Research Topics
| Adele MurrellSummaryAffiliation: Wellcome Trust Genome Campus Country: UK Publications
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Detail Information
Publications
Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loopsAdele Murrell
Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
Nat Genet 36:889-93. 2004..These interactions are epigenetically regulated and partition maternal and paternal chromatin into distinct loops. This generates a simple epigenetic switch for Igf2 through which it moves between an active and a silent chromatin domain...- From genome to epigenomeAdele Murrell
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Hum Mol Genet 14:R3-R10. 2005..Here, we review the current thinking and progress on how to get from the genome to the epigenome(s) and discuss some potential applications... - Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndromeRaffaella Nativio
Department of Oncology, Cancer Research UK Cambridge Research Institute, University of Cambridge, LiKaShing Centre, Cambridge, UK
Hum Mol Genet 20:1363-74. 2011..The two alternative chromatin conformations are differently favoured in BWS and SRS likely predisposing the locus to the activation of IGF2 or H19, respectively... - An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotypeAdele Murrell
Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
Hum Mol Genet 13:247-55. 2004..This indicates either a genetic predisposition to LOM or interactions between genotype and epigenotype that impinge on the disease phenotype... - Genomic imprinting: CTCF protects the boundariesAnnabelle Lewis
Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge, CB2 4AT, UK
Curr Biol 14:R284-6. 2004..It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline... - Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progressionAshraf E K Ibrahim
Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
Gut 60:499-508. 2011.... - Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactionsSusana Lopes
Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
Hum Mol Genet 12:295-305. 2003..These observations are likely to be relevant to other gene clusters in which epigenetic regulation plays a role, and in pathological situations in which epigenetic regulation is disrupted... - Convergence of Igf2 expression and adhesion signalling via RhoA and p38 MAPK enhances myogenic differentiationFiona A Lovett
The Babraham Institute, Babraham Research Campus, Cambridge, CB2 4AT, UK
J Cell Sci 119:4828-40. 2006..We thus define a regulatory mechanism for p38 activation that relates cell-cell-derived adhesion signalling to the synthesis of the major fetal growth factor, IGF-II... - Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancerAdele Murrell
Department of Oncology, University of Cambridge, CRUK Cambridge Research Institute, Cambridge, United Kingdom
PLoS ONE 3:e1849. 2008..This DMR, known as DMR0, has been shown to be methylated on the silent maternal IGF2 allele presumably with a role in repression. The effect of IGF2 DMR0 methylation changes in the aetiology of BWS or SRS is unknown... - Somatically acquired hypomethylation of IGF2 in breast and colorectal cancerYoko Ito
Department of Oncology, University of Cambridge, CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Hum Mol Genet 17:2633-43. 2008..These results indicate that IGF2 DMR0 hypomethylation has diagnostic potential for colon cancer rather than value as a surrogate biomarker for constitutive LOI... - Genomic imprinting controls matrix attachment regions in the Igf2 geneMichael Weber
Institut de Genetique Moleculaire, UMR 5535 CNRS, Universite Montpellier II, IFR 122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
Mol Cell Biol 23:8953-9. 2003..Our work clearly demonstrates that genomic imprinting controls matrix attachment regions in the Igf2 gene... - CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2Sreenivasulu Kurukuti
Department of Development and Genetics, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
Proc Natl Acad Sci U S A 103:10684-9. 2006.... - Genomic imprinting and cancer: from primordial germ cells to somatic cellsAdele Murrell
Department of Oncology, University of Cambridge, MRC Hutchison Centre, Hills Road Cambridge CB2 2XZ, UK
ScientificWorldJournal 6:1888-910. 2006..This review summarises what we know about imprinting in stem cells and how loss of imprinting may contribute to neoplasia...