Research Topics
| MARY KOLB ESTESSummaryAffiliation: Baylor College of Medicine Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
A viral enterotoxin. A new mechanism of virus-induced pathogenesisM K Estes
Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA
Adv Exp Med Biol 473:73-82. 1999..Currently, our best understanding of the mechanisms of rotavirus pathogenesis rely on results obtained in animal models...- Norwalk virus vaccines: challenges and progressM K Estes
1Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
J Infect Dis 181:S367-73. 2000..As pathogens with a restricted host range, the HuCVs are excellent models for understanding the mechanisms that mediate and regulate viral infection of the gastrointestinal tract and mucosal immunity in humans... - Vaccine-acquired rotavirus in infants with severe combined immunodeficiencyNiraj C Patel
Department of Pediatrics, Section of Allergy and Immunology, Baylor College of Medicine, Texas Children s Hospital, Houston, TX 77030, USA
N Engl J Med 362:314-9. 2010..These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients... - Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humansMargarita K Lay
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
Virology 406:1-11. 2010..These results demonstrate that NV does not replicate in human CD11c(+) DCs, monocyte-derived DCs and MPhi, but abortive infection may occur in a few DCs. These results suggest that NV tropism is distinct from that of murine noroviruses... - Rotavirus antigenaemia and viraemia: a common event?Sarah E Blutt
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
Lancet 362:1445-9. 2003..This finding is important for the understanding of the pathogenesis, immunology, and clinical manifestations of rotavirus infection... - Norwalk virus RNA is infectious in mammalian cellsSusana Guix
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza BCM 385, Houston, TX 77030, USA
J Virol 81:12238-48. 2007.... - Norwalk virus shedding after experimental human infectionRobert L Atmar
Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
Emerg Infect Dis 14:1553-7. 2008..Understanding of the relevance of prolonged fecal norovirus excretion must await the development of sensitive methods to measure virus infectivity... - Host, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs)Sarah E Blutt
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Vaccine 24:1170-9. 2006..Combination oral/intranasal vaccination did not improve VLP protective efficacy. These studies indicate that host, viral, and vaccine factors determine the level of protective efficacy induced by VLPs... - Sequence analysis of the VP4, VP6, VP7, and NSP4 gene products of the bovine rotavirus WC3Max Ciarlet
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
Virus Genes 24:107-18. 2002..In addition, the VP6 and VP7 of BRV WC3 were very similar to the VP6 and VP7 of both SG I and G6 BRV NCDV and UK strains. However, the NSP4 of BRV WC3 was more closely related to that BRV NCDV, the P6 prototype, than to that of BRV UK... - Initial interaction of rotavirus strains with N-acetylneuraminic (sialic) acid residues on the cell surface correlates with VP4 genotype, not species of originMax Ciarlet
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Virol 76:4087-95. 2002.... - VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachmentMax Ciarlet
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Virol 76:1109-23. 2002..Therefore, VLA-2 is not involved in the initial attachment of rotavirus to cells but may play a role at a postattachment level... - Group A rotavirus infection and age-dependent diarrheal disease in rats: a new animal model to study the pathophysiology of rotavirus infectionMax Ciarlet
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Virol 76:41-57. 2002.... - Serological correlate of protection against norovirus-induced gastroenteritisAmanda Reeck
Departments of Molecular Virology, Baylor College of Medicine, Houston, Texas, USA
J Infect Dis 202:1212-8. 2010..We hypothesized that antibodies that block NV-HBGA binding are associated with protection from clinical illness following NV exposure... - Evolutionary trace residues in noroviruses: importance in receptor binding, antigenicity, virion assembly, and strain diversitySugoto Chakravarty
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030-3498, USA
J Virol 79:554-68. 2005..The highly variable region of the capsid shows a distinct cluster whose residues may participate in norovirus-receptor interactions... - Identification of Genogroup I and Genogroup II broadly reactive epitopes on the norovirus capsidTracy Dewese Parker
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Mail Stop BCM-385, Houston, TX 77030, USA
J Virol 79:7402-9. 2005..Identification of the epitopes for these monoclonal antibodies is of significance, as they are components in a commercially available norovirus-diagnostic enzyme-linked immunosorbent assay... - Rotavirus vaccines and pathogenesis: 2008Joseph M Hyser
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
Curr Opin Gastroenterol 25:36-43. 2009..This review summarizes new data on these vaccines, their effectiveness, and remaining challenges including new data on the rotavirus enterotoxin, a potential antiviral target... - The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activationSarah E Blutt
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Virol 78:6974-81. 2004..These findings indicate that the structure and conformation of the outer capsid protein, VP7, initiate intestinal B-cell activation during rotavirus infection... - Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to miceAndrea Bertolotti-Ciarlet
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, BCM-385, Houston, TX 77030, USA
Vaccine 21:3885-900. 2003..The use of 2/6-VLPs expressed from a single recombinant baculovirus simplifies production and would reduce the cost of a VLP-based vaccine... - Two nonoverlapping domains on the Norwalk virus open reading frame 3 (ORF3) protein are involved in the formation of the phosphorylated 35K protein and in ORF3-capsid protein interactionsPamela J Glass
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Virol 77:3569-77. 2003..These results indicate that the region of the ORF3 protein between amino acids 108 and 152 is responsible for interaction with the ORF2 protein... - Cryoelectron microscopy structures of rotavirus NSP2-NSP5 and NSP2-RNA complexes: implications for genome replicationXiaofang Jiang
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
J Virol 80:10829-35. 2006.... - Norwalk virus-like particle hemagglutination by binding to h histo-blood group antigensAnne M Hutson
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Virol 77:405-15. 2003..Overall, our results indicate that carbohydrate antigens in the gut are a previously unrecognized factor in NV pathogenesis... - Norwalk virus infection and disease is associated with ABO histo-blood group typeAnne M Hutson
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Infect Dis 185:1335-7. 2002..096; 95% CI, 0.16-0.56) and symptomatic disease (OR, 0; 95% CI, 0-0.999). This is the first report demonstrating an association between a genetic factor and the risk of NV infection and symptomatic disease... - Rotavirus viremia and extraintestinal viral infection in the neonatal rat modelSue E Crawford
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
J Virol 80:4820-32. 2006.... - Inter- and intragenus structural variations in caliciviruses and their functional implicationsRong Chen
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Alkek Building N410, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Virol 78:6469-79. 2004.... - Norwalk virus infection associates with secretor status genotyped from seraAnne M Hutson
Department of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA
J Med Virol 77:116-20. 2005.... - Replication and packaging of Norwalk virus RNA in cultured mammalian cellsMiyuki Asanaka
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 102:10327-32. 2005..This work establishes a mammalian cell-based system for analysis of human norovirus replication and, thus, makes it feasible to investigate antiviral agents in mammalian cells... - Structural requirements for the assembly of Norwalk virus-like particlesAndrea Bertolotti-Ciarlet
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Virol 76:4044-55. 2002.... - Norovirus disease: changing epidemiology and host susceptibility factorsAnne M Hutson
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza BCM-385, Houston, TX 77030, USA
Trends Microbiol 12:279-87. 2004.... - Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4Joseph M Hyser
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Virology 373:211-28. 2008..The use of single epitope-specific antibodies to differentially block functions of NSP4 is a feasible approach to determine the functional domain structure of this important RV virulence factor... - Rotavirus architecture at subnanometer resolutionZongli Li
National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, Texas 77030, USA
J Virol 83:1754-66. 2009.... - Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxinNeung Seon Seo
Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 105:8811-8. 2008.... - The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 proteinAndrea Bertolotti-Ciarlet
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Virol 77:11603-15. 2003..Furthermore, VP2 increased VP1 stability and protected VP1 from disassembly and protease degradation. The increase in VP1 expression levels caused by the presence of VP2 in cis was also observed in mammalian cells... - Expression of rotavirus NSP4 alters the actin network organization through the actin remodeling protein cofilinZuzana Berkova
Department of Molecular Virology and Microbiology, Baylor College of Medicine, 1200 Moursund Street, Houston, TX 77030 3404, USA
J Virol 81:3545-53. 2007.... - Noroviruses everywhere: has something changed?Mary K Estes
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
Curr Opin Infect Dis 19:467-74. 2006..This review summarizes new information about where and why these viruses are detected as well as new developments to prevent or treat these infections... - The epidemiologic and clinical importance of norovirus infectionRobert L Atmar
Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, MS BCM280, Houston, TX 77030, USA
Gastroenterol Clin North Am 35:275-90, viii. 2006..This article reviews the epidemiology, clinical manifestations and pathogenesis of norovirus infection, and it describes the diagnostic and therapeutic approaches to this disease... - pH-induced conformational change of the rotavirus VP4 spike: implications for cell entry and antibody neutralizationJoseph B Pesavento
Verna and McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
J Virol 79:8572-80. 2005..This process involves sequential interactions with multiple receptors, and the mechanism by which the antibody neutralizes is by preventing this conformational change... - An inside job: subversion of the host secretory pathway by intestinal pathogensTyler M Sharp
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
Curr Opin Infect Dis 23:464-9. 2010..This review focuses on our current understanding of the distinct mechanisms employed by enteric pathogens to antagonize the secretory pathway... - Rotavirus enterotoxin NSP4 has mucosal adjuvant propertiesOwen V Kavanagh
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Vaccine 28:3106-11. 2010..These studies suggest that the rotavirus enterotoxin NSP4 can function as an adjuvant to enhance immune responses for a co-administered antigen... - X-ray crystallographic structure of the Norwalk virus protease at 1.5-A resolutionCorinne E Zeitler
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
J Virol 80:5050-8. 2006..Since AEBSF was not apparent in the electron density map, it is possible that these conformational changes are due to subtle changes in pH caused by its addition during crystallization... - X-ray structure of a native calicivirus: structural insights into antigenic diversity and host specificityRong Chen
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 103:8048-53. 2006..These observations suggest a mechanism for antigenic diversity and host specificity in caliciviruses and provide a structural framework for vaccine development... - Atomic resolution structural characterization of recognition of histo-blood group antigens by Norwalk virusJae Mun Choi
Verna Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 105:9175-80. 2008.... - Differential requirements for T cells in viruslike particle- and rotavirus-induced protective immunitySarah E Blutt
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Virol 82:3135-8. 2008..Our findings indicate that more than one marker of protective immunity exists and that these markers depend on the vaccine that is administered...
Research Grants
- MOLECULAR AND ANTIGENIC ANALYSIS OF HUMAN CALICIVIRUSMARY ESTES; Fiscal Year: 2004..Expression systems of full-length and subgenomic RNAs also will be established in mammalian cell systems that may permit replication of infectious particles in cell culture. ..
- MOLECULAR BIOLOGY OF THE ROTAVIRUSESMARY ESTES; Fiscal Year: 2005....
- MOLECULAR BIOLOGY OF THE ROTAVIRUSESMARY ESTES; Fiscal Year: 2007....
- Regulation of Rotavirus ReplicationMARY KOLB ESTES; Fiscal Year: 2010..The specific aims of our proposed work are (1) To determine how rotavirus NSP4 affects calcium homeostasis, and (2) To dissect NSP4 regulation of viral morphogenesis. ..
- MOLECULAR BIOLOGY OF THE ROTAVIRUSESMARY ESTES; Fiscal Year: 1999..The sequential steps by which single- shelled particles become enveloped and mature into double-shelled particles by the addition of VP4 and VP7 will be determined. ..
- MOLECULAR BIOLOGY OF THE ROTAVIRUSESMARY ESTES; Fiscal Year: 1993..It is anticipated that these studies will provide fundamental information that will help develop strategies to prevent and control this important disease in children and animals...
- Regulation of Rotavirus ReplicationMARY KOLB ESTES; Fiscal Year: 2010..The specific aims of our proposed work are (1) To determine how rotavirus NSP4 affects calcium homeostasis, and (2) To dissect NSP4 regulation of viral morphogenesis. ..