Research Topics
Genomes and Genes | John R RodgersSummaryAffiliation: Baylor College of Medicine Country: USA Publications
Research Grants
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Publications
MHC class Ib molecules bridge innate and acquired immunityJohn R Rodgers
Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
Nat Rev Immunol 5:459-71. 2005..As we discuss here, the subset of MHC class Ib molecules that presents peptides to T cells bridges innate and acquired immunity, and this provides insights into the origins of acquired immunity...- Hyperconservation of the N-formyl peptide binding site of M3: evidence that M3 is an old eutherian molecule with conserved recognition of a pathogen-associated molecular patternC Kuyler Doyle
Baylor College of Medicine, Department of Immunology, Houston, TX 77030, USA
J Immunol 171:836-44. 2003..Such MHC PRR molecules could have been preadaptations for the evolution of acquired immunity during the early vertebrate radiation... - Cotton rat Sihi-M3 is a minimally oligomorphic Mhc I-b molecule that binds the chemotactic peptide fMLF under stringent conditions. Evidence that positive selection drives inter-species diversity of residues interacting with the termini of short peptidesC Kuyler Doyle
Department of Immunology, Baylor College of Medicine, TX 77030, Houston, USA
Immunogenetics 55:389-94. 2003..8. Thus, M3 is a class I-b gene in both sigmodontine and murine murids, but positive selection operates on a small subset of residues in the traditionally defined antigen recognition site... - NOD2 signaling contributes to the innate immune response against helper-dependent adenovirus vectors independently of MyD88 in vivoMasataka Suzuki
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Hum Gene Ther 22:1071-82. 2011..These results indicate that the intracellular sensor NOD2 is required for innate responses to HDAds and can limit transgene expression during early phases of infection... - Clostridium difficile lacks detectable superantigen activityAnna Wanahita
Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
FEMS Immunol Med Microbiol 47:275-7. 2006..Elevated white blood cell counts in C. difficile colitis are probably due to increased generation of cytokines such as interleukin-6 (IL-6) or IL-8... - Selective expansion of memory CD4(+) T cells by mitogenic human CD28 generates inflammatory cytokines and regulatory T cellsManisha Singh
Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
Eur J Immunol 38:1522-32. 2008..The ability of ANC28 to expand both effectors producing inflammatory cytokines as well as suppressive regulatory T cells might be useful for ex vivo expansion of therapeutic T cells... - Toll-like receptor 9 triggers an innate immune response to helper-dependent adenoviral vectorsVincenzo Cerullo
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Ther 15:378-85. 2007..The identification of the components of the innate immune response to adenovirus will facilitate the development of combinatorial therapy directed at increasing the maximal tolerated dose of systemically delivered adenoviral vectors... - Hyperconservation of the putative antigen recognition site of the MHC class I-b molecule TL in the subfamily Murinae: evidence that thymus leukemia antigen is an ancient mammalian geneBeckley K Davis
Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
J Immunol 169:6890-9. 2002..Our results strengthen the hypotheses that TL has evolved a specialized function and represents an ancient MHC class I-b gene... - Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changesHuaizhu Wu
Section of Atherosclerosis, Department of Medicine, Baylor College of Medicine, 6565 Fannin, Houston, TX 77030, USA
J Immunol 173:297-306. 2004.... - Membrane protected apoptotic trophoblast microparticles contain nucleic acids: relevance to preeclampsiaAaron F Orozco
Department of Immunology, Baylor College of Medicine, Houston, TX, USA
Am J Pathol 173:1595-608. 2008..Apoptotic MPs are therefore a likely source of stable DNA that could be enriched for both early genetic diagnosis and monitoring of pathological pregnancies...
Research Grants
- CONTROL OF IMMUNE RESPONSES TO GENE THERAPY OF THE LUNGJohn Rodgers; Fiscal Year: 2002..Aim 3 will improve the efficiency of FasL/TNFalpha- induced tolerance to gene therapy by determining the requirements of co- stimulation. These studies will provide information crucial to the success of gene therapy of the lung. ..