Paul E Harrington

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. ncbi The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core
    Paul E Harrington
    Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 20:5544-7. 2010
  2. ncbi Calcium sensing receptor activators: calcimimetics
    Paul E Harrington
    Department of Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Dr, Thousand Oaks, CA 91320 1799, USA
    Curr Med Chem 14:3027-34. 2007
  3. ncbi Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl)methanamines as potent and efficacious type II calcimimetics
    Steve F Poon
    Amgen Inc, Thousand Oaks, California 91320, USA
    J Med Chem 52:6535-8. 2009
  4. ncbi Facile synthesis of substituted 5-amino- and 3-amino-1,2,4-thiadiazoles from a common precursor
    Paul M Wehn
    Department of Medicinal Chemistry, Amgen Inc, 1120 Veterans Boulevard, South San Francisco, California 94080, USA
    Org Lett 11:5666-9. 2009

Collaborators

Detail Information

Publications4

  1. ncbi The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core
    Paul E Harrington
    Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 20:5544-7. 2010
    ..Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model...
  2. ncbi Calcium sensing receptor activators: calcimimetics
    Paul E Harrington
    Department of Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Dr, Thousand Oaks, CA 91320 1799, USA
    Curr Med Chem 14:3027-34. 2007
    ..In this review, we provide an overview of key results in the discovery of cinacalcet HCl (Sensipar in the US, Mimpara in Europe). In addition, other recently disclosed type II calcimimetics are discussed...
  3. ncbi Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl)methanamines as potent and efficacious type II calcimimetics
    Steve F Poon
    Amgen Inc, Thousand Oaks, California 91320, USA
    J Med Chem 52:6535-8. 2009
    ..The structure-activity relationships of various substituted heterocycles and their effects on the human calcium-sensing receptor are discussed. Pyrazole 15 was shown to be efficacious in a rat in vivo pharmacodynamic model...
  4. ncbi Facile synthesis of substituted 5-amino- and 3-amino-1,2,4-thiadiazoles from a common precursor
    Paul M Wehn
    Department of Medicinal Chemistry, Amgen Inc, 1120 Veterans Boulevard, South San Francisco, California 94080, USA
    Org Lett 11:5666-9. 2009
    ..Derivatization by palladium-catalyzed Suzuki-Miyaura coupling enables the rapid preparation of analogs around this pharmaceutically relevant core. FMO calculations rationalize the observed chemoselectivity for coupling at chlorine...