W Kaszubska

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi Expression, purification, and characterization of human recombinant thrombopoietin in Chinese hamster ovary cells
    W Kaszubska
    Department of Metabolic Disease Research, Department 4MG, Building J 35, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, Illinois 60064, USA
    Protein Expr Purif 18:213-20. 2000
  2. ncbi Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line
    Wiweka Kaszubska
    Metabolic Disease Research, Global Pharmaceutical Products Division, Department 47R, Bldg AP10, 100 Abbott Park Road, Abott Park, IL 60064 6099, USA
    Mol Cell Endocrinol 195:109-18. 2002
  3. ncbi 2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists
    Michael D Serby
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6098, USA
    J Med Chem 49:2568-78. 2006
  4. ncbi Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: side chain exploration
    Bo Liu
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6098, USA
    Bioorg Med Chem Lett 16:1864-8. 2006
  5. ncbi Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists
    Hongyu Zhao
    Metabolic Disease Research, Global Pharmaceutical Research and Development, R4MC, AP 10, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6098, USA
    Bioorg Med Chem Lett 15:1825-8. 2005
  6. ncbi Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists
    Zhili Xin
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6098, USA
    Bioorg Med Chem Lett 15:1201-4. 2005
  7. ncbi Discovery of tetralin carboxamide growth hormone secretagogue receptor antagonists via scaffold manipulation
    Hongyu Zhao
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6098, USA
    J Med Chem 47:6655-7. 2004
  8. ncbi Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors
    Hongyu Zhao
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6098, USA
    Bioorg Med Chem Lett 14:5543-6. 2004
  9. ncbi Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists
    Bo Liu
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA
    Bioorg Med Chem Lett 14:5223-6. 2004
  10. ncbi Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor
    Gang Liu
    Metabolic Disease Research and Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 6098, USA
    J Med Chem 46:4232-5. 2003

Collaborators

Detail Information

Publications11

  1. ncbi Expression, purification, and characterization of human recombinant thrombopoietin in Chinese hamster ovary cells
    W Kaszubska
    Department of Metabolic Disease Research, Department 4MG, Building J 35, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, Illinois 60064, USA
    Protein Expr Purif 18:213-20. 2000
    ..rhTPO also shows activity in vivo as judged by the elevation of platelet count in treated mice...
  2. ncbi Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line
    Wiweka Kaszubska
    Metabolic Disease Research, Global Pharmaceutical Products Division, Department 47R, Bldg AP10, 100 Abbott Park Road, Abott Park, IL 60064 6099, USA
    Mol Cell Endocrinol 195:109-18. 2002
    ..Our findings indicate that PTP1B is a negative regulator of leptin signaling and suggest that PTP1B inhibitors might be efficacious in the treatment of obesity by increasing leptin sensitivity...
  3. ncbi 2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists
    Michael D Serby
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6098, USA
    J Med Chem 49:2568-78. 2006
    ..A structure-activity relationship study led to the discovery of 8a, which was effective in decreasing food intake and body weight in several acute rat studies...
  4. ncbi Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: side chain exploration
    Bo Liu
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6098, USA
    Bioorg Med Chem Lett 16:1864-8. 2006
    ..Diaminopyrimidines with 6-norbornenyl (4n) and 6-tetrahydrofuranyl (4p) substitutents were found to exhibit potent GHS-R antagonism and good selectivity (approximately 1000-fold) against dihydrofolate reductase...
  5. ncbi Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists
    Hongyu Zhao
    Metabolic Disease Research, Global Pharmaceutical Research and Development, R4MC, AP 10, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6098, USA
    Bioorg Med Chem Lett 15:1825-8. 2005
    ..It was found that certain 2-alkoxycarbonylamino substituted tetralin carboxamides are potent, selective, and orally bioavailable GHS-R antagonists...
  6. ncbi Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists
    Zhili Xin
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6098, USA
    Bioorg Med Chem Lett 15:1201-4. 2005
    ..A series of isoxazole carboxamide derivatives has been developed as potent ghrelin receptor antagonists. The synthesis and structure-activity relationship (SAR) are described...
  7. ncbi Discovery of tetralin carboxamide growth hormone secretagogue receptor antagonists via scaffold manipulation
    Hongyu Zhao
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6098, USA
    J Med Chem 47:6655-7. 2004
    ..Union of rational design and high throughput synthesis provided a quick access to high quality chemical leads...
  8. ncbi Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors
    Hongyu Zhao
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6098, USA
    Bioorg Med Chem Lett 14:5543-6. 2004
    ..Inhibitor 7 demonstrated good cellular activity against PTP1B in COS 7 cells...
  9. ncbi Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists
    Bo Liu
    Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA
    Bioorg Med Chem Lett 14:5223-6. 2004
    ..A potent analogue (32) with high aqueous solubility and good GPCR selectivity was also identified as a potential pharmacological tool for in vivo studies...
  10. ncbi Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor
    Gang Liu
    Metabolic Disease Research and Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 6098, USA
    J Med Chem 46:4232-5. 2003
    ....
  11. ncbi Characterization of ghrelin receptor activity in a rat pituitary cell line RC-4B/C
    H Douglas Falls
    Metabolic Disease Research, Global Pharmaceutical Products Division, Abbott Laboratories, R4MJ, Bldg AP9A, 100 Abbott Park Road, Abbott Park, IL 60064 6099, USA
    J Mol Endocrinol 37:51-62. 2006
    ..Overall, the data presented here suggest that the RC-4B/C parental and RC-4B/C.40 cells provide novel in vitro systems for the characterization of GHS-R pharmacophores and ghrelin signaling...