Naj A Sharif

Summary

Affiliation: Alcon Research
Country: USA

Publications

  1. ncbi 3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents
    Mark R Hellberg
    Department of Medicinal Chemistry, Alcon Research, Ltd, Pharmaceutical Products Research, 6201 South Freeway, Fort Worth, TX 76134, USA
    Bioorg Med Chem 10:2031-49. 2002
  2. ncbi Serotonin-2 receptor agonists as novel ocular hypotensive agents and their cellular and molecular mechanisms of action
    Najam A Sharif
    Pharmaceutical Products Research, Alcon Research Ltd, 6201 South Freeway, Fort Worth, TX 76248, USA
    Curr Drug Targets 11:978-93. 2010
  3. ncbi Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Ocul Pharmacol Ther 19:501-15. 2003
  4. ncbi Pharmacological characterization and identification of EP3 prostanoid receptor binding sites in hamster uterus homogenates
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research Ltd, South Freeway, Fort Worth, TX 76134 2099, USA
    J Pharm Pharmacol 56:197-203. 2004
  5. ncbi Binding affinities of ocular hypotensive beta-blockers levobetaxolol, levobunolol, and timolol at endogenous guinea pig beta-adrenoceptors
    N A Sharif
    Molecular Pharmacology, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    J Ocul Pharmacol Ther 20:93-9. 2004
  6. ncbi Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation
    Najam A Sharif
    Molecular Pharmacology Unit, Pharmaceutical Products Research, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Pharm Pharmacol 56:1267-74. 2004
  7. ncbi Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes
    Naj A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Ocul Pharmacol Ther 20:489-508. 2004
  8. ncbi Ocular hypotensive DP-class prostaglandin receptor affinities determined by quantitative autoradiography on human eye sections
    Najam A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Ocul Pharmacol Ther 21:121-32. 2005
  9. ncbi Serotonin receptor subtype mRNA expression in human ocular tissues, determined by RT-PCR
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    Mol Vis 12:1040-7. 2006
  10. ncbi Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76137, USA
    J Ocul Pharmacol Ther 22:291-309. 2006

Collaborators

Detail Information

Publications48

  1. ncbi 3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents
    Mark R Hellberg
    Department of Medicinal Chemistry, Alcon Research, Ltd, Pharmaceutical Products Research, 6201 South Freeway, Fort Worth, TX 76134, USA
    Bioorg Med Chem 10:2031-49. 2002
    ..In this manner, 136 g of AL-6598 was synthesized under GMP conditions for evaluation in phase I clinical trials...
  2. ncbi Serotonin-2 receptor agonists as novel ocular hypotensive agents and their cellular and molecular mechanisms of action
    Najam A Sharif
    Pharmaceutical Products Research, Alcon Research Ltd, 6201 South Freeway, Fort Worth, TX 76248, USA
    Curr Drug Targets 11:978-93. 2010
    ..Thus, functional 5HT(2A) receptors are present in human ocular cells involved in IOP reduction and this correlates with the ability of 5HT(2A) agonists to lower IOP in Cynomolgus monkeys, a surrogate for human subjects...
  3. ncbi Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Ocul Pharmacol Ther 19:501-15. 2003
    ....
  4. ncbi Pharmacological characterization and identification of EP3 prostanoid receptor binding sites in hamster uterus homogenates
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research Ltd, South Freeway, Fort Worth, TX 76134 2099, USA
    J Pharm Pharmacol 56:197-203. 2004
    ..002), vs cloned rat EP(3) receptor (r = 0.9, P < 0.0004), and vs EP(3) receptor-mediated functional responses (r = 0.72, P < 0.02) substantiated the conclusion that the hamster uterus contains EP(3) receptor binding sites...
  5. ncbi Binding affinities of ocular hypotensive beta-blockers levobetaxolol, levobunolol, and timolol at endogenous guinea pig beta-adrenoceptors
    N A Sharif
    Molecular Pharmacology, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    J Ocul Pharmacol Ther 20:93-9. 2004
    ..These data indicated that while levobetaxolol and betaxolol possessed a 193-233-fold selectivity for beta(1)-receptors, levobunolol exhibited a 140-fold beta(2)-receptor selectivity and (l)-timolol was essentially nonselective...
  6. ncbi Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation
    Najam A Sharif
    Molecular Pharmacology Unit, Pharmaceutical Products Research, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Pharm Pharmacol 56:1267-74. 2004
    ..58, P <0.05). The present study provides a detailed pharmacological characterization of the ch-5-HT1A receptor using binding and functional assays...
  7. ncbi Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes
    Naj A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Ocul Pharmacol Ther 20:489-508. 2004
    ..The IOP-lowering activities of these compounds may involve both the inflow and outflow mechanisms, as DP and EP2 receptors were visualized in human ocular tissues involved in such aqueous humor dynamics...
  8. ncbi Ocular hypotensive DP-class prostaglandin receptor affinities determined by quantitative autoradiography on human eye sections
    Najam A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Ocul Pharmacol Ther 21:121-32. 2005
    ..The pharmacological attributes of [3H]BWA868C-labeled receptor sites studied using in situ quantitative autoradiography matched those previously documented for several other DP-receptor-containing cells and tissues...
  9. ncbi Serotonin receptor subtype mRNA expression in human ocular tissues, determined by RT-PCR
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    Mol Vis 12:1040-7. 2006
    ..To determine the relative density and tissue localization of mRNAs for serotonin (5-hydroxytryptamine; 5HT) receptor subtypes in human ocular tissues and correlate with their possible functions in the eye...
  10. ncbi Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76137, USA
    J Ocul Pharmacol Ther 22:291-309. 2006
    ....
  11. ncbi Serotonin-2 (5-HT2) receptor-mediated signal transduction in human ciliary muscle cells: role in ocular hypotension
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Ocul Pharmacol Ther 22:389-401. 2006
    ....
  12. ncbi AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    J Ocul Pharmacol Ther 23:1-13. 2007
    ..A variety of well-documented in vitro and in vivo procedures were utilized to study the pharmacological attributes of AL-34662...
  13. ncbi Intracellular signaling in human iridial fibroblasts and iridial melanocytes in response to prostaglandins, endothelin, isoproterenol, and other pharmacological agents
    Najam A Sharif
    Pharmaceutical Research, Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    Curr Eye Res 36:310-20. 2011
    ....
  14. ncbi Cat iris sphincter smooth-muscle contraction: comparison of FP-class prostaglandin analog agonist activities
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research Ltd, Fort Worth, TX 76134, USA
    J Ocul Pharmacol Ther 24:152-63. 2008
    ..84). These data confirm the presence of functional FP-receptors in the cat iris sphincter, which are exquisitely well coupled and which respond to a variety of FP-class PG analogs with differing potencies...
  15. ncbi Synthetic FP-prostaglandin-induced contraction of rat uterus smooth muscle in vitro
    Najam A Sharif
    Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    Prostaglandins Leukot Essent Fatty Acids 78:199-207. 2008
    ....
  16. ncbi Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes
    Najam A Sharif
    Discovery Ophthalmology Research, Alcon Research Ltd, Fort Worth, TX, USA
    Exp Eye Res 88:386-97. 2009
    ....
  17. ncbi Human conjunctival epithelial cell responses to platelet-activating factor (PAF): signal transduction and release of proinflammatory cytokines
    Najam A Sharif
    Pharmaceutical Products Research, Core Pharmacology and Imaging, Alcon Research Ltd, Fort Worth, TX 76134, USA
    Mol Vis 15:1153-61. 2009
    ....
  18. ncbi Platelet-activating factor-induced intracellular signaling and release of cytokines and prostaglandin E2 in immortalized human corneal epithelial cells
    Najam A Sharif
    Pharmaceutical Products Research, Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    J Ocul Pharmacol Ther 26:21-9. 2010
    ....
  19. ncbi Human trabecular meshwork cells express functional serotonin-2A (5HT2A) receptors: role in IOP reduction
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    Invest Ophthalmol Vis Sci 47:4001-10. 2006
    ..To correlate in vitro findings with intraocular pressure (IOP) changes in conscious ocular hypertensive cynomolgus monkeys...
  20. ncbi Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques
    Najam A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    J Pharm Pharmacol 54:539-47. 2002
    ..g. ZK118182 (K = 73.4 +/- 8.6 nM) and ZK110841 (K = 166 +/- 20 nM)). All FP (e.g. travoprost acid, fluprostenol), IP (iloprost) and TP (SQ29548) receptor-specific ligands exhibited low affinity (Ki > or = 1 microM)...
  21. ncbi Pharmacological and molecular biological (RT-PCR) characterization of functional TP prostanoid receptors in immortalized human non-pigmented ciliary epithelial cells
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research Ltd, Fort Worth, Texas 76134 2099, USA
    J Ocul Pharmacol Ther 18:141-62. 2002
    ..The TPalpha receptors on NPE cells may be responsible for inhibiting aqueous humor production and may help explain the intraocular pressure-lowering effects of certain TP agonists...
  22. ncbi Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, Texas 76134 2099, USA
    J Ocul Pharmacol Ther 18:313-24. 2002
    ..0 - 2.1 microM; n = 3). These studies have demonstrated, for the first time, agonist activities of the currently known and marketed ocular hypotensive prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor...
  23. ncbi Bimatoprost and its free acid are prostaglandin FP receptor agonists
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, 6201 South Freeway, Fort Worth, TX 76134, USA
    Eur J Pharmacol 432:211-3. 2001
    ..Furthermore, AL-8810 ((5Z, 13E)-(9S,11S,15R)-9,15-dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20-pentanor-5,13-prostadienoic acid), an FP receptor antagonist, blocked the bimatoprost-induced [Ca(2+)](i) mobilization...
  24. ncbi Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes
    N A Sharif
    Molecular Pharmacology Unit, Pharmaceutical Products Research, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Ocul Pharmacol Ther 17:305-17. 2001
    ..In conclusion, levobetaxolol is a potent, high affinity and beta1-selective IOP-lowering beta-adrenoceptor antagonist...
  25. ncbi AL-3138 antagonizes FP prostanoid receptor-mediated inositol phosphates generation: comparison with some purported FP antagonists
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research Ltd, Fort Worth, TX 76134, USA
    J Pharm Pharmacol 52:1529-39. 2000
    ....
  26. ncbi Bimatoprost (Lumigan((R))) is an agonist at the cloned human ocular FP prostaglandin receptor: real-time FLIPR-based intracellular Ca(2+) mobilization studies
    N A Sharif
    Molecular Pharmacology Unit R2 19, Alcon Research Limited, 6201 South Freeway, 76134, Fort Worth, TX, USA
    Prostaglandins Leukot Essent Fatty Acids 68:27-33. 2003
    ..Therefore, the prodrug bimatoprost and its hydrolytic product, bimatoprost free acid, bind to and activate the human ocular FP prostaglandin receptor to mobilize [Ca(2+)](i), thus behaving as FP receptor agonists...
  27. ncbi Affinities, selectivities, potencies, and intrinsic activities of natural and synthetic prostanoids using endogenous receptors: focus on DP class prostanoids
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, Texas 76134 2099, USA
    J Pharmacol Exp Ther 293:321-8. 2000
    ..9-8.2, n = 5-9). The pharmacological properties of some natural and numerous DP class synthetic prostanoids have been determined using endogenous receptors...
  28. ncbi Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research Ltd, 6201 South Freeway, Fort Worth, Texas, TX 76134, USA
    Br J Pharmacol 131:1025-38. 2000
    ..3)H]-BWA868C may prove useful for future homogenate-based and autoradiographic studies on the DP receptor...
  29. ncbi Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist
    Mark R Hellberg
    Department of Medicinal Chemistry, Alcon Research Ltd, 6201 South Freeway, Fort Worth, TX 76134, USA
    Surv Ophthalmol 47:S13-33. 2002
    ..The acute and, apparently, conjunctival hyperemia associated with topical ocular AL-6598 can be attenuated while maintaining intraocular pressure-lowering efficacy by formulating with brimonidine...
  30. ncbi Human ciliary muscle cell responses to FP-class prostaglandin analogs: phosphoinositide hydrolysis, intracellular Ca2+ mobilization and MAP kinase activation
    Naj A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Ocul Pharmacol Ther 19:437-55. 2003
    ....
  31. ncbi Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other FP prostaglandin receptor agonist analogues
    Najam A Sharif
    Molecular Pharmacology Unit, Glaucoma Research, Alcon Research, Ltd, Fort Worth, Texas, USA
    Invest Ophthalmol Vis Sci 44:715-21. 2003
    ..Bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester, and their respective free acids were shown to be FP agonists in the h-TM cells...
  32. ncbi Pharmacological characterization of a serotonin receptor (5-HT7) stimulating cAMP production in human corneal epithelial cells
    Julie Y Crider
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, Texas 76134-2099, USA
    Invest Ophthalmol Vis Sci 44:4837-44. 2003
    ....
  33. ncbi Aqueous humor concentrations of bimatoprost free acid, bimatoprost and travoprost free acid in cataract surgical patients administered multiple topical ocular doses of LUMIGAN or TRAVATAN
    Robert Faulkner
    Alcon Research, Ltd, Fort Worth, TX 76134, USA
    J Ocul Pharmacol Ther 26:147-56. 2010
    ....
  34. ncbi AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey
    Robert D Selliah
    Alcon Research, Ltd, Pharmaceutical Products Research, 6201 South Freeway, MS R2-39 Fort Worth, TX 76134, USA
    Bioorg Med Chem Lett 14:4525-8. 2004
    ..AL-12182 was synthesized on multigram scale starting with D-sorbitol...
  35. ncbi Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A [(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine]
    Jesse A May
    Ophthalmology Discovery Research, Alcon Research, Ltd, 6201 South Freeway, Fort Worth, Texas 76134, United States
    Pharmacol Biochem Behav 91:307-14. 2009
    ..The pharmacological profile of AL-38022A suggests that it could be a useful tool in defining 5-HT2 receptor signaling and receptor characterization where 5-HT may function as a neurotransmitter...
  36. ncbi Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: synthesis and biological activity
    Zixia Feng
    Medicinal Chemistry, Ophthalmic Products Research, Alcon Research Ltd, 6201 South Freeway, Mail code R2 39, Fort Worth, TX 76134, USA
    Bioorg Med Chem 17:576-84. 2009
    ..8 microg). AL-16049 also produced no signs of ocular irritation or discomfort in the cat at the doses evaluated...
  37. ncbi Adenylyl cyclase activity mediated by beta-adrenoceptors in immortalized human trabecular meshwork and non-pigmented ciliary epithelial cells
    Julie Y Crider
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, Texas 76134 2099, USA
    J Ocul Pharmacol Ther 18:221-30. 2002
    ..These detailed pharmacological studies using a variety of agonists and antagonists further supported the presence of beta2-adrenergic receptors in immortalized human NPE and TM cells...
  38. ncbi A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole
    Jesse A May
    Medicinal Chemistry Department, Ophthalmic Products Research, Alcon Research, Ltd, 6201 South Freeway, Fort Worth, Texas 76134, USA
    J Med Chem 46:4188-95. 2003
    ..1 mmHg, -37%). Thus, 11 is a potent full agonist with selectivity for the 5-HT2 receptor and is anticipated to serve as a useful tool in exploring the role of the 5-HT2 receptor and its effector system in controlling intraocular pressure...
  39. ncbi Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys
    Jesse A May
    Ophthalmic Products Research, Alcon Research, Ltd, 6201 South Freeway, Ft Worth, TX 76134, USA
    J Pharmacol Exp Ther 306:301-9. 2003
    ....
  40. ncbi Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors
    Curtis R Kelly
    Molecular Pharmacology Unit, Pharmaceutical Products Research, Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    J Pharmacol Exp Ther 304:238-45. 2003
    ....
  41. ncbi 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity
    Jesse A May
    Ophthalmology Discovery Research, Alcon Research, Ltd, 6201 South Freeway, Fort Worth, Texas 76134, USA
    J Med Chem 49:318-28. 2006
    ..Compound 9 appears to be an excellent 5-HT(2) receptor agonist for conducting further studies directed toward a clinical proof-of-concept study for this class of ocular hypotensive agents...
  42. ncbi Pharmacological evidence for a functional serotonin-2B receptor in a human uterine smooth muscle cell line
    Curtis R Kelly
    Molecular Pharmacology R2 43, Alcon Research, Ltd, 6201 South Freeway, Fort Worth, TX 76134, USA
    J Pharmacol Exp Ther 317:1254-61. 2006
    ..4 nM) in the HUSMC PI turnover assays. Taken together, these studies strongly suggest the presence of a functionally active 5-HT2B receptor subtype in HUSMCs. The physiological role of this receptor in these cells remains to be defined...
  43. ncbi Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity
    Zixia Feng
    Alcon Research, Ltd, Research Chemistry, 6201 South Freeway, Fort Worth, TX 76134, USA
    Bioorg Med Chem Lett 17:2998-3002. 2007
    ..Topical ocular administration of 5, 18, and 25 effectively reduced intra-ocular pressure in the hypertensive cynomolgus monkey eye in the range of 25-37%...
  44. ncbi Changes in ocular aquaporin expression following optic nerve crush
    Adnan Dibas
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA
    Mol Vis 16:330-40. 2010
    ..This study was designed to analyze changes in the expression of AQP4 (water selective channel) and AQP9 (water and lactate channel) following ONC in the rat...
  45. ncbi NPR-B natriuretic peptide receptors in human corneal epithelium: mRNA, immunohistochemistochemical, protein, and biochemical pharmacology studies
    Parvaneh Katoli
    Pharmaceutical Research, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    Mol Vis 16:1241-52. 2010
    ....
  46. ncbi Pharmacology of serotonin receptors modulating electrically-induced [3h]-norepinephrine release from isolated mammalian iris-ciliary bodies
    Lydia C Harris
    Department of Pharmacy Sciences, School of Pharmacy and Allied Health Professions, Creighton University, Omaha, NE 68178, USA
    J Ocul Pharmacol Ther 18:339-48. 2002
    ..We conclude that the excitatory prejunctional 5-HT heteroreceptors present in bovine iris-ciliary bodies belong to the 5-HT3 receptor subtype...
  47. ncbi Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane
    Richard A Glennon
    Department of Medicinal Chemistry, Box 980540, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Med Chem 47:6034-41. 2004
    ..e., topical), and concentrations necessary to reduce intraocular pressure, compounds such as 6d should demonstrate minimal central effects at potentially useful therapeutic doses and offer useful leads for further development...
  48. ncbi Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae
    Sunny E Ohia
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA
    J Ocul Pharmacol Ther 19:599-609. 2003
    ..This process appears to be receptor-mediated and dependent on extracellular Ca2+ and is similar to previous reports pertaining to brain tissues...