Research Topics
| B BerseSummaryAffiliation: Boston University Country: USA Publications
Research Grants
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Detail Information
Publications
Activation of TrkA by nerve growth factor upregulates expression of the cholinergic gene locus but attenuates the response to ciliary neurotrophic growth factorB Berse
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
Biochem J 342:301-8. 1999..This attenuation was not due to interference with early steps of CNTF receptor signalling, as pre-treatment of SN56-trkA cells with NGF did not affect the nuclear translocation of the transcription factor, Stat3, evoked by CNTF...- Expression of high affinity choline transporter during mouse development in vivo and its upregulation by NGF and BMP-4 in vitroBrygida Berse
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 715 Albany Street, Room L 808C, Boston, MA 02118, USA
Brain Res Dev Brain Res 157:132-40. 2005..The effect of NGF was dependent on the PI3K signaling, as it was abolished by the PI3K inhibitor LY294002. This result indicates that some of the signals regulating other cholinergic-specific genes also control CHT expression... - Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9I Lopez-Coviella
Department of Psychiatry and Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Science 289:313-6. 2000..Although certain other BMPs also up-regulated the cholinergic phenotype in vitro, they were less effective than BMP-9. These data indicate that BMP-9 is a differentiating factor for cholinergic central nervous system neurons... - The cholinergic neuronal phenotype in Alzheimer's diseaseJ K Blusztajn
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, MA 02118, USA
Metab Brain Dis 15:45-64. 2000..We found that VLDL increases ACh levels, and that it can partially offset the anticholinergic actions of A beta peptides... - Differential regulation of the high affinity choline transporter and the cholinergic locus by cAMP signaling pathwaysMartina Brock
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 715 Albany Street, Room L 808C, Boston, MA 02118, USA
Brain Res 1145:1-10. 2007..Interestingly, although CHT is expressed predominantly in cholinergic cells, its regulation appears to be distinct from that of the cholinergic locus... - Modulation of cholinergic locus expression by glucocorticoids and retinoic acid is cell-type specificB Berse
Department of Pathology, Boston University School of Medicine, MA 02118, USA
FEBS Lett 410:175-9. 1997..Acetylcholine content correlated with these mRNA changes. The presence of a glucocorticoid response element consensus sequence in the VAChT/ChAT gene locus suggests direct transcriptional regulation by glucocorticoids... - Regulation of cholinergic gene expression by nerve growth factor depends on the phosphatidylinositol-3'-kinase pathwayBeata Madziar
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
J Neurochem 92:767-79. 2005..These results indicate that the PI3K pathway, but not the MEK/MAPK pathway, is the mediator of NGF-induced cholinergic differentiation... - Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neuronsIgnacio Lopez-Coviella
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Proc Natl Acad Sci U S A 102:6984-9. 2005..Approximately 30% of genes induced by BMP9 in vitro were overexpressed in purified BFCN, indicating that they belong to the BFCN transcriptome in situ and suggesting that BMP signaling contributes to maturation of BFCN in vivo... - Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrainIgnacio Lopez-Coviella
Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, Room L 810, Boston, MA 02118, USA
Brain Res 1088:49-56. 2006..These data show that BMP9 activates the canonical BMP signaling pathway and suggest that this could be one of the mechanisms responsible for the induction of the cholinergic phenotype by BMP9 in the basal forebrain... - Nerve growth factor regulates the expression of the cholinergic locus and the high-affinity choline transporter via the Akt/PKB signaling pathwayBeata Madziar
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurochem 107:1284-93. 2008..Our data indicate that, in addition to its well-described role in promoting neuronal survival, Akt can also mediate signals necessary for neurochemical differentiation... - Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expressionTiffany Mellott
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Eur J Biochem 269:850-8. 2002..Taken together, these results indicate that activation of the MEK1/MAPK pathway inhibits the CNTF-mediated stimulation of ChAT expression, possibly as a part of a feedback mechanism... - Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiencyEugene P Brandon
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Neurosci 24:5459-66. 2004..Increased ChT activity may compensate for the reduced ChAT activity in Chat+/- mice, contributing to the maintenance of apparently normal cholinergic function as reflected by normal performance of these mice in several behavioral assays...
Research Grants
- Signaling pathways directing cholinergic gene expressionBrygida Berse; Fiscal Year: 2004..Additionally, the importance of subcellular localization of TrkA for its action on cholinergic gene expression will be examined. ..