K Zacharowski

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo
    Pascal Knuefermann
    Department for Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Sigmund Freud Strasse 25, 53125 Bonn, Germany
    Respir Res 8:72. 2007
  2. ncbi [New reflections on inflammation and coagulation]
    K Zacharowski
    Dept of Anaesthesia, BHI, Bristol Royal Infirmary, BS2 8HW, Bristol, United Kingdom
    Anaesthesist 56:482-4. 2007
  3. ncbi The effects of the fibrin-derived peptide Bbeta(15-42) in acute and chronic rodent models of myocardial ischemia-reperfusion
    Kai Zacharowski
    Molecular Cardioprotection and Inflammation Group, Department of Anesthesia, University Hospital of Dusseldorf, Dusseldorf, Germany
    Shock 27:631-7. 2007
  4. ncbi Inflammatory response and cardioprotection during open-heart surgery: the importance of anaesthetics
    M S Suleiman
    Bristol Heart Institute and Department of Anaesthesia, Faculty of Medicine and Dentistry, Bristol Royal Infirmary, University of Bristol, Bristol, UK
    Br J Pharmacol 153:21-33. 2008
  5. ncbi Role of protein kinase C-epsilon (PKCepsilon) in isoflurane-induced cardioprotection
    D Obal
    Department of Anesthesiology, University Hospital, Moorenstrasse 5, , Germany
    Br J Anaesth 94:166-73. 2005
  6. ncbi Biglycan is required for adaptive remodeling after myocardial infarction
    D Westermann
    Abteilung für Kardiologie und Pneumologie, Charité Universitätsklinikum Berlin, Campus Benjamin Franklin, Berlin, Germany
    Circulation 117:1269-76. 2008

Collaborators

  • Alexander Koch
  • M S Suleiman
  • M F Young
  • B Preckel
  • N C Weber
  • C Tschope
  • D Obal
  • D Westermann
  • Pascal Knuefermann
  • L Schaefer
  • H A Baba
  • C Jacoby
  • T Freudenberger
  • J Mersmann
  • S M Brand-Herrmann
  • C Petrik
  • B Levkau
  • S-M Brand-Herrmann
  • J W Fischer
  • O Lettau
  • H P Schultheiss
  • R Lullmann-Rauch
  • J Schrader
  • T Unger
  • A Melchior
  • Christian Grohe
  • Heidi Ehrentraut
  • Andreas Hoeft
  • Rainer Meyer
  • Georg Baumgarten
  • Markus Schwederski
  • Markus Velten
  • Jan Mersmann

Detail Information

Publications6

  1. ncbi CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo
    Pascal Knuefermann
    Department for Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Sigmund Freud Strasse 25, 53125 Bonn, Germany
    Respir Res 8:72. 2007
    ..Therefore, the hypothesis was tested whether CpG-ODN administration induces an inflammatory response in the lung via TLR9 in vivo...
  2. ncbi [New reflections on inflammation and coagulation]
    K Zacharowski
    Dept of Anaesthesia, BHI, Bristol Royal Infirmary, BS2 8HW, Bristol, United Kingdom
    Anaesthesist 56:482-4. 2007
    ..Great efforts are being undertaken worldwide to understand the regulation of inflammation in order to develop new drugs which can modulate the pathologic inflammation reaction...
  3. ncbi The effects of the fibrin-derived peptide Bbeta(15-42) in acute and chronic rodent models of myocardial ischemia-reperfusion
    Kai Zacharowski
    Molecular Cardioprotection and Inflammation Group, Department of Anesthesia, University Hospital of Dusseldorf, Dusseldorf, Germany
    Shock 27:631-7. 2007
    ..In rodents, Bbeta(15-42) inhibits proinflammatory cytokine release and is cardioprotective during ischemia-reperfusion injury...
  4. ncbi Inflammatory response and cardioprotection during open-heart surgery: the importance of anaesthetics
    M S Suleiman
    Bristol Heart Institute and Department of Anaesthesia, Faculty of Medicine and Dentistry, Bristol Royal Infirmary, University of Bristol, Bristol, UK
    Br J Pharmacol 153:21-33. 2008
    ..This review describes the main mediators of myocardial injury during open heart surgery, explores available evidence of anaesthetics induced cardioprotection and addresses the efforts made to translate bench work into clinical practice...
  5. ncbi Role of protein kinase C-epsilon (PKCepsilon) in isoflurane-induced cardioprotection
    D Obal
    Department of Anesthesiology, University Hospital, Moorenstrasse 5, , Germany
    Br J Anaesth 94:166-73. 2005
    ..0 or 1.75 MAC. CONCLUSIONS: Although isoflurane preconditioning resulted in a reduction in infarct size at all concentrations used, the protection was mediated by phosphorylation and translocation of PKCepsilon only at 0.4 MAC...
  6. ncbi Biglycan is required for adaptive remodeling after myocardial infarction
    D Westermann
    Abteilung für Kardiologie und Pneumologie, Charité Universitätsklinikum Berlin, Campus Benjamin Franklin, Berlin, Germany
    Circulation 117:1269-76. 2008
    ..The present study investigates the role of the small leucine-rich proteoglycan biglycan during cardiac extracellular matrix remodeling and cardiac hemodynamics after MI...