Research Topics
Species | David W MercerSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Presidential address: academic surgery: can we adapt?David W Mercer
Department of Surgery, University of Texas Medical School at Houston/LBJ General Hospital, 77026, USA
Surgery 138:115-24. 2005- Ketamine attenuates liver injury attributed to endotoxemia: role of cyclooxygenase-2James W Suliburk
Department of Surgery, The University of Texas Medical School at Houston, 77030, USA
Surgery 138:134-40. 2005..Because ketamine anesthesia has anti-inflammatory effects in some tissues, we hypothesized that it would attenuate lipopolysaccharide (LPS)-induced liver injury... - Rat gastric injury after lipopolysaccharide: role of inducible nitric oxide synthaseEmily K Robinson
Department of Surgery, University of Texas Health Science Center, Houston, TX 77026, USA
Surgery 138:523-9. 2005..The effects of long-term treatment with LPS on gastric injury are unknown as is the role of iNOS. We hypothesized that LPS would cause macroscopic gastric injury at later time points through an iNOS-dependent pathway... - Salicylate enhances rat gastric gelatinase activityEmily K Robinson
Department of Surgery at the University of Texas Health Science Center Houston, USA
J Surg Res 133:69-75. 2006..We recently demonstrated that increased MMP-2 activity participated in lipopolysaccharide (LPS)-induced gastric injury. Thus we hypothesized that MMPs may play a role in other models of gastric injury... - Hypertonic saline resuscitation after mesenteric ischemia/reperfusion induces ileal apoptosisErnest A Gonzalez
Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
J Trauma 59:1092-8. 2005..In contrast to I/R cell necrosis, apoptosis provides controlled cell death that minimizes inflammation. We therefore hypothesized that HS resuscitation after mesenteric I/R would induce apoptosis and decrease mucosal injury... - The impact of diabetes in patients with necrotizing soft tissue infectionsLillian S Kao
Department of General Surgery, University of Texas Health Science Center at Houston, Houston, Texas, USA
Surg Infect (Larchmt) 6:427-38. 2005..Given the association of diabetes with necrotizing soft tissue infections (NSTIs) and hyperglycemia with mortality in critically ill patients, this study investigates the impact of diabetes and hyperglycemia in NSTI patients... - Rat gastric gelatinase induction during endotoxemiaEmily K Robinson
Department of Surgery, The University of Texas Health Science Center at Houston, Houston, Texas, USA
Dig Dis Sci 51:548-59. 2006..Furthermore, selective metalloproteinase inhibition ameliorated gastric injury in this model. These data suggest that lipopolysaccharide-induced gastric injury is mediated, at least in part, by increased MMP-2 production... - Effects of lipopolysaccharide on gastric stasis: role of cyclooxygenaseSonlee D West
Department of Surgery, University of Texas Medical School, Houston, Texas, 77030, USA
Dig Dis Sci 51:754-65. 2006..However, the ability of LPS to cause gastric stasis and increase gastric luminal fluid accumulation involves COX-2... - Effect of NOS inhibition on rat gastric matrix metalloproteinase production during endotoxemiaEmily K Robinson
Department of Surgery, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Shock 25:507-14. 2006..Therefore, the purpose of these studies was to compare the effects of selective and nonselective NOS inhibition on LPS-induced gastric MMP production... - Conventional dose hypertonic saline provides optimal gut protection and limits remote organ injury after gut ischemia reperfusionErnest A Gonzalez
Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
J Trauma 61:66-73; discussion 73-4. 2006..We hypothesized that a dose dependent effect exists related to increasing tonicity and that the optimal gut protective dose would provide better protection against remote organ injury than large volume isotonic crystalloids... - Ketamine-induced gastroprotection during endotoxemia: role of heme-oxygenase-1Kenneth S Helmer
Department of Surgery, University of Texas Medical School, Houston, Texas 77026, USA
Dig Dis Sci 51:1571-81. 2006..Ketamine diminishes the susceptibility of gastric mucosa to damage from luminal irritants during endotoxemia, which is mediated in part by down-regulation of iNOS and up-regulation of HO-1... - Ketamine attenuates early lipopolysaccharide-induced gastric dysfunction: role of stress-inducible phosphoproteinsJames W Suliburk
Department of General Surgery, The University of Texas Medical School at Houston, Houston, Texas, USA
J Trauma 62:316-9. 2007.... - Cyclooxygenase-1 suppresses lipopolysaccharide-induced changes in rat gastric inducible nitric oxide synthaseSonlee D West
Department of Surgery at the University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Crit Care Med 36:572-9. 2008..However, the interaction between these enzymes is not clearly understood. The objective was to clarify the interactions between NOS and COX in the rat gastric mucosa in the presence and absence of lipopolysaccharide... - Effects of anesthesia on lipopolysaccharide-induced changes in serum cytokinesSasha D Adams
Department of Surgery, University of Texas Health Science Center, Houston, Texas, USA
J Trauma 65:170-4. 2008..The effect of these anesthetics on the systemic inflammatory response and other organs remains to be fully elucidated. We hypothesized that ketamine, but not isoflurane, would blunt the cytokine response to LPS administration... - Differential effects of luminal arginine and glutamine on metalloproteinase production in the postischemic gutEmily K Robinson
Department of Surgery, University of Texas Houston Health Science Center, Houston, TX 77030, USA
JPEN J Parenter Enteral Nutr 32:433-8. 2008..We therefore hypothesized that arginine would enhance expression of MMP-2 in the postischemic gut... - Time-dependent aggravation or attenuation of lipopolysaccharide-induced gastric injury by nitric oxide synthase inhibitionJames W Suliburk
Department of Surgery, University of Texas Medical School at Houston, Houston, Texas 77026, USA
J Surg Res 129:265-71. 2005..In this setting, iNOS has a pathologic role while the constitutive NOS isoforms play gastroprotective roles... - Induction of NF-kappaB, IkappaB-alpha, and iNOS in rat gastric mucosa during endotoxemiaKenneth S Helmer
Department of Surgery, University of Texas Medical School, Houston, Texas 77030, USA
J Surg Res 104:46-52. 2002.... - Gastric nitric oxide synthase expression during endotoxemia: implications in mucosal defense in ratsKenneth S Helmer
Department of Surgery, University of Texas Medical School, Houston, Texas 77026, USA
Gastroenterology 123:173-86. 2002..Moreover, septic patients may be more susceptible to gastric injury from bile during gastrointestinal ileus... - Cholecystokinin secretagogue-induced gastroprotection: role of nitric oxide and blood flowSonlee D West
Department of Surgery, University of Texas Medical School, Houston, TX 77030, USA
Am J Physiol Gastrointest Liver Physiol 284:G399-410. 2003..The protective mechanism appears to involve increased production of nitric oxide from primarily the constitutive isoforms of NOS and a resultant increase in blood flow... - Does upregulation of inducible nitric oxide synthase play a role in hepatic injury?Terrence H Liu
Shock 18:549-54. 2002..The data also suggest that the constitutive isoforms of NOS play a hepatoprotective role in both models of hepatic injury... - Effects of ketamine/xylazine on expression of tumor necrosis factor-alpha, inducible nitric oxide synthase, and cyclo-oxygenase-2 in rat gastric mucosa during endotoxemiaKenneth S Helmer
Department of Surgery, University of Texas Medical School, LBJ General Hospital, 5656 Kelley Street, Houston, TX 77026, USA
Shock 20:63-9. 2003..Furthermore, in rat models of endotoxemia, especially those evaluating the stomach, careful consideration needs to be given if anesthetic combinations with ketamine and/or xylazine are used, as they alter LPS-induced responses... - Ketamine/xylazine attenuates LPS-induced iNOS expression in various rat tissuesKenneth S Helmer
Department of Surgery at the University of Texas Medical School, Houston, Texas 77030, USA
J Surg Res 112:70-8. 2003.... - Lipopolysaccharide-induced changes in rat gastric H/K-ATPase expressionKenneth S Helmer
Department of Surgery, Trauma Research Center University of Texas Medical School, Houston, Texas 77026, USA
Ann Surg 239:501-9. 2004..To evaluate lipopolysaccharide (LPS)-induced inhibition of gastric acid secretion... - Cholecystokinin-induced gastroprotection: a review of current protective mechanismsSonlee D West
Department of Surgery, University of Texas Medical School, Houston, Texas 77030, USA
Dig Dis Sci 49:361-9. 2004..This review focuses on the ability of CCK to render the stomach more resistant to injury from luminal insults and will summarize recent studies that examine the possible mechanisms involved... - Differential effects of anesthetics on endotoxin-induced liver injuryJames W Suliburk
Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas, USA
J Trauma 58:711-6; discussion 716-7. 2005..Thus, ketamine may be the anesthetic agent of choice for septic patients requiring anesthesia... - Ketamine inhibits lipopolysacharide (LPS) induced gastric luminal fluid accumulationJames W Suliburk
Department of General Surgery, The University of Texas Medical School at Houston, Houston, Texas 77026, USA
J Surg Res 127:203-7. 2005..Moreover, while iNOS may play a role in LPS induced gastric luminal fluid accumulation, it does not appear to be a major mediator of the gastrointestinal ileus caused by LPS... - Acute pancreatitis in intensive care unit patients: value of clinical and radiologic prognosticators at predicting clinical course and outcomeTerrence H Liu
Departments of Surgery, The University of Texas Houston Medical School and Lyndon B Johnson General Hospital, Houston, TX, USA
Crit Care Med 31:1026-30. 2003..To assess the value of clinical and/or radiographic prognostic indices in predicting the clinical course and outcome of patients with acute pancreatitis, in the intensive care unit... - Bombesin-induced gastroprotectionSonlee D West
Department of Surgery, University of Texas Medical School, Houston, TX 77026, USA
Ann Surg 241:227-31. 2005.... - Gastric alkalinization after major traumaChristine S Cocanour
Department of Surgery, UC Davis Medical Center, Sacramento, California, USA
J Trauma 64:681-7. 2008..Therefore, we hypothesized that trauma patients have an alkaline gastric environment that may be because of bile reflux... - Lipopolysaccharide-induced gastrointestinal injury in rats: role of surface hydrophobicity and bile saltsElizabeth J Dial
Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston Medical School, 77225, USA
Shock 17:77-80. 2002..We conclude that LPS disrupts gastrointestinal barrier integrity, in part by mechanisms involving bile constituents and an attenuation in the mucosa's hydrophobic characteristics...