G M Rishton

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. ncbi Nonleadlikeness and leadlikeness in biochemical screening
    Gilbert M Rishton
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Drug Discov Today 8:86-96. 2003
  2. ncbi Failure and success in modern drug discovery: guiding principles in the establishment of high probability of success drug discovery organizations
    Gilbert M Rishton
    Alzheimer s Initiative, Science Building 206, California State University, Channel Islands, One University Drive, Camarillo, CA 93012, USA
    Med Chem 1:519-27. 2005
  3. ncbi Aggregator compounds confound amyloid fibrillization assay
    Gilbert M Rishton
    Nat Chem Biol 4:159-60. 2008
  4. ncbi Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening
    Gilbert M Rishton
    Channel Islands Alzheimer s Institute, CSUCI, Aliso Hall, Camarillo, CA 93012, USA
    Curr Opin Chem Biol 12:340-51. 2008

Detail Information

Publications4

  1. ncbi Nonleadlikeness and leadlikeness in biochemical screening
    Gilbert M Rishton
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Drug Discov Today 8:86-96. 2003
    ..The physiochemical properties of leadlikeness and the surprising differences between those properties and the now classical definitions of druglikeness are becoming apparent...
  2. ncbi Failure and success in modern drug discovery: guiding principles in the establishment of high probability of success drug discovery organizations
    Gilbert M Rishton
    Alzheimer s Initiative, Science Building 206, California State University, Channel Islands, One University Drive, Camarillo, CA 93012, USA
    Med Chem 1:519-27. 2005
    ..Consideration of these guiding principles will improve our chances of success in drug discovery, and increase our ability to address unmet medical need in the future...
  3. ncbi Aggregator compounds confound amyloid fibrillization assay
    Gilbert M Rishton
    Nat Chem Biol 4:159-60. 2008
  4. ncbi Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening
    Gilbert M Rishton
    Channel Islands Alzheimer s Institute, CSUCI, Aliso Hall, Camarillo, CA 93012, USA
    Curr Opin Chem Biol 12:340-51. 2008
    ..Chemically stable low molecular weight 'minimalist' compounds (or fragments) with dense heteroatom substitution and variable conformational constraint are promoted as conceptually superior compounds for biochemical screening...