Research Topics
| P YotndaSummaryAffiliation: Baylor College of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Hypoxic tumors and their effect on immune cells and cancer therapyPatricia Yotnda
Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA
Methods Mol Biol 651:1-29. 2010..This review summarizes the most common effects of hypoxia on immune cells that play a key role in the anti-tumor response, the limitation of current therapies, and the potential solutions that were developed for hypoxic malignancies...- Comparison of the efficiency of transduction of leukemic cells by fiber-modified adenovirusesP Yotnda
Center for Cell and Gene Therapy, Baylor College of Medicine, Methodist Hospital, and Texas Children s Hospital, Houston, TX 77030, USA
Hum Gene Ther 15:1229-42. 2004..Ad5F/K21 and Ad5F/RGD should be of value for the genetic modification of human primary leukemia cells... - Targeted delivery of adenoviral vectors by cytotoxic T cellsPatricia Yotnda
Center for Cell and Gene Therapy, 6621 Fannin St, MC3 3320, Houston, TX 77030, USA
Blood 104:2272-80. 2004.... - Bilamellar cationic liposomes protect adenovectors from preexisting humoral immune responsesPatricia Yotnda
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Ther 5:233-41. 2002.... - Liposomal enhancement of the antitumor activity of conditionally replication-competent adenoviral plasmidsPatricia Yotnda
Center for Cell and Gene Therapy, Texas Children s Hospital, Baylor College of Medicine, Houston, TX 77030, USA
Mol Ther 9:489-95. 2004.... - Autologous antileukemic immune response induced by chronic lymphocytic leukemia B cells expressing the CD40 ligand and interleukin 2 transgenesS Takahashi
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Hum Gene Ther 12:659-70. 2001..These findings suggest that the combined use of genetically modified CD40L-expressing B-CLL cells in combination with IL-2-expressing B-CLL cells may induce therapeutically significant leukemia-specific immune responses... - Adenovirus-mediated BMP2 expression in human bone marrow stromal cellsE A Olmsted
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
J Cell Biochem 82:11-21. 2001..In short, the efficiency of adenovirus mediated expression of BMP2 in bone marrow stromal cells appears to be dependent on the differentiation state of these cells... - Efficient infection of primitive hematopoietic stem cells by modified adenovirusP Yotnda
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Gene Ther 8:930-7. 2001..The ability of Ad5/F35 to deliver transgenes to primitive HPC with high efficiency and low toxicity in the absence of growth factors provides an improved means of studying the consequences of transient gene expression in these cells... - Engineering human tumor-specific cytotoxic T cells to function in a hypoxic environmentHongsung Kim
Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, Methodist Hospital, Houston, Texas 77030, USA
Mol Ther 16:599-606. 2008..Hypoxia-resistant T cells may thus be of value in the treatment of human tumors in which areas of hypoxia may otherwise account for resistance to this therapeutic strategy... - Transgenic expression of CD40L and interleukin-2 induces an autologous antitumor immune response in patients with non-Hodgkin's lymphomaS Takahashi
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
Cancer Gene Ther 8:378-87. 2001..These findings suggest that the combination of CD40L and IL2 gene-modified B-NHL cells will induce a cytotoxic immune response in vivo directed against unmodified tumor cells... - Use of a chimeric adenovirus vector enhances BMP2 production and bone formationElizabeth A Olmsted-Davis
Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Hum Gene Ther 13:1337-47. 2002..Mineralized bone was radiologically identified only in muscle that received the Ad5F35BMP2 transduced hBM-MSCs. In summary, Ad5F35BMP2 can efficiently transduce hBM-MSCs leading to enhanced bone formation in vivo... - Reduced inflammatory reactions to the inoculation of helper-dependent adenoviral vectors in traumatically injured rat brainLinglong Zou
Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, USA
J Cereb Blood Flow Metab 22:959-70. 2002..The results suggest that hdAd are less immunogenic vectors than conventional adenoviral vectors, and offer improved vehicles for long-term therapeutic transgene transfer to traumatically injured brains... - An inducible caspase 9 safety switch for T-cell therapyKarin C Straathof
Center for Cell and Gene Therapy, Baylor College of Meidcine, Houston, TX 77030, USA
Blood 105:4247-54. 2005..Third, inducible caspase 9 maintains function in T cells overexpressing antiapoptotic molecules. These characteristics favor incorporation of inducible caspase 9 as a safety feature in human T-cell therapies... - Transgenic expression of CD40 ligand produces an in vivo antitumor immune response against both CD40(+) and CD40(-) plasmacytoma cellsGianpietro Dotti
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Blood 100:200-7. 2002..Hence, transgenic CD40L expression may produce an antimyeloma immune response against either CD40(+) or CD40(-) tumors and may be of therapeutic value for both types of myeloma in humans... - Fiber-modified recombinant adenoviral constructs encoding hepatitis C virus proteins induce potent HCV-specific T cell responseDuangtawan Thammanichanond
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
Clin Immunol 128:329-39. 2008..These findings provide an effective approach for the expansion of HCV-specific CTLs from PBMCs of HCV-infected patients and have potential for immunotherapeutic/vaccine development... - Induction of therapeutic T-cell responses to subdominant tumor-associated viral oncogene after immunization with replication-incompetent polyepitope adenovirus vaccineJaikumar Duraiswamy
Cooperative Research Centre for Vaccine Technology, Tumour Immunology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Bancroft Centre, 300 Herston Road, Brisbane, QLD 4029, Australia
Cancer Res 64:1483-9. 2004.... - Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcriptRoberto Rangel
Department of Immunology, M D Anderson Cancer Center, The University of Texas, Houston, Texas 77054, USA
J Biol Chem 280:17807-14. 2005..In addition, the present study confirms the co-existence of surrogate lambda and kappa receptors that are proposed to work in concert to promote B lymphocyte maturation...
Research Grants
- Adenoviral vectors to target cellsPatricia Yotnda; Fiscal Year: 2006..At the conclusion of this study we will have in place an approach that could be implemented to allow truly targeted delivery of therapeutic vectors to disseminated malignancies. ..
- Engineered tumor-specific T cells Resist Hypoxic-Tumor Immunosuppressive Attacks.Patricia Yotnda; Fiscal Year: 2010..We will reinforce the activity, persistence, and overall effectiveness of T cells by increasing their resistance to hypoxia- and oxidant-mediated immunosuppression. ..