Alan Herbert

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi A genome-wide association study of serum uric acid in African Americans
    Bashira A Charles
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892, USA
    BMC Med Genomics 4:17. 2011
  2. ncbi Development of admixture mapping panels for African Americans from commercial high-density SNP arrays
    Guanjie Chen
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    BMC Genomics 11:417. 2010
  3. ncbi The fat tail of obesity as told by the genome
    Alan Herbert
    Department of Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Curr Opin Clin Nutr Metab Care 11:366-70. 2008
  4. ncbi A common genetic variant is associated with adult and childhood obesity
    Alan Herbert
    Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
    Science 312:279-83. 2006
  5. ncbi The role of binding domains for dsRNA and Z-DNA in the in vivo editing of minimal substrates by ADAR1
    A Herbert
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 98:12132-7. 2001
  6. ncbi The -174 IL-6 GG genotype is associated with a reduced risk of type 2 diabetes mellitus in a family sample from the National Heart, Lung and Blood Institute's Framingham Heart Study
    A Herbert
    Department of Genetics and Genomics, Boston University School of Medicine, Boston, MA, USA
    Diabetologia 48:1492-5. 2005
  7. ncbi Induction of protein translation by ADAR1 within living cell nuclei is not dependent on RNA editing
    Alan Herbert
    Department of Neurology, E633, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Mol Cell 10:1235-46. 2002
  8. ncbi The four Rs of RNA-directed evolution
    Alan Herbert
    Department of Genetics and Genomics, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Genet 36:19-25. 2004
  9. ncbi BMI modifies associations of IL-6 genotypes with insulin resistance: the Framingham Study
    Alan Herbert
    Department of Genetics and Genomics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Obesity (Silver Spring) 14:1454-61. 2006
  10. ncbi Secreted modular calcium-binding protein 2 haplotypes are associated with pulmonary function
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 175:554-60. 2007

Research Grants

  1. A genetic variant in the ACC gene that decreases Body Mass Index
    Alan G Herbert; Fiscal Year: 2010
  2. A genetic variant in the ACC gene that decreases Body Mass Index
    Alan Herbert; Fiscal Year: 2009

Detail Information

Publications19

  1. ncbi A genome-wide association study of serum uric acid in African Americans
    Bashira A Charles
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892, USA
    BMC Med Genomics 4:17. 2011
    ....
  2. ncbi Development of admixture mapping panels for African Americans from commercial high-density SNP arrays
    Guanjie Chen
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    BMC Genomics 11:417. 2010
    ..The increased availability of dense marker data on commercial chips has made it feasible to develop panels wherein the markers need not be predetermined...
  3. ncbi The fat tail of obesity as told by the genome
    Alan Herbert
    Department of Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Curr Opin Clin Nutr Metab Care 11:366-70. 2008
    ..Many genes affect pathways that predispose to and protect against obesity. We ask how many different variants affect human obesity and how common are they?..
  4. ncbi A common genetic variant is associated with adult and childhood obesity
    Alan Herbert
    Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
    Science 312:279-83. 2006
    ..The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity...
  5. ncbi The role of binding domains for dsRNA and Z-DNA in the in vivo editing of minimal substrates by ADAR1
    A Herbert
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 98:12132-7. 2001
    ..An unexpected finding was that the DRBMs are not necessary for the editing of the shorter 15-bp substrates. However, mutation of the Z-DNA-binding domains of ADAR1 decreased the efficiency with which such a substrate was edited...
  6. ncbi The -174 IL-6 GG genotype is associated with a reduced risk of type 2 diabetes mellitus in a family sample from the National Heart, Lung and Blood Institute's Framingham Heart Study
    A Herbert
    Department of Genetics and Genomics, Boston University School of Medicine, Boston, MA, USA
    Diabetologia 48:1492-5. 2005
    ..We evaluated the -174 IL-6 gene polymorphism as a risk factor for type 2 diabetes mellitus in a family-based analysis...
  7. ncbi Induction of protein translation by ADAR1 within living cell nuclei is not dependent on RNA editing
    Alan Herbert
    Department of Neurology, E633, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Mol Cell 10:1235-46. 2002
    ..Point mutations within each domain are identified that reduce nuclear translation; those in the DRBM region are also known to diminish RNA binding. This report adds to the growing functionality ascribed to the nucleus...
  8. ncbi The four Rs of RNA-directed evolution
    Alan Herbert
    Department of Genetics and Genomics, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Genet 36:19-25. 2004
    ..Together, the actions of reading, 'riting, 'rithmetic and replication constitute the four Rs of RNA-directed evolution...
  9. ncbi BMI modifies associations of IL-6 genotypes with insulin resistance: the Framingham Study
    Alan Herbert
    Department of Genetics and Genomics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Obesity (Silver Spring) 14:1454-61. 2006
    ..Because white fat is a major source of IL-6 in resting individuals, we tested the hypothesis that BMI modifies the association among the IL-6 genotype, insulin resistance (IR) (measured using the homeostasis model), and risk of diabetes...
  10. ncbi Secreted modular calcium-binding protein 2 haplotypes are associated with pulmonary function
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 175:554-60. 2007
    ..Previously reported linkage to FEV(1) (LOD score = 5.0) on 6q27 in the Framingham Heart Study (FHS) led us to explore a candidate gene, SMOC2, at 168.6 Mb...
  11. ncbi Genomic screening and replication using the same data set in family-based association testing
    Kristel Van Steen
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Genet 37:683-91. 2005
    ..Our methods use the entire sample and do not require separate screening and validation samples to establish genome-wide significance, as population-based designs do...
  12. ncbi Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study
    Samer Karamohamed
    Framingham Heart Study Genetics Laboratory, Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Diabetes 52:1562-7. 2003
    ..002) and type 2 diabetes (P < 0.001, odds ratio 1.96, 95% CI 1.28-3.00). The evidence presented supports the possibility that IDE is a susceptibility gene for diabetes in populations of European descent...
  13. ncbi Influence of alcohol dehydrogenase 1C polymorphism on the alcohol-cardiovascular disease association (from the Framingham Offspring Study)
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University, Boston, MA, USA
    Am J Cardiol 96:227-32. 2005
    ..The interaction does not appear to be mediated through effects on high-density lipoprotein cholesterol...
  14. ncbi Linkage and association with pulmonary function measures on chromosome 6q27 in the Framingham Heart Study
    Jemma B Wilk
    Neurology Department, Boston University School of Medicine, Boston, MA 02118, USA
    Hum Mol Genet 12:2745-51. 2003
    ..This study supports the presence of a gene influencing pulmonary function on the q-terminus of chromosome 6 in the region of 184 cM (D6S503) to 190 cM (D6S281)...
  15. ncbi PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Obesity (Silver Spring) 14:753-8. 2006
    ..Elevated PAI-1 levels may be associated with an increased risk for diabetes as a marker for underlying endothelial dysfunction rather than by a direct effect of genetically mediated elevated levels...
  16. ncbi Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham Offspring Study
    Luc Djousse
    Division of Aging, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am Heart J 153:636-9. 2007
    ..Previous studies have suggested a positive association between phenotypes of fucosyltransferase 3 (FUT3) gene (also known as Lewis gene) and coronary heart disease...
  17. ncbi The insulin gene variable number tandem repeat and risk of type 2 diabetes in a population-based sample of families and unrelated men and women
    James B Meigs
    General Medicine Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:1137-43. 2005
    ..These data support the hypothesis that the INS VNTR is a genetic risk factor for type 2 diabetes, with the TT genotype accounting for about 6.6% of cases in the FHS population...
  18. ncbi Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham Osteoporosis Study
    Serge L Ferrari
    Division of Bone Diseases and WHO Collaborating Center for Osteoporosis, Departments of Geriatrics and Internal Medicine, Geneva University Hospital, Geneva, Switzerland
    J Bone Miner Res 19:552-9. 2004
    ..Hence, association of IL-6 polymorphisms with BMD may be limited to discrete population subgroups...
  19. ncbi Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men
    Douglas P Kiel
    Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA 02131, USA
    Bone 40:587-96. 2007
    ..These observations suggest that Wnt-LRP5 may play a role in the adaptation of bone to mechanical load in humans, and may explain some gender-related differences in bone mass...

Research Grants5

  1. A genetic variant in the ACC gene that decreases Body Mass Index
    Alan G Herbert; Fiscal Year: 2010
    ..We will then perform directed resequencing of non-coding regions and of exons to identify functional variant(s). ..
  2. A genetic variant in the ACC gene that decreases Body Mass Index
    Alan Herbert; Fiscal Year: 2009
    ..We will then perform directed resequencing of non-coding regions and of exons to identify functional variant(s). ..