Research Topics
| I M MaisonneuveSummaryAffiliation: Albany Medical College Country: USA Publications
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Detail Information
Publications
Time-dependent interactions between iboga agents and cocaineI M Maisonneuve
Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
Eur J Pharmacol 336:123-6. 1997..These time-dependent effects, which could not be attributed to the motor activity induced by the iboga agents alone, account for divergent results reported in the literature...- Attenuation of the reinforcing efficacy of morphine by 18-methoxycoronaridineI M Maisonneuve
Department of Pharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Eur J Pharmacol 383:15-21. 1999..Together, the microdialysis and self-administration data suggest that 18-methoxycoronaridine profoundly alters mechanisms crucial to the development and maintenance of opioid addiction... - The potential anti-addictive agent, 18-methoxycoronaridine, blocks the sensitized locomotor and dopamine responses produced by repeated morphine treatmentK K Szumlinski
Department of Pharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY, USA
Brain Res 864:13-23. 2000..It is suggested that the potential anti-addictive efficacy of 18-MC might be related to an ability to restore normal functioning to a hypersensitive mesolimbic dopamine system produced by previous repeated morphine administration... - Interactions between 18-methoxycoronaridine (18-MC) and cocaine: dissociation of behavioural and neurochemical sensitizationK K Szumlinski
Center for Neuropharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Brain Res 871:245-58. 2000.... - Evidence for roles of kappa-opioid and NMDA receptors in the mechanism of action of ibogaineS D Glick
Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
Brain Res 749:340-3. 1997..The data suggest that both kappa-opioid agonist and NMDA antagonist actions of ibogaine contribute to its putative anti-addictive effects... - Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in ratsS D Glick
Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
Eur J Pharmacol 422:87-90. 2001..The results also suggest that dextromethorphan should be tested extensively as a potential treatment for diverse populations of drug-abusing patients... - Differential effects of ibogaine on behavioural and dopamine sensitization to cocaineK K Szumlinski
Center for Neuropharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Eur J Pharmacol 398:259-62. 2000..This result demonstrates that ibogaine pretreatment can reverse one of the neuroadaptations produced by chronic cocaine administration, an effect that may contribute to its putative anti-addictive property... - 18-Methoxycoronardine attenuates nicotine-induced dopamine release and nicotine preferences in ratsS D Glick
Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
Psychopharmacology (Berl) 139:274-80. 1998..The results suggest that 18-MC might be the prototype of a new treatment for smoking... - Effects of cyclazocine on cocaine self-administration in ratsS D Glick
Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
Eur J Pharmacol 357:9-14. 1998..Although the mechanistic basis for the results are not entirely understood, the data suggest that (+/-)-cyclazocine should be considered as a potential treatment for cocaine dependence... - 18-Methoxycoronaridine (18-MC) and ibogaine: comparison of antiaddictive efficacy, toxicity, and mechanisms of actionS D Glick
Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
Ann N Y Acad Sci 914:369-86. 2000..The data suggest that 18-MC has a narrower spectrum of actions and will have a substantially greater therapeutic index than ibogaine... - Interactions between iboga agents and methamphetamine sensitization: studies of locomotion and stereotypy in ratsK K Szumlinski
Center for Neuropharmacology and Neuroscience, Albany Medical College, NY 12208, USA
Psychopharmacology (Berl) 151:234-41. 2000.... - Enantioselective behavioral effects of sibutramine metabolitesS D Glick
Department of Pharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Eur J Pharmacol 397:93-102. 2000..The results suggest that these enantioselective metabolites of sibutramine could be safe and effective treatments for obesity as well as possibly for depression... - (+/-)Cyclazocine blocks the dopamine response to nicotineI M Maisonneuve
Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
Neuroreport 10:693-6. 1999..The results suggest that the effects of both enantiomers contribute to the effects of the racemate; (+/-)cyclazocine may decrease the rewarding effect of nicotine and may be the prototype of a potentially novel treatment for smoking... - Development of novel medications for drug addiction. The legacy of an African shrubS D Glick
Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
Ann N Y Acad Sci 909:88-103. 2000..18-MC also has (+) and (-) enantiomers, both of which are active. Considered together, all of the data indicate that 18-MC should be safer than ibogaine and at least as efficacious as an anti-addictive medication... - Pretreatment with the putative anti-addictive drug, ibogaine, increases the potency of cocaine to elicit locomotor responding: a study with acute and chronic cocaine-treated ratsK K Szumlinski
Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
Psychopharmacology (Berl) 145:227-33. 1999..Results of single-dose studies suggest that the effects of pretreatment with the putative anti-addictive compound, ibogaine, on drug-induced locomotor behavior depends on the previous drug history of the animal... - Iboga interactions with psychomotor stimulants: panacea in the paradox?K K Szumlinski
Center for Neuropharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Toxicon 39:75-86. 2001..These data indicate that iboga agents might attenuate stimulant self-administration by reversing the neuroadaptations theoretically implicated in drug craving and compulsive drug-seeking behavior... - Sedative and anxiolytic effects of zopiclone's enantiomers and metaboliteJ N Carlson
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
Eur J Pharmacol 415:181-9. 2001.... - Biphasic dose-related effects of morphine on dopamine releaseI M Maisonneuve
Center for Neuropharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
Drug Alcohol Depend 65:55-63. 2001..The results of this study are discussed in terms of their implications for interpreting drug interactions with morphine and with relationship to morphine's mode of action at mu and kappa opioid receptors... - Iboga compounds reverse the behavioural disinhibiting and corticosterone effects of acute methamphetamine: Implications for their antiaddictive propertiesK K Szumlinski
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
Pharmacol Biochem Behav 69:485-91. 2001..Furthermore, these data indicate that this reversal is related to effects of iboga compounds on the stimulation of neuroendocrine systems by stimulant drugs...