclinical and clinical data available in the literature, to date, we infer that androgens play a critical role in maintaining erectile physiology in humans... - The physiological role of androgens in penile erection: regulation of corpus cavernosum structure and functionAbdulmaged Traish
Boston University School of Medicine, Department of Urology, Boston, MA 02118, USA
J Sex Med 2:759-70. 2005.... - Weapons of penile smooth muscle destruction: androgen deficiency promotes accumulation of adipocytes in the corpus cavernosumA M Traish
Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Aging Male 8:141-6. 2005..Androgen deficiency promotes differentiation into adipogenic lineage, and accumulation of adipocytes in the corpus cavernosum may contribute to erectile dysfunction... - Adipocyte accumulation in penile corpus cavernosum of the orchiectomized rabbit: a potential mechanism for veno-occlusive dysfunction in androgen deficiencyAbdulmaged M Traish
Department of Biochemistry, Institute for Sexual Medicine, Boston University School of Medicine, 700 Albany St, Room W607, Boston, MA 02118, USA
J Androl 26:242-8. 2005..We hypothesize that androgen deprivation promotes differentiation of progenitor stroma cells into an adipogenic lineage producing fat-containing cells, thus altering erectile function... - Sex steroid hormones differentially regulate nitric oxide synthase and arginase activities in the proximal and distal rabbit vaginaA M Traish
Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
Int J Impot Res 15:397-404. 2003..We suggest that changes in vaginal blood flow and compliance may depend on the endocrine status and the levels of circulating androgens and estrogens... - Binding characteristics of [3H]delta(5)-androstene-3beta,17beta-diol to a nuclear protein in the rabbit vaginaAbdulmaged M Traish
Department of Biochemistry, Boston University School of Medicine, 700 Albany Street, Room W607, Boston, MA 02118, USA
Steroids 69:71-8. 2004..These data suggest that rabbit vaginal tissue expresses a novel binding protein which specifically binds delta(5)-androstene-3beta,17beta-diol and is distinct from the androgen and estrogen receptors... - Testosterone and cardiovascular disease: an old idea with modern clinical implicationsAbdulmaged M Traish
Department of Biochemistry and Urology, Boston University School of Medicine, Laboratories for Sexual Medicine, Institute for Sexual Medicine, Center for Advanced Biomedical Research, 700 Albany Street, W607, Boston, MA 02118, United States
Atherosclerosis 214:244-8. 2011..Emerging evidence indicates that androgens may provide a protective effect against the development and/or progression of atherosclerosis in men... - The dark side of testosterone deficiency: II. Type 2 diabetes and insulin resistanceAbdulamaged M Traish
Department of Biochemistry and Urology, Boston University School of Medicine, Boston, MA 02118, USA
J Androl 30:23-32. 2009.... - Androgens play a pivotal role in maintaining penile tissue architecture and erection: a reviewAbdulmaged M Traish
Department of Biochemistry, Institute for Sexual Medicine, Boston University School of Medicine, Center for Advanced Biomedical Research, 700 Albany St, W607, Boston, MA 02118, USA
J Androl 30:363-9. 2009..This knowledge has a profound impact on the potential use of androgens in the clinical setting to treat patients with erectile dysfunction... - Safety of physiological testosterone therapy in women: lessons from female-to-male transsexuals (FMT) treated with pharmacological testosterone therapyAbdulmaged M Traish
Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
J Sex Med 7:3758-64. 2010..This unsubstantiated fear has hampered progress in treating women with sexual dysfunction using T therapy in physiological doses to achieve circulating levels in the normal range... - Biochemical factors modulating female genital sexual arousal physiologyAbdulmaged M Traish
Boston University School of Medicine, Department of Biochemistry, Boston, MA 02118, USA
J Sex Med 7:2925-46. 2010..These hemodynamic events are mediated by a host of neurotransmitters and vasoactive agents... - Epidermal growth factor receptor expression escapes androgen regulation in prostate cancer: a potential molecular switch for tumour growthA M Traish
Department of Biochemistry and Urology, Boston University School of Medicine, Boston, MA 02118, USA
Br J Cancer 101:1949-56. 2009..We advance the hypothesis that a molecular switch, responsible for downregulating EGFR expression by androgens in the normal prostate, is either lost or modified in PCa... - Androgen deficiency and atherosclerosis: The lipid linkAbdulmaged M Traish
Department of Biochemistry and Urology, Boston University School of Medicine, Boston, MA 02118, USA
Vascul Pharmacol 51:303-13. 2009.... - Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunctionAbdulmaged M Traish
Department of Biochemistry and Urology, Boston University School of Medicine, MA 02118, USA
FEBS J 276:5755-67. 2009..Thus, clinical screening for the risk of erectile dysfunction in obese patients should include the assessment of waist circumference, testosterone levels, body mass index and physical inactivity... - Effects of castration and androgen replacement on erectile function in a rabbit modelA M Traish
Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
Endocrinology 140:1861-8. 1999..The results of this study demonstrate that androgen deprivation alters the functional responses and structure of erectile tissue... - Development of human and rabbit vaginal smooth muscle cell cultures: effects of vasoactive agents on intracellular levels of cyclic nucleotidesA Traish
Department of Urology, Center for Advanced Biomedical Research, Boston University School of Medicine, Massachusetts 02118, USA
Mol Cell Biol Res Commun 2:131-7. 1999.... - The brain, the penis and steroid hormones: clinical correlates with endothelial dysfunctionAbdulmaged M Traish
Department of Biochemistry and Urology, Boston University School of Medicine, Center for Advanced Biomedical Research, 700 Albany Street, Boston, MA 02118, USA
Curr Pharm Des 14:3723-36. 2008.... - Cyclic AMP regulates mRNA expression of alpha-1d and alpha-2a adrenergic receptors in cultured human corpus cavernosum smooth muscle cellsA Traish
Department of Urology, Boston University School of Medicine, MA 02118, USA
Int J Impot Res 12:S41-47. 2000..These observations further support the concept that erectile function is a balance between contractile and relaxatory processes, which in turn regulate structure and function of the corpora cavernosa... - Role of alpha adrenergic receptors in erectile functionA Traish
Department of Urology, Boston University School of Medicine, MA 02118, USA
Int J Impot Res 12:S48-63. 2000.... - The dark side of testosterone deficiency: III. Cardiovascular diseaseAbdulmaged M Traish
Department of Biochemistry and Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Androl 30:477-94. 2009..It should be emphasized, however, that androgen replacement therapy should be done with very thorough and careful monitoring for prostate diseases... - Testosterone therapy in women with gynecological and sexual disorders: a triumph of clinical endocrinology from 1938 to 2008Abdulmaged M Traish
Boston University School of Medicine, Department of Biochemistry, Boston, MA, USA
J Sex Med 6:334-51. 2009.... - Intracavernosal sildenafil facilitates penile erection independent of the nitric oxide pathwayI W McAuley
Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
J Androl 22:623-8. 2001.... - The evolving role of testosterone in the treatment of erectile dysfunctionR Shabsigh
Department of Urology, Columbia University, New York, NY 10032, USA
Int J Clin Pract 60:1087-92. 2006..Screening for hypogonadism may be useful in men with ED who fail prior PDE5 inhibitors, especially in populations at risk for hypogonadism such as type 2 diabetes and the metabolic syndrome... - Loss of expression of a 55 kDa nuclear protein (nmt55) in estrogen receptor-negative human breast cancerA M Traish
Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
Diagn Mol Pathol 6:209-21. 1997.... - Effects of ovariectomy and steroid hormones on vaginal smooth muscle contractilityN N Kim
Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Int J Impot Res 16:43-50. 2004..These observations suggest that steroid hormones may be important regulators of vaginal tissue structure and contractility... - Alpha-adrenergic receptor blockade by phentolamine increases the efficacy of vasodilators in penile corpus cavernosumN N Kim
Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
Int J Impot Res 12:S26-36. 2000..These findings suggest that antagonism of alpha-adrenergic signaling enables other independent relaxatory pathways to predominate within penile trabecular smooth muscle... - Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitorN N Kim
Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
Life Sci 69:2249-56. 2001..The more pronounced increase of cGMP in the presence of NO in intact cells suggests that vardenafil will be effective at lower doses than sildenafil under clinical conditions... - Development and characterization of monoclonal antibodies to a specific domain of human estrogen receptorA M Traish
Department of Biochemistry, Boston University School of Medicine, MA 02118
Steroids 55:196-208. 1990..These results demonstrate the development of site-specific MoAbs to the native form of the hER using synthetic peptides as immunogens... - Estrogen receptor antibodies: specificity and utility in detection, localization and analyses of estrogen receptor alpha and betaM Pavao
Department of Biochemistry, Center for Advanced Biomedical Research, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA
Steroids 66:1-16. 2001..The advent of new antibodies remains a powerful tool for assessment of ER expression and post-translational modification and receptor function in many experimental systems... - Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancerR Romieu-Mourez
Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118-2394, USA
Cancer Res 61:3810-8. 2001.... - Monoclonal antibodies to human endothelin-1: characterization and utilization in radioimmunoassay and immunocytochemistryA M Traish
Department of Biochemistry, Boston University, School of Medicine, MA 02118
Hybridoma 11:147-63. 1992.... - Monoclonal and polyclonal antibodies to human progesterone receptor peptide-(533-547) recognize a specific site in unactivated (8S) and activated (4S) progesterone receptor and distinguish between intact and proteolyzed receptorsA M Traish
Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118
Endocrinology 127:1167-75. 1990.... - Binding of site-directed monoclonal antibodies to an epitope located in the A/B region (amino acids 140-154) of human estrogen receptor-induced conformational changes in an epitope in the DNA-binding domainA M Traish
Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
Steroids 61:549-56. 1996..These data further suggest that the DNA-binding region is sensitive to conformational changes induced in the native protein... - Hemodynamic evaluation of the female sexual arousal response in an animal modelK Min
Department of Urology, Boston University School of Medicine, 700 Albany Street, W607, Boston, MA 02118, USA
J Sex Marital Ther 27:557-65. 2001.... - Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscleR B Moreland
Department of Urology, Boston University School of Medicine, Boston, Massachusetts, USA
Int J Impot Res 14:446-52. 2002..These data are consistent with the expression of functional DP receptors in human corpus cavernosum. This suggests the presence of an intact prostanoid autocrine system that may play a role in regulating penile erectile function... - Binding of type II nuclear receptors and estrogen receptor to full and half-site estrogen response elements in vitroC M Klinge
Department of Biochemistry, The University of Louisville School of Medicine, Louisville, KY 40292, USA
Nucleic Acids Res 25:1903-12. 1997.... - Endothelin: localization, synthesis, activity, and receptor types in human penile corpus cavernosumI Saenz de Tejada
Department of Urology, Boston University Medical Center, Massachusetts 02118
Am J Physiol 261:H1078-85. 1991.... - Pilot study of the endothelin-A receptor selective antagonist BMS-193884 for the treatment of erectile dysfunctionNoel N Kim
Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
J Androl 23:76-83. 2002..The disparity between the laboratory and clinical studies suggests that there may be differences between species with regard to the role of endothelin in erectile function... - Laser oximetry: A novel noninvasive method to determine changes in penile hemodynamics in an anesthetized rabbit modelSeong Choi
Department of Urology, Kosin University School of Medicine, Pusan, South Korea
J Androl 23:278-83. 2002..Its sensitivity in detecting small changes in oxyhemoglobin concentration and its noninvasive nature make it advantageous over invasive methods such as ICP monitoring and laser Doppler flowmetry... - Efficacy of vardenafil and sildenafil in facilitating penile erection in an animal modelSeong Choi
Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
J Androl 23:332-7. 2002..On the basis of the biochemical data and physiological responses from this study, further clinical evaluation of vardenafil as treatment for erectile dysfunction is warranted... - Pharmacological and functional characterization of novel EP and DP receptor agonists: DP1 receptor mediates penile erection in multiple speciesNadia Brugger
EMD Serono Research Institute Medicinal Chemistry, Rockland, MA, USA
J Sex Med 5:344-56. 2008..Despite the widespread use of prostaglandin E(1) as an efficacious treatment for male erectile dysfunction for more than two decades, research on prostanoid function in penile physiology has been limited... - Biochemical and functional characterization of alpha-adrenergic receptors in the rabbit vaginaNoel N Kim
Department of Urology, School of Medicine, Boston University, 700 Albany St W607, Boston, MA 02118, USA
Life Sci 71:2909-20. 2002..Thus, vaginal tissue expresses functional alpha-1 and alpha-2 AR, which modulate vaginal smooth muscle contractility and genital engorgement... - An in vivo rat model to investigate female vaginal arousal responseSoo Woong Kim
Department of Urology, Seoul National University College of Medicine, Seoul, Korea
J Urol 171:1357-61. 2004..In addition, we used this model to demonstrate the important role of the NO-cyclic guanosine monophosphate pathway in vaginal arousal... - Testosterone and erectile function: from basic research to a new clinical paradigm for managing men with androgen insufficiency and erectile dysfunctionAbdulmaged M Traish
Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
Eur Urol 52:54-70. 2007.... - Modulation of rat vaginal blood flow and estrogen receptor by estradiolSoo Woong Kim
Department of Urology, Seoul National University College of Medicine, Seoul, Korea
J Urol 172:1538-43. 2004..These changes were paralleled by ERalpha protein levels. CONCLUSIONS: Estradiol is crucial for maintaining optimal vaginal blood flow in the rat. Lower levels of plasma estradiol trigger compensatory ERalpha up-regulation... - Role of arginase in the male and female sexual arousal responseNoel N Kim
Department of Urology and Institute for Sexual Medicine, Boston University School of Medicine, Boston, MA 02118, USA
J Nutr 134:2873S-2879S; discussion 2895S. 2004.... - Reperfusion of ischemic corporal tissue: physiologic and biochemical changes in an animal model of ischemic priapismRicardo Munarriz
Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Urology 62:760-4. 2003..There is a need to investigate the utility of ROS scavengers and antioxidants in the management of ischemic priapism... - Differential effects of estradiol, progesterone, and testosterone on vaginal structural integrityMonica A Pessina
Department of Anatomy and Neurobiology, Institute for Sexual Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Endocrinology 147:61-9. 2006..Present observations also suggest that combined replacement regimens may be required for an optimal physiological response... - Human arginase II: crystal structure and physiological role in male and female sexual arousalEvis Cama
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6323, USA
Biochemistry 42:8445-51. 2003..Therefore, arginase II is a potential target for the treatment of male and female sexual arousal disorders... - Testosterone increases blood flow and expression of androgen and estrogen receptors in the rat vaginaAbdulmaged M Traish
Departments of Biochemistry, and Urology, Boston University School of Medicine, Boston, MA, USA
J Sex Med 4:609-19. 2007..The mechanisms by which testosterone modulates female genital sexual arousal responses are poorly understood... - Physiology of female sexual function: animal modelsAnnamaria Giraldi
Rigshospitalet, Copenhagen, Denmark
J Sex Med 1:237-53. 2004..Serotonin and dopamine may modulate UG reflex activity. CONCLUSIONS: More research is needed in animal models in the physiology of female sexual function... - Dose-response relationship between testosterone and erectile function: evidence for the existence of a critical thresholdAbdullah Armagan
Department of Urology, Suleyman Demirel University Faculty of Medicine, Isparta, Turkey
J Androl 27:517-26. 2006..However, different androgen-dependent tissues may exhibit varying sensitivities to circulating testosterone with regard to growth and function... - Cocaine and ephedrine-induced priapism: case reports and investigation of potential adrenergic mechanismsRicardo Munarriz
Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Urology 62:187-92. 2003..However, chronic use of cocaine or ephedrine may deplete norepinephrine from sympathetic nerve terminals, leading to priapism... - Effects of ovariectomy and estrogen replacement on basal and pelvic nerve stimulated vaginal lubrication in an animal modelKweonsik Min
Department of Urology, Inje University School of Medicine, Pusan, South Korea
J Sex Marital Ther 29:77-84. 2003..Estrogen replacement normalized lubrication values and tissue wet weight to control levels. In conclusion, vaginal tissue integrity and lubrication are diminished by ovariectomy and are normalized by estrogen replacement... - Differential regulation of the expression of estrogen, progesterone, and androgen receptors by sex steroid hormones in the vagina: immunohistochemical studiesMonica A Pessina
Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
J Sex Med 3:804-14. 2006..CONCLUSION: Estradiol down-regulated ERalpha and up-regulated PR expression in the vagina, suggesting this may be a mechanism to prevent continued proliferation of the epithelium by surges of estradiol during the estrous cycle... - Selective P2Y2 receptor agonists stimulate vaginal moisture in ovariectomized rabbitsKweonsik Min
Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Fertil Steril 79:393-8. 2003..The P2Y(2) receptor agonists provide a potential nonhormonal alternative for treating vaginal dryness in postmenopausal women... - The multifunctional nuclear protein p54nrb is multiphosphorylated in mitosis and interacts with the mitotic regulator Pin1Ariane Proteau
CREFSIP and Département de médecine, Laval University, Pavillon C E Marchand, Room 4263 Laval University, Que, Canada, G1K 7P4
J Mol Biol 346:1163-72. 2005..Our results also showed that Pin1 binding was favored when at least two of the three threonine residues were phosphorylated, suggesting a regulation mechanism based on multisite phosphorylation... - Identification of G2/M targets for the MAP kinase pathway by functional proteomicsElisabeth C Roberts
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309-0215, USA
Proteomics 6:4541-53. 2006.... - Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destructionLorin M Henrich
Department of Microbiology and Center for Cell Signaling, University of Virginia, Charlottesville, Virginia 22908, USA
Mol Cell Biol 23:5979-88. 2003..ERK7 targets the ER alpha ligand-binding domain for destruction by enhancing its ubiquitination. Thus, ERK7 is a novel regulator of estrogen responsiveness through its control of ER alpha turnover... - Clinical biologic pathophysiologies of women's sexual dysfunctionRossella Nappi
University of Pavia, Italy
J Sex Med 2:4-25. 2005..This chapter encompasses data presented at the 2nd International Consultation on Sexual Medicine in Paris, France, June 28-July 1, 2003...
Research Grants
- FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGYAbdulmaged Traish; Fiscal Year: 2003....