D H Williams

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Ligand binding energy and catalytic efficiency from improved packing within receptors and enzymes
    Dudley H Williams
    Department of Chemistry, University of Cambridge, UK
    J Mol Biol 329:389-99. 2003
  2. ncbi Importance of structural tightening, as opposed to partially bound States, in the determination of chemical shift changes at noncovalently bonded interfaces
    Dudley H Williams
    Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK
    J Am Chem Soc 126:14267-72. 2004
  3. ncbi Enzyme catalysis from improved packing in their transition-state structures
    Dudley H Williams
    Department of Chemistry, Lensfield Rd, Cambridge, CB2 1EW, UK
    Curr Opin Chem Biol 14:666-70. 2010
  4. ncbi Ligand binding energy and enzyme efficiency from reductions in protein dynamics
    Dudley H Williams
    Department of Chemistry, Lensfield Road, Cambridge CB2 1EW, UK
    J Mol Biol 355:760-7. 2006
  5. ncbi Understanding noncovalent interactions: ligand binding energy and catalytic efficiency from ligand-induced reductions in motion within receptors and enzymes
    Dudley H Williams
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Angew Chem Int Ed Engl 43:6596-616. 2004
  6. ncbi Order changes within receptor systems upon ligand binding: receptor tightening/oligomerisation and the interpretation of binding parameters
    Dudley H Williams
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    J Mol Biol 340:373-83. 2004
  7. ncbi Noncovalent interactions: defining cooperativity. Ligand binding aided by reduced dynamic behavior of receptors. Binding of bacterial cell wall analogues to ristocetin A
    Dudley H Williams
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    J Am Chem Soc 126:2042-9. 2004
  8. ncbi Kinetic barriers and ordering of non-covalently bound states
    Simon W O'Brien
    Cambridge Centre for Molecular Recognition, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW
    Org Biomol Chem 1:472-7. 2003
  9. ncbi An analysis of the origins of a cooperative binding energy of dimerization
    D H Williams
    Cambridge Centre for Molecular Recognition, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Science 280:711-4. 1998
  10. ncbi An enthalpic component in cooperativity: the relationship between enthalpy, entropy, and noncovalent structure in weak associations
    C T Calderone
    Cambridge Centre for Molecular Recognition, University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
    J Am Chem Soc 123:6262-7. 2001

Collaborators

Detail Information

Publications23

  1. ncbi Ligand binding energy and catalytic efficiency from improved packing within receptors and enzymes
    Dudley H Williams
    Department of Chemistry, University of Cambridge, UK
    J Mol Biol 329:389-99. 2003
    ..It applies to the binding of O(2) to haemoglobin, which indeed occurs with a hitherto unreported loosening of the amide backbones of the haemoglobin monomers...
  2. ncbi Importance of structural tightening, as opposed to partially bound States, in the determination of chemical shift changes at noncovalently bonded interfaces
    Dudley H Williams
    Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK
    J Am Chem Soc 126:14267-72. 2004
    ..Model B accounts for the process of positively cooperative binding, in which noncovalent bonds are reduced in length and thereby increase the stability of the organized state...
  3. ncbi Enzyme catalysis from improved packing in their transition-state structures
    Dudley H Williams
    Department of Chemistry, Lensfield Rd, Cambridge, CB2 1EW, UK
    Curr Opin Chem Biol 14:666-70. 2010
    ..This binding is negatively cooperative in the usage stemming from Monod and co-workers...
  4. ncbi Ligand binding energy and enzyme efficiency from reductions in protein dynamics
    Dudley H Williams
    Department of Chemistry, Lensfield Road, Cambridge CB2 1EW, UK
    J Mol Biol 355:760-7. 2006
    ..Evidence is provided that comparable fractions of the binding energy of other ligands, and of the catalytic efficiency of enzymes, may be derived in the same way...
  5. ncbi Understanding noncovalent interactions: ligand binding energy and catalytic efficiency from ligand-induced reductions in motion within receptors and enzymes
    Dudley H Williams
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Angew Chem Int Ed Engl 43:6596-616. 2004
    ..Negative cooperativity induces converse effects: less efficient packing, a cost in enthalpy, and a benefit in entropy...
  6. ncbi Order changes within receptor systems upon ligand binding: receptor tightening/oligomerisation and the interpretation of binding parameters
    Dudley H Williams
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    J Mol Biol 340:373-83. 2004
    ..Here, we argue that analysis of the DeltaH and DeltaS of ligand binding may give useful information on ligand-induced changes in membrane-bound receptor oligomers, relevant to the differing effects of agonists and antagonists...
  7. ncbi Noncovalent interactions: defining cooperativity. Ligand binding aided by reduced dynamic behavior of receptors. Binding of bacterial cell wall analogues to ristocetin A
    Dudley H Williams
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    J Am Chem Soc 126:2042-9. 2004
    ..The conclusions are relevant to the binding of ligands to proteins, where ligand binding energy can be derived from stabilization of the protein in its ligand-bound form...
  8. ncbi Kinetic barriers and ordering of non-covalently bound states
    Simon W O'Brien
    Cambridge Centre for Molecular Recognition, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW
    Org Biomol Chem 1:472-7. 2003
    ..The effect should be found in general where cooperativity is exercised within an organised template (e.g., DNA duplexes and proteins)...
  9. ncbi An analysis of the origins of a cooperative binding energy of dimerization
    D H Williams
    Cambridge Centre for Molecular Recognition, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Science 280:711-4. 1998
    ..These results illustrate how, when a protein has a loose structure, the binding energy of another molecule to the protein can derive in part from changes occurring within the protein...
  10. ncbi An enthalpic component in cooperativity: the relationship between enthalpy, entropy, and noncovalent structure in weak associations
    C T Calderone
    Cambridge Centre for Molecular Recognition, University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
    J Am Chem Soc 123:6262-7. 2001
    ..Finally, we extend these results to rationalize thermodynamic observations in unrelated systems...
  11. ncbi Contributions to the catalytic efficiency of enzymes, and the binding of ligands to receptors, from improvements in packing within enzymes and receptors
    Dudley H Williams
    Department of Chemistry, University of Cambridge, England
    Methods Enzymol 380:3-19. 2004
  12. ncbi The formation of heterodimers by vancomycin group antibiotics
    T Staroske
    Dominic Cambridge Centre for Molecular Recognition, University Chemical Laboratory, Cambridge, UK
    Chemistry 6:504-9. 2000
    ..Structural information on the heterodimer interface of some of the heterodimers is obtained by using two-dimensional NMR techniques and reveals that these heterodimers are similar in structure to the homodimers...
  13. ncbi Surface plasmon resonance analysis at a supported lipid monolayer
    M A Cooper
    Department of Chemistry, Cambridge Centre for Molecular Recognition, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Biochim Biophys Acta 1373:101-11. 1998
    ..Conditions for the formation of lipid monolayers have been optimised with respect to lipid type, chemical and buffer compatibility, ligand stability and reproducibility...
  14. ncbi Cooperative binding interactions of glycopeptide antibiotics
    Hideyuki Shiozawa
    Cambridge Center for Molecular Recognition, Department of Chemistry, Lensfield Road, Cambridge CB2 1EW, United Kingdom
    J Am Chem Soc 124:3914-9. 2002
    ....
  15. ncbi A limitation of two-state analysis for transitions between disordered and weakly ordered states
    D H Williams
    Cambridge Centre for Molecular Recognition, Department of Chemistry, UK
    Chem Biol 4:507-12. 1997
    ..The accuracy of this method, however, has not yet been determined...
  16. ncbi Fragmentation characteristics of neutral N-linked glycans using a MALDI-TOF/TOF tandem mass spectrometer
    Elaine Stephens
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
    Anal Chem 76:2343-54. 2004
    ..Importantly, the cross-ring fragments reveal linkage information, unambiguously define antennae substitutions, and differentiate isomeric glycoforms...
  17. ncbi The N-linked oligosaccharides of aminopeptidase N from Manduca sexta: site localization and identification of novel N-glycan structures
    Elaine Stephens
    Department of Chemistry, University of Cambridge, UK
    Eur J Biochem 271:4241-58. 2004
    ..The paucimannosidic N-glycan (Man(3)GlcNAc(2)), commonly found on other insect glycoproteins, is the predominant oligosaccharide found at the remaining N-glycosylation site (Asn609)...
  18. ncbi Kinetic analysis of antibody-antigen interactions at a supported lipid monolayer
    M A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
    Anal Biochem 276:36-47. 1999
    ..The affinities determined by Scatchard analysis of equilibrium binding levels were similar to those values obtained from an ELISA...
  19. ncbi Recent kinase and kinase inhibitor X-ray structures: mechanisms of inhibition and selectivity insights
    M Cherry
    Structure Based Discovery, Millennium Pharmaceuticals Research and Development Ltd, Granta Park, Great Abington, Cambridge, CB1 6ET, UK
    Curr Med Chem 11:663-73. 2004
    ..The belief that an inactive kinase presents a less conserved target is reviewed using observations on the structural changes occurring during protein kinase regulation...
  20. ncbi Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp
    S J Duncan
    Contribution from the Cambridge Centre for Molecular Recognition, University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK
    J Am Chem Soc 123:554-60. 2001
    ..The discovery and structure determination of a fungal metabolite, chlorofusin, which antagonizes the p53/MDM2 interaction are reported...
  21. ncbi Analysis of the in vivo phosphorylation state of rabbit skeletal muscle glycogen synthase by fast-atom-bombardment mass spectrometry
    L Poulter
    Department of Chemistry, University of Cambridge
    Eur J Biochem 175:497-510. 1988
    ..Residue N3, a major site phosphorylated by casein kinase-I in vitro is not phosphorylated in vivo. This and other evidence indicates that casein kinase-I is not a glycogen synthase kinase in vivo...
  22. ncbi A vesicle capture sensor chip for kinetic analysis of interactions with membrane-bound receptors
    M A Cooper
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
    Anal Biochem 277:196-205. 2000
    ..No binding of the bacterial endotoxin Cry1A(c) to captured vesicles containing its cell surface receptor could be demonstrated...
  23. ncbi Mechanism of the regulation of type IB phosphoinositide 3OH-kinase byG-protein betagamma subunits
    Sonja Krugmann
    Signalling Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, U.K
    Biochem J 362:725-31. 2002
    ..We conclude that Gbetagammas activate type IB PI3K by a mechanism other than translocation to the plasma membrane...