Xiaolin Cao

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. ncbi Raman microscopic applications in the biopharmaceutical industry: in situ identification of foreign particulates inside glass containers with aqueous formulated solutions
    Xiaolin Cao
    Department of Formulation and Analytical Resources, Amgen Inc, Thousand Oaks, California 91320, USA
    Appl Spectrosc 63:830-4. 2009
  2. ncbi Identification of a mixed microparticle by combined microspectroscopic techniques: a real forensic case study in the biopharmaceutical industry
    Xiaolin Cao
    Department of Formulation and Analytical Resources, Amgen Inc, Thousand Oaks, California 91320, USA
    Appl Spectrosc 64:895-900. 2010
  3. ncbi Distribution of silicone oil in prefilled glass syringes probed with optical and spectroscopic methods
    Zai Qing Wen
    Department of Formulation and Analytical Resources, Amgen Inc, Thousand Oaks, CA 91320, USA
    PDA J Pharm Sci Technol 63:149-58. 2009
  4. ncbi Direct visualization of protein adsorption to primary containers by gold nanoparticles
    Bruce Eu
    Department of Drug Product and Device Development, Amgen Inc, Thousand Oaks, California 91320 1799, USA
    J Pharm Sci 100:1663-70. 2011
  5. ncbi Conformation and side chains environments of recombinant human interleukin-1 receptor antagonist (rh-IL-1ra) probed by raman, raman optical activity, and UV-resonance Raman spectroscopy
    Zai Qing Wen
    Department of Global Cellular and Analytical Resources, Amgen, Inc, Thousand Oaks, California 91320, USA
    J Pharm Sci 97:2228-41. 2008

Detail Information

Publications5

  1. ncbi Raman microscopic applications in the biopharmaceutical industry: in situ identification of foreign particulates inside glass containers with aqueous formulated solutions
    Xiaolin Cao
    Department of Formulation and Analytical Resources, Amgen Inc, Thousand Oaks, California 91320, USA
    Appl Spectrosc 63:830-4. 2009
    ..For all three identifications, Raman in situ detection has significantly accelerated particle analysis and avoided potential sample secondary contamination or losses owing to none or minimal sample manipulation...
  2. ncbi Identification of a mixed microparticle by combined microspectroscopic techniques: a real forensic case study in the biopharmaceutical industry
    Xiaolin Cao
    Department of Formulation and Analytical Resources, Amgen Inc, Thousand Oaks, California 91320, USA
    Appl Spectrosc 64:895-900. 2010
    ..With this methodology, the mixed microparticle investigated in this study was determined to consist of polyisobutylene, hydrated magnesium silicate, titanium dioxide, and silica, likely originating from the vial stopper material...
  3. ncbi Distribution of silicone oil in prefilled glass syringes probed with optical and spectroscopic methods
    Zai Qing Wen
    Department of Formulation and Analytical Resources, Amgen Inc, Thousand Oaks, CA 91320, USA
    PDA J Pharm Sci Technol 63:149-58. 2009
    ..These analytical techniques can be applied to monitor the silicone oil distribution in PFSs...
  4. ncbi Direct visualization of protein adsorption to primary containers by gold nanoparticles
    Bruce Eu
    Department of Drug Product and Device Development, Amgen Inc, Thousand Oaks, California 91320 1799, USA
    J Pharm Sci 100:1663-70. 2011
    ..The method is particularly valuable for high-concentration protein formulations in which adsorption of proteins to containers cannot be easily detected by other methods...
  5. ncbi Conformation and side chains environments of recombinant human interleukin-1 receptor antagonist (rh-IL-1ra) probed by raman, raman optical activity, and UV-resonance Raman spectroscopy
    Zai Qing Wen
    Department of Global Cellular and Analytical Resources, Amgen, Inc, Thousand Oaks, California 91320, USA
    J Pharm Sci 97:2228-41. 2008
    ..These results demonstrate that Raman spectroscopy offers certain advantages over X-ray diffraction for studies of detailed local environment and intermolecular interactions of side chains of proteins in solution and in crystals...