Research Topics
| H M MoultonSummaryAffiliation: AVI BioPharma Country: USA Publications
| Collaborators
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Detail Information
Publications
Active specific immunotherapy with a beta-human chorionic gonadotropin peptide vaccine in patients with metastatic colorectal cancer: antibody response is associated with improved survivalHong M Moulton
AVI BioPharma, Inc, Portland, Oregon 97258, USA
Clin Cancer Res 8:2044-51. 2002....- Inhibition and escape of SARS-CoV treated with antisense morpholino oligomersBenjamin W Neuman
The Scripps Research Institute, La Jolla, California, USA
Adv Exp Med Biol 581:567-71. 2006 - HIV Tat peptide enhances cellular delivery of antisense morpholino oligomersHong M Moulton
AVI BioPharma, Inc, Corvallis, OR 97333, USA
Antisense Nucleic Acid Drug Dev 13:31-43. 2003..The other three cationic peptides are much less effective than pTat. pTat significantly enhances delivery of PMO in 100% of cells assayed. pTat-mediated delivery is a much simpler procedure to perform than other delivery methods... - Peptide-assisted delivery of steric-blocking antisense oligomersHong M Moulton
AVI BioPharma Inc, 4575 SW Research Way, Suite 200, Corvallis, OR 97333, USA
Curr Opin Mol Ther 5:123-32. 2003..These assays, developed in cell culture and mouse models, are faster and have higher signal-to-noise ratios than downregulation assays. Thus, a convenient and effective method now exists to screen transport peptides... - Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivoH M Moulton
AVI BioPharma Inc, 4575 SW Research Way, Corvallis, OR 97333, USA
Biochem Soc Trans 35:826-8. 2007..We attribute the success of this CPP to its stability in serum and its capacity to transport PMO to RNA targets in a manner superior to that of poly-arginine CPPs... - Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptidesHong M Moulton
AVI BioPharma, Inc, Corvallis, Oregon 97333, USA
Bioconjug Chem 15:290-9. 2004..R(9)F(2)C peptide provided a simple and efficient delivery of PMO to a RNA target. Conjugation of peptide to PMO enhances the opportunities to evaluate gene functions in cell cultures... - Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicingN B Marshall
AVI BioPharma Inc, Corvallis, Oregon 97333, USA
J Immunol Methods 325:114-26. 2007.... - Inhibition of infectious haematopoietic necrosis virus in cell cultures with peptide-conjugated morpholino oligomersM Alonso
Department of Microbiology and Center for Fish Disease Research, Oregon State University, Corvallis, OR, USA
J Fish Dis 28:399-410. 2005..These data demonstrate that replication of a negative-stranded non-segmented RNA virus can be inhibited by antisense compounds that target positive polarity viral RNA, or by a compound that targets negative polarity viral RNA... - Monoclonal antibodies to two epitopes of beta-human chorionic gonadotropin for the treatment of cancerPatrick L Iversen
AVI BioPharma Inc, 4575 SW Research Way, Corvallis, OR 97333, USA
Curr Opin Mol Ther 5:156-60. 2003..The requirement for dual mAb therapy is consistent with current trends in the development of complex, non-toxic therapies for cancer... - Arginine-rich peptide conjugation to morpholino oligomers: effects on antisense activity and specificityMichelle H Nelson
AVI BioPharma, Inc, Corvallis, Oregon 97333, USA
Bioconjug Chem 16:959-66. 2005..Additionally, it is shown that the enzymatic stability of an L- or unnatural peptide used for PMO conjugation affects the antisense properties of the resulting compound... - Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugateAdams Amantana
AVI BioPharma, Inc, Corvallis, Oregon, USA
Bioconjug Chem 18:1325-31. 2007..In this study, we investigated the pharmacokinetics, tissue distribution, stability, and safety profile of an anti-c-myc PMO conjugated to the CPP, (RXR)4 (X = 6-aminohexanoic acid) in rats... - Stability of cell-penetrating peptide-morpholino oligomer conjugates in human serum and in cellsDerek S Youngblood
AVI BioPharma, Incorporated, 4575 SW Research Way, Corvallis, Oregon 97333, USA
Bioconjug Chem 18:50-60. 2007..Last, the endosomal/lysosomal trapping limits the effectiveness of a CPP-PMO conjugate, and the stability of the CPP is one of the factors affecting the ability of the conjugate to escape the endosomes/lysosomes... - Inhibition of gene expression in Escherichia coli by antisense phosphorodiamidate morpholino oligomersB L Geller
Oregon State University AVI Biopharma, Inc, Corvallis, Oregon 97331 3804, USA
Antimicrob Agents Chemother 47:3233-9. 2003..We conclude that the outer membrane of E. coli inhibits entry of PMOs and that (KFF)(3)KC-PMO conjugates are transported across both membranes and specifically inhibit expression of their genetic targets... - Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicityRebecca P Wu
AVI BioPharma, Inc, Corvallis, OR 97333, USA
Nucleic Acids Res 35:5182-91. 2007..Toxicity of X/B-containing conjugates was affected by the number of Xs, treatment time and concentration. More active, stable and less toxic CPPs can be designed by optimizing the position and number of R, D-R, X and B residues... - Peptide-morpholino conjugate: a promising therapeutic for Duchenne muscular dystrophyHong M Moulton
AVI BioPharma, Corvallis, Oregon 97333, USA
Ann N Y Acad Sci 1175:55-60. 2009..No toxicity or immunogenicity was detected. Our studies demonstrated that muscle functions can be restored with a low dose of PPMO, making it a promising therapeutic for DMD... - Morpholinos and their peptide conjugates: therapeutic promise and challenge for Duchenne muscular dystrophyHong M Moulton
College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
Biochim Biophys Acta 1798:2296-303. 2010..The toxicity of PPMOs will require caution when moving into the clinic. The first PPMO-based DMD drug is currently in preclinical development for DMD patients who can benefit from skipping exon 50... - Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomerBo Wu
McColl Lockwood Laboratory for Muscular Dystrophy, Neuromuscular ALS Center, Carolinas Medical Center, Charlotte, NC 28231, USA
Proc Natl Acad Sci U S A 105:14814-9. 2008..The high degree of potency of the oligomer in targeting all muscles and the lack of detectable toxicity and immune response support the feasibility of testing the novel oligomer in treating Duchenne muscular dystrophy patients... - Cell penetrating peptide conjugates of steric block oligonucleotidesBernard Lebleu
UMR 5235 CNRS, Universite Montpellier 2, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France
Adv Drug Deliv Rev 60:517-29. 2008..The in vivo efficacy of (R-Ahx-R)(4) AhxB PMO conjugates has been demonstrated in mouse models of Duchenne muscular dystrophy and in various viral infections... - Arginine-rich cell-penetrating peptides with uncharged antisense oligomersHong M Moulton
Drug Discov Today 9:870. 2004 - Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replicationTia S Deas
Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA
J Virol 79:4599-609. 2005.... - Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomersBenjamin W Neuman
The Scripps Research Institute, Division of Virology, Department of Neuropharmacology, La Jolla, CA 92037, USA
J Virol 79:9665-76. 2005..Those partially resistant viruses grew more slowly and formed smaller plaques than wild-type SARS-CoV. These results suggest PMO compounds have powerful therapeutic and investigative potential toward coronavirus infection... - Morpholino oligomer-mediated exon skipping averts the onset of dystrophic pathology in the mdx mouseSue Fletcher
Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Nedlands, Perth, Western Australia, Australia
Mol Ther 15:1587-92. 2007..We demonstrate dystrophin expression and near-normal muscle architecture in all muscles examined, except for cardiac muscle. The CPP greatly enhanced uptake of the PMO, resulting in widespread dystrophin expression... - Antiviral effects of antisense morpholino oligomers in murine coronavirus infection modelsRenaud Burrer
The Scripps Research Institute, Department of Molecular and Integrative Neurosciences, Mail Drop SP30 2020, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
J Virol 81:5637-48. 2007..However, the strong antiviral effect observed suggests that with further development, P-PMO may provide an effective therapeutic approach against a broad range of coronavirus infections... - Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry siteJi Yuan
The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, B.C, Canada
J Virol 80:11510-9. 2006..Thus, PPMO-6 provided potent inhibition of CVB3 amplification both in cell cultures and in vivo and appears worthy of further evaluation as a candidate for clinical development... - Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomersYan Jin Zhang
Center for Pediatric Research, Eastern Virginia Medical School, Norfolk, VA 23510, USA
Antiviral Res 73:12-23. 2007..These results suggest that RP1 P-PMO can specifically block KSHV replication, and further study is warranted... - Chemical modifications to improve the cellular uptake of oligonucleotidesFrançoise Debart
LCOBS, UMR 5625 CNRS, Universite Montpellier 2, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France
Curr Top Med Chem 7:727-37. 2007..The first part deals with ON chemical modifications aiming at improving cellular uptake as for instance the grafting of cationic groups on the ON backbone. The second part concerns ON conjugation to cell penetrating peptides... - Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx miceNatee Jearawiriyapaisarn
Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Mol Ther 16:1624-9. 2008..This is the first report of oligonucleotide-mediated exon skipping and dystrophin protein induction in the heart of treated animals... - Antisense morpholino-oligomers directed against the 5' end of the genome inhibit coronavirus proliferation and growthBenjamin W Neuman
The Scripps Research Institute, Department of Neuropharmacology, Division of Virology, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
J Virol 78:5891-9. 2004..These results suggest that this composition of antisense compound has therapeutic potential for control of coronavirus infection...