Research Topics
| C A HallerSummaryAffiliation: Amgen Inc Country: USA Publications
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Publications
Safety issues specific to clinical development of protein therapeuticsC A Haller
Department of Global Regulatory Affairs and Safety, Amgen Inc, South San Francisco, California, USA
Clin Pharmacol Ther 84:624-7. 2008- Dietary supplement adverse events: report of a one-year poison center surveillance projectChristine Haller
Amgen, Inc Department of Global Regulatory Affairs and Safety, South San Francisco, CA, USA
J Med Toxicol 4:84-92. 2008..Harmful supplements may not be identified for months or years with existing adverse event monitoring mechanisms. Retrospective review of poison center statistics to capture supplement-associated toxicity also has limitations... - Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditionsChristine A Haller
Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, San Francisco General Hospital, San Francisco, CA, USA
Br J Clin Pharmacol 65:833-40. 2008..The effect of exercise on the pharmacokinetics and pharmacodynamics of stimulant herbals is unknown... - Enhanced stimulant and metabolic effects of combined ephedrine and caffeineChristine A Haller
Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, CA 94143, USA
Clin Pharmacol Ther 75:259-73. 2004..We sought to determine whether ephedrine and caffeine have clinically significant pharmacologic interactions that explain these toxicities... - Hemodynamic effects of ephedra-free weight-loss supplements in humansChristine A Haller
Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, 94143, USA
Am J Med 118:998-1003. 2005..aurantium alone, because an eightfold higher dose of synephrine (Advantra Z) had no effect on blood pressure, but may be attributable to caffeine and other stimulants in the multi-component formulation... - Short-term metabolic and hemodynamic effects of ephedra and guarana combinationsChristine A Haller
Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, CA 94143, USA
Clin Pharmacol Ther 77:560-71. 2005..We sought to determine whether repeated dosing and multi-ingredient formulations contribute to the adverse effects of these supplements... - Seizures reported in association with use of dietary supplementsChristine A Haller
University of California, San Francisco, San Francisco, California 94143, USA
Clin Toxicol (Phila) 43:23-30. 2005..Seizures in persons using dietary supplements (DS) have been reported through the Food and Drug Administration's (FDA) MedWatch system, but not formally reviewed... - Determination of ephedra alkaloid and caffeine concentrations in dietary supplements and biological fluidsPeyton Jacob
University of California, San Francisco, Department of Medicine, Division of Clinical Pharmacology, San Francisco General Hospital, 1001 Potrero Avenue, Building 30, 3rd Floor, San Francisco, California 94110, USA
J Anal Toxicol 28:152-9. 2004..Using this method, low nanogram-per-milliliter concentrations of ephedrine, pseudoephedrine, norephedrine, norpseudoephedrine, methylephedrine, methylpseudoephedrine, and caffeine can be quantitated in a 12-min LC-MS-MS run... - Concentrations of ephedra alkaloids and caffeine in commercial dietary supplementsChristine A Haller
University of California, San Francisco, Department of Medicine, Division of Clinical Pharmacology, San Francisco General Hospital, 1001 Potrero Avenue, Building 30, 3rd Floor, San Francisco, California 94110, USA
J Anal Toxicol 28:145-51. 2004..We conclude that product inconsistency is common among some commercially available dietary supplements that contain ephedra alkaloids and caffeine... - Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement useChristine A Haller
Division of Clinical Pharmacology, San Francisco General Hospital, University of California, 94143, USA
Clin Pharmacol Ther 71:421-32. 2002..We assessed the pharmacokinetics and pharmacodynamics of a dietary supplement that contains these herbal stimulants... - Clinical approach to adverse events and interactions related to herbal and dietary supplementsChristine A Haller
University of California, San Francisco, California Poison Control System, San Francisco Division, San Francisco, California 94143, USA
Clin Toxicol (Phila) 44:605-10. 2006 - Gamma-hydroxybutyrate and ethanol effects and interactions in humansDung Thai
Amgen Corporation, Thousand Oaks, CA, USA
J Clin Psychopharmacol 26:524-9. 2006..Gamma-hydroxybutyrate-plus-ethanol resulted in more adverse effects, including gastrointestinal disturbances, hypotension, and decreased O2sat, but only minimal pharmacokinetic interactions were observed... - Effect of a multicomponent, ephedra-containing dietary supplement (Metabolife 356) on Holter monitoring and hemostatic parameters in healthy volunteersStephanie F Gardner
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W. Markham #522, Little Rock, AR 72205, USA
Am J Cardiol 91:1510-3, A9. 2003 - An evaluation of selected herbal reference texts and comparison to published reports of adverse herbal eventsChristine A Haller
Department of Medicine and Clinical Pharmacy, University of California, San Francisco, California, USA
Adverse Drug React Toxicol Rev 21:143-50. 2002..We systematically assessed six herbal reference texts to evaluate the information they contain on herbal toxicity...