Mauro Costa-Mattioli

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Translational control of long-lasting synaptic plasticity and memory
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal QCH3G1Y6, Canada
    Neuron 61:10-26. 2009
  2. ncbi Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, Montreal, Quebec, Canada
    Nature 436:1166-73. 2005
  3. ncbi p53-dependent translational control of senescence and transformation via 4E-BPs
    Emmanuel Petroulakis
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Cancer Cell 16:439-46. 2009
  4. ncbi Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection
    Maritza Jaramillo
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, Canada
    Cell Host Microbe 9:331-41. 2011
  5. ncbi Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission
    Michael Bidinosti
    Department of Biochemistry and Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada
    Mol Cell 37:797-808. 2010
  6. ncbi eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    Cell 129:195-206. 2007
  7. ncbi Translational control of gene expression: a molecular switch for memory storage
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, 3655 Promendde Sir William Osler, McGill University, Montreal, QC H3G 1Y6, Canada
    Prog Brain Res 169:81-95. 2008
  8. ncbi Translational control of the innate immune response through IRF-7
    Rodney Colina
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Nature 452:323-8. 2008
  9. ncbi A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding
    Muhammad M Karim
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 103:9494-9. 2006
  10. ncbi Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production
    Tommy Alain
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, QC H3G 1Y6, Canada
    Proc Natl Acad Sci U S A 107:1576-81. 2010

Collaborators

Detail Information

Publications12

  1. ncbi Translational control of long-lasting synaptic plasticity and memory
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal QCH3G1Y6, Canada
    Neuron 61:10-26. 2009
    ..In this review, we summarize and discuss recent progress in the field and highlight the prospects for better understanding of long-lasting changes in synaptic strength, learning, and memory and implications for neurological diseases...
  2. ncbi Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, Montreal, Quebec, Canada
    Nature 436:1166-73. 2005
    ..Our study provides genetic, physiological, behavioural and molecular evidence that GCN2 regulates synaptic plasticity, as well as learning and memory, through modulation of the ATF4/CREB pathway...
  3. ncbi p53-dependent translational control of senescence and transformation via 4E-BPs
    Emmanuel Petroulakis
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Cancer Cell 16:439-46. 2009
    ..Our data demonstrate a role for 4E-BPs in senescence and tumorigenesis and highlight a p53-mediated mechanism of senescence through a 4E-BP-dependent pathway...
  4. ncbi Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection
    Maritza Jaramillo
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, Canada
    Cell Host Microbe 9:331-41. 2011
    ..This study demonstrates that Leishmania evolved a survival mechanism by activating 4E-BPs, which serve as major targets for host translational control...
  5. ncbi Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission
    Michael Bidinosti
    Department of Biochemistry and Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada
    Mol Cell 37:797-808. 2010
    ..4E-BP2 deamidation may represent a compensatory mechanism for the developmental reduction of PI3K-Akt-mTOR signaling...
  6. ncbi eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    Cell 129:195-206. 2007
    ..These findings highlight the importance of a single phosphorylation site in eIF2alpha as a key regulator of L-LTP and LTM formation...
  7. ncbi Translational control of gene expression: a molecular switch for memory storage
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, 3655 Promendde Sir William Osler, McGill University, Montreal, QC H3G 1Y6, Canada
    Prog Brain Res 169:81-95. 2008
    ..In this chapter, we provide an overview of the role of translational control by the eIF2alpha signaling pathway in long-term synaptic plasticity and memory consolidation...
  8. ncbi Translational control of the innate immune response through IRF-7
    Rodney Colina
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Nature 452:323-8. 2008
    ..These findings highlight the role of 4E-BPs as negative regulators of type-I IFN production, via translational repression of Irf7 mRNA...
  9. ncbi A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding
    Muhammad M Karim
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 103:9494-9. 2006
    ..Thus, Paip2 can inhibit translation by a previously unrecognized mechanism, which is independent of its ability to disrupt PABP-poly(A) interaction...
  10. ncbi Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production
    Tommy Alain
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, QC H3G 1Y6, Canada
    Proc Natl Acad Sci U S A 107:1576-81. 2010
    ..These results demonstrate that reducing type I IFNs through inhibition of mTORC1 is an effective strategy to augment the therapeutic activity of VSV(DeltaM51)...
  11. ncbi RAPping production of type I interferon in pDCs through mTOR
    Mauro Costa-Mattioli
    Department of Biochemistry and the McGill Cancer Centre, McGill University, Montreal, Quebec, Canada
    Nat Immunol 9:1097-9. 2008
    ..The production of type I interferon -- the first line of defense against virus infection and critical for innate immunity -- in plasmacytoid dendritic cells relies on the mammalian target of rapamycin...
  12. ncbi La autoantigen is necessary for optimal function of the poliovirus and hepatitis C virus internal ribosome entry site in vivo and in vitro
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, McIntyre Medical Building, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 24:6861-70. 2004
    ..These results provide strong evidence for a function of the La autoantigen in IRES-dependent translation and define the step of translation which is stimulated by La...