Nicole Soranzo

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. ncbi A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function
    Nicole Soranzo
    Human Genetics Department, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    Blood 113:3831-7. 2009
  2. ncbi A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
    Nicole Soranzo
    Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK
    Nat Genet 41:1182-90. 2009
  3. ncbi Common variants at 10 genomic loci influence hemoglobin A?(C) levels via glycemic and nonglycemic pathways
    Nicole Soranzo
    Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U K
    Diabetes 59:3229-39. 2010
  4. ncbi Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
    Cathy E Elks
    Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 42:1077-85. 2010
  5. ncbi Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
    Tuomas O Kilpeläinen
    Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Nat Genet 43:753-60. 2011
  6. ncbi Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits
    Dirk S Paul
    Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    PLoS Genet 7:e1002139. 2011
  7. ncbi A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose
    Fumihiko Takeuchi
    Wellcome Trust Sanger Institute, Hinxton, UK
    PLoS Genet 5:e1000433. 2009
  8. ncbi Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size
    Nicole Soranzo
    Human Genetics Department, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Genet 5:e1000445. 2009
  9. ncbi Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
    George F Mells
    Academic Department of Medical Genetics, Cambridge University, Cambridge, UK Department of Hepatology, Cambridge University Hospitals National Health Service NHS Foundation Trust, Cambridge, UK
    Nat Genet 43:329-32. 2011

Detail Information

Publications9

  1. ncbi A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function
    Nicole Soranzo
    Human Genetics Department, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    Blood 113:3831-7. 2009
    ....
  2. ncbi A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
    Nicole Soranzo
    Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK
    Nat Genet 41:1182-90. 2009
    ....
  3. ncbi Common variants at 10 genomic loci influence hemoglobin A?(C) levels via glycemic and nonglycemic pathways
    Nicole Soranzo
    Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U K
    Diabetes 59:3229-39. 2010
    ..We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbA?(c) levels...
  4. ncbi Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
    Cathy E Elks
    Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 42:1077-85. 2010
    ..Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing...
  5. ncbi Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
    Tuomas O Kilpeläinen
    Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Nat Genet 43:753-60. 2011
    ..Our findings provide new insights into adiposity and insulin resistance...
  6. ncbi Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits
    Dirk S Paul
    Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    PLoS Genet 7:e1002139. 2011
    ..Our data suggested a molecular mechanism by which a non-coding GWA index SNP modulates platelet phenotype...
  7. ncbi A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose
    Fumihiko Takeuchi
    Wellcome Trust Sanger Institute, Hinxton, UK
    PLoS Genet 5:e1000433. 2009
    ..5% of dose variance. These GWAS results provide further impetus for conducting large-scale trials assessing patient benefit from genotype-based forecasting of warfarin dose...
  8. ncbi Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size
    Nicole Soranzo
    Human Genetics Department, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Genet 5:e1000445. 2009
    ..Further statistical tests in larger numbers of individuals will be required to verify if the height loci affect height preferentially through these subcomponents of height...
  9. ncbi Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
    George F Mells
    Academic Department of Medical Genetics, Cambridge University, Cambridge, UK Department of Hepatology, Cambridge University Hospitals National Health Service NHS Foundation Trust, Cambridge, UK
    Nat Genet 43:329-32. 2011
    ..New candidate genes include STAT4, DENND1B, CD80, IL7R, CXCR5, TNFRSF1A, CLEC16A and NFKB1. This study has considerably expanded our knowledge of the genetic architecture of PBC...