Research Topics
Genomes and GenesSpecies | Bill WicksteadSummaryAffiliation: University of Oxford Country: UK Publications
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Publications
The evolution of the cytoskeletonBill Wickstead
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
J Cell Biol 194:513-25. 2011..Much of this complexity evolved before the last common ancestor of eukaryotes. The distribution of cytoskeletal filaments puts constraints on the likely prokaryotic line that made this leap of eukaryogenesis...- A "holistic" kinesin phylogeny reveals new kinesin families and predicts protein functionsBill Wickstead
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
Mol Biol Cell 17:1734-43. 2006..Finally, we present a set of hidden Markov models that can reliably place most new kinesin sequences into families, even when from an organism at a great evolutionary distance from those in the analysis... - Patterns of kinesin evolution reveal a complex ancestral eukaryote with a multifunctional cytoskeletonBill Wickstead
University of Oxford, UK
BMC Evol Biol 10:110. 2010..Here, we have used the kinesin motor repertoire of 45 extant eukaryotes to infer the ancestral state of this superfamily in the last common eukaryotic ancestor (LCEA)... - Dyneins across eukaryotes: a comparative genomic analysisBill Wickstead
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
Traffic 8:1708-21. 2007..One diatom species builds motile axonemes without any inner-arm dyneins (IAD), and the unexpected conservation of IAD I1 in non-flagellate algae and LC8 (DYNLL1/2) in all lineages reveals a surprising fluidity to dynein function... - The expanded Kinesin-13 repertoire of trypanosomes contains only one mitotic Kinesin indicating multiple extra-nuclear rolesBill Wickstead
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
PLoS ONE 5:e15020. 2010.... - Bioinformatic insights to the ESAG5 and GRESAG5 gene families in kinetoplastid parasitesAmy R Barker
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Mol Biochem Parasitol 162:112-22. 2008..Together, these results provide insights into the structure and evolution of an important extended gene family, and present a number of testable hypotheses which will aid in elucidating the function of ESAG5... - Basal body and flagellum mutants reveal a rotational constraint of the central pair microtubules in the axonemes of trypanosomesCatarina Gadelha
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
J Cell Sci 119:2405-13. 2006..This demonstrated that orientation is independent of flagellum attachment and beating, but is influenced by constraints along its length and is entirely dependent on correct positioning at the basal plate... - Flagellar and ciliary beating in trypanosome motilityCatarina Gadelha
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
Cell Motil Cytoskeleton 64:629-43. 2007.... - The small chromosomes of Trypanosoma brucei involved in antigenic variation are constructed around repetitive palindromesBill Wickstead
Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, United Kingdom
Genome Res 14:1014-24. 2004..Moreover, palindromy appears to be a feature of (peri)centromeres in other species that can be easily overlooked. We propose that sequence inversion is one of the higher-order sequence motifs that confer chromosomal stability... - Ab initio identification of novel regulatory elements in the genome of Trypanosoma brucei by Bayesian inference on sequence segmentationSteven Kelly
Department of Plant Sciences, University of Oxford, Oxford, United Kingdom
PLoS ONE 6:e25666. 2011..These genomes, though outwardly simple in organisation and gene content, have historically challenged many theories for gene expression regulation in eukaryotes... - Cryptic paraflagellar rod in endosymbiont-containing kinetoplastid protozoaCatarina Gadelha
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
Eukaryot Cell 4:516-25. 2005..Moreover, although PFR proteins have been conserved in evolution, primary sequence differences contribute to particular PFR morphotypes characteristic of different kinetoplastid species... - Reconstructing the evolutionary history of the centriole from protein componentsMatthew E Hodges
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
J Cell Sci 123:1407-13. 2010..Finally, we demonstrate a correlation between the presence of specific centriolar proteins and eye evolution. This correlation is used to predict proteins with functions in the development of ciliary, but not rhabdomeric, eyes... - Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene lociSteven Kelly
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Mol Biochem Parasitol 154:103-9. 2007 - Cell biology of the trypanosome genomeJan Peter Daniels
University of Oxford, Oxford, United Kingdom
Microbiol Mol Biol Rev 74:552-69. 2010..We also compare this nuclear organization to those in other systems in order to shed light on the evolution of nuclear architecture in eukaryotes... - Identification of a crenarchaeal orthologue of Elf1: implications for chromatin and transcription in ArchaeaJan Peter Daniels
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
Biol Direct 4:24. 2009..Our discovery has implications for the relationship of chromatin and transcription in Archaea and the evolution of these processes in eukaryotes... - The mitotic stability of the minichromosomes of Trypanosoma bruceiBill Wickstead
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK
Mol Biochem Parasitol 132:97-100. 2003 - Conservation of ciliary proteins in plants with no ciliaMatthew E Hodges
Department of Plant Sciences, University of Oxford, South Parks Rd, Oxford OX1 3RB, UK
BMC Plant Biol 11:185. 2011..During these evolutionary losses, proteins with ancestral ciliary functions may be lost or co-opted into different functions... - Molecular evolution of FtsZ protein sequences encoded within the genomes of archaea, bacteria, and eukaryotaSue Vaughan
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
J Mol Evol 58:19-29. 2004..In addition, we identify "FtsZ-like" sequences from Bacteria and Archaea that, while showing significant sequence similarity to FtsZs, are unlikely to bind and hydrolyze GTP... - The Trypanosomatid-Specific N Terminus of RPA2 Is Required for RNA Polymerase I Assembly, Localization, and FunctionJan Peter Daniels
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
Eukaryot Cell 11:662-72. 2012.... - Repetitive elements in genomes of parasitic protozoaBill Wickstead
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
Microbiol Mol Biol Rev 67:360-75, table of contents. 2003..The story which emerges is one of opportunism and upheaval which have been employed to add genetic diversity and genomic flexibility... - Identification and characterization of two trypanosome TFIIS proteins exhibiting particular domain architectures and differential nuclear localizationsPierrick Uzureau
Laboratoire de Parasitologie Moleculaire, ULB IBMM, rue des Pr Jeneer et Brachet 12, B 6041 Gosselies, Belgium
Mol Microbiol 69:1121-36. 2008..Repetitive failure to generate a double knockout of TbTFIIS1 and TbTFIIS2-1 strongly suggests synthetical lethality and thus an essential function shared by the two proteins in trypanosome growth... - More than one way to build a flagellum: comparative genomics of parasitic protozoaLaura J Briggs
Curr Biol 14:R611-2. 2004 - The genome of the African trypanosome Trypanosoma bruceiMatthew Berriman
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Science 309:416-22. 2005..brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified... - The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas diseaseNajib M El-Sayed
Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, USA
Science 309:409-15. 2005.... - Isolation of the repertoire of VSG expression site containing telomeres of Trypanosoma brucei 427 using transformation-associated recombination in yeastMarion Becker
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Genome Res 14:2319-29. 2004..This cloning strategy could be used for any T. brucei strain, facilitating research on the biodiversity of telomeric gene families and host-pathogen interactions...