Research Topics
| GARY WILLIAM LITMANSummaryAffiliation: All Children's Hospital Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Novel genes dramatically alter regulatory network topology in amphioxusQing Zhang
Burnham Institute for Medical Research, North Torrey Pines Road, La Jolla, CA 92037, USA
Genome Biol 9:R123. 2008....- Genomic complexity of the variable region-containing chitin-binding proteins in amphioxusLarry J Dishaw
All Children s Hospital, Department of Molecular Genetics, 801 Sixth Street South, St, Petersburg, FL 33701, USA
BMC Genet 9:78. 2008..In this report, we describe VCBP genomic organization and characterize adjacent and intervening genetic features which may influence both their polymorphism and complex transcriptional repertoire... - The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domainsSalil Desai
Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
BMC Evol Biol 8:177. 2008.... - Reconstructing immune phylogeny: new perspectivesGary W Litman
Department of Pediatrics, University of South Florida College of Medicine, All Children s Hospital Children s Research Institute, 830 First Street South, Saint Petersburg, Florida 33701, USA
Nat Rev Immunol 5:866-79. 2005.... - Alternative mechanisms of immune receptor diversityGary W Litman
Department of Molecular Genetics, All Children s Hospital, 801 Sixth Street South, St Petersburg, FL 33701, United States
Curr Opin Immunol 19:526-34. 2007.... - Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptorsGary W Litman
Department of Pediatrics, University of South Florida College of Medicine, USF ACH Children s Research Institute, 830 First Street South, St Petersburg, FL 33701, USA
Immunol Res 38:294-304. 2007..Both families of molecules encode V domains that share some characteristics of adaptive immune receptors but likely mediate innate functions... - Evolution of antigen binding receptorsG W Litman
Department of Pediatrics, University of South Florida College of Medicine, All Children s Hospital, St Petersburg 33701, USA
Annu Rev Immunol 17:109-47. 1999.... - The origins of vertebrate adaptive immunityGary W Litman
Department of Molecular Genetics, All Children s Hospital, St Petersburg, Florida 33701, USA
Nat Rev Immunol 10:543-53. 2010..We combine evidence from a wide range of organisms to obtain an integrated view of the origins and patterns of divergence in adaptive immunity... - Novel immune-type receptor genesG W Litman
University of South Florida All Children s Hospital, Children s Research Institute, St Petersburg 33701, USA
Immunol Rev 181:250-9. 2001.... - New insights into alternative mechanisms of immune receptor diversificationGary W Litman
Department of Pediatrics, University of South Florida College of Medicine, USF/ACH Children's Research Institute, St. Petersburg, Florida 33701, USA
Adv Immunol 87:209-36. 2005..Unusual genetic mechanisms for diversifying recognition proteins may be a widespread characteristic of animal immunity... - Mechanisms of antigen receptor evolutionDonna D Eason
Department of Pediatrics, Children's Research Institute, University of South Florida College of Medicine, 830 First Street South, St. Petersburg, FL 33701, USA
Semin Immunol 16:215-26. 2004..Such studies have uncovered previously unknown mechanisms of generating receptor diversity... - The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxusLarry J Dishaw
Department of Molecular Genetics, All Children s Hospital, St Petersburg, FL, USA
Immunogenetics 62:623-31. 2010..The collective observations suggest that mechanisms were in place at the time of divergence of the cephalochordates that could selectively hyperdiversify immune-type receptors within a multigene family... - Ancient divergence of a complex family of immune-type receptor genesJohn P Cannon
Department of Pediatrics, University of South Florida College of Medicine, and USF/ACH Children's Research Institute, 830 First Street South, St. Petersburg, FL, 33701, USA
Immunogenetics 58:362-73. 2006.... - The phylogenetic origins of the antigen-binding receptors and somatic diversification mechanismsJohn P Cannon
Department of Molecular Genetics, All Children's Hospital, St. Petersburg, FL, USA
Immunol Rev 200:12-22. 2004..Such studies have the potential for uncovering previously unknown mechanisms of generating receptor diversity... - Variable domains and a VpreB-like molecule are present in a jawless vertebrateJohn P Cannon
Department of Molecular Genetics, All Children's Hospital, 801 Sixth Street South, St. Petersburg, FL 33701, USA
Immunogenetics 56:924-9. 2005..This is the first indication of a molecule related to the B cell receptor (BCR) complex in a species that diverged prior to the jawed vertebrates in which RAG-mediated adaptive immunity is first encountered... - Structure and diversity of T-lymphocyte antigen receptors alpha and gamma in XenopusRobert N Haire
Department of Pediatrics, University of South Florida, Children s Research Institute, 140 Seventh Avenue South, St Petersburg 33701, USA
Immunogenetics 54:431-8. 2002..This process produces a translatable cDNA that is not readily predictable from the genomic locus utilizing normal recombination and splicing mechanisms... - Haplotype exclusion: the unique case presented by multiple immunoglobulin gene loci in cartilaginous fishDonna D Eason
Department of Molecular Genetics, All Children's Hospital, St. Petersburg, FL 33701, USA
Semin Immunol 14:145-52; discussion 220. 2002.... - Recognition of additional roles for immunoglobulin domains in immune functionJohn P Cannon
University of South Florida, Department of Pediatrics, USF ACH Children s Research Institute, 140 Seventh Avenue South, St Petersburg, FL 33701, USA
Semin Immunol 22:17-24. 2010.... - Expression of individual immunoglobulin genes occurs in an unusual system consisting of multiple independent lociDonna D Eason
Department of Molecular Genetics, All Children's Hospital, St. Petersburg, FL, USA
Eur J Immunol 34:2551-8. 2004..Taken together, these findings suggest that a mechanism for haplotype exclusion arose early in the evolution of antibody diversity and is independent of a single genetic locus... - A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognitionJohn P Cannon
Department of Pediatrics, University of South Florida College of Medicine, St Petersburg, FL 33701, USA
Immunity 29:228-37. 2008.... - BIVM, a novel gene widely distributed among deuterostomes, shares a core sequence with an unusual gene in Giardia lambliaJeffrey A Yoder
Department of Pediatrics, University of South Florida, Children s Research Institute, St Petersburg, FL 33701, USA
Genomics 79:750-5. 2002..However, an unusual gene has been identified in the protozoan pathogen Giardia lamblia that is similar to the core sequence of BIVM, suggesting the possibility of a horizontal gene transfer... - Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordateJohn P Cannon
Immunology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Avenue, Tampa, FL 33612, USA
Nat Immunol 3:1200-7. 2002..Thus, multigenic families encoding diversified V regions exist in a species lacking an adaptive immune response... - The amphioxus genome illuminates vertebrate origins and cephalochordate biologyLinda Z Holland
Marine Biology Research Division, Scripps Institution of Oceanography, La Jolla, California 92093 0202, USA
Genome Res 18:1100-11. 2008..Our results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates... - Structural characteristics of zebrafish orthologs of adaptor molecules that associate with transmembrane immune receptorsJeffrey A Yoder
Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Gene 401:154-64. 2007..Their genomic organizations have been characterized, cDNA transcripts have been recovered, phylogenetic relationships have been defined and their cell lineage-specific expression patterns have been established... - Genomic insights into the immune system of the sea urchinJonathan P Rast
Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, 2075 Bayview Avenue, Room S 126B, Toronto, Ontario M4N 3M5, Canada
Science 314:952-6. 2006..The findings serve to underscore the dynamic utilization of receptors and the complexity of immune recognition that may be basal for deuterostomes and predicts features of the ancestral bilaterian form... - Lineage-restricted retention of a primitive immunoglobulin heavy chain isotype within the Dipnoi reveals an evolutionary paradoxTatsuya Ota
Department of Biosystems Science, The Graduate University for Advanced Studies (Sokendai, Hayama, Kanagawa 240-0193, Japan
Proc Natl Acad Sci U S A 100:2501-6. 2003..Moreover, its absence in other gnathostome lineages implies paradoxically that the IgW-type genes were lost from teleost and tetrapod lineages... - Individual protochordates have unique immune-type receptor repertoiresJohn P Cannon
Curr Biol 14:R465-6. 2004 - Resolution of the novel immune-type receptor gene cluster in zebrafishJeffrey A Yoder
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Proc Natl Acad Sci U S A 101:15706-11. 2004..These studies resolve a complete immune gene cluster in zebrafish and indicate that the NITRs represent the most complex family of activating/inhibitory surface receptors thus far described... - On the origins of adaptive immunity: innate immune receptors join the taleTimo K van den Berg
Department of Molecular Cell Biology, VU Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
Trends Immunol 25:11-6. 2004..We propose the existence of an evolutionary and functional link between innate and adaptive immune receptors that sheds light on the nature of the antigen receptor predecessor(s)... - Terminal deoxynucleotidyl transferases from elasmobranchs reveal structural conservation within vertebratesSimona Bartl
Moss Landing Marine Laboratories, 8272 Moss Landing Road, CA 95039, Moss Landing, USA
Immunogenetics 55:594-604. 2003..Thus, unlike other molecules of adaptive immunity, TdT is a member of an ancient gene family with a clear gene phylogeny and a high degree of similarity, which implies the existence of TdT ancestors in jawless fishes and invertebrates... - Zebrafish as an immunological model systemJeffrey A Yoder
Department of Biology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA
Microbes Infect 4:1469-78. 2002..Recent advances in mutation screening, the creation of genomic resources, including the Zebrafish Genome Project and the development of efficient transgenesis procedures, make this model increasingly attractive for immunological study... - Histocompatibility: colonial match and mismatchGary W Litman
Nature 438:437-9. 2005 - Evidence for a transposition event in a second NITR gene cluster in zebrafishJeffrey A Yoder
Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
Immunogenetics 60:257-65. 2008..Sequence features of the chromosomal region encoding nitr13 suggest that this gene arose via retrotransposition... - Crystallization and X-ray diffraction analysis of a novel immune-type receptor from Ictalurus punctatus and phasing by selenium anomalous dispersion methodsDavid A Ostrov
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
Acta Crystallogr Sect F Struct Biol Cryst Commun 63:1035-7. 2007..77 by SAD methods and experimental electron-density maps were calculated to 1.65 A. Five NITR10 molecules are predicted to be present in the asymmetric unit based on the Matthews coefficient... - Cloning novel immune-type inhibitory receptors from the rainbow trout, Oncorhynchus mykissJeffrey A Yoder
Immunology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Immunogenetics 54:662-70. 2002..Several probable scenarios that explain the origins of variant forms of NITRs are described... - Evolutionary origins of lymphocytes: ensembles of T cell and B cell transcriptional regulators in a cartilaginous fishMichele K Anderson
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
J Immunol 172:5851-60. 2004..However, certain factors relevant to the B lineage differ in their tissue-specific expression patterns from their mouse counterparts, suggesting expanded or divergent B lineage characteristics or tissue specificity in these animals...
Research Grants
- EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENESGARY WILLIAM LITMAN; Fiscal Year: 2010....
- Novel Innate Immune Receptors in ZebrafishGARY WILLIAM LITMAN; Fiscal Year: 2010....
- Novel Innate Immune Receptors in ZebrafishGARY LITMAN; Fiscal Year: 2009..Understanding this relationship has broad health consequences in terms of mechanisms of resistance to infection and susceptibility to malignancy. ..
- EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENESGARY LITMAN; Fiscal Year: 2007..Such information is fundamental to understanding the basis for self-nonself discrimination and how structural diversification relates to immune specificity. ..
- EARLY EVOLUTIONARY ORIGIN OF IMMUNOGLOBULIN GENESGARY LITMAN; Fiscal Year: 1993....
- EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENESGARY WILLIAM LITMAN; Fiscal Year: 2011....