Research Topics
| N KopellSummaryAffiliation: Boston University Country: USA Publications
Research Grants
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Detail Information
Publications
Gamma rhythms and beta rhythms have different synchronization propertiesN Kopell
Department of Mathematics, Boston University, Boston MA 02215, USA
Proc Natl Acad Sci U S A 97:1867-72. 2000..The synchronization properties are consistent with data suggesting that gamma rhythms are used for relatively local computations whereas beta rhythms are used for higher level interactions involving more distant structures...- Neuronal assembly dynamics in the beta1 frequency range permits short-term memoryN Kopell
Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 108:3779-84. 2011..In addition, cells receiving further input after assembly formation produce coexistent spiking activity, unlike the competitive spiking activity characteristic of assembly formation with gamma rhythms... - Chemical and electrical synapses perform complementary roles in the synchronization of interneuronal networksNancy Kopell
Department of Mathematics and Statistics, Center for BioDynamics, Boston University, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 101:15482-7. 2004.... - New roles for the gamma rhythm: population tuning and preprocessing for the Beta rhythmMette S Olufsen
Department of Mathematics, North Carolina State University, Raleigh, NC 27659-8205, USA
J Comput Neurosci 14:33-54. 2003..We present experimental evidence showing that such a separation can occur in hippocampal slices... - Synchronization in hybrid neuronal networks of the hippocampal formationTheoden I Netoff
Deptartment of Biomedical Engineering, Center for BioDynamics, Boston University, 44 Cummington St, Boston, Massachusetts 02215, USA
J Neurophysiol 93:1197-208. 2005..Results are largely independent of synaptic strength and synaptic kinetics, implying that our conclusions are robust and largely unaffected by synaptic plasticity... - Synaptic depression creates a switch that controls the frequency of an oscillatory circuitF Nadim
Department of Mathematics, New Jersey Institute of Technology and Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA
Proc Natl Acad Sci U S A 96:8206-11. 1999..We propose that the pyloric network can operate in either of the two modes suggested by the model, depending on the maximal conductance of the depressing synapse... - Striatal origin of the pathologic beta oscillations in Parkinson's diseaseM M McCarthy
Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 108:11620-5. 2011..These results provide evidence for amplification of normal striatal network dynamics as a mechanism responsible for the enhanced beta frequency oscillations in Parkinson's disease... - Oscillations and slow patterning in the antennal lobeEhud Sivan
Center for Biodynamic, Boston University, 111 Cummington Street, MA, 02215, USA
J Comput Neurosci 20:85-96. 2006..Consequently, the major effect of network inhibition is to redistribute the action potentials of the PNs from bursting to one action potential per cycle of the oscillations... - Potential network mechanisms mediating electroencephalographic beta rhythm changes during propofol-induced paradoxical excitationMichelle M McCarthy
Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 28:13488-504. 2008..As correlates of behavioral phenomenology, these networks may refine our understanding of the specific behavioral states associated with general anesthesia... - Slow and fast inhibition and an H-current interact to create a theta rhythm in a model of CA1 interneuron networkHoracio G Rotstein
Department of Mathematics and Statistics and Center for BioDynamics, Boston University, Boston, MA 02215, USA
J Neurophysiol 94:1509-18. 2005..A component of the model O-LM cell critical to the synchronization mechanism is the hyperpolarization-activated h-current. The model can robustly reproduce relative phases of theta frequency activity in O-LM and FS cells... - Effects of noisy drive on rhythms in networks of excitatory and inhibitory neuronsChristoph Börgers
Department of Mathematics, Tufts University, Medford, MA 02155, USA
Neural Comput 17:557-608. 2005..Together with an argument explaining why the PING mechanism does not work far above the gamma range in the presence of heterogeneity, this justifies the "G" in "PING.".. - Modeling GABA alterations in schizophrenia: a link between impaired inhibition and altered gamma and beta range auditory entrainmentDorea Vierling-Claassen
Department of Mathematics and Statistics, Center for BioDynamics, Boston University, Boston, MA, USA
J Neurophysiol 99:2656-71. 2008..In addition, the study of dynamics that underlie auditory entrainment in schizophrenia may contribute to the understanding of how gamma and beta rhythms impact cognition in general... - Encoding and retrieval in the CA3 region of the hippocampus: a model of theta-phase separationSteve Kunec
Center for BioDynamics, Department of Mathematics and Statistics, Boston University, 111 Cummington Street, Boston, Massachusetts 02215, USA
J Neurophysiol 94:70-82. 2005..Slow inhibitory neurons (O-LM cells) play a role in the disambiguation during retrieval. We compare and contrast our computational results with existing experimental data and other contemporary models... - Mechanism and circuitry for clustering and fine discrimination of odors in insectsEhud Sivan
Center for BioDynamics, Boston University, 111 Cummington Street, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 101:17861-6. 2004.... - Synchronization of strongly coupled excitatory neurons: relating network behavior to biophysicsCorey D Acker
Department of Biomedical Engineering, Center for BioDynamics, Boston University, 44 Cummington Street, Boston, MA 02215, USA
J Comput Neurosci 15:71-90. 2003..Membrane noise also supports "sparse synchrony," a phenomenon in which subthreshold behavior is uncorrelated, but there are brief periods of synchronous spiking... - Cortical gamma rhythms modulate NMDAR-mediated spike timing dependent plasticity in a biophysical modelShane Lee
Program in Neuroscience, Boston University, Boston, Massachusetts, United States of America
PLoS Comput Biol 5:e1000602. 2009..Our pause results may suggest a novel role for this theta rhythm in plasticity. Finally, we discuss our results in the context of auditory thalamocortical plasticity... - Analysis of state-dependent transitions in frequency and long-distance coordination in a model oscillatory cortical circuitDavid J Pinto
Department of Neuroscience, Brown University, Box 1953, Providence, RI 02912, USA
J Comput Neurosci 15:283-98. 2003..Spike time response curves (STRCs) are used to study the relationship between the transitions in rhythm and the underlying biophysics... - Coordination of cellular pattern-generating circuits that control limb movements: the sources of stable differences in intersegmental phasesStephanie R Jones
Department of Mathematics and Center for BioDynamics, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 23:3457-68. 2003.... - Network architecture, receptive fields, and neuromodulation: computational and functional implications of cholinergic modulation in primary auditory cortexGabriel Soto
Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
J Neurophysiol 96:2972-83. 2006.... - Delayed orexin signaling consolidates wakefulness and sleep: physiology and modelingC G Diniz Behn
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
J Neurophysiol 99:3090-103. 2008.... - The dynamic structure underlying subthreshold oscillatory activity and the onset of spikes in a model of medial entorhinal cortex stellate cellsHoracio G Rotstein
Department of Mathematics and Center for BioDynamics, Boston University, Boston, MA 02215, USA
J Comput Neurosci 21:271-92. 2006..We show that the synchronization properties in networks made up of the NAS cells are similar to those of networks using the full stellate cell models... - Representation of time-varying stimuli by a network exhibiting oscillations on a faster time scaleMaoz Shamir
Center for BioDynamics, Boston University, Boston, MA, USA
PLoS Comput Biol 5:e1000370. 2009.... - Synchronizing genetic relaxation oscillators by intercell signalingDavid McMillen
Center for BioDynamics and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 99:679-84. 2002..We provide an analytical treatment of the synchronization process, the dominant mechanism of which is "fast threshold modulation.".. - Mixed-mode oscillations in a three time-scale model for the dopaminergic neuronMartin Krupa
Department of Mathematical Sciences, New Mexico State University, P O Box 30001, Department 3MB, Las Cruces, New Mexico 88003, USA
Chaos 18:015106. 2008..Krupa, N. Popovic, and N. Kopell (unpublished)... - Olfactory bulb gamma oscillations are enhanced with task demandsJennifer Beshel
Department of Psychology and Institute for Mind and Biology, The University of Chicago, Chicago, Illinois 60637, USA
J Neurosci 27:8358-65. 2007..The results reported here indicate that enhancement of local gamma power may reflect a switch in the dynamics of the system to a strategy that optimizes stimulus resolution when input signals are ambiguous... - Noise-stabilized long-distance synchronization in populations of model neuronsDavid McMillen
Department of Chemistry, University of Toronto at Mississauga, 3359 Mississauga Road, Mississauga, Ontario L5L 1C6, Canada
J Comput Neurosci 15:143-57. 2003.... - Synchronization in networks of excitatory and inhibitory neurons with sparse, random connectivityChristoph Börgers
Department of Mathematics, Tufts University, Medford, MA 02155, U S A
Neural Comput 15:509-38. 2003..Faster decay yields tighter synchrony. In particular, in models in which the inhibitory synapses are assumed to be instantaneous, the effects of sparse, random connectivity cannot be seen... - Modeling facilitation and inhibition of competing motor programs in basal ganglia subthalamic nucleus-pallidal circuitsLeonid L Rubchinsky
Center for Neuroscience and Department of Neurology, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 100:14427-32. 2003..The loss of this ability leads to hypokinesia, known PD motor deficits characterized by a slowness or inability to switch between motor programs... - Gamma oscillations induced by kainate receptor activation in the entorhinal cortex in vitroMark O Cunningham
School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds, LS2 9NQ, United Kingdom
J Neurosci 23:9761-9. 2003..We propose that similar cellular and network mechanisms to those seen in the hippocampus generate and modulate persistent gamma oscillations in the entorhinal cortex... - Does it have to be this complicated? Focus on "Single-column thalamocortical network model exhibiting gamma oscillations, spindles, and epileptogenic bursts"Nancy Kopell
J Neurophysiol 93:1829-30. 2005
Research Grants
- Rhythms of the Nervous SystemNancy Kopell; Fiscal Year: 2005..We will also study, both experimentally and via modeling, separated networks that produce a coherent gamma rhythm, and networks distributed over space. ..
- High-Frequency Rhythms of the Neocortex: Mechanisms and InteractionsNancy Kopell; Fiscal Year: 2009....
- CRCNS: Gamma Rhythms and Cell AssembliesNancy Kopell; Fiscal Year: 2009..Finally, the specific project will also help train two graduate students and a postdoctoral fellow. ..
- CRCNS: Gamma Rhythms and Cell AssembliesNancy Kopell; Fiscal Year: 2010..Finally, the specific project will also help train two graduate students and a postdoctoral fellow. ..
- High-Frequency Rhythms of the Neocortex: Mechanisms and InteractionsNancy Kopell; Fiscal Year: 2010....
- CRCNS: Gamma Rhythms and Cell AssembliesNancy Kopell; Fiscal Year: 2010..Finally, the specific project will also help train two graduate students and a postdoctoral fellow. ..