A V Alexandrov

Summary

Country: USA

Publications

  1. ncbi Correlation of peak systolic velocity and angiographic measurement of carotid stenosis revisited
    A V Alexandrov
    Neurovascular Doppler Laboratory, Sunnybrook Health Science Center, University of Toronto, Canada
    Stroke 28:339-42. 1997
  2. ncbi How to write a research paper
    Andrei V Alexandrov
    Stroke Treatment Team, Houston Medical School, University of Texas, Houston, TX 77030, USA
    Cerebrovasc Dis 18:135-8. 2004
  3. ncbi Citicoline. Ferrer Internacional
    A V Alexandrov
    Department of Neurology, University of Texas, Houston 77030, USA
    Curr Opin Investig Drugs 2:1757-62. 2001
  4. ncbi Arterial status after intravenous TPA therapy for ischaemic stroke. A need for further interventions
    I Christou
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, Texas, USA
    Int Angiol 20:208-13. 2001
  5. ncbi Speed of intracranial clot lysis with intravenous tissue plasminogen activator therapy: sonographic classification and short-term improvement
    A V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, Texas, USA
    Circulation 103:2897-902. 2001
  6. ncbi High rate of complete recanalization and dramatic clinical recovery during tPA infusion when continuously monitored with 2-MHz transcranial doppler monitoring
    A V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, USA
    Stroke 31:610-4. 2000
  7. ncbi Yield of transcranial Doppler in acute cerebral ischemia
    A V Alexandrov
    Center for Noninvasive Brain Perfusion Studies and the Stroke Treatment Team, University of Texas Houston Medical School, USA
    Stroke 30:1604-9. 1999
  8. ncbi Brain single-photon emission CT with HMPAO and safety of thrombolytic therapy in acute ischemic stroke. Proceedings of the meeting of the SPECT Safe Thrombolysis Study Collaborators and the members of the Brain Imaging Council of the Society of Nuclear Me
    A V Alexandrov
    University of Texas, Houston 77030, USA
    Stroke 28:1830-4. 1997
  9. ncbi A broad diagnostic battery for bedside transcranial Doppler to detect flow changes with internal carotid artery stenosis or occlusion
    I Christou
    Center for Noninvasive Brain Perfusion Studies, Stroke Program, University of Texas-Houston, USA
    J Neuroimaging 11:236-42. 2001
  10. ncbi Thrombotic occlusion of the common carotid artery (CCA) in acute ischemic stroke treated with intravenous tissue plasminogen activator (TPA)
    V K Sharma
    Department of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Eur J Neurol 14:237-40. 2007

Detail Information

Publications81

  1. ncbi Correlation of peak systolic velocity and angiographic measurement of carotid stenosis revisited
    A V Alexandrov
    Neurovascular Doppler Laboratory, Sunnybrook Health Science Center, University of Toronto, Canada
    Stroke 28:339-42. 1997
    ..We compared PSV and angiographic measurements at our center together with known physiological relationships to investigate the accuracy of ultrasound...
  2. ncbi How to write a research paper
    Andrei V Alexandrov
    Stroke Treatment Team, Houston Medical School, University of Texas, Houston, TX 77030, USA
    Cerebrovasc Dis 18:135-8. 2004
    ..They sometimes develop a mental condition equivalent to that known by neurologists as writer's cramp. It may result in permanent damage to academic career. This paper provides advice how to prevent or treat this condition...
  3. ncbi Citicoline. Ferrer Internacional
    A V Alexandrov
    Department of Neurology, University of Texas, Houston 77030, USA
    Curr Opin Investig Drugs 2:1757-62. 2001
    ..In December 1999, US rights to the commercialization of citicoline were licensed to Takeda...
  4. ncbi Arterial status after intravenous TPA therapy for ischaemic stroke. A need for further interventions
    I Christou
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, Texas, USA
    Int Angiol 20:208-13. 2001
    ..Intravenous tissue plasminogen activator (TPA) is an approved therapy for acute ischaemic stroke in the United States. We aimed to noninvasively monitor the therapy to determine arterial recanalisation and persisting vascular abnormalities...
  5. ncbi Speed of intracranial clot lysis with intravenous tissue plasminogen activator therapy: sonographic classification and short-term improvement
    A V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, Texas, USA
    Circulation 103:2897-902. 2001
    ..Arterial recanalization precedes clinical improvement or may lead to hemorrhage or reperfusion injury. Speed of clot lysis was not previously measured in human stroke...
  6. ncbi High rate of complete recanalization and dramatic clinical recovery during tPA infusion when continuously monitored with 2-MHz transcranial doppler monitoring
    A V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, USA
    Stroke 31:610-4. 2000
    ..Transcranial Doppler (TCD) with low MHz frequency can determine arterial occlusion and monitor recanalization and may potentiate thrombolysis...
  7. ncbi Yield of transcranial Doppler in acute cerebral ischemia
    A V Alexandrov
    Center for Noninvasive Brain Perfusion Studies and the Stroke Treatment Team, University of Texas Houston Medical School, USA
    Stroke 30:1604-9. 1999
    ..The objective of this study was to evaluate the yield of emergent transcranial Doppler (TCD) for the evaluation of acute cerebral ischemia...
  8. ncbi Brain single-photon emission CT with HMPAO and safety of thrombolytic therapy in acute ischemic stroke. Proceedings of the meeting of the SPECT Safe Thrombolysis Study Collaborators and the members of the Brain Imaging Council of the Society of Nuclear Me
    A V Alexandrov
    University of Texas, Houston 77030, USA
    Stroke 28:1830-4. 1997
    ....
  9. ncbi A broad diagnostic battery for bedside transcranial Doppler to detect flow changes with internal carotid artery stenosis or occlusion
    I Christou
    Center for Noninvasive Brain Perfusion Studies, Stroke Program, University of Texas-Houston, USA
    J Neuroimaging 11:236-42. 2001
    ....
  10. ncbi Thrombotic occlusion of the common carotid artery (CCA) in acute ischemic stroke treated with intravenous tissue plasminogen activator (TPA)
    V K Sharma
    Department of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Eur J Neurol 14:237-40. 2007
    ..Recanalization occurred in intracranial vessels only. Marked early neurological improvement occurred in two of three patients. CCA occlusions should not be considered contra-indication to systemic thrombolysis...
  11. ncbi Intravenous tissue-type plasminogen activator therapy for ischemic stroke: Houston experience 1996 to 2000
    J C Grotta
    Stroke Treatment Team, University of Texas Houston Medical School, Box 7 044, 6431 Fannin St, Houston, TX 77030, USA
    Arch Neurol 58:2009-13. 2001
    ..Our center is experienced in treating large numbers of stroke patients with intravenous tPA...
  12. ncbi tPA-associated reperfusion after acute stroke demonstrated by SPECT
    J C Grotta
    Department of Neurology, University of Texas Health Science Center, Houston 77030, USA
    Stroke 29:429-32. 1998
    ....
  13. ncbi Grading carotid stenosis with ultrasound. An interlaboratory comparison
    A V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, University of Texas Houston Medical School 77030, USA
    Stroke 28:1208-10. 1997
    ..We compared the performance of two independent laboratories using similar equipment (ATL-HDI Ultramark 9) but different interpretation criteria...
  14. ncbi Thrombolysis, stroke units and other strategies for reducing acute stroke costs
    T H Wein
    Department of Neurology, University of Texas Houston Medical School, USA
    Pharmacoeconomics 14:603-11. 1998
    ..Because only a minority of patients who have a stroke are currently eligible for thrombolysis, implementation of specialised and standardised stroke care may further enhance cost benefits and improve patient outcomes...
  15. ncbi Thrombolytic therapy in an adolescent ischemic stroke
    E A Noser
    Department of Neurology, University of Texas Houston Medical School, 77030 1501, USA
    J Child Neurol 16:286-8. 2001
    ..This case illustrates the importance of early recognition of stroke and the utility of thrombolytics in treating ischemic infarcts in the adolescent population...
  16. ncbi Acute stroke: therapeutic transcranial Doppler sonography
    R Mikulik
    Department of Neurology, University of Texas Health Science Center at Houston, 77030, USA
    Front Neurol Neurosci 21:150-61. 2006
    ..Also, the potential enhancement of sonothrombolysis with microbubbles is discussed...
  17. ncbi Predictors of tube feeding in acute stroke patients with dysphagia
    A W Wojner
    School of Nursing, Department of Neurology, University of Texas at Houston, Houston, Texas, USA
    AACN Clin Issues 11:531-40. 2000
    ..Findings from this study may assist healthcare providers in the early identification of stroke patients at risk for clinically significant neurogenic oropharyngeal dysphagia, facilitating reduction of untoward outcomes...
  18. ncbi Current and future recanalization strategies for acute ischemic stroke
    A V Alexandrov
    Comprehensive Stroke Center, Neurovascular Ultrasound Laboratory, University of Alabama Hospital, Birmingham, AL, USA
    J Intern Med 267:209-19. 2010
    ..Arterial re-occlusion can occur with any of these approaches, and it remains a challenge since it leads to poor outcomes and no clinical trial data are available yet to determine safe strategies to prevent or reverse re-occlusion...
  19. ncbi Association of reversed Robin Hood syndrome with risk of stroke recurrence
    P Palazzo
    Comprehensive Stroke Center Neurology, The University of Alabama at Birmingham, RWUH M226, 619 19 St, South Birmingham, AL 35249 3280, USA
    Neurology 75:2003-8. 2010
    ..We sought to investigate the association of RRHS with risk of stroke recurrence in a single-center cohort study...
  20. ncbi Outcome in hyperglycemic stroke with ultrasound-augmented thrombolytic therapy
    S R Martini
    Department of Neurology, Baylor College of Medicine and the Michael E. DeBakey Veterans Affairs Medical Center Stroke Program, Houston, TX 77030, USA
    Neurology 67:700-2. 2006
    ..We found that ultrasound's benefit on 90-day outcome was primarily apparent at higher glucose levels, suggesting that ultrasound therapy may improve outcome following hyperglycemic stroke...
  21. ncbi Ultrasound-enhanced thrombolysis in acute ischemic stroke: potential, failures, and safety
    Georgios Tsivgoulis
    Comprehensive Stroke Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Neurotherapeutics 4:420-7. 2007
    ..7-2.1 MHz pulsed-wave ultrasound (EKOS catheter). Multinational dose escalation studies of microspheres and the development of an operator-independent ultrasound device are underway...
  22. ncbi The accuracy of transcranial Doppler in the diagnosis of middle cerebral artery stenosis
    Jose C Navarro
    Department of Neurology and Psychiatry, University of Santo Tomas Hospital, Manila, Philippines
    Cerebrovasc Dis 23:325-30. 2007
    ....
  23. ncbi Association of pretreatment blood pressure with tissue plasminogen activator-induced arterial recanalization in acute ischemic stroke
    Georgios Tsivgoulis
    Neurosonology and Stroke Research Program, Barrow Neurological Institute, Phoenix, Arizona, USA
    Stroke 38:961-6. 2007
    ..We aimed to evaluate the potential relationship between pretreatment SBP and tPA-induced recanalization...
  24. ncbi Accuracy of serial National Institutes of Health Stroke Scale scores to identify artery status in acute ischemic stroke
    Robert Mikulik
    Department of Neurology, University of Texas Health Science Center at Houston, USA
    Circulation 115:2660-5. 2007
    ..We sought to determine the accuracy of serial National Institutes of Health Stroke Scale (NIHSS) scores to detect complete early recanalization of the middle cerebral artery...
  25. ncbi Practice standards for transcranial Doppler ultrasound: part I--test performance
    Andrei V Alexandrov
    Barrow Neurological Institute, Phoenix, AZ 85013, USA
    J Neuroimaging 17:11-8. 2007
    ....
  26. ncbi The Spencer's Curve: clinical implications of a classic hemodynamic model
    Andrei V Alexandrov
    Stroke Research and Neurosonology Program, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    J Neuroimaging 17:6-10. 2007
    ....
  27. ncbi Writing good abstracts
    Andrei V Alexandrov
    Stroke Research Program, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    Cerebrovasc Dis 23:256-9. 2007
    ..If selected appropriately, your abstract is more likely to be graded by peers with similar interests and familiarity with your work or field. Methods should describe the study design and tools of data acquisition shortly, not data...
  28. ncbi Therapeutic applications of transcranial ultrasound devices
    Andrei V Alexandrov
    Expert Rev Med Devices 4:1-3. 2007
  29. ncbi Clinical deterioration after intravenous recombinant tissue plasminogen activator treatment: a multicenter transcranial Doppler study
    Maher Saqqur
    University of Alberta, Department of Medicine, Division of Neurology, 2 E3 Walter Mckenzie Center, 8440 112 Ave, Edmonton, Alberta T6G 2B7, Canada
    Stroke 38:69-74. 2007
    ..We evaluated the ability of flow findings on transcranial Doppler to predict CD and outcomes on modified Rankin Scale...
  30. ncbi Derivation of power M-mode transcranial Doppler criteria for angiographic proven MCA occlusion
    Maher Saqqur
    Department of Medicine, University of Alberta, Alberta, Canada
    J Neuroimaging 16:323-8. 2006
    ..Validation of these criteria will require multicenter studies...
  31. ncbi Argatroban tPA stroke study: study design and results in the first treated cohort
    Rebecca M Sugg
    Department of Neurology, University of Texas-Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    Arch Neurol 63:1057-62. 2006
    ....
  32. ncbi Painless aortic dissection with unusual extension into intracranial internal carotid arteries
    Iyadurai Stanley
    Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA
    Cerebrovasc Dis 24:314-5. 2007
  33. ncbi Highlights of the guidelines for screening of extracranial carotid artery disease: a statement for healthcare professionals from the Multidisciplinary Practice Guidelines Committee of the American Society of Neuroimaging; cosponsored by the Society of Vas
    Adnan I Qureshi
    Zeenat Qureshi Stroke Research Center, University of Minnesota, Minneapolis 55415
    J Endovasc Ther 14:469-74. 2007
  34. ncbi Timeframe for thrombolysis in acute ischaemic stroke
    Georgios Tsivgoulis
    Comprehensive Stroke Center, University of Alabama at Birmingham Hospital, Birmingham, Alabama 35294, USA
    Lancet 372:1275-6. 2008
  35. ncbi Ultrasound enhanced thrombolysis for stroke
    Andrei V Alexandrov
    Stroke Research and Neurosonology Program, Barrow Neurologic Institute, Phoenix, AZ, USA
    Int J Stroke 1:26-9. 2006
    ..Dose escalation studies of microbubbles, ultrasound exposure, and the development of an operator-independent ultrasound device are underway...
  36. ncbi Design of a PROspective multi-national CLOTBUST collaboration on reperfusion therapies for stroke (CLOTBUST-PRO)
    Maher Saqqur
    Department of Medicine Neurology, University of Alberta, Alberta, Canada
    Int J Stroke 3:66-72. 2008
    ..The benefit of intravenous (i.v.) tissue plasminogen activator (tPA) in acute ischemic stroke (IS) is attributable to lysis of thrombus and restoration of perfusion to ischemic but not yet infarcted brain...
  37. ncbi Priorities in stroke research: a US perspective
    Andrei V Alexandrov
    Comprehensive Stroke Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Int J Stroke 3:14-5. 2008
  38. ncbi Stroke and atherothrombosis: an update on the role of antiplatelet therapy
    Andrei V Alexandrov
    Comprehensive Stroke Center, University of Alabama, Birmingham, AL 35294 0017, USA
    Int J Stroke 3:175-81. 2008
    ..We examined current recommendations for the prevention of atherothrombotic events, focusing on the role of oral antiplatelet agents in patients with ischemic stroke...
  39. ncbi Perfusion augmentation in acute stroke using mechanical counter-pulsation-phase IIa: effect of external counterpulsation on middle cerebral artery mean flow velocity in five healthy subjects
    Anne W Alexandrov
    Comprehensive Stroke Center, University of Alabama, Birmingham, AL 35249 3280, USA
    Stroke 39:2760-4. 2008
    ..We sought to determine ECPs effect on middle cerebral artery (MCA) blood flow augmentation in normal controls as a first step to support future clinical trials in acute stroke...
  40. ncbi Ultrasound enhanced thrombolysis in acute arterial ischemia
    Georgios Tsivgoulis
    Comprehensive Stroke Center, Department of Neurology, University of Alabama at Birmingham, Suite 226, RWUHM, 1719 6th Avenue South, Birmingham, AL 35294, USA
    Ultrasonics 48:303-11. 2008
    ..Multi-national dose escalation studies of microspheres and the development of an operator independent ultrasound device are underway...
  41. ncbi Acute stroke imaging research roadmap
    Max Wintermark
    University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143 0628, USA
    Stroke 39:1621-8. 2008
    ..The present article summarizes these recommendations and examines practical steps to achieve them...
  42. ncbi Quantification of microspheres appearance in brain vessels: implications for residual flow velocity measurements, dose calculations, and potential drug delivery
    Vijay K Sharma
    Comprehensive Stroke Center, University of Alabama at Birmingham, AL 35249 3280, USA
    Stroke 39:1476-81. 2008
    ..Characteristics of ultrasound-activated gaseous microspheres (muS) reflective of their size and quantities are needed for future dose-escalation and drug delivery trials...
  43. ncbi A pilot randomized clinical safety study of sonothrombolysis augmentation with ultrasound-activated perflutren-lipid microspheres for acute ischemic stroke
    Andrei V Alexandrov
    Comprehensive Stroke Center Neurology, The University of Alabama at Birmingham, RWUH M226, 619 19th St South, Birmingham, AL 35249 3280, USA
    Stroke 39:1464-9. 2008
    ..Ultrasound transiently expands perflutren-lipid microspheres (muS), transmitting energy momentum to surrounding fluids. We report a pilot safety/feasibility study of ultrasound-activated muS with systemic tissue plasminogen activator (tPA)...
  44. ncbi Applications and advantages of power motion-mode Doppler in acute posterior circulation cerebral ischemia
    Georgios Tsivgoulis
    Comprehensive Stroke Center, University of Alabama at Birmingham Hospital RWUH M226, 619 19th St S, Birmingham, AL 35294, USA
    Stroke 39:1197-204. 2008
    ..We aimed to evaluate the diagnostic accuracy of PMD-TCD against angiography in detection of acute posterior circulation stenoocclusive disease...
  45. ncbi Association of pretreatment ASPECTS scores with tPA-induced arterial recanalization in acute middle cerebral artery occlusion
    Georgios Tsivgoulis
    Neurosonology and Stroke Research Program, Barrow Neurological Institute, Phoenix, Arizona, USA
    J Neuroimaging 18:56-61. 2008
    ..We evaluated the potential relationship between pretreatment ASPECTS and tPA-induced recanalization in patients with MCA occlusions...
  46. ncbi Reversed Robin Hood syndrome in acute ischemic stroke patients
    Andrei V Alexandrov
    Stroke 38:3045-8. 2007
    ..If the steal is confirmed as the cause of neurological worsening, reversed Robin Hood syndrome may identify a target group for testing blood pressure augmentation and noninvasive ventilatory correction in stroke patients...
  47. ncbi Slow recruitment in clinical trials: failure is not an option!
    Andrei V Alexandrov
    Stroke Research and Neurosonology Program, Barrow Neurological Institute, Suite 300 Neurology, 500 West Thomas Rd, Phoenix, AZ 85013, USA
    Int J Stroke 1:160. 2006
  48. ncbi Validation of transcranial Doppler with computed tomography angiography in acute cerebral ischemia
    Georgios Tsivgoulis
    Neurosonology and Stroke Research Program, Barrow Neurological Institute, Phoenix, AZ, USA
    Stroke 38:1245-9. 2007
    ..We aimed to evaluate the diagnostic accuracy of TCD against CTA in patients with acute cerebral ischemia...
  49. ncbi Does clinical-CT 'mismatch' predict early response to treatment with recombinant tissue plasminogen activator?
    John Y Choi
    Stroke Program, University of Texas Houston Medical School, Houston, TX 77030, USA
    Cerebrovasc Dis 22:384-8. 2006
    ..e., clinical-CT mismatch) may respond better to intravenous recombinant tissue plasminogen activator (i.v. rt-PA) within 3 h of symptom onset...
  50. ncbi CLOTBUST: design of a randomized trial of ultrasound-enhanced thrombolysis for acute ischemic stroke
    Andrei V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, TX, USA
    J Neuroimaging 14:108-12. 2004
    ....
  51. ncbi Ischemic stunning of the brain: early recanalization without immediate clinical improvement in acute ischemic stroke
    Andrei V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, 77030, USA
    Stroke 35:449-52. 2004
    ..Early arterial recanalization (ER) with intravenous tissue plasminogen activator (tPA) can lead to dramatic clinical recovery, whereas some patients do not experience immediate clinical improvement...
  52. ncbi Improving the predictive accuracy of recanalization on stroke outcome in patients treated with tissue plasminogen activator
    Carlos A Molina
    Neurovascular Unit, Department of Neurology, Hospital Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Stroke 35:151-6. 2004
    ..Therefore, we sought to investigate whether the predictive accuracy of early recanalization on stroke outcome is improved when combined with clinical and radiological information...
  53. ncbi Detection of reversed basilar flow with power-motion Doppler after acute occlusion predicts favorable outcome
    Marc Ribo
    Stroke Treatment Team, Medical School, The University of Texas Houston, USA
    Stroke 35:79-82. 2004
    ..We aimed to determine clinical significance of PMD-TCD demonstration of reversed basilar flow in patients with basilar artery (BA) occlusion...
  54. ncbi Is the benefit of early recanalization sustained at 3 months? A prospective cohort study
    Lise A Labiche
    Center for Noninvasive Brain Perfusion Studies, Stroke Program, University of Texas, Houston Medical School, Houston, USA
    Stroke 34:695-8. 2003
    ..Complete or partial early recanalization leads to better outcome at 3 months after stroke. Fewer patients achieve good long-term outcome without early recanalization...
  55. ncbi Residual flow signals predict complete recanalization in stroke patients treated with TPA
    Lise A Labiche
    Stroke Program, University of Texas Medical School at Houston, TX, USA
    J Neuroimaging 13:28-33. 2003
    ..The authors aimed to correlate the presence of residual flow signals in the middle cerebral artery (MCA) with completeness of recanalization after intravenous tissue plasminogen activator (TPA)...
  56. ncbi Ultrasound and angiography in the selection of patients for carotid endarterectomy
    Andrei V Alexandrov
    The University of Texas Houston Medical School, MSB 7 044, 6431 Fannin Street, Houston, TX 77030, USA
    Curr Cardiol Rep 5:141-7. 2003
    ..Currently, more invasive angiograms are being performed, due to a variety of new experimental interventions such as angioplasty and stenting, a subject of current clinical trials...
  57. ncbi Ultrasound-enhanced thrombolysis for stroke: clinical significance
    Andrei V Alexandrov
    Department of Neurology and Radiology, Houston Medical School, The University of Texas, MSB 7044 6431 Fannin Street, Houston, TX 77030, USA
    Eur J Ultrasound 16:131-40. 2002
    ..Dramatic clinical recovery from stroke and complete recanalization shortly after TPA bolus are feasible goals for thrombolysis assisted with TCD monitoring...
  58. ncbi Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator
    Andrei V Alexandrov
    Stroke Treatment Team, University of Texas Houston Medical School, Houston, TX 77030, USA
    Neurology 59:862-7. 2002
    ....
  59. ncbi Insonation method and diagnostic flow signatures for transcranial power motion (M-mode) Doppler
    Andrei V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, TX, USA
    J Neuroimaging 12:236-44. 2002
    ..Insonation protocol for PMD and spectral transcranial Doppler (TCD) with typical PMD flow signatures is described in serial patients with acute stroke symptoms examined via conventional windows with a PMD/TCD unit...
  60. ncbi Early dramatic recovery during intravenous tissue plasminogen activator infusion: clinical pattern and outcome in acute middle cerebral artery stroke
    Robert A Felberg
    Stroke Program, Department of Neurology, University of Texas Houston Medical School, USA
    Stroke 33:1301-7. 2002
    ..The prevalence, clinical characteristics, and outcome of patients experiencing dramatic recovery is not well described...
  61. ncbi Intravenous tissue plasminogen activator and flow improvement in acute ischemic stroke patients with internal carotid artery occlusion
    Ioannis Christou
    Department of Neurology, University of Texas-Houston Medical School, 6431 Fannin, MSB 7.044, Houston, TX 77030, USA
    J Neuroimaging 12:119-23. 2002
    ..However, recanalization of associated proximal MCA clot, found in 45% of our patients, or improved MCA collateral flow was strongly associated with good outcome...
  62. ncbi Effect of head positioning on intracranial blood flow velocities in acute ischemic stroke: a pilot study
    Anne W Wojner
    Department of Neurology, University of Texas-Houston Medical School, USA
    Crit Care Nurs Q 24:57-66. 2002
    ....
  63. ncbi Screening for intracranial stenosis with transcranial Doppler: the accuracy of mean flow velocity thresholds
    Robert A Felberg
    Stroke Program, Department of Neurology, Ochsner Foundation Clinic and Hospital, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    J Neuroimaging 12:9-14. 2002
    ..Transcranial Doppler (TCD) is a convenient noninvasive screen for intracranial stenosis. The accuracy of different mean flow velocity (MFV) thresholds for determining the degree of stenosis remains uncertain...
  64. ncbi Ultrasound-enhanced thrombolysis for acute ischemic stroke: phase I. Findings of the CLOTBUST trial
    Andrei V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, TX, USA
    J Neuroimaging 14:113-7. 2004
    ..The authors present Phase I data of the CLOTBUST (Combined Lysis of Thrombus in Brain ischemia using transcranial Ultrasound and Systemic TPA)...
  65. ncbi The accuracy of transcranial Doppler in the diagnosis of stenosis or occlusion of the terminal internal carotid artery
    Jose C Navarro
    University of Santo Tomas, Espana, Manila, Philippines
    J Neuroimaging 14:314-8. 2004
    ..The accuracy parameters for lesions located in the terminal internal carotid artery (TICA) are less known, unlike other basal cerebral vessels...
  66. ncbi Ultrasound identification and lysis of clots
    Andrei V Alexandrov
    Department of Neurology and Radiology, Cerebrovascular Ultrasound and Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, The University of Texas Houston Medical School, Houston, Texas, USA
    Stroke 35:2722-5. 2004
    ..Early brain perfusion augmentation, complete recanalization, and dramatic clinical recovery are feasible goals for ultrasound-enhanced thrombolysis...
  67. ncbi Nonpulsatile cerebral perfusion in patient with acute neurological deficits
    Yo Sik Kim
    Department of Neurology, Wonkwang University School of Medicine, Jeonbuk, Korea
    Stroke 37:1562-4. 2006
    ..We report a patient who had complete recovery from initial neurological deficits in spite of nonpulsatile perfusion in the middle cerebral artery...
  68. ncbi Advances in neurosonology 2005
    Andrei V Alexandrov
    Stroke Research and Neurosonology Program, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Stroke 37:299-300. 2006
  69. ncbi Telemedicine-guided carotid and transcranial ultrasound: a pilot feasibility study
    Robert Mikulik
    Department of Neurology, University of Texas Health Science Center, Houston, TX 77030, USA
    Stroke 37:229-30. 2006
    ..CONCLUSIONS: Our pilot study showed the feasibility of TCD/CD by an inexperienced health professional guided by a sonographer via TM. Tests were completed within times comparable to outpatient setting in a vascular laboratory...
  70. ncbi Flow diversion in transcranial Doppler ultrasound is associated with better improvement in patients with acute middle cerebral artery occlusion
    Yo Sik Kim
    Department of Neurology, Wonkwang University School of Medicine and Wonkwang Medical Science Research Center, Jeonbuk, Korea
    Cerebrovasc Dis 21:74-8. 2006
    ..FD is thought to represent the collateral blood flow to the occluded MCA territory, but it is unclear whether or not FD lessens the stroke severity or leads to improved outcome...
  71. ncbi Can the therapeutic window for tissue plasminogen activator be extended to 6 hours after stroke onset?
    Andrei V Alexandrov
    The Cerebrovascular Ultrasound Stroke Treatment Team, University of Texas-Houston Medical School, TX 77030, USA
    Nat Clin Pract Cardiovasc Med 2:342-3. 2005
  72. ncbi Intravenous TPA for very old stroke patients
    Chin I Chen
    Stroke Treatment Team, The University of Texas, Houston, USA
    Eur Neurol 54:140-4. 2005
    ..We studied safety and recanalization/recovery in patients older than 80 years treated with TPA and compared them with younger stroke patients...
  73. ncbi Houston paramedic and emergency stroke treatment and outcomes study (HoPSTO)
    Anne W Wojner-Alexandrov
    Department of Neurology, University of Texas Houston, Houston, TX 77030, USA
    Stroke 36:1512-8. 2005
    ..We wanted to measure and improve paramedic and hospital performance through implementation of the Brain Attack Coalition and American Stroke Association guidelines...
  74. ncbi Aortic dissection presenting as an acute ischemic stroke for thrombolysis
    Ken Uchino
    Department of Neurology, University of Texas Houston Medical School, Houston, TX, USA
    J Neuroimaging 15:281-3. 2005
    ..An experienced sonographer with skills to perform rapid intra- and extracranial examinations may help to change the treatment plan for acute stroke patients...
  75. ncbi Heads down: flat positioning improves blood flow velocity in acute ischemic stroke
    Anne W Wojner-Alexander
    Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Neurology 64:1354-7. 2005
    ..Acute stroke patients are routinely positioned with the head of the bed (HOB) elevated at 30 degrees despite lack of evidence for increased intracranial pressure...
  76. ncbi Early recanalization rates and clinical outcomes in patients with tandem internal carotid artery/middle cerebral artery occlusion and isolated middle cerebral artery occlusion
    Yo Sik Kim
    Department of Neurology, Wonkwang University, School of Medicine, Iksan, South Korea
    Stroke 36:869-71. 2005
    ..CONCLUSIONS: The tandem lesion group showed lower early recanalization rate and ENI rate than the isolated MCA occlusion group. Despite this, good outcomes were similar in both groups...
  77. ncbi Safety and feasibility of a lower dose intravenous TPA therapy for ischemic stroke beyond the first three hours
    Ken Uchino
    Stroke Program, Department of Neurology, University of Texas Houston Medical School, USA
    Cerebrovasc Dis 19:260-6. 2005
    ..The risk/benefit ratio is more unfavorable beyond this time, but some patients might still benefit. We designed a pilot study with the hypothesis that lower dose TPA might be safe in selected patients treated beyond 3 h...
  78. ncbi Aggressive mechanical clot disruption: a safe adjunct to thrombolytic therapy in acute stroke?
    Elizabeth A Noser
    Department of Neurology, University of Texas-Houston Medical School, USA
    Stroke 36:292-6. 2005
    ..Early deployment of this technique leads to immediate recanalization in one third of patients. AMCD may potentially shorten the time to flow restoration and improve overall recanalization rates achieved with IA therapy...
  79. ncbi Yield and accuracy of urgent combined carotid/transcranial ultrasound testing in acute cerebral ischemia
    Oleg Y Chernyshev
    Stroke Treatment Team, University of Texas-Houston, Texas 77005, USA
    Stroke 36:32-7. 2005
    ..CONCLUSIONS: Bedside neurovascular ultrasound examination, combining carotid/vertebral duplex with TCD yields a substantial proportion of LAITs in excellent agreement with urgent DSA...
  80. ncbi Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke
    Andrei V Alexandrov
    Stroke Treatment Team, University of Texas Houston Medical School, Houston 77030, USA
    N Engl J Med 351:2170-8. 2004
    ..Our objective was to determine whether ultrasonography can safely enhance the thrombolytic activity of t-PA...
  81. ncbi Clinical and sonographic patterns of tandem internal carotid artery/middle cerebral artery occlusion in tissue plasminogen activator-treated patients
    Ashraf El-Mitwalli
    University of Texas-Houston Medical School, Mansoura University, Mansoura, Egypt
    Stroke 33:99-102. 2002
    ..Lower NIHSS scores were seen in patients with a higher number of major collateral flow channels and higher Thrombolysis in Brain Ischemia (TIBI) flow grades at the MCA origin...