Research Topics
Genomes and Genes | David R WithersSummaryAffiliation: University of Birmingham Country: UK Publications
| Collaborators
|
Detail Information
Publications
The role of lymphoid tissue inducer cells in splenic white pulp developmentDavid R Withers
MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK
Eur J Immunol 37:3240-5. 2007..Our studies indicate that a combination of LT signals from LTi cells and LT-independent signals from lymphocytes is sufficient for expression of podoplanin and CCL21 on splenic T cell zone stroma and subsequent T cell organisation...- Developmentally programmed expression of AID in chicken B cellsDavid R Withers
Immunology and Pathology Division, Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
Dev Comp Immunol 29:651-62. 2005..Expression was also detected at earlier stages, implying either that expression of AID is not the only controlling factor for gene conversion, or that gene conversion can precede the formation of bursal follicles... - The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signalsDavid R Withers
Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom
J Immunol 183:5079-84. 2009..Collectively, these data demonstrate that signals through CD30 and OX40 are required for the survival of CD4(+) T cells within the small intestine lamina propria... - NK cells protect secondary lymphoid tissue from cytomegalovirus via a CD30-dependent mechanismVasileios Bekiaris
Medical Research Council Centre for Immune Regulation, School of Medicine, University of Birmingham, Birmingham, UK
Eur J Immunol 39:2800-8. 2009..Our data define the necessity of NK cells for protection of secondary lymphoid organs and describe a mechanism by which this protection is conferred... - Splenic stromal cells mediate IL-7 independent adult lymphoid tissue inducer cell survivalTie Zheng Hou
School of Immunity and Infection, MRC Centre for Immune Regulation, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
Eur J Immunol 40:359-65. 2010..Our findings show that adult LTi-like cells require extrinsic signals from podoplanin(+) splenic stromal cells to survive and suggest that IL-7 is not necessary to mediate their survival in the adult spleen... - Synergistic OX40 and CD30 signals sustain CD8+ T cells during antigenic challengeVasileios Bekiaris
Medical Research Council Centre for Immune Regulation, Birmingham Medical School, University of Birmingham, Birmingham, UK
Eur J Immunol 39:2120-5. 2009.... - Critical synergy of CD30 and OX40 signals in CD4 T cell homeostasis and Th1 immunity to SalmonellaFabrina Gaspal
Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
J Immunol 180:2824-9. 2008..Finally, Salmonella and lymphopenia are shown to act synergistically in selectively depleting CD4 T cells deficient in OX40 and CD30. Collectively these findings identify a novel mechanism by which Th1 responses are sustained... - OX40 and CD30 signals in CD4(+) T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4(+) T-cell memory but not effector functionDavid R Withers
MRC Centre for Immune Regulation, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Immunol Rev 244:134-48. 2011.... - Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organizationStephanie H Glanville
MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK
Eur J Immunol 39:280-9. 2009..The model described here demonstrates a method of transferring whole splenic microenvironments and dissecting the stromal and hematopoietic signals involved in spleen development and organization... - Lymphoid tissue inducer cells: innate cells critical for CD4+ T cell memory responses?Peter J L Lane
MRC Centre for Immune Regulation, College of Medical and Dental Sciences, University of Birmingham, UK
Ann N Y Acad Sci 1247:1-15. 2012.... - Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adultNatalie A Roberts
MRC Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, UK
Eur J Immunol 39:2395-402. 2009..Collectively, our data argue against a temporal window of thymocyte crosstalk, and instead demonstrates continued receptiveness of thymic epithelium for the formation of functionally competent thymic microenvironments... - Rank Signaling Links the Development of Invariant ?? T Cell Progenitors and Aire(+) Medullary EpitheliumNatalie A Roberts
MRC Centre for Immune Regulation, University of Birmingham, Birmingham, B15 2TT, UK
Immunity 36:427-37. 2012.... - Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular inputAndrea J White
MRC Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham Medical School, Birmingham, UK
Eur J Immunol 38:942-7. 2008.... - Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liverYe H Oo
Centre for Liver Research, Institute of Biomedical Research, The University of Birmingham Medical School, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
J Immunol 184:2886-98. 2010..Thus, different chemokine receptors play distinct roles in the recruitment and positioning of T(regs) at sites of hepatitis in chronic liver disease...