Research Topics
Species | Steve J WinderSummaryAffiliation: University of Sheffield Country: UK Publications
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Detail Information
Publications
Filopodia formation and Disabled degradation downstream of ReelinSteven J Winder
Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
Biochem J 384:e1-2. 2004....- SCP1 encodes an actin-bundling protein in yeastSteven J Winder
Institute of Biomedical and Life Sciences, Davidson Building, University of Glasgow, Glasgow G12 8QQ, UK
Biochem J 375:287-95. 2003..Our data support a role for Scp1p in bundling actin filaments and, in concert with Sac6p, acting as a second actin-bundling activity crucial to the stability of the yeast actin cytoskeleton... - Dystroglycan versatility in cell adhesion: a tale of multiple motifsChris J Moore
Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK
Cell Commun Signal 8:3. 2010..Thus dystroglycan presents as a multifunctional scaffold involved in adhesion and adhesion-mediated signalling with its functions under exquisite spatio-temporal regulation... - Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycanOliver Thompson
Departments of Biomedical Science, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
J Cell Sci 123:118-27. 2010..For the first time, we also demonstrate unequivocally that beta-dystroglycan is a resident of focal adhesions... - The WASP homologue Las17 activates the novel actin-regulatory activity of Ysc84 to promote endocytosis in yeastAlastair S Robertson
Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom
Mol Biol Cell 20:1618-28. 2009.... - Direct interaction of beta-dystroglycan with F-actinYun-Ju Chen
Institute of Biomedical and Life Sciences, Davidson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
Biochem J 375:329-37. 2003.... - Interactions between the yeast SM22 homologue Scp1 and actin demonstrate the importance of actin bundling in endocytosisDana M Gheorghe
Departments of Molecular Biology and Biotechnology, Biomedical Science, University of Sheffield, Sheffield, S10 2TN, United Kingdom
J Biol Chem 283:15037-46. 2008..Additionally, we observe a dramatic increase in patch lifetime in a strain lacking both sac6 and scp1, demonstrating the central role played by actin-bundling proteins in the endocytic process... - A role for the actin cytoskeleton in cell death and aging in yeastCampbell W Gourlay
Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
J Cell Biol 164:803-9. 2004..Homology between Scp1p and mammalian SM22/transgelin, which itself has been isolated in senescence screens, suggests a conserved mechanism linking aging to actin stability... - Recruitment of Dbl by ezrin and dystroglycan drives membrane proximal Cdc42 activation and filopodia formationClare L Batchelor
Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, UK
Cell Cycle 6:353-63. 2007..Depletion of dystroglycan inhibited Cdc42-induced filopodia formation. For the first time we also demonstrate co-localization of Cdc42 and dystroglycan at the tips of dynamic filopodia... - Two billion years of actin. Meeting on cytoskeletal dynamics: from cell biology to developmental diseaseKathryn R Ayscough
Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
EMBO Rep 5:947-52. 2004 - Dystroglycan, Tks5 and Src mediated assembly of podosomes in myoblastsOliver Thompson
Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, UK
PLoS ONE 3:e3638. 2008..Less is known of the role of dystroglycan in more fundamental aspects of cell adhesion in other cell types, nor of its role in myoblast cell adhesion... - Structural insights into actin-binding, branching and bundling proteinsSteven J Winder
Institute of Biomedical and Life Sciences, Cell Biology Group, Davidson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
Curr Opin Cell Biol 15:14-22. 2003.... - Depletion of the actin bundling protein SM22/transgelin increases actin dynamics and enhances the tumourigenic phenotypes of cellsOliver Thompson
Department of Biomedical Science, University of Sheffield, Sheffield, UK
BMC Cell Biol 13:1. 2012..In this study we aimed to determine whether reducing levels of SM22 could actively contribute to a tumourigenic phenotype... - Loss of dystroglycan function in oesophageal cancerCharlotte Parberry-Clark
Department of Biomedical Science Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK
Histopathology 59:180-7. 2011..Dystroglycan and E-cadherin are cell adhesion molecules, the loss of which is often related to tumour differentiation, aggressiveness and invasiveness. The aim was therefore to evaluate their roles in oesophageal carcinogenesis... - Actin-binding proteinsSteven J Winder
Department of Biomedical Sciences, University of Sheffield, Sheffield, S10 2TN, UK
J Cell Sci 118:651-4. 2005 - Towards a complete atomic structure of spectrin family proteinsMichael J F Broderick
Institute of Biomedical and Life Sciences, Glasgow Cell Biology Group, University of Glasgow, Scotland, United Kingdom
J Struct Biol 137:184-93. 2002..High-resolution structures, coupled with lower resolution methods to determine the overall molecular shape of these proteins, allow us for the first time to build complete atomic structures of the spectrin family of proteins... - The WW domain: linking cell signalling to the membrane cytoskeletonJane L Ilsley
IBLS, Glasgow Cell Biology Group, Division of Biochemistry and Molecular Biology, University of Glasgow, G12 8QQ, Glasgow, UK
Cell Signal 14:183-9. 2002.... - Phenotypic responses to mechanical stress in fibroblasts from tendon, cornea and skinJennifer R Mackley
Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
Biochem J 396:307-16. 2006..These findings provide the first in-depth analysis of phenotypic differences between fibroblast cells from different tissue sources and reveal the responses of these cells to mechanical stress... - Functional plasticity of CH domainsMario Gimona
Department of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg, Austria
FEBS Lett 513:98-106. 2002.... - Solution structure of the calponin CH domain and fitting to the 3D-helical reconstruction of F-actin:calponinJanice Bramham
Department of Biochemistry, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, United Kingdom
Structure 10:249-58. 2002..We thus provide a structural insight into the mode of interaction between F-actin and CH domain-containing proteins... - Muscular dystrophies, the cytoskeleton and cell adhesionHeather J Spence
Institute of Biological and Life Sciences, Glasgow Cell Biology Group, Scotland
Bioessays 24:542-52. 2002..This review will consider recent advances in our understanding of the molecules involved and bring together data that suggest a role for the cytoskeleton and cell adhesion in muscular dystrophies... - Dystroglycan, a scaffold for the ERK-MAP kinase cascadeHeather J Spence
The Beatson Institute for Cancer Research, CRUK Beatson Laboratories, Switchback Road, Glasgow G61 1BD, UK
EMBO Rep 5:484-9. 2004..These findings have important implications for our understanding of the role of dystroglycan in normal cellular processes and in disease states such as muscular dystrophy...