B Attardi

Summary

Affiliation: BIOQUAL Inc
Country: USA

Publications

  1. ncbi Development of dimethandrolone 17beta-undecanoate (DMAU) as an oral male hormonal contraceptive: induction of infertility and recovery of fertility in adult male rabbits
    Barbara J Attardi
    Division of Reproductive Endocrinology and Toxicology, BIOQUAL Inc, 9600 Medical Center Dr, Rockville, MD 20850, USA
    J Androl 32:530-40. 2011
  2. ncbi Long-term effects of dimethandrolone 17?-undecanoate and 11?-methyl-19-nortestosterone 17?-dodecylcarbonate on body composition, bone mineral density, serum gonadotropins, and androgenic/anabolic activity in castrated male rats
    Barbara J Attardi
    Molecular Endocrinology Laboratory, Division of Reproductive Endocrinology and Toxicology, BIOQUAL Inc, 9600 Medical Center Drive, Rockville, MD 20850, USA
    J Androl 32:183-92. 2011
  3. ncbi The potent synthetic androgens, dimethandrolone (7?,11?-dimethyl-19-nortestosterone) and 11?-methyl-19-nortestosterone, do not require 5?-reduction to exert their maximal androgenic effects
    Barbara J Attardi
    Division of Reproductive Endocrinology and Toxicology, BIOQUAL, Inc, 9600 Medical Center Dr, Rockville, MD 20850, United States
    J Steroid Biochem Mol Biol 122:212-8. 2010
  4. ncbi Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male rat
    Barbara J Attardi
    BIOQUAL, Inc Division of Reproductive Endocrinology and Toxicology, 9600 Medical Center Dr, Rockville, MD 20850, USA
    Mol Cell Endocrinol 328:16-21. 2010
  5. ncbi Dimethandrolone undecanoate: a new potent orally active androgen with progestational activity
    Barbara J Attardi
    Molecular Endocrinology Laboratory, BIOQUAL, Inc, Rockville, Maryland 20850, USA
    Endocrinology 147:3016-26. 2006
  6. ncbi Facilitation or inhibition of the oestradiol-induced gonadotrophin surge in the immature female rat by progesterone: effects on pituitary responsiveness to gonadotrophin-releasing hormone (GnRH), GnRH self-priming and pituitary mRNAs for the progesterone
    B Attardi
    Department of Neurobiology and Behavior, The Rockefeller University, New York, NY, USA
    J Neuroendocrinol 19:988-1000. 2007
  7. ncbi Dimethandrolone (7alpha,11beta-dimethyl-19-nortestosterone) and 11beta-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase
    Barbara J Attardi
    Division of Reproductive Endocrinology and Toxicology, BIOQUAL Inc, 9600 Medical Center Drive, Rockville, MD 20850, USA
    J Steroid Biochem Mol Biol 110:214-22. 2008
  8. ncbi Mechanism of action of bolandiol (19-nortestosterone-3beta,17beta-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities
    Barbara J Attardi
    BIOQUAL, Inc, 9600 Medical Center Dr, Rockville, MD 20850, USA
    J Steroid Biochem Mol Biol 118:151-61. 2010
  9. ncbi Mechanism of action of l-CDB-4022, a potential nonhormonal male contraceptive, in the seminiferous epithelium of the rat testis
    Sailaja Koduri
    Division of Reproductive Endocrinology and Toxicology, BIOQUAL Inc, 9600 Medical Center Drive, Rockville, MD 20850 3336, USA
    Endocrinology 149:1850-60. 2008
  10. ncbi CDB-4124 and its putative monodemethylated metabolite, CDB-4453, are potent antiprogestins with reduced antiglucocorticoid activity: in vitro comparison to mifepristone and CDB-2914
    Barbara J Attardi
    Molecular Endocrinology Laboratory, BIOQUAL, Inc, 9600 Medical Center Drive, Rockville, MD 20850, USA
    Mol Cell Endocrinol 188:111-23. 2002

Detail Information

Publications15

  1. ncbi Development of dimethandrolone 17beta-undecanoate (DMAU) as an oral male hormonal contraceptive: induction of infertility and recovery of fertility in adult male rabbits
    Barbara J Attardi
    Division of Reproductive Endocrinology and Toxicology, BIOQUAL Inc, 9600 Medical Center Dr, Rockville, MD 20850, USA
    J Androl 32:530-40. 2011
    ..Collectively, these data indicate that DMAU has the potential to be an orally active single-agent male hormonal contraceptive at an appropriate dose level and should be tested for contraceptive efficacy in nonhuman primates...
  2. ncbi Long-term effects of dimethandrolone 17?-undecanoate and 11?-methyl-19-nortestosterone 17?-dodecylcarbonate on body composition, bone mineral density, serum gonadotropins, and androgenic/anabolic activity in castrated male rats
    Barbara J Attardi
    Molecular Endocrinology Laboratory, Division of Reproductive Endocrinology and Toxicology, BIOQUAL Inc, 9600 Medical Center Drive, Rockville, MD 20850, USA
    J Androl 32:183-92. 2011
    ..05). Collectively, our data indicate that androgen replacement with DMAU or 11?-MNTDC in Cx rats resulted in favorable changes in body composition and maintenance of BMD comparable to those of T...
  3. ncbi The potent synthetic androgens, dimethandrolone (7?,11?-dimethyl-19-nortestosterone) and 11?-methyl-19-nortestosterone, do not require 5?-reduction to exert their maximal androgenic effects
    Barbara J Attardi
    Division of Reproductive Endocrinology and Toxicology, BIOQUAL, Inc, 9600 Medical Center Dr, Rockville, MD 20850, United States
    J Steroid Biochem Mol Biol 122:212-8. 2010
    ..These results indicate that inhibition of 5?-reductase activity in vivo does not affect the androgenic potency of DMA, MNT, or MENT...
  4. ncbi Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male rat
    Barbara J Attardi
    BIOQUAL, Inc Division of Reproductive Endocrinology and Toxicology, 9600 Medical Center Dr, Rockville, MD 20850, USA
    Mol Cell Endocrinol 328:16-21. 2010
    ..2mg/kg/day; and NES and CPA showed no or minimal LH suppression at doses up to 3.2mg/kg/day. We concluded, therefore, that suppression of LH is correlated with androgenic, rather than progestational, potency of the synthetic progestins...
  5. ncbi Dimethandrolone undecanoate: a new potent orally active androgen with progestational activity
    Barbara J Attardi
    Molecular Endocrinology Laboratory, BIOQUAL, Inc, Rockville, Maryland 20850, USA
    Endocrinology 147:3016-26. 2006
    ....
  6. ncbi Facilitation or inhibition of the oestradiol-induced gonadotrophin surge in the immature female rat by progesterone: effects on pituitary responsiveness to gonadotrophin-releasing hormone (GnRH), GnRH self-priming and pituitary mRNAs for the progesterone
    B Attardi
    Department of Neurobiology and Behavior, The Rockefeller University, New York, NY, USA
    J Neuroendocrinol 19:988-1000. 2007
    ..The differences between progesterone-facilitation and progesterone-inhibition are not due to differences in regulation of pituitary PR-B mRNA...
  7. ncbi Dimethandrolone (7alpha,11beta-dimethyl-19-nortestosterone) and 11beta-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase
    Barbara J Attardi
    Division of Reproductive Endocrinology and Toxicology, BIOQUAL Inc, 9600 Medical Center Drive, Rockville, MD 20850, USA
    J Steroid Biochem Mol Biol 110:214-22. 2008
    ....
  8. ncbi Mechanism of action of bolandiol (19-nortestosterone-3beta,17beta-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities
    Barbara J Attardi
    BIOQUAL, Inc, 9600 Medical Center Dr, Rockville, MD 20850, USA
    J Steroid Biochem Mol Biol 118:151-61. 2010
    ..As bolandiol exhibits tissue selectivity in vivo, it may act via AR, PR, and/or ER, utilize alternative signaling pathway(s) or transcriptional coregulators, and/or be metabolized to a more potent selective steroid...
  9. ncbi Mechanism of action of l-CDB-4022, a potential nonhormonal male contraceptive, in the seminiferous epithelium of the rat testis
    Sailaja Koduri
    Division of Reproductive Endocrinology and Toxicology, BIOQUAL Inc, 9600 Medical Center Drive, Rockville, MD 20850 3336, USA
    Endocrinology 149:1850-60. 2008
    ....
  10. ncbi CDB-4124 and its putative monodemethylated metabolite, CDB-4453, are potent antiprogestins with reduced antiglucocorticoid activity: in vitro comparison to mifepristone and CDB-2914
    Barbara J Attardi
    Molecular Endocrinology Laboratory, BIOQUAL, Inc, 9600 Medical Center Drive, Rockville, MD 20850, USA
    Mol Cell Endocrinol 188:111-23. 2002
    ..In agreement with our in vivo results, CDB-4124 and CDB-4453, as well as CDB-2914, are potent antiprogestins in vitro, but show considerably less antiglucocorticoid activity than mifepristone...
  11. ncbi Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis)
    Sheri Ann Hild
    Division of Reproductive Endocrinology and Toxicology, BIOQUAL, Inc, 9600 Medical Center Drive, Rockville, Maryland 20850, USA
    Endocrinology 148:1784-96. 2007
    ....
  12. ncbi Steroid hormonal regulation of growth, prostate specific antigen secretion, and transcription mediated by the mutated androgen receptor in CWR22Rv1 human prostate carcinoma cells
    Barbara J Attardi
    Molecular Endocrinology Laboratory, BIOQUAL Inc, 9600 Medical Center Drive, Rockville, MD 20850, USA
    Mol Cell Endocrinol 222:121-32. 2004
    ....
  13. ncbi In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone
    Barbara J Attardi
    Molecular Endocrinology Laboratory, BIOQUAL Inc, 9600 Medical Center Drive, Rockville, MD 20850, USA
    J Steroid Biochem Mol Biol 88:277-88. 2004
    ..Furthermore, the reduced antiglucocorticoid activity of CDB-2914 and CDB-4124 compared to mifepristone in vivo may be due in part to decreased activity of their putative proximal metabolites...
  14. ncbi The ability of a gonadotropin-releasing hormone antagonist, acyline, to prevent irreversible infertility induced by the indenopyridine, CDB-4022, in adult male rats: the role of testosterone
    Sheri Ann Hild
    BIOQUAL, Inc, Rockville, Maryland 20850, USA
    Biol Reprod 71:348-58. 2004
    ..Continued development of CDB-4022 as a potential male contraceptive will depend largely on its safety profile and whether its antispermatogenic activity is reversible in primates...
  15. ncbi Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha hydroxyprogesterone caproate, and related progestins
    Barbara J Attardi
    Molecular Endocrinology Laboratory, BIOQUAL, Inc, Rockville, MD, USA
    Am J Obstet Gynecol 197:599.e1-7. 2007
    ....