Research Topics
Species | K Lance GouldSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Partial volume correction incorporating Rb-82 positron range for quantitative myocardial perfusion PET based on systolic-diastolic activity ratios and phantom measurementsNils P Johnson
Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
J Nucl Cardiol 18:247-58. 2011..Quantitative myocardial PET perfusion imaging requires partial volume corrections...- Positron emission tomography in coronary artery diseaseK Lance Gould
Weatherhead P E T Center for Preventing and Reversing Atherosclerosis, Department of Medicine, Division of Cardiology, University of Texas Medical School, Houston, Texas, USA
Curr Opin Cardiol 22:422-8. 2007.... - Frequent diagnostic errors in cardiac PET/CT due to misregistration of CT attenuation and emission PET images: a definitive analysis of causes, consequences, and correctionsK Lance Gould
The Weatherhead PET Center For Preventing and Reversing Atherosclerosis, University of Texas Medical School and Memorial Hermann Hospital, Houston, Texas 77030, USA
J Nucl Med 48:1112-21. 2007..Cardiac PET combined with CT is rapidly expanding despite artifactual defects and false-positive results due to misregistration of PET and CT attenuation correction data-the frequency, cause, and correction of which remain undetermined... - Coronary artery disease: Percent stenosis in CAD--a flaw in current practiceK Lance Gould
Weatherhead PET Imaging Center for Preventing and Reversing Atherosclerosis, University of Texas Medical School, 6431 Fannin, Houston, TX 77030, USA
Nat Rev Cardiol 7:482-4. 2010..we call for a paradigm shift in CAD care, with coronary flow measurements by PET as key to diagnosis and clinical decision-making... - Does coronary flow trump coronary anatomy?K Lance Gould
Weatherhead PET Center for Preventing and Reversing Atherosclerosis, University of Texas Medical School at Houston, Memorial Hermann Hospital, Houston, Texas 77030, USA
JACC Cardiovasc Imaging 2:1009-23. 2009..Should the concept of anatomically "critical" coronary stenosis be replaced by the concept of "critical" CFR reduction for managing CAD?.. - Reducing radiation dose in rest-stress cardiac PET/CT by single poststress cine CT for attenuation correction: quantitative validationK Lance Gould
Weatherhead PET Center for Preventing and Reversing Atherosclerosis, University of Texas Medical School at Houston, Houston, Texas 77030, USA
J Nucl Med 49:738-45. 2008..To reduce radiation dose, we tested quantitative accuracy of using a single poststress cine CT attenuation scan for reconstructing rest perfusion images to eliminate resting CT attenuation scans... - Coronary branch steal: experimental validation and clinical implications of interacting stenosis in branching coronary arteriesK Lance Gould
The Weatherhead P E T Center For Preventing and Reversing Atherosclerosis and The Department of Medicine, Division of Cardiology, University of Texas Medical School at Houston, and Memorial Hermann Hospital, Houston, Tex, USA
Circ Cardiovasc Imaging 3:701-9. 2010.... - Mechanisms of progression and regression of coronary artery disease by PET related to treatment intensity and clinical events at long-term follow-upStefano Sdringola
The Weatherhead PET Center For Preventing and Reversing Atherosclerosis, University of Texas Medical School at Houston, 77030, USA
J Nucl Med 47:59-67. 2006..To our knowledge, these data provide the first direct evidence on mechanisms for disproportionately greater reduction in cardiac events than changes in single stenosis severity with lipid treatment... - Common artifacts in PET myocardial perfusion images due to attenuation-emission misregistration: clinical significance, causes, and solutionsCatalin Loghin
Department of Medicine, University of Texas Medical School, Memorial Hermann Hospital, Houston, Texas 77030, USA
J Nucl Med 45:1029-39. 2004.... - Impact of unexpected factors on quantitative myocardial perfusion and coronary flow reserve in young, asymptomatic volunteersStefano Sdringola
Department of Medicine, University of Texas Medical School, Houston, TX, USA
JACC Cardiovasc Imaging 4:402-12. 2011..We sought to quantify ranges of normal myocardial perfusion and flow reserve in young, asymptomatic volunteers after systematic historical and laboratory screening for unexpected factors affecting coronary flow... - Physiological basis for angina and ST-segment change PET-verified thresholds of quantitative stress myocardial perfusion and coronary flow reserveNils P Johnson
Weatherhead PET Center for Preventing and Reversing Atherosclerosis, Division of Cardiology, Department of Medicine, University of Texas Medical School and Memorial Hermann Hospital, Houston, Texas, USA
JACC Cardiovasc Imaging 4:990-8. 2011..This study aimed to determine the quantitative low-flow threshold for stress-induced perfusion defects with severe angina and/or significant ST-segment depression during dipyridamole hyperemia... - Clinical evaluation of a new concept: resting myocardial perfusion heterogeneity quantified by markovian analysis of PET identifies coronary microvascular dysfunction and early atherosclerosis in 1,034 subjectsNils P Johnson
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
J Nucl Med 46:1427-37. 2005.... - Does coronary vasodilation after adenosine override endothelin-1-induced coronary vasoconstriction?Catalin Loghin
Weatherhead P E T Center, Univ of Texas Medical School, 6431 Fannin St, Rm 4 256 MSB, Houston, TX 77030, USA
Am J Physiol Heart Circ Physiol 292:H496-502. 2007.... - A 6 month randomized, double blind, placebo controlled, multi-center trial of high dose atorvastatin on myocardial perfusion abnormalities by positron emission tomography in coronary artery diseaseStefano Sdringola
The Weatherhead P E T Center For Preventing and Reversing Atherosclerosis and The Department of Medicine, Division of Cardiology, University of Texas Medical School at Houston, Houston, TX 77030, USA
Am Heart J 155:245-53. 2008..In coronary artery disease (CAD), statins decrease morbidity and mortality but changes in myocardial perfusion abnormalities remain poorly defined... - Is discordance of coronary flow reserve and fractional flow reserve due to methodology or clinically relevant coronary pathophysiology?Nils P Johnson
Weatherhead PET Center for Preventing and Reversing Atherosclerosis, Division of Cardiology, Department of Medicine, University of Texas Medical School and Memorial Hermann Hospital, Houston, Texas, USA
JACC Cardiovasc Imaging 5:193-202. 2012..The purpose of this study was to determine whether observed discordance between coronary flow reserve (CFR) and fractional flow reserve (FFR) is due to methodology or reflects basic coronary pathophysiology... - Shifted helical computed tomography to optimize cardiac positron emission tomography-computed tomography coregistration: quantitative improvement and limitationsNils P Johnson
Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Mol Imaging 9:256-67. 2010.... - Combined intense lifestyle and pharmacologic lipid treatment further reduce coronary events and myocardial perfusion abnormalities compared with usual-care cholesterol-lowering drugs in coronary artery diseaseStefano Sdringola
Weatherhead P.E.T. Center for Preventing and Reversing Atherosclerosis, Houston, Texas, USA
J Am Coll Cardiol 41:263-72. 2003..Perfusion changes parallel treatment intensity and predict outcomes... - Economic Methods in the Century Trial-a Comprehensive Lifestyle Modification Study for Managing Coronary Artery DiseaseJames R Langabeer
Center for Emergency Research, University of Texas School of Public Health, 1200 Herman Pressler Street, RAS W310, Houston, TX, 77030, USA
J Cardiovasc Transl Res 5:333-6. 2012..The approach we follow should provide further evidence on the cost-effectiveness of comprehensive lifestyle modification programs in regressing coronary artery disease... - Integrating noninvasive absolute flow, coronary flow reserve, and ischemic thresholds into a comprehensive map of physiological severityNils P Johnson
Weatherhead PET Center for Preventing and Reversing Atherosclerosis, Division of Cardiology, Department of Medicine, University of Texas Medical School and Memorial Hermann Hospital, Houston, Texas
JACC Cardiovasc Imaging 5:430-40. 2012..Our standardized framework could prompt future studies leading to a trial of revascularization guided by absolute flow measurements... - Tumor blood flow measured by PET dynamic imaging of first-pass 18F-FDG uptake: a comparison with 15O-labeled water-measured blood flowNizar A Mullani
University of Texas Medical School Houston, Houston, TX, USA
J Nucl Med 49:517-23. 2008..The purpose of this study was to determine if the early uptake of 18F-FDG could be used to measure regional blood flow in tumors in the absence of 15O-water... - Assessing progression or regression of CAD: the role of perfusion imagingK Lance Gould
J Nucl Cardiol 12:625-38. 2005 - Novel insights into coronary lumen preservation during progression of coronary atherosclerosis in coronary atherosclerosis-prone rabbitsMasashi Shiomi
The Institute for Experimental Animals, Kobe University School of Medicine, Kobe, Japan
Coron Artery Dis 15:419-26. 2004.... - Physiological severity of coronary artery stenosisK Lance Gould
Am J Physiol Heart Circ Physiol 291:H2583-5. 2006 - Myocardial ischemia, fluorodeoxyglucose, and severity of coronary artery stenosis: the complexities of metabolic remodeling in hibernating myocardiumK Lance Gould
Circulation 109:e167-70; author reply e167-70. 2004 - Why angina in aortic stenosis with normal coronary arteriograms?K Lance Gould
Circulation 107:3121-3. 2003