Shixia Huang

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice
    Shixia Huang
    Program in Cancer Biology and Genetics, Sloan Kettering Institute, New York, NY 10021, USA
    Genome Biol 6:R84. 2005
  2. ncbi Wnt-1 is dominant over neu in specifying mammary tumor expression profiles
    Shixia Huang
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Technol Cancer Res Treat 5:565-71. 2006
  3. ncbi Comparison of expression profiles of metastatic versus primary mammary tumors in MMTV-Wnt-1 and MMTV-Neu transgenic mice
    Shixia Huang
    Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030 USA
    Neoplasia 10:118-24. 2008
  4. ncbi Development of resistance to targeted therapies transforms the clinically associated molecular profile subtype of breast tumor xenografts
    Chad J Creighton
    The Dan L Duncan Cancer Center, Baylor College of Medicine, Room N1230 02, One Baylor Plaza BCM 600, Houston, TX 77030, USA
    Cancer Res 68:7493-501. 2008
  5. ncbi Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones
    Jie Dong
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 346:196-203. 2010
  6. ncbi ID4 regulates mammary gland development by suppressing p38MAPK activity
    Jie Dong
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Development 138:5247-56. 2011
  7. ncbi Somatic expression of PyMT or activated ErbB2 induces estrogen-independent mammary tumorigenesis
    Michael J Toneff
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Neoplasia 12:718-26. 2010
  8. ncbi Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models
    Zhijun Du
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:17396-401. 2006
  9. ncbi Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis
    Chad J Creighton
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Clin Oncol 26:4078-85. 2008
  10. ncbi Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations
    Xiaomei Zhang
    Breast Center, Baylor College of Medicine, One Baylor Plaza, N1210 03, Houston, TX 77030, USA
    Oncogene 24:4220-31. 2005

Collaborators

Detail Information

Publications12

  1. ncbi Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice
    Shixia Huang
    Program in Cancer Biology and Genetics, Sloan Kettering Institute, New York, NY 10021, USA
    Genome Biol 6:R84. 2005
    ..These mice might therefore be useful models for discovering changes in gene expression during cancer development...
  2. ncbi Wnt-1 is dominant over neu in specifying mammary tumor expression profiles
    Shixia Huang
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Technol Cancer Res Treat 5:565-71. 2006
    ..These observations suggest that Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles...
  3. ncbi Comparison of expression profiles of metastatic versus primary mammary tumors in MMTV-Wnt-1 and MMTV-Neu transgenic mice
    Shixia Huang
    Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030 USA
    Neoplasia 10:118-24. 2008
    ....
  4. ncbi Development of resistance to targeted therapies transforms the clinically associated molecular profile subtype of breast tumor xenografts
    Chad J Creighton
    The Dan L Duncan Cancer Center, Baylor College of Medicine, Room N1230 02, One Baylor Plaza BCM 600, Houston, TX 77030, USA
    Cancer Res 68:7493-501. 2008
    ..Over time, the molecular phenotype of breast cancer can change...
  5. ncbi Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones
    Jie Dong
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 346:196-203. 2010
    ....
  6. ncbi ID4 regulates mammary gland development by suppressing p38MAPK activity
    Jie Dong
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Development 138:5247-56. 2011
    ..This p38MAPK activation is required for the reduced proliferation and increased apoptosis in Id4-ablated mammary glands. Therefore, ID4 promotes mammary gland development by suppressing p38MAPK activity...
  7. ncbi Somatic expression of PyMT or activated ErbB2 induces estrogen-independent mammary tumorigenesis
    Michael J Toneff
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Neoplasia 12:718-26. 2010
    ....
  8. ncbi Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models
    Zhijun Du
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:17396-401. 2006
    ..We conclude that infection of mammary glands with retrovirus vectors is an efficient means to screen candidate oncogenes for their capacity to initiate or promote mammary carcinogenesis in the mouse...
  9. ncbi Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis
    Chad J Creighton
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Clin Oncol 26:4078-85. 2008
    ..To more clearly elucidate the role of IGF in human breast cancer, we identified and then examined gene expression patterns of IGF-I-treated breast cancer cells...
  10. ncbi Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations
    Xiaomei Zhang
    Breast Center, Baylor College of Medicine, One Baylor Plaza, N1210 03, Houston, TX 77030, USA
    Oncogene 24:4220-31. 2005
    ..This is a first report of a mouse model of antiestrogen-resistant ER-positive breast cancers, and could provide a powerful tool to study the molecular mechanisms that control antiestrogen resistance...
  11. ncbi Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function
    Suleiman Massarweh
    Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA
    Cancer Res 68:826-33. 2008
    ..This study provides a rationale to combine HER inhibitors with tamoxifen in clinical studies, even in tumors that do not initially overexpress EGFR/HER2...
  12. ncbi Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
    Yi Li
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:15853-8. 2003
    ..Thus, the developmental heterogeneity of different breast cancers is in part a consequence of differential effects of oncogenes on distinct cell types in the breast...