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Genomes and Genes | N RudermanSummaryAffiliation: Boston University Country: USA Publications
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Publications
AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndromeNeil Ruderman
Department of Medicine, Boston University School of Medicine and Diabetes Unit, Section of Endocrinology, Boston Medical Center, 715 Albany Street, Boston, Massachusetts 02118, USA
Nat Rev Drug Discov 3:340-51. 2004- Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetesN B Ruderman
Diabetes Unit, Section of Endocrinology and Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
Biochem Soc Trans 31:202-6. 2003..v) The comparative roles of AMPK in regulating metabolism, signalling and gene expression in muscle and endothelial cells warrant further study... - Minireview: malonyl CoA, AMP-activated protein kinase, and adiposityNeil B Ruderman
D Phil, Diabetes Unit, Boston Medical Center, 650 Albany Street, X825, Boston, Massachusetts 02118, USA
Endocrinology 144:5166-71. 2003..In addition, preliminary studies suggest that malonyl CoA and AMPK take part in fuel-sensing and signaling mechanisms in the hypothalamus that could regulate food intake and energy expenditure... - Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cellsZ Dagher
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
Circ Res 88:1276-82. 2001..Finally, they suggest that AMPK is likely to be a major factor in modulating the response of the endothelium to stresses that alter its energy state... - The metabolically obese, normal-weight individual revisitedN Ruderman
Evans Department of Medicine, Boston University Medical Center, Massachusetts 02118, USA
Diabetes 47:699-713. 1998.... - AMPK, the metabolic syndrome and cancerZhijun Luo
Diabetes Research Unit, Section of Endocrinology, Department of Medicine, 650 Albany Street, EBRC 820, Boston University School of Medicine, Boston, MA 02118, USA
Trends Pharmacol Sci 26:69-76. 2005..In addition, other studies indicate that mammalian homolog of target of rapamycin (mTOR), which has been implicated in the pathogenesis of insulin resistance and many types of cancer, is inhibited by AMPK... - AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cellsJose M Cacicedo
Diabetes and Metabolism Research Unit, Department of Medicine and Section of Endocrinology, Boston University School of Medicine, 650 Albany St, 8th Floor, Room 820, Boston, MA 02118, USA
Biochem Biophys Res Commun 324:1204-9. 2004.... - Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exerciseCarsten Roepstorff
The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
Am J Physiol Endocrinol Metab 288:E133-42. 2005..They also suggest that, with high muscle glycogen, the availability of free carnitine may limit fat oxidation during exercise, due to its increased use for acetylcarnitine formation... - AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cellsMengwei Zang
Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Biol Chem 279:47898-905. 2004..Metformin lowers hepatic lipid content by activating AMPK, thereby mediating beneficial effects in hyperglycemia and insulin resistance... - AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed ratsMurwarid M Assifi
Diabetes and Metabolism Unit, Boston Univ Medical Center, Boston, MA 02118, USA
Am J Physiol Endocrinol Metab 289:E794-800. 2005..They also suggest that the changes in these enzymes, and later occurring increases in enzymes regulating fatty acid and glycerolipid synthesis, could be coordinated by AMPK... - Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of ratsEdward W Kraegen
Garvan Institute of Medical Research, Sydney NSW 2010 Australia
Am J Physiol Endocrinol Metab 290:E471-9. 2006..In contrast, it was not associated with increased whole tissue LCA-CoA content in any tissue or triglyceride in muscle, although both are observed at later times... - Why might thiazolidinediones increase exercise capacity in patients with type 2 diabetes?Nathan K Lebrasseur
Diabetes Care 28:2975-7. 2005 - Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonistsAndrea R Nawrocki
Department of Cell Biology, Division of Endocrinology, and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 281:2654-60. 2006..In summary, adiponectin is an important contributor to PPARgamma-mediated improvements in glucose tolerance through mechanisms that involve the activation of the AMPK pathway... - Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscleJeanette E Kuhl
Dept of Molecular Medicine and Surgery, Karolinska Institutet, S 171 76 Stockholm, Sweden
Am J Physiol Endocrinol Metab 290:E1296-303. 2006..These changes persist after the increases in AMPK activity and whole body insulin sensitivity and fatty acid oxidation, typically caused by an acute bout of exercise in healthy individuals, have dissipated... - Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissuesNathan K Lebrasseur
Diabetes and Metabolism Research Unit, Boston University School of Medicine, 650 Albany St, X-820, Boston, MA 02118, USA
Am J Physiol Endocrinol Metab 291:E175-81. 2006..They suggest that this effect is associated with a change in cellular energy state and that it is not dependent on PPARgamma-mediated gene transcription... - Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme ANeil B Ruderman
Division of Endocrinology, Boston University Medical Center, Boston, MA 02118, USA
Obesity (Silver Spring) 14:25S-33S. 2006..The possibility is also raised that pharmacological agents and other factors that activate AMPK and/or decrease malonyl CoA could be therapeutic targets... - AMPK regulation of the growth of cultured human keratinocytesAsish K Saha
Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Biochem Biophys Res Commun 349:519-24. 2006..They also suggest that AMPK activators, such as AICAR and troglitazone, inhibit keratinocyte growth and that the inhibition of cell growth by 1,25-dihydroxyvitamin D3 is AMPK-independent... - Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndromeNeil B Ruderman
Section of Endocrinology, Diabetes Unit, Boston Medical Center, 650 Albany St, X-820, Boston, MA 02118, USA
Diabetes 55:S48-54. 2006.... - AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevanceMarie Soleil Gauthier
Diabetes and Metabolism Unit, Department of Medicine Section of Endocrinology, Boston University Medical Center, Boston, Massachusetts 02118, USA
J Biol Chem 283:16514-24. 2008..Finally, this AMPK activation appears to restrain the energy depletion and oxidative stress caused by lipolysis... - AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanismsXiaoqin Xiang
Diabetes Research Unit, Section of Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Biochem Biophys Res Commun 321:161-7. 2004..The results suggest that AMPK is a potential target for the treatment of prostate cancer... - Metabolic and hormonal interactions between muscle and adipose tissueEva Tomas
Department of Medicine, Physiology and Biophysics, Diabetes Unit, Boston University Medical Center, Boston, MA, USA
Proc Nutr Soc 63:381-5. 2004..Thus, hormonal communications exist between the adipocyte and muscle that could enable them to talk to each other. The physiological relevance of this cross talk clearly warrants further study... - AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exerciseMeghan Kelly
Diabetes Unit, Section of Endocrinology, Boston Medical Center and Departments of Medicine and Physiology, Boston University School of Medicine, Boston, MA 02118, USA
Biochem Biophys Res Commun 320:449-54. 2004..They also suggest that a genetic lack of IL-6 is associated with a decrease in AMPK activity... - Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesusEleazar Shafrir
Department of Biochemistry and Diabetes Research Unit, Hadassah University Hospital, Jerusalem 91120, Israel
Diabetes Metab Res Rev 18:217-23. 2002..In keeping with this it shows a low rate of glucose transport and a failure of insulin to suppress hepatic glucose production during a hyperinsulinemic-euglycemic clamp... - AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed ratsMiguel A Iglesias
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Diabetes 51:2886-94. 2002..Independent of this, the results suggest that pharmacological activation of AMPK may have potential in treating insulin-resistant states and type 2 diabetes... - Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alphaSamar I Itani
Diabetes Unit, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
Diabetes 51:2005-11. 2002..Whether acute FFA-induced insulin resistance in human skeletal muscle is caused by the activation of these specific PKC isoforms and the IKK-beta/IkappaB/NFkappaB pathway remains to be established... - Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activationEva Tomas
Diabetes Unit, Section of Endocrinology, Boston Medical Center and Departments of Medicine and Physiology, Boston University School of Medicine, Boston, MA 02118, USA
Proc Natl Acad Sci U S A 99:16309-13. 2002..Thus, gACRP30 most likely exerts its actions on muscle fatty acid oxidation by inactivating ACC via activation of AMPK and perhaps other signal transduction proteins... - Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulationPeter N Bavenholm
Division of Medicine, Departments of Emergency and Cardiovascular Medicine, Karolinska Hospital and Institute, S 17176 Stockholm, Sweden
J Clin Endocrinol Metab 88:82-7. 2003..Whether the unexpectedly high levels of malonyl CoA in muscle, together with the diminished suppression of plasma free fatty acid, explains the insulin resistance of the diabetic patients during the clamp remains to be determined... - Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exerciseHaejoe Park
Diabetes Unit, Section of Endocrinology and Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
J Biol Chem 277:32571-7. 2002..They also suggest that in each of them, it acts to increase fatty acid oxidation and decrease its esterification... - Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinaseSamar I Itani
Diabetes and Metabolism Unit and Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
Diabetes 52:1635-40. 2003.... - Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in ratsGabriela Suchankova
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Biochem Biophys Res Commun 326:851-8. 2005.... - Malonyl-CoA and AMP-activated protein kinase: an expanding partnershipAsish K Saha
Diabetes Research Unit, Section of Endocrinology and Departments of Medicine and Physiology, Boston University Medical Center, Boston, MA 02118, USA
Mol Cell Biochem 253:65-70. 2003..This review will describe the current literature on the regulation of malonyl CoA/AMPK mechanism and its physiological function... - Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivoAsish K Saha
Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
Biochem Biophys Res Commun 314:580-5. 2004..They also suggest that this activation of AMPK may be mediated by a change in cellular energy state. Whether these effects of pioglitazone contribute to its insulin-sensitizing and other actions in vivo remains to be determined... - Alterations of nPKC distribution, but normal Akt/PKB activation in denervated rat soleus muscleYenshou Lin
Diabetes and Metabolism Unit and Department of Physiology, Boston University Medical Center, Boston, Massachusettes 02118, USA
Am J Physiol Endocrinol Metab 283:E318-25. 2002..The significance of the observed alterations to GSK-3 and PP1 alpha distribution remain to be determined... - Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteersNaomi M Hamburg
Section of Cardiology, Boston Medical Center, 88 East Newton Street, Boston, MA 02118, USA
Arterioscler Thromb Vasc Biol 27:2650-6. 2007..Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance... - Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytesErik Joly
Molecular Nutrition Unit and the Montreal Diabetes Research Center, Centre de Recherche du CHUM, Pavillon de Sève, Y 4603, 1560 Sherbrooke Est, and the Department of Nutrition and Biochemistry, Universite de Montreal, Montreal PQ, Canada, H3T 1C5
FEBS Lett 579:6581-6. 2005.... - Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytesThomas A Miller
Molecular Stress Response Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
Biochem Biophys Res Commun 336:309-15. 2005..These results support a model for palmitate-induced apoptosis, activation of SAPKs, and protein oxidative stress in myocytes that involves cytosolic accumulation of saturated fatty acids... - Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramideJose M Cacicedo
Diabetes and Metabolism Research Unit, Department of Medicine and Section of Endocrinology, Boston University School of Medicine, 650 Albany St, 8th Floor, Room 820, Boston, MA 02118, USA
Diabetes 54:1838-45. 2005..The precise interactions between these molecules in causing apoptosis and the importance of oxidant stress as a contributory factor remain to be determined... - Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathwaysTsu Shuen Tsao
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
J Biol Chem 278:50810-7. 2003..Thus, trimeric and HMW/hexameric Acrp30 activate different signal transduction pathways, and Acrp30 represents a novel example of the control of ligand signaling via changes in its oligomerization state... - Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activitySandeep Gupta
Diabetes and Metabolism Unit, Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Am J Physiol Cell Physiol 282:C560-6. 2002..These data suggest that hyperglycemia induces an increase in endothelial superoxide that inhibits the stimulatory effect of NO on vascular Na+-K+-ATPase activity...