Research Topics
Genomes and GenesSpecies | ZAVEN J KAPRIELIANSummaryAffiliation: Albert Einstein College of Medicine Country: USA Publications
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Detail Information
Publications
Axon guidance at the midline of the developing CNSZ Kaprielian
Albert Einstein College of Medicine, Department of Pathology, Kennedy Center, Bronx, NY 10461, USA
Anat Rec 261:176-97. 2000..Thus, this exquisitely controlled guidance system prevents commissural axons from crossing the midline more than once. Strikingly, many of the molecular mechanisms that control midline guidance appear to be evolutionarily conserved...- Axon guidance at the midline choice pointZ Kaprielian
Departments of Pathology and Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
Dev Dyn 221:154-81. 2001..Despite rapid and dramatic progress in elucidating the molecular mechanisms that control midline guidance, many questions remain... - Mis-expression of L1 on pre-crossing spinal commissural axons disrupts pathfinding at the ventral midlineRalph Imondi
Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
Mol Cell Neurosci 36:462-71. 2007..These observations suggest that L1-mediated pathfinding decisions are normally delayed until axons have crossed the ventral midline (VM)... - Molecular control of spinal accessory motor neuron/axon development in the mouse spinal cordAllison K Dillon
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 25:10119-30. 2005..Furthermore, in the absence of the transcription factor Nkx2.9, SACMN axons fail to exit the CNS. Together, these findings suggest molecular mechanisms that are likely to regulate key steps in SACMN development... - EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cordStephanie R Kadison
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 26:8909-14. 2006..In contrast to the midline guidance defects observed in EphB and ephrin-B3 mutant embryos, wild-type-like contralateral projections were observed in mice lacking ephrin-B1 and/or ephrin-B2... - The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cordStephanie R Kadison
Department of Pathology and Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Kennedy Center Rm 624, 1410 Pelham Parkway South, Bronx, NY 10461, USA
Dev Biol 296:499-513. 2006..Thus, compared to FP contact, Slit-Robo interactions are more critical for driving commissural axons out of the VM and facilitating the elaboration of a subset of contralateral commissural projections... - Diversity of contralateral commissural projections in the embryonic rodent spinal cordStephanie Rebecca Kadison
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Comp Neurol 472:411-22. 2004..These results provide a basis for examining the mechanisms that regulate commissural axon pathfinding on the contralateral side of the floor plate in the embryonic rodent spinal cord... - Manipulating Robo expression in vivo perturbs commissural axon pathfinding in the chick spinal cordStacey L Reeber
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 28:8698-708. 2008..Together, these findings support key and selective in vivo roles for Robo receptors in presumably altering the responsiveness of decussated commissural axons and facilitating their expulsion from the VM within the chick spinal cord... - Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cordAngela R Jevince
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Comp Neurol 497:734-50. 2006..In addition, we unexpectedly find that mesenchymal cells, which surround the spinal cord and dorsal root ganglion, express ephrin-B1... - Expression of Vema in the developing mouse spinal cord and optic chiasmErik Runko
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Comp Neurol 451:289-99. 2002..The expression of Vema at two key choice points for pathfinding axons suggests an important role for this protein in regulating axon guidance at the midline of the developing mouse central nervous system... - Leaving the midline: how Robo receptors regulate the guidance of post-crossing spinal commissural axonsStacey L Reeber
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA
Cell Adh Migr 3:300-4. 2009.... - Caenorhabditis elegans VEM-1, a novel membrane protein, regulates the guidance of ventral nerve cord-associated axonsErik Runko
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 24:9015-26. 2004..Consistent with these genetic data, we also show that VEM-1 is capable of physically interacting with UNC-40 but not SAX-3...
Research Grants
- AXON GUIDANCE IN THE SPINAL CORDZaven Kaprielian; Fiscal Year: 2007..The proposed studies should provide a basis for devising strategies aimed at directing the re-growth of regenerating nerve fibers. ..