VICKI D HUFF

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Wilms tumor genetics: a new, UnX-pected twist to the story
    Vicki Huff
    Department of Cancer Genetics, Unit 1010, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Cell 11:105-7. 2007
  2. ncbi Wilms tumor genetics
    V Huff
    University of Texas, M D Anderson Cancer Center, Department of Experimental Pediatrics, Houston 77030, USA
    Am J Med Genet 79:260-7. 1998
  3. ncbi Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene
    Vicki Huff
    Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Cancer 11:111-21. 2011
  4. ncbi Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumors
    E Cristy Ruteshouser
    Department of Cancer Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Chromosomes Cancer 47:461-70. 2008
  5. ncbi Familial Wilms tumor
    E Cristy Ruteshouser
    Section of Cancer Genetics, Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Med Genet C Semin Med Genet 129:29-34. 2004
  6. ncbi Genome-wide loss of heterozygosity analysis of WT1-wild-type and WT1-mutant Wilms tumors
    E Cristy Ruteshouser
    Department of Molecular Genetics, Section of Cancer Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Chromosomes Cancer 43:172-80. 2005
  7. ncbi Upregulation of c-MYC in WT1-mutant tumors: assessment of WT1 putative transcriptional targets using cDNA microarray expression profiling of genetically defined Wilms' tumors
    Malini Udtha
    Department of Molecular Genetics Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Oncogene 22:3821-6. 2003
  8. ncbi The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome
    Fei Gao
    Department of Molecular Genetics Cancer Genetics, Box 011, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77025, USA
    Mol Cell Biol 24:9899-910. 2004
  9. ncbi Bilateral gonadoblastoma with dysgerminoma and pilocytic astrocytoma with WT1 GT-IVS9 mutation: A 46 XY phenotypic female with Frasier syndrome
    Vivek Subbiah
    Department of Pediatrics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Pediatr Blood Cancer 53:1349-51. 2009
  10. ncbi The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis
    Fei Gao
    Department of Molecular Genetics Cancer Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:11987-92. 2006

Collaborators

  • E Cristy Ruteshouser
  • Fei Gao
  • Malini Udtha
  • Vivek Subbiah
  • Jian Min Deng
  • Sourindra Maiti
  • Richard R Behringer
  • John Stewart
  • Leena Ketonen
  • Frederick F Lang
  • Cynthia E Herzog
  • Lauren Langford
  • Johannes E A Wolff
  • Nargis Alam
  • Zhen Zhang
  • Florian Guillou
  • Charlotte Lecureuil
  • Nelson G Ordonez
  • Guizhi Sun
  • Sang Joon Lee
  • Kevin Coombes
  • Rita Alam
  • Sang-Joon Lee

Detail Information

Publications10

  1. ncbi Wilms tumor genetics: a new, UnX-pected twist to the story
    Vicki Huff
    Department of Cancer Genetics, Unit 1010, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Cell 11:105-7. 2007
    ....
  2. ncbi Wilms tumor genetics
    V Huff
    University of Texas, M D Anderson Cancer Center, Department of Experimental Pediatrics, Houston 77030, USA
    Am J Med Genet 79:260-7. 1998
    ....
  3. ncbi Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene
    Vicki Huff
    Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Cancer 11:111-21. 2011
    ..Is WT1 a chameleon, functioning as either a TSG or an oncogene, depending on cellular context? Are these labels even appropriate for describing and understanding the function of WT1?..
  4. ncbi Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumors
    E Cristy Ruteshouser
    Department of Cancer Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Chromosomes Cancer 47:461-70. 2008
    ..Our findings indicate that WT1 and WTX mutations occur with similar frequency, that they partially overlap in Wilms tumors, and that mutations in WT1, WTX, and CTNNB1 underlie the genetic basis of about one-third of Wilms tumors...
  5. ncbi Familial Wilms tumor
    E Cristy Ruteshouser
    Section of Cancer Genetics, Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Med Genet C Semin Med Genet 129:29-34. 2004
    ..Identification of the FWT1 and FWT2 genes will help clarify this and will also likely aid in our understanding in general of the roles of the various WT genes and their genetic interactions in the development of WT...
  6. ncbi Genome-wide loss of heterozygosity analysis of WT1-wild-type and WT1-mutant Wilms tumors
    E Cristy Ruteshouser
    Department of Molecular Genetics, Section of Cancer Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Chromosomes Cancer 43:172-80. 2005
    ..Our results implicate 9q22.2-q31.1 as a region containing such a gene...
  7. ncbi Upregulation of c-MYC in WT1-mutant tumors: assessment of WT1 putative transcriptional targets using cDNA microarray expression profiling of genetically defined Wilms' tumors
    Malini Udtha
    Department of Molecular Genetics Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Oncogene 22:3821-6. 2003
    ..These data, in addition to the coexpression of c-MYC and WT1 in embryonic renal mesenchyme, strongly suggest that c-MYC is a biologically relevant target of WT1 in Wilmstumors...
  8. ncbi The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome
    Fei Gao
    Department of Molecular Genetics Cancer Genetics, Box 011, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77025, USA
    Mol Cell Biol 24:9899-910. 2004
    ..Thus, it will be a powerful and biologically relevant model for investigating the pathobiology of the earliest events in glomerulosclerosis...
  9. ncbi Bilateral gonadoblastoma with dysgerminoma and pilocytic astrocytoma with WT1 GT-IVS9 mutation: A 46 XY phenotypic female with Frasier syndrome
    Vivek Subbiah
    Department of Pediatrics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Pediatr Blood Cancer 53:1349-51. 2009
    ..We present the clinical, radiological, and genetic (WT1 mutation analysis) of a 46 XY phenotypic female with Frasier syndrome with bilateral gonadoblastoma with dysgerminoma who developed pilocytic astrocytoma...
  10. ncbi The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis
    Fei Gao
    Department of Molecular Genetics Cancer Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:11987-92. 2006
    ..Our data, along with previous work demonstrating the role of Wt1 at early stages of gonadal development, thus indicate that Wt1 is essential at multiple steps in testicular development...