H L Lazar

Summary

Affiliation: Boston University School of Medicine
Country: USA

Publications

  1. ncbi The insulin cardioplegia trial
    Harold L Lazar
    J Thorac Cardiovasc Surg 123:842-4. 2002
  2. ncbi Should all patients receive statins before cardiac surgery: are more data necessary?
    Harold L Lazar
    J Thorac Cardiovasc Surg 131:520-2. 2006
  3. ncbi Alterations in myocardial metabolism in the diabetic myocardium
    Harold L Lazar
    Boston University School of Medicine, Department of Cardiothoracic Surgery, Boston Medical Center, Boston, MA 02118, USA
    Semin Thorac Cardiovasc Surg 18:289-92. 2006
  4. ncbi All coronary artery bypass graft surgery patients will benefit from angiotensin-converting enzyme inhibitors
    Harold L Lazar
    Circulation 117:6-8. 2008
  5. ncbi High tissue affinity angiotensin-converting enzyme inhibitors improve endothelial function and reduce infarct size
    H L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine, Boston Medical Center, Massachusetts 02118, USA
    Ann Thorac Surg 72:548-53; discussion 553-4. 2001
  6. ncbi Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine and Boston Medical Center, 88 E Newton St, B402, Boston, Mass 02118, USA
    Circulation 109:1497-502. 2004
  7. ncbi Beneficial effects of complement inhibition with soluble complement receptor 1 (TP10) during cardiac surgery: is there a gender difference?
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine and The Boston Medical Center, 88 East Newton Street, Suite B402, Boston, MA 02118, USA
    Circulation 116:I83-8. 2007
  8. ncbi Role of statin therapy in the coronary bypass patient
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine and The Boston Medical Center, 88 E Newton Street, B404, Boston, MA 02118, USA
    Ann Thorac Surg 78:730-40. 2004
  9. ncbi Soluble human complement receptor 1 limits ischemic damage in cardiac surgery patients at high risk requiring cardiopulmonary bypass
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine and Boston Medical Center, Boston, Mass 02118, USA
    Circulation 110:II274-9. 2004
  10. ncbi Does off-pump revascularization reduce coronary endothelial dysfunction?
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Card Surg 19:440-3. 2004

Detail Information

Publications42

  1. ncbi The insulin cardioplegia trial
    Harold L Lazar
    J Thorac Cardiovasc Surg 123:842-4. 2002
  2. ncbi Should all patients receive statins before cardiac surgery: are more data necessary?
    Harold L Lazar
    J Thorac Cardiovasc Surg 131:520-2. 2006
  3. ncbi Alterations in myocardial metabolism in the diabetic myocardium
    Harold L Lazar
    Boston University School of Medicine, Department of Cardiothoracic Surgery, Boston Medical Center, Boston, MA 02118, USA
    Semin Thorac Cardiovasc Surg 18:289-92. 2006
    ..The mechanisms by which intravenous insulin infusions can be used to modulate these changes in myocardial metabolism to improve clinical outcomes are discussed...
  4. ncbi All coronary artery bypass graft surgery patients will benefit from angiotensin-converting enzyme inhibitors
    Harold L Lazar
    Circulation 117:6-8. 2008
  5. ncbi High tissue affinity angiotensin-converting enzyme inhibitors improve endothelial function and reduce infarct size
    H L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine, Boston Medical Center, Massachusetts 02118, USA
    Ann Thorac Surg 72:548-53; discussion 553-4. 2001
    ..This study was, therefore, undertaken to determine whether high tissue affinity ACE inhibitors would improve endothelial function and thereby decrease tissue necrosis during ischemia...
  6. ncbi Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine and Boston Medical Center, 88 E Newton St, B402, Boston, Mass 02118, USA
    Circulation 109:1497-502. 2004
    ..This study sought to determine whether tight glycemic control with a modified glucose-insulin-potassium (GIK) solution in diabetic coronary artery bypass graft (CABG) patients would improve perioperative outcomes...
  7. ncbi Beneficial effects of complement inhibition with soluble complement receptor 1 (TP10) during cardiac surgery: is there a gender difference?
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine and The Boston Medical Center, 88 East Newton Street, Suite B402, Boston, MA 02118, USA
    Circulation 116:I83-8. 2007
    ....
  8. ncbi Role of statin therapy in the coronary bypass patient
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine and The Boston Medical Center, 88 E Newton Street, B404, Boston, MA 02118, USA
    Ann Thorac Surg 78:730-40. 2004
    ..In this review statin therapy will be shown to improve vein graft patency, minimize recurrent ischemic events, and decrease the need for repeat revascularization procedures in patients who have undergone coronary artery bypass grafting...
  9. ncbi Soluble human complement receptor 1 limits ischemic damage in cardiac surgery patients at high risk requiring cardiopulmonary bypass
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine and Boston Medical Center, Boston, Mass 02118, USA
    Circulation 110:II274-9. 2004
    ....
  10. ncbi Does off-pump revascularization reduce coronary endothelial dysfunction?
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Card Surg 19:440-3. 2004
    ..This experimental study sought to determine whether OPCAB reduces endothelial dysfunction, compared to standard cardiopulmonary bypass (CPB) with and without the anticomplement agent soluble complement receptor-1 (sCR(1))...
  11. ncbi Role of angiotensin-converting enzyme inhibitors in the coronary artery bypass patient
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine, Boston, Massachussetts, USA
    Ann Thorac Surg 79:1081-9. 2005
    ....
  12. ncbi The use of angiotensin-converting enzyme inhibitors in patients undergoing coronary artery bypass graft surgery
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine and Boston Medical Center, 88 East Newton Street, B402, Boston, MA 02118, USA
    Vascul Pharmacol 42:119-23. 2005
    ....
  13. ncbi Aprotinin decreases ischemic damage during coronary revascularization
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Card Surg 20:519-23. 2005
    ..This study sought to determine whether the favorable anti-inflammatory effects of aprotinin might limit ischemic damage during the revascularization of ischemic myocardium...
  14. ncbi Novel adhesive skin closures improve wound healing following saphenous vein harvesting
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston Medical Center and Boston University, School of Medicine, Boston, MA 02118, USA
    J Card Surg 23:152-5. 2008
    ..This prospective, randomized study was undertaken to compare the results of the noninvasive skin closure method to the traditional subcuticular skin closure technique on saphenous vein harvest sites...
  15. ncbi Pretreatment with statins enhances myocardial protection during coronary revascularization
    Harold L Lazar
    Department of Cardiothoracic Surgery, The Boston Medical Center and The Boston University School of Medicine, Boston, MA 02118, USA
    J Thorac Cardiovasc Surg 125:1037-42. 2003
    ..This experimental study was undertaken to determine whether pretreatment with statins would enhance myocardial protection and minimize ischemic injury during revascularization of acutely ischemic myocardium...
  16. ncbi Endograft collapse after thoracic stent-graft repair for traumatic rupture
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine, Boston, Massachussetts, USA
    Ann Thorac Surg 87:1582-3. 2009
    ..In this report, we describe a case of endograft collapse after a traumatic aortic rupture...
  17. ncbi The effect of topical vancomycin applied to sternotomy incisions on postoperative serum vancomycin levels
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Card Surg 26:461-5. 2011
    ..This study was undertaken to determine: (1) whether serum levels of vancomycin remain elevated when applied topically to the sternum and (2) whether the use of topical vancomycin can potentiate postoperative drug-resistant infections...
  18. ncbi Effects of aggressive versus moderate glycemic control on clinical outcomes in diabetic coronary artery bypass graft patients
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine, Boston, MA 02118, USA
    Ann Surg 254:458-63; discussion 463-4. 2011
    ....
  19. ncbi Early discharge after coronary artery bypass graft surgery: are patients really going home earlier?
    H L Lazar
    Department of Cardiothoracic Surgery, The Boston Medical Center, Suite B404, 88 E Newton St, Boston, MA 02118, USA
    J Thorac Cardiovasc Surg 121:943-50. 2001
    ..This study was undertaken to determine whether early discharge after coronary artery bypass grafting allows patients to return home earlier or merely increases the use of outpatient nursing and inpatient rehabilitation services...
  20. ncbi Nesiritide enhances myocardial protection during the revascularization of acutely ischemic myocardium
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston Medical Center, Boston, MA 02118, USA
    J Card Surg 24:600-5. 2009
    ..This study was, therefore, undertaken to determine whether nesiritide alone could enhance myocardial protection when given intraoperatively in a porcine model simulating urgent coronary artery bypass graft surgery...
  21. ncbi Acute anterolateral papillary muscle rupture in the absence of coronary artery disease
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Card Surg 25:518-9. 2010
    ..We present a case of spontaneous rupture of the anterolateral papillary muscle due to an isolated infarct of the papillary muscle in the absence of epicardial coronary artery disease...
  22. ncbi Expression of inducible nitric oxide synthase in conduits used in patients with diabetes mellitus undergoing coronary revascularization
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston University School of Medicine, The Boston Medical Center, Boston, Massachusetts, USA
    J Card Surg 25:120-6. 2010
    ....
  23. ncbi Pretreatment with angiotensin-converting enzyme inhibitors attenuates ischemia-reperfusion injury
    Harold L Lazar
    Department of Cardiothoracic Surgery, Boston Medical Center, Massachusetts 02118, USA
    Ann Thorac Surg 73:1522-7. 2002
    ..This study sought to determine whether pretreatment with ACE inhibitors would attentuate ischemic injury during surgical revascularization of ischemic myocardium...
  24. ncbi Reversal of paraplegia following repair of an ascending aortic dissection
    Harold L Lazar
    Department of Cardiothoracic Surgery, The Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA
    J Card Surg 25:65-6. 2010
    ..The paraplegia was fully reversed following an emergent replacement of the ascending aorta and hemi-arch repair...
  25. ncbi Excision of a mediastinal parathyroid adenoma after coronary artery bypass surgery
    Harold L Lazar
    Division of Radiology, Department of Cardiothoracic Surgery, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA
    Ann Thorac Surg 80:1105-6. 2005
    ..The surgical approach and intraoperative localization of the adenoma under these unusual circumstances are reviewed...
  26. ncbi Heparin-bonded circuits improve clinical outcomes in emergency coronary artery bypass grafting
    G S Aldea
    Department of Cardiothoracic Surgery, Boston Medical Center, Massachusetts 02118 2393, USA
    J Card Surg 12:389-97. 1997
    ..1 vs 11.0 +/- 8.9 days, p = 0.008), and therefore cost. In conclusion, the use of HBC/LAP in EM-CABG resulted in a reduction of homologous transfusion and postoperative complications associated with decreased hospital stays and cost...
  27. ncbi Reduction of allogeneic blood transfusions after open heart operations by lowering cardiopulmonary bypass prime volume
    O M Shapira
    Department of Cardiothoracic Surgery, Boston Medical Center, Massachusetts 02118, USA
    Ann Thorac Surg 65:724-30. 1998
    ....
  28. ncbi Improved clinical outcomes in patients undergoing coronary artery bypass grafting with coronary endarterectomy
    O M Shapira
    Department of Cardiothoracic Surgery, Boston University School of Medicine, Massachusetts, USA
    Ann Thorac Surg 68:2273-8. 1999
    ..We sought to evaluate the impact of recent advances in operative and perioperative management on outcomes after CE...
  29. ncbi OPCAB for acute LAD dissection due to blunt chest trauma
    Amit Korach
    Department of Cardiothoracic Surgery, Boston Medical Center, Boston, Massachusetts 02118, USA
    Ann Thorac Surg 82:312-4. 2006
    ..Due to extent and location, the lesion was not amenable for angioplasty. Multiple associated injuries and severely impaired coagulation studies directed us to perform emergency off-pump coronary artery bypass grafting...
  30. ncbi Heparin-bonded cardiopulmonary bypass circuits reduce bleeding and transfusion requirements in proximal aortic surgery
    O M Shapira
    Department of Cardiothoracic Surgery, Boston University School of Medicine, Massachusetts, USA
    J Card Surg 15:229-38. 2000
    ..Methods to improve hemostasis in aortic surgery continue to evolve. Use of heparin-bonded cardiopulmonary bypass circuits (HBC) has been shown previously to effectively reduce bleeding and improve outcomes in coronary and valve operations...
  31. ncbi Clinical outcomes in patients undergoing coronary artery bypass grafting with preferred use of the radial artery
    O M Shapira
    Department of Cardiothoracic Surgery, Boston Medical Center, Massachusetts 02118, USA
    J Card Surg 12:381-8. 1997
    ..The use of the radial artery (RA) for coronary artery bypass grafting (CABG) is still not widely accepted. The purpose of this study was to evaluate the impact of preferred RA utilization on clinical outcomes...
  32. ncbi Coronary artery bypass grafting in patients with severe left ventricular dysfunction--early and mid-term outcomes
    Oz M Shapira
    Department of Cardiothoracic Surgery, Boston Medical Center, Boston, Massachusetts, USA
    J Card Surg 21:225-32. 2006
    ..The aim of the present study was to assess the outcomes of patients with severe LVD undergoing CABG...
  33. ncbi Endoscopic versus conventional radial artery harvest--is smaller better?
    Oz M Shapira
    Department of Cardiothoracic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Card Surg 21:329-35. 2006
    ..We sought to assess our initial experience with the recently introduced technique of endoscopic radial artery harvest (ERH) for coronary artery bypass grafting (CABG)...
  34. ncbi Endoscopic versus conventional radial artery harvest for coronary artery bypass grafting: functional and histologic assessment of the conduit
    Oz M Shapira
    Department of Cardiothoracic Surgery, Boston Medical Center, Boston, Mass 02118, USA
    J Thorac Cardiovasc Surg 131:388-94. 2006
    ..The radial artery's propensity for vasospasm and vulnerability to surgical trauma are well known. A less invasive endoscopic method to harvest the radial artery was recently introduced, but its effect on radial artery integrity is unknown...
  35. ncbi U-clip anastomoses in coronary artery bypass grafting: initial clinical experience
    Richard J Shemin
    Boston Medical Center, Boston, Massachusetts 02118, USA
    Heart Surg Forum 6:362-5. 2003
    ..par..
  36. ncbi Endoscopic radial artery harvest for coronary artery bypass grafting: initial clinical experience
    Oz M Shapira
    Department of Cardiothoracic Surgery, Boston Medical Center, Boston, Massachusetts 02118, USA
    Heart Surg Forum 7:E411-5. 2004
    ..The aim of this study was to evaluate our initial clinical experience with this technology...
  37. ncbi Antioxidant improves smooth muscle sarco/endoplasmic reticulum Ca(2+)-ATPase function and lowers tyrosine nitration in hypercholesterolemia and improves nitric oxide-induced relaxation
    Takeshi Adachi
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine and Cardiothoracic Surgery, Boston University Medical Center, Boston, Mass, USA
    Circ Res 90:1114-21. 2002
    ..These beneficial effects may depend on reducing the direct effects on SERCA of reactive oxygen species that are augmented in HC...
  38. ncbi Cardiopulmonary bypass: it's not the size, it's how you use it! Review of a comprehensive blood-conservation strategy
    Kevin J Lilly
    Department of Cardiothoracic Surgery, Brigham and Woman s Hospital Cape Cod Hospital, Hyannis, MA 02601, USA
    J Extra Corpor Technol 36:263-8. 2004
    ..In an effort to clearly evaluate this new technology, in this article we review our current technique at Boston Medical Center...
  39. ncbi Hyperglycemia during cardiac surgery
    Harold L Lazar
    J Thorac Cardiovasc Surg 131:11-3. 2006
  40. ncbi Quinaprilat during cardioplegic arrest
    Harold L Lazar
    J Thorac Cardiovasc Surg 125:974-5. 2003
  41. ncbi Cardioprotective strategies to improve long-term outcomes following coronary artery bypass surgery
    Rohit Arora
    Department of Medicine, Robert Wood Johnson University Hospital, New Brunswick, New Jersey
    J Card Surg 21:198-204. 2006
    ..CONCLUSIONS: NNT analyses and evidence-based medicine recommendations provide surgeons with cardioprotective strategies to improve long-term outcomes following CABG surgery...
  42. ncbi Coronary sinus retroperfusion: can forward progress still be achieved by using a backward technique?
    Harold L Lazar
    J Thorac Cardiovasc Surg 127:1549-52. 2004