Research Topics
Genomes and Genes | D L HadsellSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Technical note: assessing the functional capacity of mitochondria isolated from lactating mammary tissue: choose your chelating agent wiselyD L Hadsell
USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
J Dairy Sci 92:2038-45. 2009..This work will facilitate future studies aimed at determining the importance of mammary mitochondria to milk production...- Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4GDarryl L Hadsell
United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 17:2251-67. 2003.... - Genetic manipulation of mammary gland development and lactationDarryl L Hadsell
The USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Adv Exp Med Biol 554:229-51. 2004..Limitations serve as the driving force behind development of new experimental strategies and genetic engineering schemes that will allow for a full understanding of gene function within the mammary gland... - Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactationDarryl L Hadsell
USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
Biol Reprod 73:1116-25. 2005.... - Genetic manipulation of the IGF-I axis to regulate mammary gland development and functionD L Hadsell
Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
J Dairy Sci 85:365-77. 2002..Data from our laboratory on the expression of IGF-signaling molecules in the mammary gland suggest that this effect of physiological context may be related to the expression of members of the insulin receptor substrate family... - Changes in secretory cell turnover, and mitochondrial oxidative damage in the mouse mammary gland during a single prolonged lactation cycle suggest the possibility of accelerated cellular agingDarryl L Hadsell
USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston TX, 77030 USA
Exp Gerontol 41:271-81. 2006..The results suggest that a single prolonged lactation cycle may replicate on an accelerated basis some of the changes that occur with a lifetime of aging in organs possessing more stable cell populations... - The declining phase of lactation: peripheral or central, programmed or pathological?Darryl Hadsell
USDA Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St, Houston, TX 77030, USA
J Mammary Gland Biol Neoplasia 12:59-70. 2007..These alternatives are not presented as mutually exclusive of each other or other possible mechanisms, but are proposed as potential contributing mechanisms... - Inability of overexpressed des(1-3)human insulin-like growth factor I (IGF-I) to inhibit forced mammary gland involution is associated with decreased expression of IGF signaling moleculesD L Hadsell
Department of Pediatrics, U S Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Houston, Texas 77030, USA
Endocrinology 142:1479-88. 2001.... - IGF and insulin action in the mammary gland: lessons from transgenic and knockout modelsD L Hadsell
USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
J Mammary Gland Biol Neoplasia 5:19-30. 2000..This review discusses these observations in detail and attempts to fit them into a larger picture of IGF and insulin action in the mammary gland... - Enhancement of maternal lactation performance during prolonged lactation in the mouse by mouse GH and long-R3-IGF-I is linked to changes in mammary signaling and gene expressionDarryl L Hadsell
Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Houston, Texas 77030, USA
J Endocrinol 198:61-70. 2008.... - Rapid induction of IGF-IR signaling in normal and tumor tissue following intravenous injection of IGF-I in miceA V Lee
The Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Horm Metab Res 35:651-5. 2003..This study shows how IV IGF injection can be used to examine the signaling mechanisms used by IGF-IR, in both normal mammary tissue and during tumor growth, and may provide a model for the characterization of IGF inhibitors... - Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expressionD L Hadsell
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 137:321-30. 1996..These changes are believed to occur through autocrine and paracrine effects of des(1-3)-hIGF-I on both epithelial and stromal cells... - Targeted disruption of the IGF-I receptor gene decreases cellular proliferation in mammary terminal end budsS G Bonnette
U S Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 142:4937-45. 2001..Additionally, this study indicates that pregnancy-dependent compensatory mechanisms can stimulate mammary development in the absence of an IGF-IR... - Regulation of cell apoptosis by insulin-like growth factor ID L Hadsell
USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Adv Exp Med Biol 501:79-85. 2001..These results support the conclusion that inhibition of apoptosis within the mammary gland by IGF-I involves decreased activity of AP-1 and predisposes the tissue to tumors... - Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud developmentBrandy M Heckman
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Dev Biol 309:137-49. 2007..These results indicate that IGF signaling through p190-B and IRS proteins is critical for mammary bud formation and ensuing epithelial-mesenchymal interactions necessary to sustain mammary bud morphogenesis... - Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary glandA V Lee
The Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 144:2683-94. 2003..These data indicate that IRS undergo complex developmental and hormonal regulation in the mammary gland, and that IRS-1 is more likely to regulate mammary function in lactating mice than in virgin or pregnant mice... - Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesisD L Hadsell
Department of Pediatrics, USDA ARS Children s Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Oncogene 19:889-98. 2000..Oncogene (2000) 19, 889 - 898... - The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growthJana Divisova
Department of Medicine, Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
Breast Cancer Res Treat 98:315-27. 2006..This data supports previous studies indicating a role for GH/IGF in mammary gland development, and suggests that pegvisomant maybe useful for the prevention and/or treatment of estrogen receptor positive breast cancer... - Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary AktDarryl L Hadsell
Department of Pediatrics, The Breast Center, Baylor College of Medicine, USDAS ARS Chiuldren s Nutrition Research Center, 1100 Bates Street, Houston, TX 77030, USA
J Endocrinol 194:327-36. 2007.... - Estrogen-mediated down-regulation of E-cadherin in breast cancer cellsSteffi Oesterreich
The Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Cancer Res 63:5203-8. 2003..We propose that estrogen-mediated down-regulation of E-cadherin is a novel way of reducing E-cadherin levels in estrogen receptor-positive breast cancer... - Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2Robert K Dearth
Breast Cancer, Baylor College of Medicine and Methodist Hospital, Department of Medicine, Houston, TX 77030, USA
Mol Cell Biol 26:9302-14. 2006..This study defines IRSs as oncogene proteins in vivo and provides new models to develop inhibitors against IRSs for anticancer therapy... - New mechanisms of signal transduction inhibitor action: receptor tyrosine kinase down-regulation and blockade of signal transactivationAdrian V Lee
Department of Medicine, Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA
Clin Cancer Res 9:516S-23S. 2003..This review will highlight how recent studies using these STIs have elucidated novel mechanisms of STI action that may be used in the development of new therapeutic strategies for the treatment of cancer... - Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesisP J Kaplan-Lefko
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
Oncogene 27:2868-76. 2008..Selection against IGF-1 action appears requisite for progression of localized disease and metastogenesis... - Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptomePatricia D Maningat
Department of Pediatrics Nutrition, Baylor College of Medicine, Children s Nutrition Research Center, Houston, Texas 77030, USA
Physiol Genomics 37:12-22. 2009..This paper is the first to describe the MFG transcriptome in sequential human samples over a 24 h period, providing valuable insights into gene expression in the human MEC... - Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2Robert K Dearth
Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Cell Cycle 6:705-13. 2007..In this review we will discuss the role of IRSs in both transformation and cancer progression... - Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X proteinVictor V Keasler
Department of Molecular Virology and Microbiology, Baylor College of Medicine (BCM-385, One Baylor Plaza, Houston, TX 77030-3411, USA
Virology 347:466-75. 2006..These results indicate that HBx expression contributes to increased liver pathogenesis in HCV transgenic mice by a mechanism that involves an imbalance in hepatocyte death and regeneration within the context of severe steatosis... - Regulation of gene expression in human mammary epithelium: effect of breast pumpingPatricia D Maningat
Department of Pediatrics Nutrition, Baylor College of Medicine, Children s Nutrition Research Center 7062, 1100 Bates, Houston, Texas 77030, USA
J Endocrinol 195:503-11. 2007..We conclude that MFGs provide a unique source to study the in vivo regulation of gene expression in mammary epithelial cells. alpha-LA mRNA is abundant in the MFG and its expression may be regulated by hormonal and temporal factors... - Local insulin-like growth factor-II mediates prolactin-induced mammary gland developmentRussell C Hovey
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1402, USA
Mol Endocrinol 17:460-71. 2003..Together, these data demonstrate a role for IGF-II as a mediator of PRL action in the mouse mammary gland during ductal branching and alveolar development... - Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptorJoan M Carboni
Oncology Drug Discovery and Discovery Toxicology, Bristol Myers Squibb Research Institute, Princeton, New Jersey 08534, USA
Cancer Res 65:3781-7. 2005..This new model should provide new opportunities for further understanding how aberrant IGF-IR signaling leads to tumorigenesis and for optimizing novel antagonists of the receptor kinase...
Research Grants
- IGF-1 Receptor Signaling in Mammary Gland DevelopmentDarryl Hadsell; Fiscal Year: 2006..abstract_text> ..