Jan Charles Biro

Summary

Country: USA

Publications

  1. ncbi Frequent occurrence of recognition site-like sequences in the restriction endonucleases
    Jan C Biro
    Karolinska Institute, Stockholm, Sweden
    BMC Bioinformatics 5:30. 2004
  2. ncbi Protein folding information in nucleic acids which is not present in the genetic code
    Jan C Biro
    Homulus Foundation, 88 Howard 1205, San Francisco, CA 94195, USA
    Ann N Y Acad Sci 1091:399-411. 2006
  3. ncbi Indications that "codon boundaries" are physico-chemically defined and that protein-folding information is contained in the redundant exon bases
    Jan Charles Biro
    Homulus Foundation, San Francisco, CA 94105, USA
    Theor Biol Med Model 3:28. 2006
  4. ncbi Amino acid size, charge, hydropathy indices and matrices for protein structure analysis
    J C Biro
    Homulus Foundation, San Francisco, CA, USA
    Theor Biol Med Model 3:15. 2006
  5. ncbi A novel intra-molecular protein-protein interaction code based on partial complementary coding of co-locating amino acids
    Jan C Biro
    Homulus Foundation, 88 Howard, 1205, San Francisco, CA 94 105, USA
    Med Hypotheses 66:137-42. 2006
  6. ncbi Nucleic acid chaperons: a theory of an RNA-assisted protein folding
    Jan C Biro
    Homulus Foundation, San Francisco, CA 94105, USA
    Theor Biol Med Model 2:35. 2005
  7. ncbi SeqX: a tool to detect, analyze and visualize residue co-locations in protein and nucleic acid structures
    Jan C Biro
    Homulus Foundation, San Francisco, CA 94105 1649, USA
    BMC Bioinformatics 6:170. 2005
  8. ncbi Seven fundamental, unsolved questions in molecular biology. Cooperative storage and bi-directional transfer of biological information by nucleic acids and proteins: an alternative to "central dogma"
    J C Biro
    Karolinska Institute, Stockholm, Sweden
    Med Hypotheses 63:951-62. 2004
  9. ncbi A novel sequence similarity searching and visualization method based on overlappingly translated nucleic acids: the blastNP
    Jan C Biro
    Homulus Informatics, 88 Howard, 1205, San Francisco, CA 94105, USA
    Med Hypotheses 62:568-74. 2004
  10. ncbi In search of the nature of specific nucleic acid-protein interactions
    J C Biro
    Karolinska Institute, Stockholm, Sweden
    Acta Physiol Hung 92:1-10. 2005

Collaborators

Detail Information

Publications12

  1. ncbi Frequent occurrence of recognition site-like sequences in the restriction endonucleases
    Jan C Biro
    Karolinska Institute, Stockholm, Sweden
    BMC Bioinformatics 5:30. 2004
    ..This question is fundamental to understand the nature of specific protein-nucleic acid interactions...
  2. ncbi Protein folding information in nucleic acids which is not present in the genetic code
    Jan C Biro
    Homulus Foundation, 88 Howard 1205, San Francisco, CA 94195, USA
    Ann N Y Acad Sci 1091:399-411. 2006
    ....
  3. ncbi Indications that "codon boundaries" are physico-chemically defined and that protein-folding information is contained in the redundant exon bases
    Jan Charles Biro
    Homulus Foundation, San Francisco, CA 94105, USA
    Theor Biol Med Model 3:28. 2006
    ..It is suspected that additional folding information is present in protein coding nucleic acid sequences, but this is not represented by the known genetic code...
  4. ncbi Amino acid size, charge, hydropathy indices and matrices for protein structure analysis
    J C Biro
    Homulus Foundation, San Francisco, CA, USA
    Theor Biol Med Model 3:15. 2006
    ..It is believed that such prediction will prove possible if Anfinsen's thermodynamic principle is correct for all kinds of proteins, and all the information necessary to form a concrete 3D structure is indeed present in the sequence...
  5. ncbi A novel intra-molecular protein-protein interaction code based on partial complementary coding of co-locating amino acids
    Jan C Biro
    Homulus Foundation, 88 Howard, 1205, San Francisco, CA 94 105, USA
    Med Hypotheses 66:137-42. 2006
    ..Furthermore it might be useful even in protein design...
  6. ncbi Nucleic acid chaperons: a theory of an RNA-assisted protein folding
    Jan C Biro
    Homulus Foundation, San Francisco, CA 94105, USA
    Theor Biol Med Model 2:35. 2005
    ..It seems to be a logical to try to find the "missing" information in nucleic acids, in the redundant codon base...
  7. ncbi SeqX: a tool to detect, analyze and visualize residue co-locations in protein and nucleic acid structures
    Jan C Biro
    Homulus Foundation, San Francisco, CA 94105 1649, USA
    BMC Bioinformatics 6:170. 2005
    ..We developed a JAVA tool, called SeqX for this purpose...
  8. ncbi Seven fundamental, unsolved questions in molecular biology. Cooperative storage and bi-directional transfer of biological information by nucleic acids and proteins: an alternative to "central dogma"
    J C Biro
    Karolinska Institute, Stockholm, Sweden
    Med Hypotheses 63:951-62. 2004
    ..The flow of information between nucleic acids and proteins is bi-directional and reverse translation might exist; 7. Complex genetic information is always carried and stored by nucleic acids and proteins together...
  9. ncbi A novel sequence similarity searching and visualization method based on overlappingly translated nucleic acids: the blastNP
    Jan C Biro
    Homulus Informatics, 88 Howard, 1205, San Francisco, CA 94105, USA
    Med Hypotheses 62:568-74. 2004
    ..This novel method was proved to find significant sequence similarities which remained hidden for other methods and is a promising tool for further understanding (and annotating) the function of many old and new sequences...
  10. ncbi In search of the nature of specific nucleic acid-protein interactions
    J C Biro
    Karolinska Institute, Stockholm, Sweden
    Acta Physiol Hung 92:1-10. 2005
    ..These results indicate that the smallest possible units of specific nucleic acid-protein interaction are indeed the stereochemically compatible codons and amino acids...
  11. ncbi A common periodic table of codons and amino acids
    J C Biro
    Karolinska Institute, Stockholm, Sweden
    Biochem Biophys Res Commun 306:408-15. 2003
    ..The table emphasizes the importance of the central nucleotide in the codons and predicts that purines control the charge while pyrimidines determine the polarity of the amino acids. This prediction was experimentally tested...
  12. ncbi Speculations about alternative DNA structures
    Jan Charles Biro
    Karolinska Institute and Homulus Informatics, Karlaplan, Sweden
    Med Hypotheses 61:86-97. 2003
    ..It is possible that a small portion of the total DNA, the transcribed, 'working DNA', might be built by this way...