June Chen

Summary

Affiliation: Allergan Inc
Country: USA

Publications

  1. ncbi Prostanoid FP receptor mediated, endothelium dependent vasodilatation and the ocular surface hyperemic response to PGF2 alpha and related compounds
    June Chen
    Department of Biological Sciences Allergan, Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Adv Exp Med Biol 507:331-6. 2002
  2. ncbi Studies using isolated uterine and other preparations show bimatoprost and prostanoid FP agonists have different activity profiles
    June Chen
    Department of Biological Sciences, Allergan, Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Br J Pharmacol 144:493-501. 2005
  3. ncbi Finding of endocannabinoids in human eye tissues: implications for glaucoma
    June Chen
    Department of Biological Sciences, Allergan Inc, Irvine, CA, USA
    Biochem Biophys Res Commun 330:1062-7. 2005
  4. ncbi Bimatoprost: mechanism of ocular surface hyperemia associated with topical therapy
    June Chen
    Department of Biological Sciences RD3, Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Cardiovasc Drug Rev 23:231-46. 2005
  5. ncbi Bimatoprost-induced calcium signaling in human T-cells does not involve prostanoid FP or TP receptors
    June Chen
    Department of Biological Sciences, Allergan, Inc, Irvine, California 92612, USA
    Curr Eye Res 34:184-95. 2009
  6. ncbi Bimatoprost and prostaglandin F(2 alpha) selectively stimulate intracellular calcium signaling in different cat iris sphincter cells
    Clayton S Spada
    Department of Biological Sciences, Pharmaceutical Research and Development, Allergan, Inc, Irvine, CA 92612 1599, USA
    Exp Eye Res 80:135-45. 2005
  7. ncbi Ocular hypotensive activity of prostaglandin F2 alpha (PGF2 alpha) analogs with neutral substituents at position 1 is predicted by the isolated cat iris sphincter smooth muscle preparation but not Ca+ signalling in Swiss 3T3 cells
    Robert M Burk
    Department of Chemistry, Allergan, Inc, 2525 Dupont Drive, Irvine, CA 92623-9543, USA
    Adv Exp Med Biol 507:327-30. 2002
  8. ncbi Fixed-combination and emerging glaucoma therapies
    David F Woodward
    Allergan, Inc, 2525 Dupont Drive, Mail Code RD3 2B, Irvine, CA 92612, USA
    Expert Opin Emerg Drugs 12:313-27. 2007

Detail Information

Publications8

  1. ncbi Prostanoid FP receptor mediated, endothelium dependent vasodilatation and the ocular surface hyperemic response to PGF2 alpha and related compounds
    June Chen
    Department of Biological Sciences Allergan, Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Adv Exp Med Biol 507:331-6. 2002
  2. ncbi Studies using isolated uterine and other preparations show bimatoprost and prostanoid FP agonists have different activity profiles
    June Chen
    Department of Biological Sciences, Allergan, Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Br J Pharmacol 144:493-501. 2005
    ..The potent contractile effects of bimatoprost in the rabbit uterus provide further pharmacological evidence for the presence of a novel receptor population that preferentially recognises bimatoprost...
  3. ncbi Finding of endocannabinoids in human eye tissues: implications for glaucoma
    June Chen
    Department of Biological Sciences, Allergan Inc, Irvine, CA, USA
    Biochem Biophys Res Commun 330:1062-7. 2005
    ..The findings suggest that these endogenous compounds may have a role in this disease, particularly with respect to regulation of IOP...
  4. ncbi Bimatoprost: mechanism of ocular surface hyperemia associated with topical therapy
    June Chen
    Department of Biological Sciences RD3, Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Cardiovasc Drug Rev 23:231-46. 2005
    ..These studies suggest that conjunctival hyperemia, a side effect of bimatoprost treatment, results from non-inflammatory, pharmacologically based vasodilatation...
  5. ncbi Bimatoprost-induced calcium signaling in human T-cells does not involve prostanoid FP or TP receptors
    June Chen
    Department of Biological Sciences, Allergan, Inc, Irvine, California 92612, USA
    Curr Eye Res 34:184-95. 2009
    ..The presence of both prostamide and prostanoid FP receptors in bimatoprost-sensitive preparations has made prostamide receptor classification difficult. This study investigated a novel bimatoprost-sensitive preparation...
  6. ncbi Bimatoprost and prostaglandin F(2 alpha) selectively stimulate intracellular calcium signaling in different cat iris sphincter cells
    Clayton S Spada
    Department of Biological Sciences, Pharmaceutical Research and Development, Allergan, Inc, Irvine, CA 92612 1599, USA
    Exp Eye Res 80:135-45. 2005
    ..These studies provide further evidence for the existence of a bimatoprost-sensitive receptor that is distinct from any of the known prostaglandin receptor types...
  7. ncbi Ocular hypotensive activity of prostaglandin F2 alpha (PGF2 alpha) analogs with neutral substituents at position 1 is predicted by the isolated cat iris sphincter smooth muscle preparation but not Ca+ signalling in Swiss 3T3 cells
    Robert M Burk
    Department of Chemistry, Allergan, Inc, 2525 Dupont Drive, Irvine, CA 92623-9543, USA
    Adv Exp Med Biol 507:327-30. 2002
  8. ncbi Fixed-combination and emerging glaucoma therapies
    David F Woodward
    Allergan, Inc, 2525 Dupont Drive, Mail Code RD3 2B, Irvine, CA 92612, USA
    Expert Opin Emerg Drugs 12:313-27. 2007
    ..Efforts continue to improve existing antiglaucoma drugs in an attempt to design second-generation cholinomimetics, adrenergics, prostaglandins and prostamides...