J M Pollock

Summary

Affiliation: Veterinary Sciences Division
Country: UK

Publications

  1. ncbi Immune responses in bovine tuberculosis: towards new strategies for the diagnosis and control of disease
    J M Pollock
    Veterinary Sciences Division, The Department of Agriculture and Rural Development, Stoney Road, Stormont, Belfast BT4 3SD, UK
    Vet Immunol Immunopathol 108:37-43. 2005
  2. ncbi The WC1(+) gammadelta T-cell population in cattle: a possible role in resistance to intracellular infection
    J M Pollock
    The Department of Agriculture and Rural Development, Veterinary Sciences Division, Stoney Road, Stormont, Belfast BT4 3SD, UK
    Vet Immunol Immunopathol 89:105-14. 2002
  3. ncbi Mycobacterium bovis infection and tuberculosis in cattle
    J M Pollock
    Veterinary Sciences Division, Department of Agriculture and Rural Development, Belfast, UK
    Vet J 163:115-27. 2002
  4. ncbi Characterization of the early antibody response in bovine tuberculosis: MPB83 is an early target with diagnostic potential
    J McNair
    Veterinary Sciences Division, Department of Agriculture and Rural Development, Stoney Road, Belfast BT4 3SD, Northern Ireland, UK
    Scand J Immunol 53:365-71. 2001
  5. ncbi The role of WC1(+) gamma delta T-cells in the delayed-type hypersensitivity (DTH) skin-test reaction of Mycobacterium bovis-infected cattle
    H E Kennedy
    Department of Veterinary Science, Queen's University, Belfast, UK
    Vet Immunol Immunopathol 93:169-76. 2003
  6. ncbi Shedding of Mycobacterium bovis in the nasal mucus of cattle infected experimentally with tuberculosis by the intranasal and intratracheal routes
    T McCorry
    Department of Veterinary Science, Queen's University of Belfast, Stoney Road, Stormont
    Vet Rec 157:613-8. 2005
  7. ncbi Experimental exposure of cattle to a precise aerosolised challenge of Mycobacterium bovis: a novel model to study bovine tuberculosis
    J D Rodgers
    Department of Veterinary Sciences, The Queen s University of Belfast, Stoney Road, Belfast, Northern Ireland, UK
    Tuberculosis (Edinb) 87:405-14. 2007
  8. ncbi Immune responses in bovine tuberculosis
    J M Pollock
    Veterinary Sciences Division, Department of Agriculture and Rural Development, Stoney Road, Stormont, Belfast, BT4 3SD, UK
    Tuberculosis (Edinb) 81:103-7. 2001
  9. ncbi Lymphocyte subtypes in experimentally induced early-stage bovine tuberculous lesions
    J P Cassidy
    Veterinary Sciences Division, Department of Agriculture and Rural Development for Northern Ireland, Stoney Road, Stormont, Belfast BT4 3SD, Northern Ireland
    J Comp Pathol 124:46-51. 2001
  10. ncbi Discrimination of isolates of Mycobacterium bovis in Northern Ireland on the basis of variable numbers of tandem repeats (VNTRs)
    R A Skuce
    Bacteriology Branch, Veterinary Sciences Division, Department of Agriculture and Rural Development for Northern Ireland, Stormont, Belfast BT4 3SD
    Vet Rec 157:501-4. 2005

Detail Information

Publications30

  1. ncbi Immune responses in bovine tuberculosis: towards new strategies for the diagnosis and control of disease
    J M Pollock
    Veterinary Sciences Division, The Department of Agriculture and Rural Development, Stoney Road, Stormont, Belfast BT4 3SD, UK
    Vet Immunol Immunopathol 108:37-43. 2005
    ..This paper considers how recent developments in knowledge of immune responses and mycobacterial antigens can be used in the logical development of more efficient strategies for the identification of infected cattle...
  2. ncbi The WC1(+) gammadelta T-cell population in cattle: a possible role in resistance to intracellular infection
    J M Pollock
    The Department of Agriculture and Rural Development, Veterinary Sciences Division, Stoney Road, Stormont, Belfast BT4 3SD, UK
    Vet Immunol Immunopathol 89:105-14. 2002
    ..In combination, these observations allow speculation regarding a possible role for WC1(+) gammadelta T-cells as a link between the innate and acquired immune systems which is instrumental in establishing an appropriate response...
  3. ncbi Mycobacterium bovis infection and tuberculosis in cattle
    J M Pollock
    Veterinary Sciences Division, Department of Agriculture and Rural Development, Belfast, UK
    Vet J 163:115-27. 2002
    ..bovis exposure and subsequent infection in cattle would be of significant benefit in developing new tools appropriate for disease control and to designing optimal approaches for their application...
  4. ncbi Characterization of the early antibody response in bovine tuberculosis: MPB83 is an early target with diagnostic potential
    J McNair
    Veterinary Sciences Division, Department of Agriculture and Rural Development, Stoney Road, Belfast BT4 3SD, Northern Ireland, UK
    Scand J Immunol 53:365-71. 2001
    ..5 and 89%, respectively. These results indicate potential for MPB83 in the development of assays for serological diagnosis of bovine tuberculosis...
  5. ncbi The role of WC1(+) gamma delta T-cells in the delayed-type hypersensitivity (DTH) skin-test reaction of Mycobacterium bovis-infected cattle
    H E Kennedy
    Department of Veterinary Science, Queen's University, Belfast, UK
    Vet Immunol Immunopathol 93:169-76. 2003
    ....
  6. ncbi Shedding of Mycobacterium bovis in the nasal mucus of cattle infected experimentally with tuberculosis by the intranasal and intratracheal routes
    T McCorry
    Department of Veterinary Science, Queen's University of Belfast, Stoney Road, Stormont
    Vet Rec 157:613-8. 2005
    ..Two of the 15 confirmed shedders had no visible lesions at postmortem examination; both of these calves gave IFN-gamma responses but only one was skin test positive...
  7. ncbi Experimental exposure of cattle to a precise aerosolised challenge of Mycobacterium bovis: a novel model to study bovine tuberculosis
    J D Rodgers
    Department of Veterinary Sciences, The Queen s University of Belfast, Stoney Road, Belfast, Northern Ireland, UK
    Tuberculosis (Edinb) 87:405-14. 2007
    ..bovis almost exclusively to the LRT. The distribution of M. bovis and lesions indicative of tuberculosis suggests this aerosol method replicates the primary mode of tuberculosis transmission in cattle...
  8. ncbi Immune responses in bovine tuberculosis
    J M Pollock
    Veterinary Sciences Division, Department of Agriculture and Rural Development, Stoney Road, Stormont, Belfast, BT4 3SD, UK
    Tuberculosis (Edinb) 81:103-7. 2001
    ..bovis -infected macrophages provides opportunities for the development of better methods for disease control...
  9. ncbi Lymphocyte subtypes in experimentally induced early-stage bovine tuberculous lesions
    J P Cassidy
    Veterinary Sciences Division, Department of Agriculture and Rural Development for Northern Ireland, Stoney Road, Stormont, Belfast BT4 3SD, Northern Ireland
    J Comp Pathol 124:46-51. 2001
    ..On the other hand, aggregates of B lymphocytes did not become prominent in areas adjacent to lesions until day 42. The results suggest that these lymphocyte phenotypes play a role in the pathogenesis of early-stage lesions...
  10. ncbi Discrimination of isolates of Mycobacterium bovis in Northern Ireland on the basis of variable numbers of tandem repeats (VNTRs)
    R A Skuce
    Bacteriology Branch, Veterinary Sciences Division, Department of Agriculture and Rural Development for Northern Ireland, Stormont, Belfast BT4 3SD
    Vet Rec 157:501-4. 2005
    ..This VTNR typing assay was found to be highly discriminating, with the performance characteristics to support its systematic application to the molecular epidemiology of bovine TB...
  11. ncbi Molecular analyses of mycobacteria other than the M. tuberculosis complex isolated from Northern Ireland cattle
    M S Hughes
    Department of Agriculture and Rural Development, Veterinary Sciences Division, Stoney Road, Stormont, Belfast BT4 3SD, Northern Ireland, UK
    Vet Microbiol 108:101-12. 2005
    ..This study supported restricted species distribution of these genes as well as identifying a different range of MOTT species that could be included in specificity testing of new diagnostic reagents for bovine tuberculosis...
  12. ncbi Pathogenesis of tuberculosis in cattle
    S D Neill
    Veterinary Sciences Division, Department of Agriculture and Rural Development, Stoney Road, Belfast, BT4 3ND, Northern Ireland
    Tuberculosis (Edinb) 81:79-86. 2001
    ....
  13. ncbi Pathogenesis of bovine tuberculosis: the role of experimental models of infection
    J M Pollock
    Veterinary Sciences Division, The Department of Agriculture and Rural Development, Stoney Road, Stormont, Belfast BT4 3SD, UK
    Vet Microbiol 112:141-50. 2006
    ....
  14. ncbi Investigations into an outbreak of tuberculosis in a flock of sheep in contact with tuberculous cattle
    F E Malone
    Veterinary Sciences Division, Department of Agriculture and Rural Development for Northern Ireland, 43 Beltany Road, Omagh, County Tyrone, BT78 5NF, UK
    J Vet Med B Infect Dis Vet Public Health 50:500-4. 2003
    ..The report describes immunology and pathology findings and, using molecular typing techniques, suggests that the sheep had been infected from in-contact cattle...
  15. ncbi Towards more accurate diagnosis of bovine tuberculosis using defined antigens
    J M Pollock
    Veterinary Sciences Division, Stormont, Belfast, UK
    Tuberculosis (Edinb) 81:65-9. 2001
    ....
  16. ncbi The immunology of bovine tuberculosis and progression toward improved disease control strategies
    J McNair
    Veterinary Sciences Division, Agri Food and Biosciences Institute, Stoney Road, Stormont, Belfast BT4 3SD, Northern Ireland, United Kingdom
    Vaccine 25:5504-11. 2007
    ..This paper describes those recent advances which may lead to the introduction of improved disease control strategies...
  17. ncbi Mycobacterium nonchromogenicum in nasal mucus from cattle in a herd infected with bovine tuberculosis
    T P McCorry
    Department of Veterinary Science, The Queen's University of Belfast, Stoney Road, Stormont, Belfast BT4 3SD, Northern Ireland, UK
    Vet Microbiol 99:281-5. 2004
    ..nonchromogenicum in nasal mucus of cattle. The observation highlights the importance of integrating definitive tests such as the PCR for diagnosis of bovine tuberculosis and indicates a possible zoonotic risk...
  18. ncbi Specific delayed-type hypersensitivity responses to ESAT-6 identify tuberculosis-infected cattle
    J M Pollock
    Veterinary Sciences Division, Department of Agriculture and Rural Development, Belfast, United Kingdom
    J Clin Microbiol 41:1856-60. 2003
    ..Larger investigations are required to refine cutoff points for any new diagnostic test, but the present results indicate great potential for skin tests based on specific antigens for accurate in vivo diagnosis of tuberculosis...
  19. ncbi Tuberculosis--new light from an old window
    S D Neill
    Agriculture, Food and Environmental Sciences Division, Department of Agriculture and Rural Development for Northern Ireland, Newforge Lane, Belfast BT9 5PX, Northern Ireland, UK
    J Appl Microbiol 98:1261-9. 2005
  20. ncbi Antibody responses in reindeer (Rangifer tarandus) infected with Mycobacterium bovis
    W R Waters
    United States Department of Agriculture, Agricultural Research Service, National Animal Disease Center, P O Box 70, Ames, IA 50010 0070, USA
    Clin Diagn Lab Immunol 12:727-35. 2005
    ..bovis infection of reindeer elicits an antibody response to multiple antigens that can be boosted by skin testing. Serological tests using carefully selected specific antigens have potential for early detection of infections in reindeer...
  21. ncbi T- and B-cell epitopes in the secreted Mycobacterium bovis antigen MPB70 in mice
    S Tollefsen
    Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway
    Scand J Immunol 57:151-61. 2003
    ....
  22. ncbi Optimizing antigen cocktails for detection of Mycobacterium bovis in herds with different prevalences of bovine tuberculosis: ESAT6-CFP10 mixture shows optimal sensitivity and specificity
    C Aagaard
    Statens Serum Institut, Department of TB Immunology, Copenhagen, Denmark
    J Clin Microbiol 44:4326-35. 2006
    ..Furthermore, TB10.4, PE13, and PE5 have the potential to supplement ESAT6 and CFP10 in a future five-component diagnostic cocktail...
  23. ncbi Early antibody responses to experimental Mycobacterium bovis infection of cattle
    W R Waters
    Bacterial Diseases of Livestock Research Unit, Agricultural Research Service, National Animal Disease Center, United States Department of Agriculture, P O Box 70, Ames, IA 50010 0070, USA
    Clin Vaccine Immunol 13:648-54. 2006
    ..These findings demonstrate the potential for new-generation antibody-based tests for the early detection of M. bovis infection in cattle...
  24. ncbi Immune responses to defined antigens of Mycobacterium bovis in cattle experimentally infected with Mycobacterium kansasii
    W R Waters
    United States Department of Agriculture, Agricultural Research Service, National Animal Disease Center, P O Box 70, Ames, IA 50010 0070, USA
    Clin Vaccine Immunol 13:611-9. 2006
    ..bovis infection. These findings indicate that M. kansasii infection of calves elicits specific responses that may confound the interpretation of bovine tuberculosis tests...
  25. ncbi Progress in the development of vaccines and diagnostic reagents to control tuberculosis in cattle
    H M Vordermeier
    Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vet J 171:229-44. 2006
    ....
  26. ncbi Antigen recognition by serum antibodies in white-tailed deer (Odocoileus virginianus) experimentally infected with Mycobacterium bovis
    W R Waters
    National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Bacterial Diseases of Livestock Research Unit, Ames, IA 50010 0070, USA
    Clin Diagn Lab Immunol 11:849-55. 2004
    ..Of the 12 antigens tested, the most immunodominant protein was MPB83; however, a highly sensitive serodiagnostic test will likely require use of multiple antigens...
  27. ncbi Novel monoclonal antibodies against major antigens of Mycobacterium bovis
    K P Lyashchenko
    Chembio Diagnostic Systems, Inc, New York, USA
    Scand J Immunol 53:498-502. 2001
    ..Ten MoAbs were generated by immunizing mice with fractions derived from a whole cell sonic extract of M. bovis. These antibodies reacted preferentially with the surface exposed MPB83 lipoglycoprotein...
  28. ncbi Identification of Mycobacterium bovis antigens by analysis of bovine T-cell responses after infection with a virulent strain
    A Alito
    Institute of Biotechnology, CICVyA-INTA, Castelar, Argentina
    Braz J Med Biol Res 36:1523-31. 2003
    ..These data show that protein fractions with high lymphoproliferative activity for bovine PBMC can be characterized and antigens which have been already described and new protein antigens can also be identified in these fractions...
  29. ncbi Use of mycobacterial peptides and recombinant proteins for the diagnosis of bovine tuberculosis in skin test-positive cattle
    B M Buddle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    Vet Rec 153:615-20. 2003
    ....
  30. ncbi Generation of antibodies to the signal peptide of the MPT83 lipoprotein of Mycobacterium tuberculosis
    M Harboe
    Institute of Immunology, The National Hospital, Oslo, Norway
    Scand J Immunol 55:82-7. 2002
    ....