Research Topics
Genomes and Genes | R F SmithSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
BCM Search Launcher--an integrated interface to molecular biology data base search and analysis services available on the World Wide WebR F Smith
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Genome Res 6:454-62. 1996..The BCM Search Launcher and batch client are available on the WWW at URL http:@gc.bcm.tmc.edu:8088/search-launcher.html...- Developments in ghrelin biology and potential clinical relevanceRoy G Smith
Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Trends Endocrinol Metab 16:436-42. 2005.... - Molecular endocrinology and physiology of the aging central nervous systemRoy G Smith
Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, M320, Houston, TX 77030, USA
Endocr Rev 26:203-50. 2005.... - Growth hormone secretagogues: prospects and potential pitfallsRoy G Smith
Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza N704, M320, Houston, TX 77030 3498, USA
Best Pract Res Clin Endocrinol Metab 18:333-47. 2004..Ghrelin levels are reported to decline during ageing, therefore long-acting GHSs are ideal candidates for ghrelin replacement therapy... - Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during agingRoy G Smith
Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, MS BCM M230, Houston, TX 77030, USA
Ann N Y Acad Sci 1119:147-64. 2007..We speculate that aging is associated with deficient endogenous ghrelin signaling that can be rescued by intervention with GHS-R1a agonists to improve quality of life and maintain independence... - Huffington Center on AgingRoy G Smith
Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, N704, Houston, TX 77030-3498, USA
Exp Gerontol 37:963-9. 2002 - Growth hormone secretagogue receptor family members and ligandsR G Smith
Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030 3498, USA
Endocrine 14:9-14. 2001..We also confirmed that the endogenous ligand ghrelin is a full agonist of the GHS-R... - Adenosine: A partial agonist of the growth hormone secretagogue receptorR G Smith
Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, USA
Biochem Biophys Res Commun 276:1306-13. 2000..We propose, that adenosine is a physiologically important endogenous GHS-R ligand and speculate that GHS-R ligands modulate dopamine release from hypothalamic neurons... - The aging process: where are the drug opportunities?R G Smith
Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Curr Opin Chem Biol 4:371-6. 2000..The orphan nuclear receptor Nurr1 appears to be a target for treatment of Parkinson's disease, and propargylamines are emerging as inhibitors of oxidative damage in neurons... - Growth hormone releasing substances: types and their receptorsR G Smith
Huffington Center on Aging and Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030 3498, USA
Horm Res 51:1-8. 1999..This new information is consistent with a natural ligand for the GHS-R playing a fundamentally important and conserved role in physiology... - Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptorYuxiang Sun
Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 101:4679-84. 2004..Our results suggest that chronic treatment with ghrelin antagonists will have little effect on growth or appetite... - BEAUTY: an enhanced BLAST-based search tool that integrates multiple biological information resources into sequence similarity search resultsK C Worley
Department of Molecular and Human Genetics, W M Keck Center for Computational Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Genome Res 5:173-84. 1995..BEAUTY searches can be performed remotely on our system using the "BCM Search Launcher" World-Wide Web pages (URL is < http:/ /gc.bcm.tmc.edu:8088/ search-launcher/launcher.html > )... - Growth hormone corrects proliferation and transcription of phosphoenolpyruvate carboxykinase in livers of old mice via elimination of CCAAT/enhancer-binding protein alpha-Brm complexGuo Li Wang
Huffington Center on Aging and Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 282:1468-78. 2007..GH-dependent elimination of the complex is mediated by the inhibition of cyclin D3-CDK4 activity and by elevation of a phosphatase, protein phosphatase 2A, which dephosphorylates C/EBPalpha and dissociates the complex... - Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob miceYuxiang Sun
Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Cell Metab 3:379-86. 2006..Hence, chronically, ghrelin controls glucose homeostasis by regulating pancreatic Ucp2 expression and insulin sensitivity... - Ghrelin and growth hormone secretagogue receptor expression in mice during agingYuxiang Sun
Huffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, M320, Houston, TX 77030, USA
Endocrinology 148:1323-9. 2007..In the brain, Ghsr1a mRNA levels remained stable during aging. Hence, in C57BL/6J male mice, aging is not associated with changes in circulating ghrelin levels or changes in ghrelin receptor expression in the pituitary gland and brain... - Central and peripheral roles of ghrelin on glucose homeostasisYuxiang Sun
Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
Neuroendocrinology 86:215-28. 2007..This review focuses on the newly emerging role of ghrelin in glucose homeostasis and exploration of whether ghrelin is a potential therapeutic target for diabetes... - Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexesGuo Li Wang
Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Mol Cell Biol 26:2570-82. 2006..The inhibition of cyclin D3 blocks the formation of these complexes. Thus, these studies provide a new function of cyclin D3, which is to support the growth-inhibitory activity of C/EBPalpha... - The steroidogenic acute regulatory protein is expressed in steroidogenic cells of the day-old brainSteven R King
Room N730, Scott Department of Urology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 3498, USA
Endocrinology 145:4775-80. 2004..Importantly, StAR protein is present in cells that also express P450scc. These data suggest that, as with the adult, neurosteroid production during development occurs through a StAR-mediated pathway... - Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexiaJose M Garcia
Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism and The Huffington Center on Aging, Baylor College of Medicine, and Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
J Clin Endocrinol Metab 90:2920-6. 2005..Changes in the active to total ghrelin ratio suggest that a mechanism other than increased secretion must be responsible for the increase in active ghrelin levels. PYY is unlikely to play an important role in cancer-induced cachexia... - Mutations in NR4A2 associated with familial Parkinson diseaseWei Dong LE
Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nat Genet 33:85-9. 2003..Additionally, mutations in NR4A2 affect transcription of the gene encoding tyrosine hydroxylase. These data suggest that mutations in NR4A2 can cause dopaminergic dysfunction, associated with Parkinson disease... - BEAUTY-X: enhanced BLAST searches for DNA queriesK C Worley
Human Genome Center, Department of Molecular and Human Genetics, Baylor College of Medicine, N 1519 08, One Baylor Plaza, Houston, TX 77030, USA
Bioinformatics 14:890-1. 1998..6) (ftp://gc.bcm.tmc. edu/pub/software/search-launcher/). SUPPLEMENTARY INFORMATION: Example figures are available at http://dot.bcm.tmc. edu:9331/papers/beautypp.html CONTACT: (kworley,culpep)@bcm.tmc.edu.. - Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexiaJose M Garcia
Division of Endocrinology, Diabetes and Metabolism, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
Endocrinology 149:455-60. 2008..Attenuation of mechanical hyperalgesia in the rat by the hormone ghrelin provides a unique model for elucidating the mechanisms involved, which are essential toward our understanding of these complications... - Development of growth hormone secretagoguesRoy G Smith
Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Room M320, Houston, Texas 77030-3498, USA
Endocr Rev 26:346-60. 2005..Reverse pharmacology was completed when the cloned GHS-R was exploited to identify an endogenous agonist (ghrelin) and a partial agonist (adenosine); ghsr-knockout mice studies confirmed that GHS are ghrelin mimetics... - Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimersHong Jiang
Huffington Center of Aging, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 20:1772-85. 2006..Most importantly, these results indicate that ghrelin has the potential to amplify dopamine signaling selectively in neurons that coexpress D1R and GHS-R... - Deletion of ghrelin impairs neither growth nor appetiteYuxiang Sun
Department of Molecular and Cellular Biology, Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Mol Cell Biol 23:7973-81. 2003..Therefore, antagonists of ghrelin are unlikely to have broad utility as antiobesity agents... - A comparative transcription map of the murine bare patches (Bpa) and striated (Str) critical regions and human Xq28M L Levin
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Genome Res 6:465-77. 1996.... - Perspectives: sequence data base searching in the era of large-scale genomic sequencingR F Smith
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030 USA
Genome Res 6:653-60. 1996..Improved data base annotation tools and construction of smaller data bases of representative and highly-annotated sequences for first-pass analyses will be essential to deal with the impending flood of new genomic sequence... - Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balanceYuxiang Sun
Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
Endocrinology 149:843-50. 2008..These results support our hypothesis that the primary metabolic function of ghrelin in adult mice is to modulate glucose sensing and insulin sensitivity, rather than directly regulate energy intake and energy expenditure... - An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brainSteven R King
Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030-3498, USA
J Neurosci 22:10613-20. 2002..These data support a role for StAR in the production of neurosteroids and identify potential sites of active de novo steroid synthesis in the brain... - The growth hormone secretagogue receptorConrad Russell Young Cruz
Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA
Vitam Horm 77:47-88. 2008..But science has barely scratched the surface, and we can be assured that the mysteries surrounding the precise nature of ghrelin and its receptor(s) are only beginning to unravel... - The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasisMichael A Cowley
The Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
Neuron 37:649-61. 2003..We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis... - Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptorKoji Toshinai
Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
Endocrinology 147:2306-14. 2006..Central des-acyl ghrelin may activate orexin-expressing neurons, perhaps functioning in feeding regulation through interactions with a target protein distinct from the GHS-R... - Agonist-specific coupling of growth hormone secretagogue receptor type 1a to different intracellular signaling systems. Role of adenosineMarcos C Carreira
Department of Medicine, Research Area, Molecular Endocrinology Laboratory, Complejo Hospitalario Universitario de Santiago CHUS and University of Santiago de Compostela, Santiago de Compostela, Spain
Neuroendocrinology 79:13-25. 2004..The regulation of the ghrelin-activated earliest signaling pathways by adenosine may have unexpected implications in the GHSR-1a actions... - Nonhereditary enhancement of progeny growthAmir S Khan
Baylor Coll Med, Houston, TX
Endocrinology 143:3561-7. 2002..These unique findings demonstrate that enhanced GH-releasing hormone expression in pregnant dams can result in intergenerational growth promotion by altering development of the pituitary gland in the offspring... - Ghrelin promotes thymopoiesis during agingVishwa Deep Dixit
Clinical Immunology Section, Laboratory of Immunology, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, USA
J Clin Invest 117:2778-90. 2007.... - Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout miceEva Szentirmai
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
Am J Physiol Regul Integr Comp Physiol 293:R510-7. 2007..It is possible that redundancy in the arousal systems of the brain or activation of compensatory mechanisms during development allow for normal sleep-wake regulation in ghrelin KO mice... - Growth hormone secretagogues modulate the electrical and contractile properties of rat skeletal muscle through a ghrelin-specific receptorSabata Pierno
Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Italy
Br J Pharmacol 139:575-84. 2003..This peripheral action may account for the lack of restoration of skeletal muscle function in long-term GHS-treated aged animals... - Antidiabetic activity of a highly potent and selective nonpeptide somatostatin receptor subtype-2 agonistMathias Z Strowski
Medizinische Klinik m S Hepatologie, Gastroenterologie, Endokrinologie und Stoffwechsel, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
Endocrinology 147:4664-73. 2006..In summary, small-molecule sst(2)-selective agonists that suppress glucagon secretion offer a novel approach toward the development of orally bioavailable drugs for treatment of type 2 diabetes...
Research Grants
- Regulatory Role of Growth Hormone Secretagogue ReceptorRoy Smith; Fiscal Year: 2007..We hypothesize that clinical use of ghrelin mimetics will translate to improved cognitive function in the elderly. ..