Gary T Wang

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors
    Qun Li
    Cancer Research, GPRD, Abbott Laboratories, Abbott Park, IL 60064 6101, USA
    Bioorg Med Chem Lett 14:5371-6. 2004
  2. ncbi Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores
    G T Wang
    Pharmaceutical Product Division, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Med Chem 44:1192-201. 2001
  3. ncbi Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids
    Gary T Wang
    Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 17:2817-22. 2007
  4. ncbi 1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities
    Gary T Wang
    Cancer Research, Global Pharmaceutical R and D, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Med Chem 48:3118-21. 2005
  5. ncbi Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding
    Gary T Wang
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park Road, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 15:195-201. 2005
  6. ncbi Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase
    Gary T Wang
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 15:153-8. 2005
  7. ncbi Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core
    Gary T Wang
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 15:125-8. 2005
  8. ncbi Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases
    Gary T Wang
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 20:6067-71. 2010
  9. ncbi Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors
    Gaoquan Li
    Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 16:2293-8. 2006
  10. ncbi Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding
    George S Sheppard
    Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Department R47A, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
    J Med Chem 49:3832-49. 2006

Detail Information

Publications14

  1. ncbi Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors
    Qun Li
    Cancer Research, GPRD, Abbott Laboratories, Abbott Park, IL 60064 6101, USA
    Bioorg Med Chem Lett 14:5371-6. 2004
    ..The compounds are characterized as being simple, easier to make, and possess no chiral center involved...
  2. ncbi Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores
    G T Wang
    Pharmaceutical Product Division, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Med Chem 44:1192-201. 2001
    ....
  3. ncbi Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids
    Gary T Wang
    Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 17:2817-22. 2007
    ..Introduction of a tertiary amino moiety at the ortho-position of the sulfonyl phenyl ring gave reduced protein binding and improved cellular activity, but led to lower oral bioavailability...
  4. ncbi 1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities
    Gary T Wang
    Cancer Research, Global Pharmaceutical R and D, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Med Chem 48:3118-21. 2005
    ..Flow cytometry (FACS) analysis confirmed that 2e abrogated G2 checkpoint arrest of H1299 cells caused by doxorubicin and S checkpoint arrest caused by camptothecin...
  5. ncbi Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding
    Gary T Wang
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park Road, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 15:195-201. 2005
    ..Applying this isosterism to previously reported p-arylthio cinnamides resulted in the identification of 4-amino-6-(p-arylthio)phenyl-pyrimidines and 2-amino-4-(p-arylthio)phenyl-pyridines as potent antagonists of LFA-1/ICAM-1 binding...
  6. ncbi Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase
    Gary T Wang
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 15:153-8. 2005
    ..Optimization of this lead resulted in compounds 2e and 2g, with FT IC(50) values of 1.3 and 1.8 nM, GGT IC(50) of 1400 nM, and EC(50) (Ras processing) values of 13 and 11 nM, respectively...
  7. ncbi Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core
    Gary T Wang
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 15:125-8. 2005
    ..Both compounds 9 and 14 inhibit influenza NA A with an IC(50) of about 0.5 microM and NA B with an IC(50) of 1.0 microM...
  8. ncbi Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases
    Gary T Wang
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 20:6067-71. 2010
    ....
  9. ncbi Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors
    Gaoquan Li
    Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 16:2293-8. 2006
    ..7 microM) and enhanced doxorubicin cytotoxicity (IC50=0.44 microM) while displaying no single agent activity...
  10. ncbi Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding
    George S Sheppard
    Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Department R47A, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
    J Med Chem 49:3832-49. 2006
    ....
  11. ncbi Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor
    Nan horng Lin
    Cancer Research, R 47B, Global Pharmaceutical Products Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
    Bioorg Med Chem Lett 14:5057-62. 2004
    ..The most promising compound identified from this series is analog 29 that possesses potent enzymatic and cellular activities...
  12. ncbi Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors
    Le Wang
    Globe Pharmaceutical R and Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 6101, USA
    J Med Chem 47:612-26. 2004
    ..Medicinal chemistry efforts led to the discovery of compound 64 with potent cellular activity (EC(50) = 3.5 nM) and outstanding pharmacokinetic profiles in dog (96% bioavailable, 18.4 h oral t(1/2), and 0.19 L/(h x kg) plasma clearance)...
  13. ncbi Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation
    Julie L Wilsbacher
    Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    J Biol Chem 283:23721-30. 2008
    ..Thus, targeting both IGF-1R and ErbB receptors simultaneously results in cell cycle arrest and apoptosis through combined effects on Akt, cyclin D1, and Bax activation...
  14. ncbi Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases
    Steve D Fidanze
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 20:2452-5. 2010
    ..The design and enzyme activities of a novel class of imidazo[2,1-b]thiazoles is presented...