Research Topics
| P SatirSummaryAffiliation: Albert Einstein College of Medicine Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Controlling the direction of divisionPeter Satir
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, 10461 New York, USA
Stem Cell Res Ther 1:21. 2010..In the developing kidney, Apc acts downstream from primary cilium signaling to influence spindle orientation when noncanonical Wnt signaling predominates. Do gut stem cells also have primary cilia?..- Primary cilia: integral to development and diseasePeter Satir
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Dev Dyn 237:1953-4. 2008 - Tour of organelles through the electron microscope: a reprinting of Keith R. Porter's classic Harvey Lecture with a new introductionPeter Satir
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Anat Rec A Discov Mol Cell Evol Biol 287:1184-5. 2005 - Overview of structure and function of mammalian ciliaPeter Satir
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
Annu Rev Physiol 69:377-400. 2007..Unique motile 9 + 0 cilia, found during development at the embryonic node, determine left-right asymmetry of the body... - Cilia biology: stop overeating now!Peter Satir
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, USA
Curr Biol 17:R963-5. 2007..Knocking out primary cilia of adult mouse tissues or a specific subset of cilia from POMC-expressing neurons in the brain initiates uncontrolled eating. This behavior leads to obesity and kidney disease... - Evolution and persistence of the ciliumPeter Satir
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cell Motil Cytoskeleton 64:906-13. 2007..The viral envelope evolves into a sensory bud. The host cell supplies the transport machinery and molecular motors to construct the axoneme. Polymerization of cytoplasmic microtubules in the 9+0 axoneme completes the 9+2 pattern... - GEF1 is a ciliary Sec7 GEF of Tetrahymena thermophilaAaron J Bell
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, USA
Cell Motil Cytoskeleton 66:483-99. 2009..GEF2-HA localized near basal bodies but not to cilia. These results indicate that GEF1 is the resident Tetrahymena ciliary protein orthologous to PSec7. Cell Motil. Cytoskeleton 2009. (c) 2009 Wiley-Liss, Inc... - Mirror-imaged doublets of Tetmemena pustulata: implications for the development of left-right asymmetryAaron J Bell
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Forchheimer Building, Room 610, Bronx, NY 10461, USA
Dev Biol 314:150-60. 2008..These observations suggest a mechanistic hypothesis with implications for the development of left-right asymmetry not only in ciliates, but perhaps also in development of left-right asymmetry in general... - Kin5 knockdown in Tetrahymena thermophila using RNAi blocks cargo transport of Gef1Aashir Awan
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America
PLoS ONE 4:e4873. 2009..We suggest that one important cargo of Kin5 is Gef1 and knockdown of Kin5 results in cell lethality... - Cloning and characterization of Kin5, a novel Tetrahymena ciliary kinesin IIAashir Awan
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cell Motil Cytoskeleton 58:1-9. 2004..These findings suggest that Kin5 is an ICT motor like Osm3. Osm3 orthologs apparently transport membrane proteins and Kin5 may be the homodimeric kinesin II that performs this function in Tetrahymena cilia... - High speed sliding of axonemal microtubules produced by outer arm dyneinRaviraja N Seetharam
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cell Motil Cytoskeleton 60:96-103. 2005..The rate of sliding is consistent with a low duty ratio of the outer arm dynein and with the operation of each arm along a doublet once per beat... - Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machineryEnko N Kiprilov
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Cell Biol 180:897-904. 2008..These findings show that hESCs contain primary cilia associated with working Hh machinery... - How did the cilium evolve?Peter Satir
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, USA
Curr Top Dev Biol 85:63-82. 2008..The sensory function of cilia evolved first and the ciliary axoneme evolved gradually with ciliary motility, an important selection mechanism, as one of the driving forces... - Coordination of outer arm dynein activity along axonemal doublet microtubulesRaviraja N Seetharam
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cell Motil Cytoskeleton 65:572-80. 2008..These conclusions are consistent with Sugino and Naitoh's [1982; Nature 295:609-611] proposal, whereby during each beat, every ODA along a doublet becomes activated in succession, with repetitive activation determining beat frequency... - Structure and function of mammalian ciliaPeter Satir
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, USA
Histochem Cell Biol 129:687-93. 2008..This view has had unanticipated consequences for our understanding of developmental processes and human disease... - Sensory cilia and integration of signal transduction in human health and diseaseSøren T Christensen
Department of Molecular Biology, Section of Biochemistry, The August Krogh Building, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen OE, Denmark
Traffic 8:97-109. 2007..Finally, we discuss the functions of these cilia-associated signal transduction pathways and their role in human health and development... - PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblastsLinda Schneider
Department of Biochemistry, Institute for Molecular Biology and Physiology, University of Copenhagen, The August Krogh Building, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
Curr Biol 15:1861-6. 2005..We propose that ciliary PDGFRalphaalpha signaling is linked to tissue homeostasis and to mitogenic signaling pathways...
Research Grants
- CYTOSKELETAL ORGANIZATION AND MALIGNANT TRANSFORMATIONPeter Satir; Fiscal Year: 2002..A steering committee, together with the program director, acts as an executive board for selection of fellows, their reappointments and evaluation of their progress. ..
- Core--Imaging and Cell StructurePeter Satir; Fiscal Year: 2007..In addition, the Core provides histological, histochemical, and immunohistochemical services as needed for Liver Center Investigators. ..