A P Babenko

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells
    A P Babenko
    Departments of Cell Biology and Medicine, Baylor College of Medicine, Houston, TX, USA
    Circ Res 83:1132-43. 1998
  2. ncbi K(ATP) channels "vingt ans après": ATG to PDB to Mechanism
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Mol Cell Cardiol 39:79-98. 2005
  3. ncbi Sur domains that associate with and gate KATP pores define a novel gatekeeper
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza 112C, Houston, TX 77030, USA
    J Biol Chem 278:41577-80. 2003
  4. ncbi SUR-dependent modulation of KATP channels by an N-terminal KIR6.2 peptide. Defining intersubunit gating interactions
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:43997-4004. 2002
  5. ncbi A conserved inhibitory and differential stimulatory action of nucleotides on K(IR)6.0/SUR complexes is essential for excitation-metabolism coupling by K(ATP) channels
    A P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 276:49083-92. 2001
  6. ncbi Hetero-concatemeric KIR6.X4/SUR14 channels display distinct conductivities but uniform ATP inhibition
    A P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:31563-6. 2000
  7. ncbi Pharmaco-topology of sulfonylurea receptors. Separate domains of the regulatory subunits of K(ATP) channel isoforms are required for selective interaction with K(+) channel openers
    A P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:717-20. 2000
  8. ncbi The tolbutamide site of SUR1 and a mechanism for its functional coupling to K(ATP) channel closure
    A P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    FEBS Lett 459:367-76. 1999
  9. ncbi Two regions of sulfonylurea receptor specify the spontaneous bursting and ATP inhibition of KATP channel isoforms
    A P Babenko
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 274:11587-92. 1999
  10. ncbi Sulfonylurea receptors set the maximal open probability, ATP sensitivity and plasma membrane density of KATP channels
    A P Babenko
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    FEBS Lett 445:131-6. 1999

Detail Information

Publications14

  1. ncbi Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells
    A P Babenko
    Departments of Cell Biology and Medicine, Baylor College of Medicine, Houston, TX, USA
    Circ Res 83:1132-43. 1998
    ....
  2. ncbi K(ATP) channels "vingt ans après": ATG to PDB to Mechanism
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Mol Cell Cardiol 39:79-98. 2005
    ....
  3. ncbi Sur domains that associate with and gate KATP pores define a novel gatekeeper
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza 112C, Houston, TX 77030, USA
    J Biol Chem 278:41577-80. 2003
    ..The results explain and predict pathologies associated with alteration of the 5' ends of clustered ABCC8 (9)/KCNJ11 (8) genes...
  4. ncbi SUR-dependent modulation of KATP channels by an N-terminal KIR6.2 peptide. Defining intersubunit gating interactions
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:43997-4004. 2002
    ....
  5. ncbi A conserved inhibitory and differential stimulatory action of nucleotides on K(IR)6.0/SUR complexes is essential for excitation-metabolism coupling by K(ATP) channels
    A P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 276:49083-92. 2001
    ....
  6. ncbi Hetero-concatemeric KIR6.X4/SUR14 channels display distinct conductivities but uniform ATP inhibition
    A P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:31563-6. 2000
    ..We propose that SUR-dependent, inhibitory ATP-enhanced interactions of the cytoplasmic domains of both K(IR)6.1 and K(IR)6.2 stabilize a closed form of the M2 bundle in the gating apparatus...
  7. ncbi Pharmaco-topology of sulfonylurea receptors. Separate domains of the regulatory subunits of K(ATP) channel isoforms are required for selective interaction with K(+) channel openers
    A P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:717-20. 2000
    ..These data are incorporated into a functional topology model for the regulatory SUR subunits of K(ATP) channels...
  8. ncbi The tolbutamide site of SUR1 and a mechanism for its functional coupling to K(ATP) channel closure
    A P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    FEBS Lett 459:367-76. 1999
    ..These findings uncover a molecular basis for an inhibitory influence of SUR1, an ATP-binding cassette (ABC) protein, on K(IR)6.2, a ion channel subunit...
  9. ncbi Two regions of sulfonylurea receptor specify the spontaneous bursting and ATP inhibition of KATP channel isoforms
    A P Babenko
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 274:11587-92. 1999
    ..This is the first identification of parts of an ABC protein that interact with an ion channel subunit to modulate the spontaneous activity and ATP sensitivity of the heteromeric channel...
  10. ncbi Sulfonylurea receptors set the maximal open probability, ATP sensitivity and plasma membrane density of KATP channels
    A P Babenko
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    FEBS Lett 445:131-6. 1999
    ..2 modification. The results demonstrate allosteric interaction(s) are essential for normal intrinsic activity, ATP inhibition, and trafficking of KATP channels...
  11. ncbi The N-terminus of KIR6.2 limits spontaneous bursting and modulates the ATP-inhibition of KATP channels
    A P Babenko
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochem Biophys Res Commun 255:231-8. 1999
    ..The results identify the N-terminus of KIR6.2 as a determinant of the interburst kinetics of KATP channels and suggest that the two cytoplasmic domains of KIR6.2 participate in ATP-inhibitory gating through distinct mechanisms...
  12. ncbi Insulin secretagogues, sulfonylurea receptors and K(ATP) channels
    J Bryan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Pharm Des 11:2699-716. 2005
    ..The model has a central chamber which could serve as a multifaceted binding pocket...
  13. ncbi Activating mutations in the ABCC8 gene in neonatal diabetes mellitus
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA
    N Engl J Med 355:456-66. 2006
    ..We hypothesized that activating mutations in ABCC8, which encodes SUR1, cause neonatal diabetes...
  14. ncbi A novel ABCC8 (SUR1)-dependent mechanism of metabolism-excitation uncoupling
    Andrey P Babenko
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    J Biol Chem 283:8778-82. 2008
    ..These findings show the key role of SUR in sensing the metabolic index in humans and urge others to (re)test mutant SUR/K(IR)6 channels from probands in physiologic MgATP...