Jan Blusztajn

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi The cholinergic neuronal phenotype in Alzheimer's disease
    J K Blusztajn
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, MA 02118, USA
    Metab Brain Dis 15:45-64. 2000
  2. ncbi Generation of choline for acetylcholine synthesis by phospholipase D isoforms
    D Zhao
    Department of Pathology, Boston University, School of Medicine, Boston, MA, USA
    BMC Neurosci 2:16. 2001
  3. ncbi Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin
    Robyn M Carey
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    BMC Cell Biol 12:20. 2011
  4. ncbi Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9
    I Lopez-Coviella
    Department of Psychiatry and Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Science 289:313-6. 2000
  5. ncbi Modulation of cholinergic locus expression by glucocorticoids and retinoic acid is cell-type specific
    B Berse
    Department of Pathology, Boston University School of Medicine, MA 02118, USA
    FEBS Lett 410:175-9. 1997
  6. ncbi [Bone morphogenetic proteins and cholinergic neurons in the central nervous system]
    I Lopez-Coviella
    Department of Psychiatry Boston University School of Medicine, Boston, MA, 02118, USA
    Rev Neurol 33:1054-60. 2001
  7. ncbi Activation of TrkA by nerve growth factor upregulates expression of the cholinergic gene locus but attenuates the response to ciliary neurotrophic growth factor
    B Berse
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
    Biochem J 342:301-8. 1999
  8. ncbi Apolipoprotein serum amyloid A down-regulates smooth-muscle cell lipid biosynthesis
    B M Schreiber
    Department of Biochemistry, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, USA
    Biochem J 344:7-13. 1999
  9. ncbi A cyclic peptide that binds p75(NTR) protects neurones from beta amyloid (1-40)-induced cell death
    M Yaar
    Department of Dermatology, Boston University School of Medicine, Boston, MA 02118 2394, USA
    Neuropathol Appl Neurobiol 33:533-43. 2007
  10. ncbi Sexually dimorphic activation of liver and brain phosphatidylethanolamine N-methyltransferase by dietary choline deficiency
    P I Johnson
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, MA 02118, USA
    Neurochem Res 23:583-7. 1998

Research Grants

  1. BMP actions on cholinergic cells
    Jan Blusztajn; Fiscal Year: 2004
  2. In utero availability of the essential nutrient, choline, and mammary cancer risk
    Jan Blusztajn; Fiscal Year: 2007
  3. Juvenile trophic factors for the prevention and treatment of hippocampal aging
    Jan Krzysztof Blusztajn; Fiscal Year: 2010

Collaborators

Detail Information

Publications15

  1. ncbi The cholinergic neuronal phenotype in Alzheimer's disease
    J K Blusztajn
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, MA 02118, USA
    Metab Brain Dis 15:45-64. 2000
    ..We found that VLDL increases ACh levels, and that it can partially offset the anticholinergic actions of A beta peptides...
  2. ncbi Generation of choline for acetylcholine synthesis by phospholipase D isoforms
    D Zhao
    Department of Pathology, Boston University, School of Medicine, Boston, MA, USA
    BMC Neurosci 2:16. 2001
    ..ACh levels were examined in cells incubated in a choline-free medium, to ensure that their ACh was synthesized entirely from intracellular choline...
  3. ncbi Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin
    Robyn M Carey
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    BMC Cell Biol 12:20. 2011
    ..This was accompanied by a reduction in A? generation. In the present study, we investigated whether surface expression of the ?-secretase ADAM (a disintegrin and metalloprotease)10 is also regulated by dynamin-dependent endocytosis...
  4. ncbi Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9
    I Lopez-Coviella
    Department of Psychiatry and Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Science 289:313-6. 2000
    ..Although certain other BMPs also up-regulated the cholinergic phenotype in vitro, they were less effective than BMP-9. These data indicate that BMP-9 is a differentiating factor for cholinergic central nervous system neurons...
  5. ncbi Modulation of cholinergic locus expression by glucocorticoids and retinoic acid is cell-type specific
    B Berse
    Department of Pathology, Boston University School of Medicine, MA 02118, USA
    FEBS Lett 410:175-9. 1997
    ..Acetylcholine content correlated with these mRNA changes. The presence of a glucocorticoid response element consensus sequence in the VAChT/ChAT gene locus suggests direct transcriptional regulation by glucocorticoids...
  6. ncbi [Bone morphogenetic proteins and cholinergic neurons in the central nervous system]
    I Lopez-Coviella
    Department of Psychiatry Boston University School of Medicine, Boston, MA, 02118, USA
    Rev Neurol 33:1054-60. 2001
    ..The discovery and characterization of factors that induce and maintain specific neurotransmitter phenotypes has profound clinical implications, and continues to be one of the major objectives in the neurosciences...
  7. ncbi Activation of TrkA by nerve growth factor upregulates expression of the cholinergic gene locus but attenuates the response to ciliary neurotrophic growth factor
    B Berse
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
    Biochem J 342:301-8. 1999
    ..This attenuation was not due to interference with early steps of CNTF receptor signalling, as pre-treatment of SN56-trkA cells with NGF did not affect the nuclear translocation of the transcription factor, Stat3, evoked by CNTF...
  8. ncbi Apolipoprotein serum amyloid A down-regulates smooth-muscle cell lipid biosynthesis
    B M Schreiber
    Department of Biochemistry, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, USA
    Biochem J 344:7-13. 1999
    ..The implications of these findings for atherosclerosis and Alzheimer's disease are discussed...
  9. ncbi A cyclic peptide that binds p75(NTR) protects neurones from beta amyloid (1-40)-induced cell death
    M Yaar
    Department of Dermatology, Boston University School of Medicine, Boston, MA 02118 2394, USA
    Neuropathol Appl Neurobiol 33:533-43. 2007
    ..Our data suggest that a cyclic peptide homologous to amino acids 28-36 of NGF known to mediate binding to p75(NTR) can interfere with Abeta (1-40) signalling and rescue neurones from Abeta (1-40)-induced toxicity...
  10. ncbi Sexually dimorphic activation of liver and brain phosphatidylethanolamine N-methyltransferase by dietary choline deficiency
    P I Johnson
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, MA 02118, USA
    Neurochem Res 23:583-7. 1998
    ..Activation of the PE methylation pathway in female brain may constitute a compensatory mechanism to sustain PC synthesis during choline deficiency...
  11. ncbi Rat and human mammary tissue can synthesize choline moiety via the methylation of phosphatidylethanolamine
    E K Yang
    Department of Pathology, Boston University School of Medicine, MA 02118
    Biochem J 256:821-8. 1988
    ..The rate of PtdCho formation was of similar magnitude to that seen in rat tissue. This evidence supports the hypothesis that some of the choline found in milk could have been synthesized de novo in the mammary gland...
  12. ncbi Collagen type I selectively activates ectodomain shedding of the discoidin domain receptor 1: involvement of Src tyrosine kinase
    Barbara E Slack
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 98:672-84. 2006
    ..Delayed shedding of the DDR1 ectodomain may represent a mechanism that limits DDR1-dependent cell adhesion and migration on collagen matrices...
  13. ncbi Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain
    Ignacio Lopez-Coviella
    Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, Room L 810, Boston, MA 02118, USA
    Brain Res 1088:49-56. 2006
    ..These data show that BMP9 activates the canonical BMP signaling pathway and suggest that this could be one of the mechanisms responsible for the induction of the cholinergic phenotype by BMP9 in the basal forebrain...
  14. ncbi Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes
    Barbara E Slack
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 104:1818-31. 2008
    ..The results demonstrate that multiple muscarinic receptor subtypes regulate mTOR, and that both MAPK-dependent and -independent mechanisms may mediate the response in a cell context-specific manner...
  15. ncbi Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression
    Vesela P Kovacheva
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 282:31777-88. 2007
    ..g. Igf2) DNA methylation. These epigenomic responses to gestational choline supply may initiate the long term developmental changes observed in rats exposed to varied choline intake in utero...

Research Grants9

  1. BMP actions on cholinergic cells
    Jan Blusztajn; Fiscal Year: 2004
    ..Taken together this research will provide basic and preclinical data on the mechanisms of action of BMPs in the brain and the potential for their use in treating neurological disorders affecting cholinergic neurons. ..
  2. In utero availability of the essential nutrient, choline, and mammary cancer risk
    Jan Blusztajn; Fiscal Year: 2007
    ..The ultimate goal of our studies is to relate our results to humans and to develop perinatal nutritional strategies which could benefit people. ..
  3. Juvenile trophic factors for the prevention and treatment of hippocampal aging
    Jan Krzysztof Blusztajn; Fiscal Year: 2010
    ..The ultimate goal of our studies is to relate our results to the age-associated changes in memory in humans, and to develop juvenile growth-factor replacement strategies that could benefit people. ..