Research Topics
| AUBREY D DE GREYSummaryAffiliation: Methuselah Foundation Country: United Kingdom Publications
Research Grants
|
Detail Information
Publications
The natural biogerontology portfolio: "defeating aging" as a multi-stage ultra-grand challengeAubrey D N J de Grey
Methuselah Foundation, P O Box 1143, Lorton, VA 22199, USA
Ann N Y Acad Sci 1100:409-23. 2007....- The singularity and the Methuselarity: similarities and differencesAubrey D N J de Grey
Methuselah Foundation
Stud Health Technol Inform 149:195-202. 2009..quot; In this essay I compare and contrast these two concepts... - Protagonistic pleiotropy: Why cancer may be the only pathogenic effect of accumulating nuclear mutations and epimutations in agingAubrey D N J de Grey
Methuselah Foundation, PO Box 1143, Lorton, VA 22079, USA
Mech Ageing Dev 128:456-9. 2007..If this conclusion is correct, the implications for the feasibility of greatly postponing mammalian (and eventually human) aging and age-related pathology are far-reaching... - Understanding and tackling aging: two fields communicating (a little) at lastAubrey D N J de Grey
Methuselah Foundation, Cambridge, United Kingdom
Rejuvenation Res 10:637-40. 2007.... - Alzheimer's, atherosclerosis, and aggregates: a role for bacterial degradationAUBREY D DE GREY
Methuselah Foundation, Cambridge, United Kingdom
Nutr Rev 65:S221-7. 2007..As the size of our elderly population grows, the incidence of age-related diseases will increase, necessitating the exploration of radical, but potentially powerful, therapeutic strategies... - Dissertations: a survey of selected recent theses relevant to combating agingAubrey D N J de Grey
Methuselah Foundation, Cambridge, United Kingdom
Rejuvenation Res 10:641-6. 2007 - Is SENS a farrago?Aubrey D N J de Grey
Methuselah Foundation, Cambridge, United Kingdom
Rejuvenation Res 9:436-9. 2006..Here I briefly respond to these criticisms... - Rejuvenation Research in 2007Aubrey D N J de Grey
Methuslah Foundation, Cambridge, U.K
Rejuvenation Res 11:837-9. 2008 - How is mutant mitochondrial DNA clonally amplified? Much new evidence, still no answersAubrey D N J de Grey
SENS Foundation, Cambridge, United Kingdom
Rejuvenation Res 12:217-9. 2009..While these reports surely bring us closer to an understanding of this phenomenon, and thus probably to a better understanding of how it might be combated or even reversed, they currently raise more questions than they answer... - Calorie restriction, post-reproductive life span, and programmed aging: a plea for rigorAubrey D N J de Grey
Methuselah Foundation, Cambridge, UK
Ann N Y Acad Sci 1119:296-305. 2007..Greater precision on these points will, I believe, benefit biogerontology at many levels, avoiding confusion among biogerontologists, among other biologists, and among the general public... - Free radicals in aging: causal complexity and its biomedical implicationsAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, UK
Free Radic Res 40:1244-9. 2006..This has led me to pursue the alternative, "repair and maintenance" approach that sidesteps our ignorance of metabolism and may be feasible relatively soon... - Resistance to debate on how to postpone ageing is delaying progress and costing lives. Open discussions in the biogerontology community would attract public interest and influence funding policyAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, UK
EMBO Rep 6:S49-53. 2005 - The unfortunate influence of the weather on the rate of ageing: why human caloric restriction or its emulation may only extend life expectancy by 2-3 yearsAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, UK
Gerontology 51:73-82. 2005.... - Time to talk SENS: critiquing the immutability of human agingAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, UK
Ann N Y Acad Sci 959:452-62; discussion 463-5. 2002..Given the major demographic consequences if it came about, this possibility merits urgent debate... - Rejuvenation Research 2004: a relaunch with a differenceAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Rejuvenation Res 8:58-60. 2005 - Inter-species therapeutic cloning: the looming problem of mitochondrial DNA and two possible solutionsAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Rejuvenation Res 7:95-8. 2004 - Reactive oxygen species production in the mitochondrial matrix: implications for the mechanism of mitochondrial mutation accumulationAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Rejuvenation Res 8:13-7. 2005..quot; It may also prove to explain other recent observations in mitochondrially mutant cells in vivo... - The 8th International Symposium on the Maillard reaction (Charleston, South Carolina, August 28 to September 1, 2004)Aubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Rejuvenation Res 7:257-60. 2004 - Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseasesAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Ageing Res Rev 4:315-38. 2005..We discuss how microbes capable of degrading them can be isolated, characterised and their relevant enzymes engineered for this purpose and ways to avoid potential side-effects... - Challenging but essential targets for genuine anti-ageing drugsAubrey D N J de Grey
Expert Opin Ther Targets 7:1-5. 2003.... - The case for prioritizing research on late-onset life-extension interventions in mammalsAubrey D N J de Grey
Rejuvenation Res 10:257-9. 2007 - Like it or not, life-extension research extends beyond biogerontologyAubrey D N J de Grey
EMBO Rep 6:1000. 2005 - The SENS challenge: 20,000 US dollars says the foreseeable defeat of aging is not laughableAubrey D N J de Grey
Rejuvenation Res 8:207-10. 2005 - Combating the Tithonus error: what works?Aubrey D N J de Grey
Rejuvenation Res 11:713-5. 2008 - SENS survives the challenge: now let's get to workAubrey D N J de Grey
Rejuvenation Res 9:429-30. 2006 - Man, machines, manufacturing, and maintenance: merits of a much-maligned metaphorAubrey D N J de Grey
Rejuvenation Res 11:277-9. 2008 - Edmonton: a future center for pioneering biomedical gerontology?Aubrey D N J de Grey
Rejuvenation Res 10:345-7. 2007 - Dissertations: a survey of selected recent theses relevant to combating agingAubrey D N J de Grey
Rejuvenation Res 10:339-43. 2007 - Antiaging technology and pseudoscienceAubrey D N J de Grey
Science 296:656. 2002 - Three self-evident life-extension truthsAubrey D N J de Grey
Rejuvenation Res 7:165-7. 2004 - The foreseeability of real anti-aging medicine: focusing the debateAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Exp Gerontol 38:927-34. 2003..It is hoped that, by clearing the debate on future anti-aging advances of these obfuscations, the many aspects of this topic that have hitherto received much less attention than they warrant will be brought to the fore... - Biogerontologists' duty to discuss timescales publiclyAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Ann N Y Acad Sci 1019:542-5. 2004.... - Bioremediation meets biomedicine: therapeutic translation of microbial catabolism to the lysosomeAubrey D N J de Grey
Dept of Genetics, University of Cambridge, UK
Trends Biotechnol 20:452-5. 2002..This article examines the feasibility and biomedical potential of such lysosomal enhancement as an approach to retarding or treating age-related physiological decline and disease... - Is human aging still mysterious enough to be left only to scientists?Aubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Bioessays 24:667-76. 2002..Consequently, we suggest that serious public debate on this subject is now warranted, and we survey here several of the biological, social and political issues relating to it... - Long live the unreasonable manAubrey D N J de Grey
Rejuvenation Res 11:541-2. 2008 - Total deletion of in vivo telomere elongation capacity: an ambitious but possibly ultimate cure for all age-related human cancersAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Ann N Y Acad Sci 1019:147-70. 2004..Hence, given the absence of alternatives with comparable anticancer promise, we advocate working toward such a therapy... - Mitochondria in homeotherm aging: will detailed mechanisms consistent with the evidence now receive attention?Aubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Aging Cell 3:77. 2004 - Three detailed hypotheses implicating oxidative damage to mitochondria as a major driving force in homeotherm agingAubrey D N J de Grey
Department of Genetics, University of Cambridge, UK
Eur J Biochem 269:1995. 2002 - Retrospective: Rejuvenation Research in 2006Aubrey D N J de Grey
Rejuvenation Res 10:335-8. 2007 - The reductive hotspot hypothesis of mammalian aging: membrane metabolism magnifies mutant mitochondrial mischiefAubrey D N J de Grey
Department of Genetics, University of Cambridge, UK
Eur J Biochem 269:2003-9. 2002..In this minireview, recent results relevant to this hypothesis are surveyed and approaches to intervening in the proposed process are discussed... - Overzealous maximum-likelihood fitting falsely convicts the slope heterogeneity hypothesisAubrey D N J de Grey
Exp Gerontol 38:921-3. 2003 - The need to debalkanize gerontology: a case studyAubrey D N J de Grey
Rejuvenation Res 10:431-4. 2007 - HO2*: the forgotten radicalAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
DNA Cell Biol 21:251-7. 2002..It is suggested that a more widespread appreciation of the possible role of HO2* in biological systems would be of considerable benefit to biomedical research... - Dissertations: a survey of selected recent theses relevant to combating agingAubrey D N J de Grey
Rejuvenation Res 11:689-95. 2008 - Appropriating microbial catabolism: a proposal to treat and prevent neurodegenerationAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Neurobiol Aging 27:589-95. 2006..Thus, microbes may exist that can degrade these lysosomal toxins. If so, it should be possible to isolate the genes responsible and modify them for therapeutic activity in the mammalian lysosome... - An engineer's approach to the development of real anti-aging medicineAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Sci Aging Knowledge Environ 2003:VP1. 2003..This approach should help to prevent the development of these age-related changes into life-threatening pathologies and possibly, in due course, allow a large increase in healthy human life expectancy... - Report on the open discussion on the future of life extension researchAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Ann N Y Acad Sci 1019:552-3. 2004.... - "The rate of aging": a counterproductively undefinable termAubrey D N J de Grey
Rejuvenation Res 8:77-8. 2005 - The ethical status of efforts to postpone aging: a reply to HurlbutAubrey D N J de Grey
Rejuvenation Res 8:129-30. 2005 - When and where to publish important findings: a casualty of biogerontology's rise to respectabilityAubrey D N J de Grey
Rejuvenation Res 8:1-2. 2005 - Aging, childlessness, or overpopulation: the future's right to chooseAubrey D N J de Grey
Rejuvenation Res 7:237-8. 2004 - Regenerate 2004: tissue engineering the human body, June 10-12, 2004, SeattleAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
Rejuvenation Res 7:226-8. 2004 - International Association of Biomedical Gerontology, 11th Congress (Aarhus, Denmark, August 13-16, 2005)Aubrey D N J de Grey
Department of Genetics, University of Cambridge, UK
Rejuvenation Res 8:264-6. 2005 - Compression of morbidity: the hype and the reality, part 1Aubrey D N J de Grey
Rejuvenation Res 9:1-2. 2006 - Compression of morbidity: the hype and the reality, part 2Aubrey D N J de Grey
Rejuvenation Res 9:167-8. 2006 - Extrapolaholics anonymous: why demographers' rejections of a huge rise in cohort life expectancy in this century are overconfidentAubrey D N J de Grey
Department of Genetics, University of Cambridge, UK
Ann N Y Acad Sci 1067:83-93. 2006.... - Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?Konstantin Khrapko
Gerontology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Aging Cell 5:279-82. 2006..Thus, mtDNA mutations may indeed be relevant to human aging, but they probably differ by origin, type, distribution, and spectra of affected tissues from those observed in mutator mice... - Has Hippocrates had his day?Aubrey D N J de Grey
Rejuvenation Res 9:371-3. 2006 - Mitochondrial mutations in mammalian aging: an over-hasty about-turn?Aubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
Rejuvenation Res 7:171-4. 2004..However, there are compelling reasons to doubt the relevance of this mouse to normal mammalian aging, and thus to seek further testing of specific mechanistic hypotheses for how mtDNA mutations could cause age-related dysfunction... - Foreseeable pharmaceutical repair of age-related extracellular damageAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Curr Drug Targets 7:1469-77. 2006..In this article, the major types of age-related extracellular damage and promising avenues for their repair are reviewed... - Leon Kass: quite substantially rightAubrey D N J de Grey
Rejuvenation Res 7:89-91. 2004 - Aging and airborne HIV: a reassuring analogyAubrey D N J de Grey
Rejuvenation Res 10:1-3. 2007 - Whole-body interdiction of lengthening of telomeres: a proposal for cancer preventionAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
Front Biosci 10:2420-9. 2005..Here, I describe why WILT might prove to be an exceptionally powerful anti-cancer modality...
Research Grants
- Strategies for Engineered Negligible Senescence, 2nd ConferenceAubrey de Grey; Fiscal Year: 2005..The upcoming meeting has been able to build on the reputation of the 2003 meeting and has already attracted a host of illustrious confirmed speakers. ..