Research Topics
| Nelly MaurasSummaryAffiliation: Alfred I. duPont Hospital for Children Country: USA Publications
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Detail Information
Publications
Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young malesNelly Mauras
Nemours Children s Clinic and Research Programs, Jacksonville, Florida 32207, USA
J Clin Endocrinol Metab 88:5951-6. 2003..The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study...- Anastrozole increases predicted adult height of short adolescent males treated with growth hormone: a randomized, placebo-controlled, multicenter trial for one to three yearsNelly Mauras
Nemours Children s Clinic, Division of Endocrinology, 807 Children s Way, Jacksonville, Florida 32207, USA
J Clin Endocrinol Metab 93:823-31. 2008..The process of epiphyseal fusion during puberty is regulated by estrogen, even in males... - Metabolic effects of oral versus transdermal estrogen in growth hormone-treated girls with turner syndromeNelly Mauras
Nemours Children s Clinic, 807 Childrens Way, Jacksonville, Florida 32207, USA
J Clin Endocrinol Metab 92:4154-60. 2007..Transdermal (TD) estrogen is often preferred over the oral route in postmenopausal and GH-deficient women taking estrogen, but this has not been studied in detail in girls... - Amino-terminal propeptide of C-type natriuretic peptide and linear growth in children: effects of puberty, testosterone, and growth hormoneRobert C Olney
Division of Pediatric Endocrinology, Nemours Children s Clinic Jacksonville, Jacksonville, Florida 32207, USA
J Clin Endocrinol Metab 92:4294-8. 2007..The amino-terminal propeptide of CNP (NTproCNP) is produced in equimolar amounts with CNP and is measurable in plasma, providing a potential biomarker for growth plate activity and, hence, linear growth... - A randomized controlled trial of insulin pump therapy in young children with type 1 diabetesLarry A Fox
Nemours Children s Clinic, NE Florida Pediatric Diabetes Center, 807 Children s Way, Jacksonville, FL 32207, USA
Diabetes Care 28:1277-81. 2005..This study assesses the effects of insulin pump therapy on diabetes control and family life in children 1-6 years old with type 1 diabetes... - Acute changes in blood glucose do not alter blood glutathione synthesis in adolescents with poorly controlled type 1 diabetes mellitusDominique Darmaun
Division of Endocrinology, Diabetes, and Metabolism, Nemours Children s Clinic, Jacksonville, FL 32207, USA
Metabolism 61:373-8. 2012..This finding suggests that, in adolescents with poorly controlled T1D, either (a) blood glucose per se does not regulate GSH metabolism or (b) GSH may only respond to sustained, more chronic changes in blood glucose level... - Effects of growth hormone and nutritional therapy in boys with constitutional growth delay: a randomized controlled trialJoan C Han
Division of Endocrinology, Nemours Children s Clinic, Jacksonville, FL 32207, USA
J Pediatr 158:427-32. 2011..To examine whether supplemental nutrition augments the anabolic actions of growth hormone (GH) in boys with constitutional delay of growth and maturation (CDGM)... - Effects of behavioral family systems therapy for diabetes on adolescents' family relationships, treatment adherence, and metabolic controlTim Wysocki
Center for Pediatric Psychology Research, Nemours Children s Clinic, 807 Children s Way, Jacksonville, Florida 32207, USA
J Pediatr Psychol 31:928-38. 2006..We evaluated a revised intervention, BFST for diabetes (BFST-D)... - Poorly controlled type 1 diabetes is associated with altered glutathione homeostasis in adolescents: apparent resistance to N-acetylcysteine supplementationDominique Darmaun
Endocrine Research, Nemours Children s Clinic, Jacksonville, FL 32207, USA
Pediatr Diabetes 9:577-82. 2008..In the presence of relative insulinopenia, either higher amino acid doses or aggressive insulin therapy may be needed to achieve this goal. This would require further study... - Growth hormone has anabolic effects in glucocorticosteroid-dependent children with inflammatory bowel disease: a pilot studyNelly Mauras
Nemours Children's Clinic, Jacksonville, FL, USA
Metabolism 51:127-35. 2002..We conclude that treatment with rhGH has beneficial effects in prednisone-dependent growing children. Larger studies will be needed to assess the long-term safety and efficacy of this approach... - Effects of glutamine and recombinant human growth hormone on protein metabolism in prepubertal children with cystic fibrosisDominique Darmaun
Division of Endocrinology, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
J Clin Endocrinol Metab 89:1146-52. 2004.... - Randomized trial of behavioral family systems therapy for diabetes: maintenance of effects on diabetes outcomes in adolescentsTim Wysocki
Nemours Childrens Clinic, Department of Biomedical Research, 807 Children s Way, Jacksonville, FL 32207, USA
Diabetes Care 30:555-60. 2007..This study evaluates a revised intervention, BFST for Diabetes (BFST-D), modified to achieve greater impact on diabetes-related family conflict, treatment adherence, and metabolic control... - Can growth hormone counteract the catabolic effects of steroids?Nelly Mauras
Division of Endocrinology, Nemours Children s Clinic, Jacksonville, FL 32207, USA
Horm Res 72:48-54. 2009..CONCLUSIONS: Both GH and IGF-I may decrease the catabolic effects of chronic steroid use in humans, particularly by enhancing lean body mass accrual and, in children, by increasing linear growth... - Obesity without established comorbidities of the metabolic syndrome is associated with a proinflammatory and prothrombotic state, even before the onset of puberty in childrenNelly Mauras
Nemours Children s Clinic, 807 Children s Way, Jacksonville, Florida 32207, USA
J Clin Endocrinol Metab 95:1060-8. 2010..Whether biomarkers like hsCRP and fibrinogen are useful in assessing cardiovascular risk and whether these abnormalities are reversible with earlier therapeutic interventions in very young obese children requires further study... - Strategies for maximizing growth in puberty in children with short statureNelly Mauras
Division of Endocrinology and Metabolism, Nemours Children s Clinic, Jacksonville, FL 32207, USA
Pediatr Clin North Am 58:1167-79, x. 2011..Safety issues regarding bone health also require further study... - Effects of glutamine on glycemic control during and after exercise in adolescents with type 1 diabetes: a pilot studyNelly Mauras
Division of Endocrinology, Diabetes and Metabolism, Nemours Children s Clinic, Jacksonville, Florida, USA
Diabetes Care 33:1951-3. 2010..To investigate if oral glutamine ameliorates exercise and postexercise nighttime hypoglycemia in type 1 diabetic adolescents... - Pharmacokinetics and pharmacodynamics of oral and transdermal 17? estradiol in girls with turner syndromeMartha Taboada
Chief, Division of Endocrinology, Diabetes, and Metabolism, Nemours Children s Clinic, Jacksonville, Florida 32207
J Clin Endocrinol Metab 96:3502-10. 2011..Whether the long-term metabolic effects of estrogen differ using the same form of E(2), depending on route, awaits further study in TS... - Pharmacokinetics and pharmacodynamics of anastrozole in pubertal boys with recent-onset gynecomastiaNelly Mauras
Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
J Clin Endocrinol Metab 94:2975-8. 2009..Anastrozole (Arimidex) is a potent and selective reversible inhibitor of the aromatase enzyme in females... - Strategies for maximizing growth in puberty in children with short statureNelly Mauras
Division of Endocrinology and Metabolism, Nemours Children s Clinic, Jacksonville, FL 32207, USA
Endocrinol Metab Clin North Am 38:613-24. 2009..Safety issues regarding bone health also require further study... - Influence of sex and beta2 adrenergic receptor haplotype on resting and terbutaline-stimulated whole body lipolysisJohn J Lima
Centers for Clinical Pediatric Pharmacology and Pharmacogenetics, Nemours Children s Clinic, Jacksonville, FL 32207, USA
Metabolism 54:492-9. 2005..We conclude that compared to haplotype, sex is a more important determinant of basal lipolysis after a 12-hour fast in healthy, non-obese individuals... - Evidence for hypermetabolism in boys with constitutional delay of growth and maturationJoan C Han
Division of Endocrinology, Nemours Children's Clinic--Jacksonville, 807 Children's Way, Jacksonville, Florida 32207, USA
J Clin Endocrinol Metab 91:2081-6. 2006..Additional studies are needed to determine whether augmenting nutrition to match their energy needs (with or without hormonal therapy) can improve linear and ponderal growth in patients with CDGM... - Are the metabolic effects of GH and IGF-I separable?Nelly Mauras
Division of Endocrinology, The Department of Pediatrics at the Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
Growth Horm IGF Res 15:19-27. 2005..A comparison of these and other effects of these hormones is provided in this brief review. Subsequent studies are still needed to fully elucidate the safety and efficacy of IGF-I for use in humans... - Evidence for accelerated rates of glutathione utilization and glutathione depletion in adolescents with poorly controlled type 1 diabetesDominique Darmaun
Nemours Children s Clinic, Research Department, 5 North, 807 Children s Way, Jacksonville, FL 32207, USA
Diabetes 54:190-6. 2005..This weakened antioxidant defense may play a role in the pathogenesis of diabetes complications... - Increased synthesis rate of fibrinogen as a basis for its elevated plasma levels in obese female adolescentsPrabhakaran Balagopal
Nemours Research Program, Department of Research, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
Am J Physiol Endocrinol Metab 282:E899-904. 2002..This finding may have important implications in the design of therapies for modulating plasma fibrinogen levels in obesity and/or CVD in childhood... - Absence of adverse effects of severe hypoglycemia on cognitive function in school-aged children with diabetes over 18 monthsTim Wysocki
Division of Psychology and Psychiatry, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
Diabetes Care 26:1100-5. 2003..The objective of this study was to determine whether severe hypoglycemia (SH) in children with type 1 diabetes is associated with cognitive decline over 18 months... - Self-management competence as a predictor of outcomes of intensive therapy or usual care in youth with type 1 diabetesTim Wysocki
Nemours Children s Clinic, Jacksonville, Florida 32207, USA
Diabetes Care 26:2043-7. 2003..This article evaluates prediction of HbA(1c) during an 18-month randomized trial of intensive therapy (IT) versus usual care (UC) for type 1 diabetes in 142 youth... - Growth hormone action in puberty: effects by genderNelly Mauras
Division of Pediatric Endocrinology and Metabolism, Nemours Children s Clinic, Jacksonville, FL 32207, United States
Growth Horm IGF Res 17:463-71. 2007..Adult females receiving GH may be less sensitive to the metabolic effects of GH than males, however these differences are less well studied in adolescence. We aimed to investigate if metabolic effects of GH vary by gender during puberty... - An open label 12-month pilot trial on the effects of the aromatase inhibitor anastrozole in growth hormone (GH)-treated GH deficient adolescent boysNelly Mauras
Nemours Children s Clinics in Jacksonville, FL, USA
J Pediatr Endocrinol Metab 17:1597-606. 2004..To investigate whether 12 mo treatment with the aromatase inhibitor anastrozole can achieve sustained suppression of estrogen production and delay epiphyseal fusion in growth hormone deficient (GHD) adolescent males... - A randomized clinical trial to assess the efficacy and safety of real-time continuous glucose monitoring in the management of type 1 diabetes in young children aged 4 to <10 yearsNelly Mauras
Division of Pediatric Endocrinology, Nemours Children s Clinic, Jacksonville, Florida, USA
Diabetes Care 35:204-10. 2012..We designed a study to assess CGM benefit in young children aged 4 to 9 years with type 1 diabetes... - GH use in the transition of adolescence to adulthoodNelly Mauras
Division Endocrinology and Metabolism, Nemours Children s Clinic, Jacksonville, FL 32207, USA
Endocr Dev 18:109-25. 2010..Those with multiple pituitary hormone deficiencies on the other hand should be replaced indefinitely with GH. The treatment of the GH-deficient adolescent in transition should be individualized... - Sperm analysis in growth hormone-deficient adolescents previously treated with an aromatase inhibitor: comparison with normal controlsNelly Mauras
Nemours Children s Clinic and Research Programs, Jacksonville, Florida 32207, USA
Fertil Steril 84:239-42. 2005.... - Limited efficacy of growth hormone (GH) during transition of GH-deficient patients from adolescence to adulthood: a phase III multicenter, double-blind, randomized two-year trialNelly Mauras
Division of Endocrinology, Nemours Children s Clinic, 807 Children s Way, Jacksonville, Florida 32207, USA
J Clin Endocrinol Metab 90:3946-55. 2005..Treatment of GH-deficient adolescents in transition to adulthood remains challenging... - Self-care autonomy and outcomes of intensive therapy or usual care in youth with type 1 diabetesTim Wysocki
Center for Pediatric Psychology Research, Nemours Children s Clinic, 807 Children s Way, Jacksonville, Florida 32207, USA
J Pediatr Psychol 31:1036-45. 2006..This article evaluated whether deviation from developmentally appropriate self-care autonomy moderated the effects of intensive therapy (IT) or usual care (UC) on glycosylated hemoglobin (HbA(1C)) in 142 youths with diabetes... - Synergistic effects of testosterone and growth hormone on protein metabolism and body composition in prepubertal boysNelly Mauras
Nemours Children's Clinic Division of Endocrinology and Nemours Research Program, Jacksonville, FL 32207, USA
Metabolism 52:964-9. 2003..GH and T both potentiate the development of the full body composition and metabolic changes of puberty... - Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humansOlivier Le Bacquer
INSERM U 539, Centre de Recherche en Nutrition Humaine, Nantes, France
Clin Nutr 26:231-8. 2007.... - Endocrine control of body composition in infancy, childhood, and pubertyJohannes D Veldhuis
Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
Endocr Rev 26:114-46. 2005..The present critical review examines hormonal regulation of body composition in infancy, childhood, and puberty... - GlucoWatch G2 Biographer alarm reliability during hypoglycemia in childrenEva Tsalikian
DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA
Diabetes Technol Ther 6:559-66. 2004..The "down alert" alarm is triggered when extrapolation of the current glucose trend anticipates hypoglycemia to occur within the next 20 min... - A randomized multicenter trial comparing the GlucoWatch Biographer with standard glucose monitoring in children with type 1 diabetesH Peter Chase
DirecNet Coordinating Center, Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA
Diabetes Care 28:1101-6. 2005..This study assesses whether use of the GlucoWatch G2 Biographer (GW2B) in addition to standard glucose monitoring lowers HbA(1c) and reduces hypoglycemia compared with standard glucose monitoring alone... - Salutary effects of combining early very low-dose systemic estradiol with growth hormone therapy in girls with Turner syndromeRobert L Rosenfield
The University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
J Clin Endocrinol Metab 90:6424-30. 2005..Optimizing pubertal estrogen replacement in girls with Turner syndrome is important... - Impact of exercise on overnight glycemic control in children with type 1 diabetes mellitusEva Tsalikian
DirectNet Coordinating Center, Jaeb Center for Health Research, Tampa, Florida 33647, USA
J Pediatr 147:528-34. 2005..To examine the effect of exercise on overnight hypoglycemia in children with type 1 diabetes mellitus (T1DM)... - JDRF randomized clinical trial to assess the efficacy of real-time continuous glucose monitoring in the management of type 1 diabetes: research design and methodsWilliam V Tamborlane
Diabetes Technol Ther 10:310-21. 2008..RESULTS: Recruitment for the study was completed on December 15, 2007. CONCLUSION: Results of this clinical trial should help establish whether or not current RT-CGM devices are beneficial to patients with T1D... - Use of stable isotopes to assess protein and amino acid metabolism in children and adolescents: a brief reviewDominique Darmaun
INSERM U539, Human Nutrition Research Center, Nantes, France
Horm Res 64:32-7. 2005..Attempts have also been made to measure amino acid/protein metabolism in selected body compartments, and to measure the kinetics of specific tissue proteins, for example, muscle, gut, or plasma proteins... - Continuous glucose monitoring in children with type 1 diabetesBruce Buckingham
J Pediatr 151:388-93, 393.e1-2. 2007..The results provide a compelling rationale for conducting a randomized trial of daily use of a continuous glucose monitor in children with T1D... - FreeStyle navigator continuous glucose monitoring system use in children with type 1 diabetes using glargine-based multiple daily dose regimens: results of a pilot trial Diabetes Research in Children Network (DirecNet) Study GroupStuart Weinzimer
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
Diabetes Care 31:525-7. 2008 - Corticosteroids increase glutamine utilization in human splanchnic bedRonan Thibault
INRA, UMR 1280, Physiologie des Adaptations Nutritionnelles, Universite de Nantes, 44093 Nantes Cedex 1, France
Am J Physiol Gastrointest Liver Physiol 294:G548-53. 2008..The role of such changes in patients receiving chronic corticoid treatment for inflammatory diseases or suffering from severe illness remains to be determined... - The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetesMichael J Tansey
DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA
Diabetes Care 29:20-5. 2006..To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes... - Predictors of first-year growth response to a fixed-dose growth hormone treatment in children born small for gestational age: results of an open-label, multicenter trial in the United StatesRobert Rapaport
Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
J Pediatr Endocrinol Metab 21:411-22. 2008..The GH dose was the major predictor of first year growth response... - Continuous glucose monitoring and intensive treatment of type 1 diabetesWilliam V Tamborlane
N Engl J Med 359:1464-76. 2008..Further work is needed to identify barriers to effectiveness of continuous monitoring in children and adolescents. (ClinicalTrials.gov number, NCT00406133.).. - Use of the DirecNet Applied Treatment Algorithm (DATA) for diabetes management with a real-time continuous glucose monitor (the FreeStyle Navigator)Bruce Buckingham
Pediatr Diabetes 9:142-7. 2008..CONCLUSIONS: These results show the feasibility of implementing the DATA when real-time continuous glucose monitoring is initiated and support its use in future clinical trials of real-time continuous glucose monitoring... - Accuracy of the modified Continuous Glucose Monitoring System (CGMS) sensor in an outpatient setting: results from a diabetes research in children network (DirecNet) studyMichael J Tansey
DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA
Diabetes Technol Ther 7:109-14. 2005..19%; P < 0.001]. Baseline data from a subsequent outpatient study provide an opportunity to further assess the accuracy of the modified sensor in a much larger sample of children with type 1 diabetes... - Lack of accuracy of continuous glucose sensors in healthy, nondiabetic children: results of the Diabetes Research in Children Network (DirecNet) accuracy studyNelly Mauras
DirecNet Coordinating Center, Tampa, Florida, USA
J Pediatr 144:770-5. 2004..CONCLUSIONS: Neither the CGMS nor the GW2B is accurate enough to establish population standards of the glycemic profile of healthy children and cannot be recommended in the workup of hypoglycemia in nondiabetic youth... - The accuracy of the Guardian RT continuous glucose monitor in children with type 1 diabetesMichael Tansey
Diabetes Technol Ther 10:266-72. 2008..The Guardian RT has an accuracy similar to that of other available continuous glucose monitors and can give important and useful clinical information...