Rubina Heptulla

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia
    Rubina A Heptulla
    Department of Pediatrics, Division of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 94:1608-11. 2009
  2. ncbi Gastric emptying and postprandial glucose excursions in adolescents with type 1 diabetes
    Rubina A Heptulla
    Department of Pediatrics, Division of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Diabetes 9:561-6. 2008
  3. ncbi The role of amylin and glucagon in the dampening of glycemic excursions in children with type 1 diabetes
    Rubina A Heptulla
    Department of Pediatrics, Division of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas 77030, USA
    Diabetes 54:1100-7. 2005
  4. ncbi The role of prandial pramlintide in the treatment of adolescents with type 1 diabetes
    Luisa M Rodriguez
    Department of Pediatrics, Division of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston Texas 77030, USA
    Pediatr Res 62:746-9. 2007
  5. ncbi New potential adjuncts to treatment of children with type 1 diabetes mellitus
    Vandana S Raman
    Department of Pediatrics, Division of Pediatric Endocrinology, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Res 65:370-4. 2009
  6. ncbi Reducing postprandial hyperglycemia with adjuvant premeal pramlintide and postmeal insulin in children with type 1 diabetes mellitus
    Krishnavathana Hassan
    Section of Endocrinology and Metabolism, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Pediatr Diabetes 10:264-8. 2009
  7. ncbi Effects of mixing glargine and short-acting insulin analogs on glucose control
    Walid Kaplan
    Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas 77030, USA
    Diabetes Care 27:2739-40. 2004
  8. ncbi Continuous glucose monitoring in children with type 1 diabetes: before and after insulin pump therapy
    Rubina A Heptulla
    Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, TX 77030 2399, USA
    Pediatr Diabetes 5:10-5. 2004
  9. ncbi A randomized, controlled trial comparing twice-a-day insulin glargine mixed with rapid-acting insulin analogs versus standard neutral protamine Hagedorn (NPH) therapy in newly diagnosed type 1 diabetes
    Krishnavathana Hassan
    Department of Pediatric Endocrinology and Metabolism, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas, USA
    Pediatrics 121:e466-72. 2008
  10. ncbi Targeting blood glucose management in school improves glycemic control in children with poorly controlled type 1 diabetes mellitus
    Thanh M Nguyen
    Department of Pediatrics, Division of Endocrinology and Metabolism, Baylor College of Medicine and Texas Children s Hospital, Houston, TX, USA
    J Pediatr 153:575-8. 2008

Research Grants

  1. Pediatric Type 1 diabetes: Intervention Trials With Glucagon Suppressors
    Rubina A Heptulla; Fiscal Year: 2010
  2. Novel Glucagon Modulators and the Closed Loop System
    Rubina A Heptulla; Fiscal Year: 2010
  3. Pediatric Type 1 diabetes: Intervention Trials With Glucagon Suppressors
    Rubina A Heptulla; Fiscal Year: 2010
  4. Novel Glucagon Modulators and the Closed Loop System
    Rubina Heptulla; Fiscal Year: 2009
  5. New Therapeutic Targets in Pediatric Type 1 Diabetes
    Rubina Heptulla; Fiscal Year: 2007
  6. Pediatric Type 1 diabetes: Intervention Trials With Glucagon Suppressors
    Rubina A Heptulla; Fiscal Year: 2010

Collaborators

Detail Information

Publications24

  1. ncbi Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia
    Rubina A Heptulla
    Department of Pediatrics, Division of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 94:1608-11. 2009
    ..The purpose of this study was to examine the effect of continuous sc replacement of amylin and insulin for a 24-h period on glucose homeostasis in adolescents with type 1diabetes...
  2. ncbi Gastric emptying and postprandial glucose excursions in adolescents with type 1 diabetes
    Rubina A Heptulla
    Department of Pediatrics, Division of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Diabetes 9:561-6. 2008
    ..Factors other than amylin play a role in control of gastric motility in T1DM. Subcutaneous insulin delivery fails to reach adequate concentrations in the postprandial period to curtail peak glucose concentration in T1DM...
  3. ncbi The role of amylin and glucagon in the dampening of glycemic excursions in children with type 1 diabetes
    Rubina A Heptulla
    Department of Pediatrics, Division of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas 77030, USA
    Diabetes 54:1100-7. 2005
    ..In summary, in type 1 diabetes, glucagon modulation with pramlintide as an adjunct to insulin therapy may prove beneficial in controlling postmeal glycemic swings...
  4. ncbi The role of prandial pramlintide in the treatment of adolescents with type 1 diabetes
    Luisa M Rodriguez
    Department of Pediatrics, Division of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston Texas 77030, USA
    Pediatr Res 62:746-9. 2007
    ..01) compared with infusion. We conclude that pramlintide bolus may result in an increase in risk of immediate postprandial hypoglycemia. Further modifications in pramlintide delivery are indicated before it can be safely used in children...
  5. ncbi New potential adjuncts to treatment of children with type 1 diabetes mellitus
    Vandana S Raman
    Department of Pediatrics, Division of Pediatric Endocrinology, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Res 65:370-4. 2009
    ..This article reviews the potential use of these newer pharmacologic agents as adjunctive therapy in T1DM in children and adolescents...
  6. ncbi Reducing postprandial hyperglycemia with adjuvant premeal pramlintide and postmeal insulin in children with type 1 diabetes mellitus
    Krishnavathana Hassan
    Section of Endocrinology and Metabolism, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Pediatr Diabetes 10:264-8. 2009
    ..The purpose of this study was to determine the effect of adjuvant premeal pramlintide with postmeal insulin on postprandial hyperglycemia in children with type 1 diabetes mellitus (T1DM)...
  7. ncbi Effects of mixing glargine and short-acting insulin analogs on glucose control
    Walid Kaplan
    Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas 77030, USA
    Diabetes Care 27:2739-40. 2004
  8. ncbi Continuous glucose monitoring in children with type 1 diabetes: before and after insulin pump therapy
    Rubina A Heptulla
    Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, TX 77030 2399, USA
    Pediatr Diabetes 5:10-5. 2004
    ..This study was undertaken to determine the specific areas of improved glycemic control in subjects after initiation of insulin pump therapy and times where further improvement is needed. Research..
  9. ncbi A randomized, controlled trial comparing twice-a-day insulin glargine mixed with rapid-acting insulin analogs versus standard neutral protamine Hagedorn (NPH) therapy in newly diagnosed type 1 diabetes
    Krishnavathana Hassan
    Department of Pediatric Endocrinology and Metabolism, Texas Children s Hospital, Baylor College of Medicine, Houston, Texas, USA
    Pediatrics 121:e466-72. 2008
    ....
  10. ncbi Targeting blood glucose management in school improves glycemic control in children with poorly controlled type 1 diabetes mellitus
    Thanh M Nguyen
    Department of Pediatrics, Division of Endocrinology and Metabolism, Baylor College of Medicine and Texas Children s Hospital, Houston, TX, USA
    J Pediatr 153:575-8. 2008
    ..A total of 36 subjects were enrolled and 18 subjects were randomized to receive the 3-month intervention. Their average HbA(1c) was lowered by 1.6%, suggesting that this intervention helps this difficult group of patients...
  11. ncbi Case report: pathological features of aberrant pancreatic development in congenital hyperinsulinism due to ABCC8 mutations
    Nicola Brunetti-Pierri
    Department of Molecular and Human Genetics, Baylor College of Medicine, and Department of Pathology, Texas Children s Hospital, 6621 Fannin St MC2 2261, Houston, TX 77030, USA
    Ann Clin Lab Sci 38:386-9. 2008
    ..This case suggests that abnormal function of ABCC8 may result in aberrant pancreatic development...
  12. ncbi Newer therapeutic options for children with diabetes mellitus: theoretical and practical considerations
    George S Jeha
    Department of Pediatrics, Division of Pediatric Endocrinology [corrected] and Metabolism, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Diabetes 7:122-38. 2006
    ..Pediatricians caring for children with T1DM and T2DM should become familiar with these agents and investigate their applicability, as they seem likely to enhance our therapeutic armamentarium to treat children with diabetes mellitus...
  13. ncbi The role of adjunctive exenatide therapy in pediatric type 1 diabetes
    Vandana S Raman
    Division of Endocrinology and Metabolism, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Diabetes Care 33:1294-6. 2010
    ..Exenatide could benefit type 1 diabetes as well. We aimed to determine an effective and safe glucose-lowering adjuvant exenatide dose in adolescents with type 1 diabetes...
  14. ncbi In situ evidence that peripheral insulin resistance in adolescents with poorly controlled type 1 diabetes is associated with impaired suppression of lipolysis: a microdialysis study
    Rubina A Heptulla
    Department of Pediatrics, Baylor College of Medicine, Clinical Care Center, Houston, TX 77030 2399, USA
    Pediatr Res 53:830-5. 2003
    ..63, p < 0.01). Our data suggest that failure of insulin to inhibit lipolysis in muscle and adipose tissue contributes to the severe peripheral insulin resistance that characterizes poorly controlled T1DM during adolescence...
  15. ncbi Total parenteral nutrition associated with severe insulin resistance following hematopoietic stem cell transplantation in patients with hemophagocytic syndrome: report on two cases
    Deepa Suresh
    Department of Pediatrics, Division of Diabetes and Endocrinology, Texas Children s Hospital, Baylor College of Medicine, Houston, TX, USA
    Pediatr Diabetes 11:70-3. 2010
    ..These cases aim to increase awareness and stimulate research to unravel the associated underling mechanisms...
  16. ncbi Glycemic control in pediatric type 1 diabetes: role of caregiver literacy
    Krishnavathana Hassan
    Department of Pediatric Endocrinology, Baylor College of Medicine, Houston, Texas, USA
    Pediatrics 125:e1104-8. 2010
    ..We hypothesized that poorly controlled diabetes is associated with lower literacy/numerical skills of caregivers of children with type 1 diabetes...
  17. ncbi Continuous glucose monitoring in subjects after simultaneous pancreas-kidney and kidney-alone transplantation
    Luisa M Rodriguez
    Endocrinology Section, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Diabetes Technol Ther 12:347-51. 2010
    ..Kidney-alone (KA) transplantation is associated with a high incidence of post-transplant diabetes...
  18. ncbi Serum 1,5-anhydroglucitol (Glycomark) levels in children with and without type 1 diabetes mellitus
    Thanh M Nguyen
    Department of Pediatrics, Division of Endocrinology and Metabolism, Baylor College of Medicine and Texas Children s Hospital, Houston, TX, USA
    Pediatr Diabetes 8:214-9. 2007
    ..The data are comparable with previous studies in normal adults and in those with T1DM and T2DM. They support the use of 1,5-AG concentrations, together with HgbA(1c), to evaluate therapy, especially to target postprandial hyperglycemia...
  19. ncbi The role of socioeconomic status, depression, quality of life, and glycemic control in type 1 diabetes mellitus
    Krishnavathana Hassan
    Department of Pediatric Endocrinology and Metabolism, Texas Children s Hospital, Baylor College of Medicine, Houston, TX 77030, USA
    J Pediatr 149:526-31. 2006
    ..To test the hypothesis that poor glycemic control in type 1 diabetes mellitus (T1DM) is associated with depression and poor quality of life (QOL), with a higher prevalence in persons of lower socioeconomic status (SES)...
  20. ncbi Disaster preparedness in pediatric type 1 diabetes mellitus
    Venkat S Renukuntla
    Department of Pediatric Endocrinology and Metabolism, Baylor College of Medicine, Houston, Texas, USA
    Pediatrics 124:e973-7. 2009
    ..The goal was to assess emergency preparedness among families caring for children with type 1 diabetes mellitus...
  21. ncbi An unusual presentation of mastocytosis: unilateral swelling of the vulva
    Joydip Roy
    Department of Pediatrics, Endocrinology, Dermatology, and Pathology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA
    Pediatr Dermatol 22:554-7. 2005
    ..In the appropriate setting, mastocytosis should be included in the differential diagnosis of labium majus swelling...
  22. ncbi Effects of hypoglycemia on human brain activation measured with fMRI
    Adam W Anderson
    Department of Biomedical Engineering, School of Engineering, Vanderbilt University, Nashville, TN 37232 2675, USA
    Magn Reson Imaging 24:693-7. 2006
    ....
  23. ncbi The influence of insulin on circulating ghrelin
    Daniel E Flanagan
    Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Endocrinol Metab 284:E313-6. 2003
    ..Our data suggest that insulin may suppress circulating ghrelin independently of glucose, although glucose may have an additional effect. We conclude that the GH response seen during hypoglycemia is not regulated by circulating ghrelin...
  24. ncbi Randomized controlled trial evaluating response to metformin versus standard therapy in the treatment of adolescents with polycystic ovary syndrome
    Holley F Allen
    Baystate Medical Center Children s Hospital, Tufts University School of Medicine, Springfield, MA 01199, USA
    J Pediatr Endocrinol Metab 18:761-8. 2005
    ..We evaluated the hypothesis that metformin would improve signs and symptoms of polycystic ovary syndrome (PCOS) in adolescents as compared to oral contraceptive pills (OCP) and have a favorable effect on obesity...

Research Grants10

  1. Pediatric Type 1 diabetes: Intervention Trials With Glucagon Suppressors
    Rubina A Heptulla; Fiscal Year: 2010
    ..Uses of exenatide and/or pramlintide provide us with potentially new tools to improve glycemic control in children and adolescents with T1 DM and thus reduce associated long-term microvascular complications of this debilitating disease. ..
  2. Novel Glucagon Modulators and the Closed Loop System
    Rubina A Heptulla; Fiscal Year: 2010
    ..Pramlintide and exenatide are meal-related hormones that are not appropriately regulated in diabetes;this proposal tests the use of these hormones with the closed loop system to address meal-related high blood glucose. ..
  3. Pediatric Type 1 diabetes: Intervention Trials With Glucagon Suppressors
    Rubina A Heptulla; Fiscal Year: 2010
    ....
  4. Novel Glucagon Modulators and the Closed Loop System
    Rubina Heptulla; Fiscal Year: 2009
    ..Pramlintide and exenatide are meal-related hormones that are not appropriately regulated in diabetes; this proposal tests the use of these hormones with the closed loop system to address meal-related high blood glucose. ..
  5. New Therapeutic Targets in Pediatric Type 1 Diabetes
    Rubina Heptulla; Fiscal Year: 2007
    ..abstract_text> ..
  6. Pediatric Type 1 diabetes: Intervention Trials With Glucagon Suppressors
    Rubina A Heptulla; Fiscal Year: 2010
    ..abstract_text> ..