Research Topics
| MICHAEL PAUL BUSCHSummaryAffiliation: Blood Systems Research Institute Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Transfusion-transmitted viral infections: building bridges to transfusion medicine to reduce risks and understand epidemiology and pathogenesisMichael P Busch
Blood Systems Research Institute, University of California at San Francisco, California 94118, USA
Transfusion 46:1624-40. 2006- Temporal changes in HCV genotype distribution in three different high risk populations in San Francisco, CaliforniaPaulo Telles Dias
Núcleo de Estudos e Pesquisas em Atenção ao Uso de Drogas NEPAD Universidade do Estado do Rio de Janeiro State University of Rio de Janeiro, 20940 200 Rio de Janeiro, RJ, Brasil
BMC Infect Dis 11:208. 2011..In the United States (U.S.) HCV GT 1 is reported as the most common infecting GT among chronically infected patients. In Europe, however, recent studies have suggested that the epidemiology of HCV GTs is changing... - Estimating past hepatitis C infection risk from reported risk factor histories: implications for imputing age of infection and modeling fibrosis progressionPeter Bacchetti
Box 0560, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA
BMC Infect Dis 7:145. 2007..We sought to examine the accuracy of such imputation and implications for modeling factors that influence progression rates... - West Nile virus infections projected from blood donor screening data, United States, 2003Michael P Busch
Blood Systems Research Institute, San Francisco, California 94118, USA
Emerg Infect Dis 12:395-402. 2006..In addition to preventing transfusion-transmitted WNV infection, donor screening can serve as a tool to monitor seasonal incidence in the general population... - Risk assessment and cost-effectiveness/utility analysisMichael Busch
Blood Systems Research Institute, San Francisco, CA, USA
Biologicals 37:78-87. 2009..This set of articles will introduce risk assessment and cost-effectiveness methodologies and discuss recent applications of these methods in transfusion medicine... - Evolving approaches to estimate risks of transfusion-transmitted viral infections: incidence-window period model after ten yearsM R Busch
Blood Systems Research Institute, San Francisco, CA 94118, USA
Dev Biol (Basel) 127:87-112. 2007 - Virus and antibody dynamics in acute west nile virus infectionMichael P Busch
Blood Systems Research Institute, San Francisco, CA 94118, USA
J Infect Dis 198:984-93. 2008..The dynamics of the early stages of West Nile virus (WNV) infection can be assessed by follow-up studies of viremic blood donors... - Screening the blood supply for West Nile virus RNA by nucleic acid amplification testingMichael P Busch
Blood Systems Research Institute, San Francisco, USA
N Engl J Med 353:460-7. 2005..These data support the use of targeted nucleic acid amplification testing of individual donations in high-prevalence regions, a strategy that was implemented successfully in 2004... - Relative sensitivities of licensed nucleic acid amplification tests for detection of viremia in early human immunodeficiency virus and hepatitis C virus infectionMichael P Busch
Blood Systems Research Institute, San Francisco, California 94118, USA
Transfusion 45:1853-63. 2005..We compared these assays with respect to detection of RNA in early HIV and HCV infection... - Should HBV DNA NAT replace HBsAg and/or anti-HBc screening of blood donors?Michael P Busch
Blood Systems Research Institute, University of California, 270 Masonic Avenue, San Francisco, CA 94904, USA
Transfus Clin Biol 11:26-32. 2004..Finally it will address the cost effectiveness of incorporation of HBV DNA detection into HBV screening and NAT testing algorithms... - Blood transfusion is associated with donor leukocyte microchimerism in trauma patientsGarth H Utter
Department of Surgery, University of California, Davis, Medical Center, Blood Centers of the Pacific, San Francisco, California 95817, USA
J Trauma 57:702-7; discussion 707-8. 2004..Because the median time from transfusion to sampling for PCR analysis was not longer in the group without microchimerism, it is unlikely microchimerism is due merely to failure of the recipient to clear transfused donor leukocytes... - Correlates of hepatitis C virus (HCV) RNA negativity among HCV-seropositive blood donorsMichael P Busch
Blood Systems Research Institute, San Francisco, California 94118, USA
Transfusion 46:469-75. 2006..Factors associated with resolution of viremia are not well defined. Implementation of routine nucleic acid testing (NAT) of blood donors has yielded a large data set for analysis of demographic correlates of resolved viremia... - Current and emerging infectious risks of blood transfusionsMichael P Busch
Blood Centers of the Pacific, and University of California, San Francisco, 270 Masonic Ave, San Francisco, CA 94118, USA
JAMA 289:959-62. 2003 - Testing strategy to identify cases of acute hepatitis C virus (HCV) infection and to project HCV incidence ratesKimberly Page-Shafer
University of California, San Francisco, California, USA
J Clin Microbiol 46:499-506. 2008..4; 95% CI, 28.0 to 39.9). This study demonstrates the value of applying a cross-sectional screening strategy to detect acute HCV infections and to estimate HCV incidence... - Hepatitis C virus prevalence and clearance among US blood donors, 2006-2007: associations with birth cohort, multiple pregnancies, and body mass indexEdward L Murphy
University of California, San Francisco, CA, USA
J Infect Dis 202:576-84. 2010..During the period 1992-1993, the prevalence of hepatitis C virus (HCV) antibodies (anti-HCV) among US blood donors was 0.36%, but contemporary data on the prevalence of antibody to HCV and the prevalence of HCV RNA are lacking... - A new strategy for estimating risks of transfusion-transmitted viral infections based on rates of detection of recently infected donorsMichael P Busch
Blood Systems Research Institute, San Francisco, California 94118, USA
Transfusion 45:254-64. 2005.... - Safety and donor acceptance of an abbreviated donor history questionnaireHany T Kamel
Blood Systems, Inc, Scottsdale, Arizona 85257, USA
Transfusion 46:1745-53. 2006..Surveys have shown donor dissatisfaction with the duration of the donation process and repetitive questioning. An abbreviated donor history questionnaire (AQ) may improve satisfaction, but must be safe... - Triggers for switching from minipool testing by nucleic acid technology to individual-donation nucleic acid testing for West Nile virus: analysis of 2003 data to inform 2004 decision makingBrian Custer
Blood Systems Research Institute, San Francisco, California 94118, USA
Transfusion 44:1547-54. 2004..Strategies were investigated for the application of limited ID-NAT capacity in 2004... - Quantifying losses to the donated blood supply due to donor deferral and miscollectionBrian Custer
Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, Washington, USA
Transfusion 44:1417-26. 2004..Donors are deferred for multiple reasons. Losses related to disease marker rates are well established. Donor and donation losses for other reasons, however, have not been extensively quantified... - The cost-effectiveness of screening the U.S. blood supply for West Nile virusBrian Custer
Blood Systems Research Institute, University of California, San Francisco, CA 94118 4417, USA
Ann Intern Med 143:486-92. 2005..The spread of West Nile virus across North America and evidence of transmission by transfusion prompted the U.S. Food and Drug Administration to encourage the development of methods to screen the blood supply... - Elevations in IL-10, TNF-alpha, and IFN-gamma from the earliest point of HIV Type 1 infectionPhilip J Norris
Blood Systems Research Institute, San Francisco, California 94118, USA
AIDS Res Hum Retroviruses 22:757-62. 2006..Cytokine alterations occurred within 7 days of detectable HIV-1 viremia, emphasizing the need to study the earliest events of infection... - Integration of nucleic acid amplification test results into hepatitis C virus supplemental serologic testing algorithms: implications for donor counseling and revision of existing algorithmsSteven H Kleinman
Blood Systems Research Institute, San Francisco, California, USA
Transfusion 46:695-702. 2006.... - High-level long-term white blood cell microchimerism after transfusion of leukoreduced blood components to patients resuscitated after severe traumatic injuryTzong Hae Lee
Blood Systems Research Institute, Department of Pathology, University of California, Davis, California 94118, USA
Transfusion 45:1280-90. 2005..Twenty-seven patients transfused with LR and non-LR blood products were studied after severe traumatic injury. A secondary aim was to explore donor-recipient mixed lymphocyte reactivity in vitro... - Long-term in vitro reactivity for human leukocyte antigen antibodies and comparison of detection using serum versus plasmaPhilip J Norris
Blood Systems Research Institute, University of California, San Francisco, USA
Transfusion 49:243-51. 2009..Serum is the manufacturer's recommended sample, but plasma may be easier to obtain for studies of HLA antibody prevalence and TRALI case investigations... - Surveillance of the genetic variation in incident HIV, HCV, and HBV infections in blood and plasma donors: implications for blood safety, diagnostics, treatment, and molecular epidemiologyEric Delwart
Blood Systems Research Institute, and Department of Laboratory Medicine, University of California, San Francisco, California, USA
J Med Virol 78:S30-5. 2006..A systematic program is proposed for the genetic characterization of viral genomes in donors with incident HIV, HCV, or HBV infections... - Community blood supply model: development of a new model to assess the safety, sufficiency, and cost of the blood supplyBrian Custer
Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, USA
Med Decis Making 25:571-82. 2005..However, as a result of increasingly stringent screening measures, one of the greatest threats may be an insufficient supply. The balance between safety and adequacy of the blood supply has not received enough attention... - Enhanced ascertainment of microchimerism with real-time quantitative polymerase chain reaction amplification of insertion-deletion polymorphismsTzong Hae Lee
Blood Systems Research Institute, San Francisco, California 94118, USA
Transfusion 46:1870-8. 2006..To address this, a panel of 12 MC assays based on insertion-deletion (InDel) polymorphisms had been optimized... - Transfusion-associated microchimerism: a new complication of blood transfusions in severely injured patientsWilliam Reed
Blood Systems Research Institute, San Francisco, CA 94118, USA
Semin Hematol 44:24-31. 2007.... - Evaluation of a new enzyme-linked immunosorbent assay for detection of Chagas antibody in US blood donorsLeslie H Tobler
Blood Systems Research Institute, San Francisco, California 94118, USA
Transfusion 47:90-6. 2007..An anonymized preclinical study of a prototype T. cruzi lysate-based enzyme-linked immunosorbent assay (ELISA) developed by Ortho-Clinical Diagnostics was conducted... - Effects of blood sample age at time of separation on measured cytokine concentrations in human plasmaRachael P Jackman
Blood Systems Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
Clin Vaccine Immunol 18:318-26. 2011..When this is not possible, care should be taken to account for differences due to sample age... - Cost-effectiveness of screening the US blood supply for Trypanosoma cruziMaria Agapova
Blood Systems Research Institute, San Francisco, California 94117, USA
Transfusion 50:2220-32. 2010..Component-specific strategies are based on screening platelet-containing donations... - A case-control study of factors associated with resolution of hepatitis C viremia in former blood donors (CME)Leslie H Tobler
Blood Systems Research Institute, San Francisco, California, USA
Transfusion 50:1513-23. 2010..We report a case-control study of factors associated with HCV resolution... - Identification of specificities of antibodies against human leukocyte antigens in blood donorsRobert O Endres
Blood Systems Research Institute, San Francisco, California 85282, USA
Transfusion 50:1749-60. 2010..Blood centers are implementing TRALI risk reduction strategies based on screening apheresis donors for antibodies to human leukocyte antigens (HLA)... - Acute hepatitis C virus infection in young adult injection drug users: a prospective study of incident infection, resolution, and reinfectionKimberly Page
Department of Epidemiology and Biostatistics, University of California, San Francisco, 50 Beale St, Ste 1200, San Francisco, CA 94105, USA
J Infect Dis 200:1216-26. 2009..Hepatitis C virus (HCV) infection, clearance, and reinfection are best studied in injection drug users (IDUs), who have the highest incidence of HCV and are likely to represent most infections... - Associations between West Nile virus infection and symptoms reported by blood donors identified through nucleic acid test screeningBrian Custer
Blood Systems Research Institute, University of California, San Francisco, USA
Transfusion 49:278-88. 2009..Little data are available on subsequent manifestations of WNV-specific disease outcomes in viremic donors... - Intermittent low-level viremia in very early primary HIV-1 infectionEberhard W Fiebig
Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA
J Acquir Immune Defic Syndr 39:133-7. 2005..It is not known if blood is infectious during this period; however, given the low viral concentrations and transient nature of the observed viremic "blips," the risk of infectivity can be assumed to be small... - Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infectionEberhard W Fiebig
Department of Laboratory Medicine, University of California, San Francisco, CA, USA
AIDS 17:1871-9. 2003..Quantitative analysis of preseroconversion replication rates of HIV is useful for projecting the yield and predictive value of assays targeting primary HIV infection... - Interferon and interferon-induced chemokine expression is associated with control of acute viremia in West Nile virus-infected blood donorsLeslie H Tobler
University of California, San Francisco, CA 94118, USA
J Infect Dis 198:979-83. 2008..These findings suggest that IFN-mediated innate immunity plays a key role in initial control of WNV replication... - Clinical significance of nondiscriminated reactive results with the Chiron Procleix HIV-1 and HCV assayJoan D McAuley
Blood Systems Laboratory and Arizona State University, Tempe, 85282, USA
Transfusion 44:91-6. 2004..This study was designed to determine the clinical significance of NDR results... - The consequences of temporary deferral on future whole blood donationBrian Custer
Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA
Transfusion 47:1514-23. 2007..The consequences of temporary deferral are not well understood. This study sought to investigate blood donor return after deferral expiration... - HIV RNA testing in the context of nonoccupational postexposure prophylaxisMichelle E Roland
Positive Health Program at San Francisco General Hospital, Department of Medicine, University of California, San Francisco, CA 94110, USA
J Infect Dis 190:598-604. 2004..The specificity and positive predictive value of human immunodeficiency virus (HIV) RNA assays have not been evaluated in the setting of postexposure prophylaxis (PEP)... - Hepatitis B and C viral load changes following initiation of highly active antiretroviral therapy (HAART) in patients with advanced HIV infectionDavid M Asmuth
Department of Internal Medicine, University of California Davis Medical Center, Sacramento, CA, USA
Antiviral Res 63:123-31. 2004.... - Tregs control the development of symptomatic West Nile virus infection in humans and miceMarion C Lanteri
Blood Systems Research Institute, San Francisco, California 94118, USA
J Clin Invest 119:3266-77. 2009..Together, these results suggest that higher levels of peripheral Tregs after infection protect against severe WNV disease in immunocompetent animals and humans... - Performance of a transcription-mediated-amplification HIV-1 RNA assay in pooled specimensNicola M Zetola
Division of Infectious Diseases, University of California San Francisco, San Francisco, CA, United States
J Clin Virol 40:68-70. 2007..Very limited data exist on the comparative performance of nucleic acid amplification tests (NATs) for the screening of pooled specimens for acute human immunodeficiency virus (HIV) infection... - Phylogenetic analysis of WNV in North American blood donors during the 2003-2004 epidemic seasonsBelinda L Herring
Blood Systems Research Institute, San Francisco, CA 94118, USA
Virology 363:220-8. 2007..Amino acid mutations associated with newly expanding genetic variants reflect either selectively neutral mutational drift and/or mutations providing replicative advantages over the previously dominant forms of WNV... - Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapyHiroyu Hatano
San Francisco General Hospital, Building 80, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA
J Virol 83:329-35. 2009..This confirms the failure to eradicate the virus, even in these unique individuals who are able to reduce plasma viremia to very low levels without antiretroviral therapy... - Hepatitis C virus seroconversion among young injection drug users: relationships and risksJudith A Hahn
Department of Epidemiology, University of California, San Francisco, 94110, USA
J Infect Dis 186:1558-64. 2002..Interventions to reduce HCV transmission must recognize the importance of relationships on injecting risk... - Use of the sensitive/less-sensitive (detuned) EIA strategy for targeting genetic analysis of HIV-1 to recently infected blood donorsDaisy M Machado
Blood Centers of the Pacific, San Francisco, California 94118, USA
AIDS 16:113-9. 2002.... - Persistence of primary drug resistance among recently HIV-1 infected adultsJason D Barbour
Gladstone Institute of Virology and Immunology, San Francisco, California 94141-9100, USA
AIDS 18:1683-9. 2004..Surveillance and clinical detection of primary resistance is feasible in the first year of infection... - Two percent of HIV-positive U.S. blood donors are infected with non-subtype B strainsEric L Delwart
Blood Systems Research Institute, San Francisco 94118, California, USA
AIDS Res Hum Retroviruses 19:1065-70. 2003..The frequency of genetically confirmed non-subtype-B HIV infection in a geographically dispersed group of infected U.S. blood donors in 1977-2000 was therefore 2.0% (6/312)... - Higher CD4+ T cell counts associated with low viral pol replication capacity among treatment-naive adults in early HIV-1 infectionJason D Barbour
Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
J Infect Dis 190:251-6. 2004..The pol RC value of 43% may represent a threshold below which HIV-1 has lowered virulence and is less able to deplete CD4(+) T cell counts... - Impact of HCV 3.0 EIA relative to HCV 2.0 EIA on blood-donor screeningLeslie H Tobler
Blood Centers of the Pacific, Irwin Center, San Francisco, California 94118, USA
Transfusion 43:1452-9. 2003..0 EIA; the second study evaluated the differential performance of HCV 3.0 EIA in plasma donors acutely infected with HCV, identified during routine Abbott HCV 2.0 EIA and HCV NAT (using Roche Ampliscreen plate assay) donor screening... - The TNF (-308A) polymorphism is associated with microchimerism in transfused trauma patientsRyan M Gill
Department of Laboratory Medicine, University of California, San Francisco, USA
Blood 111:3880-3. 2008..Hence predisposing genetic factors may explain, in part, why only a subset of trauma patients develops transfusion-associated microchimerism... - Seroreversion in subjects receiving antiretroviral therapy during acute/early HIV infectionC Bradley Hare
Positive Health Program, University of California, San Francisco, San Francisco, CA, USA
Clin Infect Dis 42:700-8. 2006.... - Absence of activation of CMV by blood transfusion to HIV-infected, CMV-seropositive patientsW Lawrence Drew
University of California, San Francisco, Mount Zion Medical Center, California 94115, USA
Transfusion 43:1351-7. 2003.... - Comprehensive analysis of west nile virus-specific T cell responses in humansMarion C Lanteri
Blood Systems Research Institute, San Francisco, CA 94118, USA
J Infect Dis 197:1296-306. 2008..However, little is known about the immunogenic regions of the virus or the phenotype of responding T cells in human infection... - Estimating blood donor loss due to the variant CJD travel deferralEdward L Murphy
University of California and Blood Centers of the Pacific, San Francisco, California, USA
Transfusion 44:645-50. 2004..The FDA recommended new travel deferrals in May 2002 to prevent the potential transmission of variant CJD (vCJD). The predicted impact of such deferrals on the blood supply was controversial... - Increased all-cause, liver, and cardiac mortality among hepatitis C virus-seropositive blood donorsAnne M Guiltinan
Blood Systems Research Institute, San Francisco, CA 94118, USA
Am J Epidemiol 167:743-50. 2008..High rates of mortality from drug/alcohol and trauma/suicide causes are likely due to lifestyle factors and may be at least partially preventable... - Emerging infections in transfusion medicineEberhard W Fiebig
Department of Laboratory Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Clin Lab Med 24:797-823, viii. 2004.... - Time trends in primary HIV-1 drug resistance among recently infected personsRobert M Grant
Gladstone Institute of Virology and Immunology, PO Box 914100, San Francisco, CA 94141, USA
JAMA 288:181-8. 2002..Transmission of multiclass drug-resistant human immunodeficiency virus type 1 (HIV-1) may increase with wider use of antiretroviral therapy... - Development of a new less-sensitive enzyme immunoassay for detection of early HIV-1 infectionBhupat D Rawal
Blood Centers of the Pacific, San Francisco, California 94118, USA
J Acquir Immune Defic Syndr 33:349-55. 2003..These results support the potential use of the Vironostika-LS EIA for detection of recent HIV-1 infections for incidence projections and for other epidemiologic, clinical, and molecular surveillance applications... - Clinical investigation of posttransfusion Kidd blood group typing using a rapid normalized quantitative polymerase chain reactionLani Montalvo
Blood Systems Research Institute, Blood Centers of the Pacific, San Francisco, California 94118, USA
Transfusion 44:694-702. 2004..The assay performs well in the clinical setting. With further study, and inclusion of other blood group systems, this may become an important supplemental technique for selected patients in the immunohematology reference laboratory... - Quantitation of HTLV-I and II proviral load using real-time quantitative PCR with SYBR Green chemistryTzong-Hae Lee
Blood Systems Research Institute, San Francisco, CA 94118, USA
J Clin Virol 31:275-82. 2004..The sensitivity and high dynamic range allow determination of a broad range of HTLV-I/II proviral load in clinical subjects. This assay will facilitate the study of the relationship between proviral load and pathogenesis... - Use of laboratory tests and clinical symptoms for identification of primary HIV infectionFrederick M Hecht
Positive Health Program HIV Section at San Francisco General Hospital, tUniversity of California at San Francisco, 94110, USA
AIDS 16:1119-29. 2002..False-positive results can be reduced through duplicate testing and considering tests < 5000 copies/ml as indeterminate results requiring additional testing. p24 antigen was more specific than HIV-1 RNA testing but less sensitive... - Experience of German Red Cross blood donor services with nucleic acid testing: results of screening more than 30 million blood donations for human immunodeficiency virus-1, hepatitis C virus, and hepatitis B virusMichael K Hourfar
Institute of Transfusion and Immunohematology, German Red Cross Baden Württemberg Hessen, Johann Wolfgang Goethe University, Frankfurt, Germany
Transfusion 48:1558-66. 2008..In 1997, nucleic acid amplification technique (NAT)-testing was introduced at the German Red Cross (GRC) blood donor services to reduce this diagnostic window period (WP)... - Dengue viremia in blood donors from Honduras, Brazil, and AustraliaJeffrey M Linnen
Gen Probe, Inc, San Diego, California, USA
Transfusion 48:1355-62. 2008..Documented transfusion transmission of West Nile virus raised concern regarding transfusion-transmitted DENV... - International application of the incidence rate/window period modelSimone A Glynn
Transfusion 42:966-72. 2002 - Effect of a national disaster on blood supply and safety: the September 11 experienceSimone A Glynn
Westat, Rockville, Md 20850 2062, USA
JAMA 289:2246-53. 2003..An understanding of characteristics of blood donors donating in times of crisis may help predict blood supply safety and donor return patterns... - Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCVEishiro Mizukoshi
Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA
J Infect Dis 198:203-12. 2008..To identify immunological correlates for this apparent protection, we studied HCV-specific immune responses in long-term IDUs (duration, >10 years)... - HCV viral load in anti-HCV-reactive donors and infectivity for their recipientsEva A Operskalski
Transfusion Viruses Program, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9560, USA
Transfusion 43:1433-41. 2003..This is important for considerations about assay sensitivity, use of minipool versus single-donation testing, and continued use of serologic testing... - Frequency of HBV DNA detection in US blood donors testing positive for the presence of anti-HBc: implications for transfusion transmission and donor screeningSteven H Kleinman
Westat, Rockville, Maryland, USA
Transfusion 43:696-704. 2003..An estimate of the rate of HBV DNA-positive, anti-HBc-positive units is important for evaluating the need for anti-HBc donor screening, especially in the context of HBV NAT... - Impact of changes in viral marker screening assaysUsha K Sharma
Westat, Rockville, Maryland, USA
Transfusion 43:202-14. 2003..Before considering changes in screening tests, blood centers should be aware of, and evaluate, the potential impact on donor loss... - Frequency and duration of plasma CMV viremia in seroconverting blood donors and recipientsW Lawrence Drew
UCSF Mount Zion Medical Center, University of California and the Blood Centers of the Pacific, USA
Transfusion 43:309-13. 2003..To explain this residual risk, evidence of cell-free viremia was sought in seroconverting and seroprevalent blood donors and seroconverting transfusion recipients by means of a plasma-based assay for CMV DNA... - Risk factors for incident HIV infection among anonymous HIV testing site clients in Santos, Brazil: 1996-1999Katia Alves
Blood Centers of the Pacific, San Francisco, California, U.S.A
J Acquir Immune Defic Syndr 32:551-9. 2003..Results from this study will help to target appropriate prevention strategies directed toward at-risk populations in Santos... - Human immunodeficiency virus-1 infection correlates strongly with herpes simplex virus-2 (genital herpes) seropositivity in South African and United States blood donationsRichard J Benjamin
Biomedical Services, Medical Office, American Red Cross, Washington, DC 20006, USA
Transfusion 48:295-303. 2008.... - Behavioral and infectious disease risks in young blood donors: implications for recruitmentMark A Damesyn
Westat, Rockville, Maryland 20850-2062, USA
Transfusion 43:1596-603. 2003..The message not to donate when a behavioral risk is present or for obtaining HIV tests needs to be reinforced in younger donors... - Prevalence of HIV-1 in blood donations following implementation of a structured blood safety policy in South AfricaAnthon du P Heyns
South African National Blood Service, Weltevreden Park, South Africa
JAMA 295:519-26. 2006..The prevalence of HIV-1 in blood donations increased to 0.26% (1:385) in 1998, indicating that a significant number of window-period infective units were entering the blood supply (risk 3.4/100,000)... - Utilization of follow-up specimens from viremic blood donors to assess the value of west nile virus immunoglobulin G avidity as an indicator of recent infectionHarry E Prince
Focus Diagnostics, Cypress, CA 90630, USA
Clin Diagn Lab Immunol 12:1123-6. 2005..Low avidity accurately indicated infection within the previous 4 months. However, due to rapid avidity maturation in some individuals, high avidity did not accurately indicate past infection... - Trends in antiretroviral drug resistance and clade distributions among HIV-1--infected blood donors in Sao Paulo, BrazilClaudia C Barreto
, , , Brazil
J Acquir Immune Defic Syndr 41:338-41. 2006..Although HIV-1 subtype B remains predominant, subtypes F and C and recombinant forms are present in substantial proportions in infected donors... - Yield of hepatitis C virus nucleic acid testing among antibody-reactive or confirmed-positive samplesMichael Schmidt
Transfusion 45:1040-2. 2005 - Dynamics of viremia in early hepatitis C virus infectionSimone A Glynn
Westat, Rockville, Maryland, USA
Transfusion 45:994-1002. 2005..Animal inoculation studies are in progress to evaluate if transfusion of low-level viremic plasma can transmit HCV infection... - Microchimerism in transfused trauma patients is associated with diminished donor-specific lymphocyte responseGarth H Utter
Department of Surgery, University of California, Davis, Medical Center, Sacramento, California 95817, USA
J Trauma 58:925-31; discussion 931-2. 2005..The blood donor associated with this diminished alloantigenic lymphocyte response may be the source of microchimeric cells present in the recipient... - The impact of male-to-male sexual experience on risk profiles of blood donorsAna M Sanchez
Westat, Rockville, Maryland 20850, USA
Transfusion 45:404-13. 2005..For donors with a more remote history of male-to-male sex, the findings were equivocal. A better understanding of the association between male-to-male sex and other UDRs appears needed... - Lessons and opportunities from epidemiologic and molecular investigations of infected blood donorsMichael P Busch
Transfusion 46:1663-6. 2006 - Leukoreduction of blood transfusions does not diminish transfusion-associated microchimerism in trauma patientsGarth H Utter
Department of Surgery, Harborview Medical Center University of Washington, Seattle, Washington, USA
Transfusion 46:1863-9. 2006..The aim was to determine whether leukoreduction of blood transfusions, advocated to reduce the immunomodulatory effect of transfusion, decreases the likelihood of developing TA-MC... - Strategies for testing blood donors for West Nile virusSusan L Stramer
Transfusion 46:2036-7. 2006 - Lack of correlation between HBsAg and HBV DNA levels in blood donors who test positive for HBsAg and anti-HBc: implications for future HBV screening policyMary C Kuhns
Abbott Laboratories, Abbott Park, Illinois, USA
Transfusion 44:1332-9. 2004..Studies showing a significant correlation between hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) deoxyribonucleic acid (DNA) levels have focused on the HBV seroconversion window period... - Detection of HIV-1 and HCV infections among antibody-negative blood donors by nucleic acid-amplification testingSusan L Stramer
American Red Cross, Gaithersburg, MD, USA
N Engl J Med 351:760-8. 2004.... - Donation archives and prospective donor-recipient repositories: indispensable tools for monitoring blood safetyJean Pierre Allain
Transfusion 47:1110-4. 2007 - Persistence of West Nile virus-specific antibodies in viremic blood donorsHarry E Prince
Focus Diagnostics, Cypress, California, USA
Clin Vaccine Immunol 14:1228-30. 2007..At 1-year of follow-up, 17% of the donors (n = 23) were positive for WNV IgM, 57% were positive for WNV IgA, and 100% were positive for WNV IgG... - Development and persistence of West Nile virus-specific immunoglobulin M (IgM), IgA, and IgG in viremic blood donorsHarry E Prince
Focus Diagnostics, Cypress, CA 90630, USA
J Clin Microbiol 43:4316-20. 2005..Thus, unlike some other flavivirus infections, WNV infection is not characterized by a relatively rapid disappearance of virus-specific IgA... - Prevalence, incidence, and residual risk of human immunodeficiency virus among community and replacement first-time blood donors in São Paulo, BrazilClaudia C Barreto
, Brazil
Transfusion 45:1709-14. 2005..Community FT donors had higher HIV prevalence than replacement FT donors. The yield of p24 antigen or RNA screening will be low in Brazilian donors, but substantially higher than in US donors...
Research Grants
- Mechanisms and clinical effects of microchimerism in transfused trauma patientsMichael Busch; Fiscal Year: 2009..TA-MC also offers an opportunity to better understand, and potentially exploit, injury-induced tolerance for future therapeutic purposes. ..
- Natural History and Pathogenesis of WNV in Viremic Dono*Michael Busch; Fiscal Year: 2007..abstract_text> ..
- Mechanisms and clinical effects of microchimerism in transfused trauma patientsMichael Busch; Fiscal Year: 2007..TA-MC also offers an opportunity to better understand, and potentially exploit, injury-induced tolerance for future therapeutic purposes. ..
- Natural history of acute and chronic HCV in blood donorsMichael Busch; Fiscal Year: 2007..These investigations will yield important insights into HCV pathogenesis and clarify the natural history of disease for the large number of HCV infected persons identified through donor screening. ..
- Natural History and Pathogenesis of WNV in Viremic Dono*Michael Busch; Fiscal Year: 2006..abstract_text> ..
- Mechanisms and clinical effects of microchimerism in transfused trauma patientsMICHAEL PAUL BUSCH; Fiscal Year: 2010..TA-MC also offers an opportunity to better understand, and potentially exploit, injury-induced tolerance for future therapeutic purposes. ..