Megan E Cavet

Summary

Affiliation: Bausch and Lomb
Country: USA

Publications

  1. ncbi Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells
    Megan E Cavet
    Global Pharmaceutical R and D, Bausch Lomb, Rochester, NY 14609, USA
    Mol Vis 17:533-42. 2011
  2. ncbi Comparison of the effect of multipurpose contact lens solutions on the viability of cultured corneal epithelial cells
    Megan E Cavet
    Pharmaceutical R and D, Bausch and Lomb, 1400 North Goodman Street, Rochester, NY 14609, USA
    Cont Lens Anterior Eye 32:171-5. 2009
  3. ncbi Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells
    Megan E Cavet
    Pharmaceutical R and D, Bausch and Lomb, Inc, Rochester, NY 14609, USA
    Mol Vis 16:1791-800. 2010
  4. ncbi BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells
    Jin Zhong Zhang
    Pharmaceutical R and D, Bausch and Lomb Inc, Rochester, NY 14603, USA
    Mol Vis 15:2606-16. 2009
  5. ncbi Reduced myocilin expression in cultured monkey trabecular meshwork cells induced by a selective glucocorticoid receptor agonist: comparison with steroids
    Bruce A Pfeffer
    Preclinical Pharmacology Department, Pharmaceutical Research and Development, Bausch and Lomb, Inc, Rochester, New York 14609, USA
    Invest Ophthalmol Vis Sci 51:437-46. 2010
  6. ncbi Anti-inflammatory effects of besifloxacin, a novel fluoroquinolone, in primary human corneal epithelial cells
    Jin Zhong Zhang
    Global Preclinical Development, Bausch and Lomb, Rochester, New York 14603, USA
    Curr Eye Res 33:923-32. 2008
  7. ncbi Nonclinical safety evaluation of boric acid and a novel borate-buffered contact lens multi-purpose solution, Biotrue™ multi-purpose solution
    David M Lehmann
    Bausch and Lomb Incorporated, 1400 North Goodman Street, Rochester, NY 14609, United States
    Cont Lens Anterior Eye 33:S24-32. 2010
  8. ncbi Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB
    Megan E Cavet
    Aab Cardiovascular Research Institute, University of Rochester, Box 679, Rochester, NY 14642, USA
    Hypertension 56:105-11. 2010
  9. ncbi GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells
    Jinjiang Pang
    Aab Cardiovascular Research Institute and the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Arterioscler Thromb Vasc Biol 28:892-8. 2008
  10. ncbi 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity
    Megan E Cavet
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 278:18376-83. 2003

Collaborators

Detail Information

Publications10

  1. ncbi Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells
    Megan E Cavet
    Global Pharmaceutical R and D, Bausch Lomb, Rochester, NY 14609, USA
    Mol Vis 17:533-42. 2011
    ..To determine the anti-inflammatory and anti-oxidant effects of epigallocatechin gallate (EGCG), the major polyphenol component of green tea, in human corneal epithelial cells (HCEpiC)...
  2. ncbi Comparison of the effect of multipurpose contact lens solutions on the viability of cultured corneal epithelial cells
    Megan E Cavet
    Pharmaceutical R and D, Bausch and Lomb, 1400 North Goodman Street, Rochester, NY 14609, USA
    Cont Lens Anterior Eye 32:171-5. 2009
    ..To determine the effect of four marketed multipurpose contact lens solutions (MPSs) on corneal epithelial cell viability...
  3. ncbi Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells
    Megan E Cavet
    Pharmaceutical R and D, Bausch and Lomb, Inc, Rochester, NY 14609, USA
    Mol Vis 16:1791-800. 2010
    ..This study assessed the anti-inflammatory effects of mapracorat in an in vitro osmotic stress model which mimics some of the pathophysiological changes seen in dry eye...
  4. ncbi BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells
    Jin Zhong Zhang
    Pharmaceutical R and D, Bausch and Lomb Inc, Rochester, NY 14603, USA
    Mol Vis 15:2606-16. 2009
    ..Data from in vitro and in vivo studies suggest an improved side-effect profile of this compound compared to classical glucocorticoids. The aim of this study was to determine the anti-inflammatory effect of BOL-303242-X in ocular cells...
  5. ncbi Reduced myocilin expression in cultured monkey trabecular meshwork cells induced by a selective glucocorticoid receptor agonist: comparison with steroids
    Bruce A Pfeffer
    Preclinical Pharmacology Department, Pharmaceutical Research and Development, Bausch and Lomb, Inc, Rochester, New York 14609, USA
    Invest Ophthalmol Vis Sci 51:437-46. 2010
    ..To assess in vitro myocilin (MYOC) expression in trabecular meshwork (TM) cells exposed to BOL-303242-X, a selective glucocorticoid receptor (GR) agonist (SEGRA), in comparison with dexamethasone (DEX), and prednisolone acetate (PA)...
  6. ncbi Anti-inflammatory effects of besifloxacin, a novel fluoroquinolone, in primary human corneal epithelial cells
    Jin Zhong Zhang
    Global Preclinical Development, Bausch and Lomb, Rochester, New York 14603, USA
    Curr Eye Res 33:923-32. 2008
    ..The aim of this study was to determine the anti-inflammatory effects of besifloxacin, a novel fluoroquinolone under clinical evaluation for the treatment of ophthalmic infections, in human corneal epithelial cells (HCEpiC)...
  7. ncbi Nonclinical safety evaluation of boric acid and a novel borate-buffered contact lens multi-purpose solution, Biotrue™ multi-purpose solution
    David M Lehmann
    Bausch and Lomb Incorporated, 1400 North Goodman Street, Rochester, NY 14609, United States
    Cont Lens Anterior Eye 33:S24-32. 2010
    ..Our findings provide evidence that ocular effects reported for some borate-buffered MPS may be incorrectly attributed to boric acid and are more likely a function of the unique combination of ingredients in the MPS formulation tested...
  8. ncbi Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB
    Megan E Cavet
    Aab Cardiovascular Research Institute, University of Rochester, Box 679, Rochester, NY 14642, USA
    Hypertension 56:105-11. 2010
    ..This interaction provides a direct link between Axl and molecular motors crucial for directed cell migration, which may mediate increased migration in vascular dysfunction...
  9. ncbi GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells
    Jinjiang Pang
    Aab Cardiovascular Research Institute and the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Arterioscler Thromb Vasc Biol 28:892-8. 2008
    ..Here we investigated the hypothesis that Ang II-mediated vascular smooth muscle cell (VSMC) gene transcription involves GIT1-CamK II-dependent phosphorylation of HDAC5...
  10. ncbi 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity
    Megan E Cavet
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 278:18376-83. 2003
    ..These data suggest that 14-3-3beta binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation...